http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
CoMFA 법을 이용한 3-아릴이소퀴놀린 화합물들의 SK-OV-3 암세포에 대한 가상의 약물 작용 수용체 해석
김의기,민선영,정병호,천승훈,최보길,조원제 전남대학교 약품개발연구소 2002 약품개발연구지 Vol.11 No.-
We have performed a 3D-QSAR/ CoMFA analysis of the cytotoxiv activities of thirty-five 3-arylisoquinoline derivative against SK-OV-3 tumor cell line. The results suggested that the electrostatic, steric and hydrophobic factors of 3-arylisoquinoline were strongly correlated with the antitumor activity. Considerable predictive ability (cross-validated r2 as high as 0.841) was obtained through CoMFA.
김의한(Eui Han Kim),강훈(Hoon Kang),조상현(Sang Hyun Cho),박영민(Young Min Park) 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.3
Solar urticaria is a rare disorder in which immediate erythema and wheals are induced by ultraviolet or visible irradiation. This condition usually occurs in the third and fifth decades of life and is very rare in childhood. A 3-year-old girl presented with a history of an erythematous rash which had occurred on the face and neck, immediately after exposure to sunlight for one month. A diagnosis of solar urtiacria was made on the clinical reviews and phototest. Other photosensitive disorders could be excluded by the clinical and laboratory findings. She was treated with ketotifen and sun protection showing good early results.
김의한,김대중,강상균,양승하,홍기언 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
In order to observe the expression of bcl-2 and p53 protein in the 29 cases of invasive ductal carcinomas and to evaluate the correlationship between the two results, the author has carried out immunohistochemical staining with mononuclear antibodies against bcl-2 and p53. The results are obtained as follows: 1. bc1-2 showed positive reaction in normal duct, lobule and hyperplastic epithelium, and p53 showed no reaction in the same tissue. 2. In 15 cases of well differentiated type, the bc1-2 was positive in 14 cases (93%), and the p53 was positive only in 4 cases (26%). In 6 poorly differentiated type, the bcl-2 was positive in 2 cases (33%), and the p53 was positive in 3 cases (50%). The relationship between the bcl-2 and the p53 showed that in well differentiated type, bcl-2(+)/p53(-) expression was most commonly observed, while the bcl-2(-)/p53(+) expression was not seen in well differentiated type. 3. The size of tumor appeared to have no direct relationship to bcl-2 and p53 positive rate. 4. The expression of bcl-2 and p53 in intraductal carcinoma portion showed that when intraductal tumor component was positive, the invasive portion tumor cell was also positive. However the bcl-2 positive tumor cells in some intraductal component apeared to be negative in p53. Above findings showed that the bcl-2 protein was more frequently expressed in low grade lesion and the p53 protein was in high grade lesion. Also bcl-2 and p53 positive or negative findings showed different results in the same tumor cells.
위선암에서 Compylobacter Pylori의 발견율
김의한,최득린,정태은 순천향대학교 1993 논문집 Vol.16 No.2
A close relationship between Campylobactor Pylori and gastric disease was reemphasized by many authors. Campylobactor was mainly observed in the antrum of the gastric mucosa, and considered as a cause of gastric ulcer following to gastritis or intestinal metaplasia. This study was carried out to observe the incidence of C.Pylori in the gastric carcinoma diagnosed by endoscopic biopsy. The following results were obtained. 1. Campylobactor pylori was identified in 61 cases(68.5%) of gastric carcinoma among 89 cases of gastric carcinoma. 2. C.Pylori was identified in 35 cases of carcinoma with intestinal metaplasia and 26 cases of that without intestinal metaplasia, indicating no difference between two groups. 3. C.Pylori was equally identified in well differentiated, moderately differentiated and poorly differentiated carcinoma. 4. C.Pylori was more frequently identified in carcinoma of antrum and pylori than that of body. The above result indicate that C.pylori may play a part of roll for the carcinogenesis of the gastric carcinoma following gastritis intestinal metaplasia and gastric ulcer