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공명현상과 파워도플러를 이용한 유방조직 팬텀의 미세 석회화 병변 진단
김정구,하명진,Kim, Jeong-Koo,Ha, Myeung-Jin 한국음향학회 2008 韓國音響學會誌 Vol.27 No.2
유방초음파 검사는 유방암 검사에 있어 유방촬영술에 비하여 많은 장점이 있으나, 미세석회화 발견에는 적합하지 않은 단점이 있다. 이에 유방초음파 검사에서 기존의 7.5 MHz 선형 탐촉자를 사용하여 파워도플러와 매질의 공명현상을 이용한 유방조직 석회화 병변을 관측할 수 있는 방법을 연구하였다. 먼저 gelatin을 이용하여 유방조직 팬텀을 제작하였으며, 외부 진동을 변화시켜 가며 석회화 병변을 관측하였다. 유방조직 팬텀 안에 주입된 석회화는 주변 조직과 다른 공명을 일으키면서 외부진동에 따라 음향공명의 정도가 파워도플러의 ROI 영역 내의 색상의 밝기와 영역의 차이로 나타내었다. 낮은 주파수 영역에는 음향공명이 거의 나타나지 않았으며, 약 $300{\sim}600\;Hz$ 사이에서 일정한 플래토우 영역을 나타내었으며, 이후 주파수가 증가함에 따라 색상이 사라짐을 확인하였다. Breast ultrasound has many advantages over mammography but suffers from a shortcoming of being not suitable in detecting microcalcification. We studied on a method based on acoustic resonance and power Doppler to detect calcification of breast tissue using a typical 7.5 MHz linear probe used in breast ultrasound examination. We first constructed a breast tissue phantom made of gelatin and then observed calcified legions as external vibrations varied. Calcification injected to the breast tissue phantom being resonated different from the surrounding medium, and its acoustic resonance driven by external vibrations was visualized by differences for color brightness and area in ROI of power doppler. In low frequency regions, the acoustic resonance almost not appeared and showed a plateau in $300{\sim}600\;Hz$ and the color vanished as the frequency further increased.
LiDAR 센서 기반 연석 추출과 DGPS 기반 매핑을 통한차량의 자율 주행에 대한 연구
김정구,김진욱,김진형,고윤호,정슬 제어·로봇·시스템학회 2019 제어·로봇·시스템학회 논문지 Vol.25 No.2
This article presents a study on seeking possible drive paths for an autonomous automobile by a curb extraction algorithm using LiDAR sensor mounted on a car. For an autonomous driving car on the road, the car can be localized through road markers such as curbs by a DGPS and a LiDAR sensor. The detection of road boundary plays an important role to determine the possible paths on the road that guarantee the safety of the vehicle. A sensor fusion technique among DGPS and a LiDAR sensor should be applied for an autonomous driving system. The LiDAR sensor is used for extracting curbs on the road. Possible drive-ways for the vehicle are found by extracting curbs on the road with the help of a DGPS sensor for the global map. Experimental studies of using the test vehicle are successfully conducted.
김정구,김훈,서창석,최영민,문신용,지병철 대한의학회 2009 Journal of Korean medical science Vol.24 No.3
We investigated the association between single nucleotide polymorphisms (SNPs) in the frizzled (FZD) genes in the Wnt signal pathway and circulating osteoprotegerin (OPG), soluble receptor activator of NF-κB ligand (sRANKL) levels, bone turnover markers, and bone mineral density (BMD) in postmenopausal women. The SNPs in the FZD1, FZD5, FZD6, FZD7, and FZD9 genes were analyzed by direct sequencing in 371 postmenopausal Korean women. Levels of serum OPG, sRANKL, osteocalcin, C-telopeptide of type I collagen, calcium, parathyroid hormone and calcitonin, and BMD at the lumbar spine and femoral neck were measured. The SNPs in the FZD1, FZD5, FZD7, and FZD9 genes, and in exon 2 of the FZD6 gene were not observed. No significant differences in the adjusted BMD of lumbar spine and femoral neck and serum levels of OPG, sRANKL, and bone markers were noted among the single or haplotype genotypes of the L345M and E664A SNPs in the FZD6 gene and the distributions of these single or haplotype genotypes were not different according to the bone mass status. In conclusion, the polymorphisms of the FZD genes are not associated with BMD of the lumbar spine and femoral neck, bone turnover markers, or circulating OPG-sRANKL in Korean women
폐경 후 여성에서의 혈청 인슐린 유사 성장인자 결합 단백질들의 분포 양상과 골 밀도와의 연관성에 관한 연구
김정구,최영민,문신용,이진용 대한폐경학회 1996 대한폐경학회지 Vol.2 No.2
The objective of this study was to evaluate the relationship between serum insulin-like growth factor-binding proteins (IGFBPs) profiles and bone mineral density (BMD) measurements and biochemical makers of bone tumover in postmenopausal women. Sera from 37 normal healthy postmenopausal women and 14 postmenopausal women with osteoporosis were analyzed for IGFBPs and osteocalcin by western ligand blotting and radioimmunoassay, respectively. BMD measurements were performed by dual energy X-ray absorptiometry(DEXA). Urinary calcium and creatinine excretion were also determined. The data were analyzed statistically by analysis of variance and the least squares method. Serum IGFBP-2 ratio(IGFBP-2 intensity/total IGFBPs intensity) in postmenopausal women with osteoporosis was significantly higher(p$lt;0.02) than that in normai healthy postmenopausal women, but serum IGFBP-3 ratio(IGFBP-3 intensity/total IGFBPs intensity) in women with osteoporosis was significantly lower (p$lt;0.01). Serum IGFBP-2 ratio correlated negatively with BMD of lumbar spine(p$lt;0.0001 ), femoral neck(p$lt;0.05), trochanter(p$lt;0.01) and Ward's triangle(p$lt;0.05) but there was a significant positive correlation between serum IGFBP-3 ratio and BMD of lumbar spine(p$lt;0.001) and trochanter(p$lt;0.05). No corrdations between serum IGFBPs levels or serum IGFBPs ratios and biochemical markers of bone tumover were noted. Our data indicate that the measurement of serum IGFBP profiles might be useful in identifying postmenopausal women at risk for osteoporosis.