http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
허혈성 급성신부전에서 TGF-β-induced gene product βig-h3의 변화와 초기 표지자로서의 의의
최민정 ( Min Jeong Choi ),박선희 ( Sun Hee Park ),김찬덕 ( Chan Duck Kim ),김용림 ( Yong Lim Kim ),권태환 ( Tae Hwan Kwon ),김인산 ( In San Kim ),김용진 ( Yong Jin Kim ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.3
Purpose : Acute renal failure remains a potentially devastating clinical problem. This study aimed to examine whether the expression of TGF-β-induced gene product, βig-h3, is altered in ischemiareperfusion (I/R) injury and urinary excretion of βig-h3 is changed in I/R injury. Methods : I/R injury was performed by clamping both renal arteries. Daily urine output, serum creatinine and urinary TGF-β and βig-h3 were measured after I/R injury. Also, the renal expression of βig-h3 by western blotting and immunohistochemistry were investigated. In the second step, urinary βig-h3 was measured at 4, 10, 16, and 24 hours after I/R injury to investigate whether it could be used as an early and sensitive marker for detecting I/R injury. Results : Urinary βig-h3 was significantly elevated at 24 hours and maintained higher than the controls until 2 days after I/R injury. In contrast, western blotting did not reveal any changes of βig-h3 expression. Immunohistochemistry showed that labeling of βig-h3 was seen at the basement membranes of proximal tubule cells mainly located at the medullary ray (S3 segment) in both groups. Following I/injury, the labeling was also seen in the basement membrane of injured or regenerated proximal tubular epithelial cells. Within 24 hours, urinary βig-h3 was significantly increased at 4 hours after I/R injury. Importantly, the urinary appearance of βig-h3 preceded that of N-acetyl-β-D-glucosaminidase. Conclusion : These results suggest that endogenous renal βig-h3 may serve to promote tissue regeneration in I/R injury and urinary βig-h3 could be used as an early and sensitive marker demonstrating I/R injury.
흰쥐의 간섬유화 과정에서의 교원질의 다형성 및 양적 변동
조준승,류현모,은선진,김인산 ( Joon Seung Jo,Hyun Mo Ryoo,Sun Jin Eun,In San Kim ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.4
Macromolecular collagen components in rat liver at different stage of fibrosis induced by common bile duct ligation were studied. Animals were killed on the 3rd, 7th, 14th, 21st and 29th day after bile duct ligation and liver specimens and blood samples were obtained. Hepatic collagen was fractionated into neutral salt soluble, acid soluble, pepsin soluble and insoluble fractions, and hydroxyproline content of each fraction was determined. The collagen content, especially in insoluble fraction, was increased as the duration of biliary obstruction increased. Pepsin solubilized collagens were subjected to determination of the collagen types by SDS-polyacrylamide disc gel electrophoresis. The ratio of type I to type III collagen was decreased gradually with progression of fibrosis. These results indicate that an alteration in tissue collagen polymorphism as well as variations in the collagen solubility accompany the fibrotic process, suggesting possible pathogenetic implication.
Collagen Dynamics and Polymorphism in Rat Liver During Fibrogenesis
조준승,류현모,은선진,김인산,Jo, Joon-Seung,Ryoo, Hyun-Mo,Eun, Sun-Jin,Kim, In-San Korean Society for Biochemistry and Molecular Biol 1991 한국생화학회지 Vol.24 No.4
Macromolecular collagen components in rat liver at different stage of fibrosis induced by common bile duct ligation were studied. Animals were killed on the 3rd, 7th, 14th, 21st and 29th day after bile duct ligation and liver specimens and blood samples were obtained. Hepatic collagen was fractionated into neutral salt soluble, acid soluble, pepsin soluble and insoluble fractions, and hydroxyproline content of each fraction was determined. The collagen content, especially in insoluble fraction, was increased as the duration of biliary obstruction increased. Pepsin solubilized collagens were subjected to determination of the collagen types by SDS-polyacrylamide disc gel electrophoresis. The ratio of type I to type III collagen was decreased gradually with progression of fibrosis. These results indicate that an alteration in tissue collagen polymorphism as well as variations in the collagen solubility accompany the fibrotic process, suggesting possible pathogenetic implication. 백서의 총담관을 결찰하여 간섬유화를 유발하고, 그 진행에 따른 간조직내 교원질의 양적 및 질적 변화를 조사하였다. 실험동물의 총담관을 결찰하고 각각 3,7,14,21 그리고 28일째 되는 날에 얻은 간조직과 혈액을 시료로 사용하였다. 간조직내 교원질을 neutral soluble, acid soluble, pepsin soluble 그리고 insoluble fraction으로 분획채취 하였으며, 각 분획의 hydroxyproline 함량으로 교원질을 측정하였다. 담관폐쇄 이후 간기능의 저하가 나타났고, 기간이 길어짐에 따라 간경화의 척도인 간장과 비장의 종대 및 복수의 생성을 관찰하였다. 또한 담관 폐쇄기간이 길수록 간조직의 교원질 함량은 증가하였으며, 특히 insoluble fraction의 증가가 주를 이루었다. Pepsin soluble fraction을 SDS-PAGE한 결과, type I에 대한 type III 교원질의 상대적 비율이 정상조직의 20%에서 4주군에서는 45%까지 증가하였다. 이러한 결과는 섬유화가 진행됨에 따라 교원질의 양적인 변화 뿐 아니라 용해도의 변화 혹은 결합조직을 형성하는 교원질 구성의 변화 등 질적인 변화가 발생함을 보여주고 있으며, 섬유화의 발생기작과 관계가 있을 것으로 볼 수 있다.
점프와 관련된 순발력 테스트 종목간의 신뢰성에 관한 연구
권태원(Kwon Tae-Won),최영철(Choi Young-Choel),김인산(Kim In-San) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.4
The purpose of the study is to gain the tests of reliability among the Power Tests related to Jump Power Tests. For this study, The subjects were the students who has involved in this study were thirty male students who majored in physical education and thirty female students who majored in physical education, and thirty male students and thirty female students who majored in non physical education as all one hundred twenty students in H university where is located in Ansan, Gyunggido. 1. The results on the male students who majored in physical education The level of significance which is followed by Pearson correlation has not showed between the Standing Long Jump and Standing Backward Jump In addition to, the standard Error of Measurements for reliability showed 14.452 for the standing long jump on the standing backward jump and showed 13.731 for standing backward jump on the standing long jump. It means that the range of reliability between two tests would not be adapted the results caused probably by standing backward jump. Therefore, The subjects need to be considered by more corrected methods for standing backward jump. 2. The results on the female students who majored in physical education The level of significance which is followed by Pearson correlation has showed between the Standing Long Jump and Standing Backward Jump above the students in comparison with male