거대세포바이러스 감염에 의한 소장폐색

나양원(Yang Won Nah),서재희(Jae-Hee Suh),김성숙(Sung Sook Kim),김도하(Do Ha Kim),박능화(Neung Hwa Park),조홍래(Hong Rae Cho),최대화(Dae Hwa Choi),고병균(Byung Kyun Ko),남창우(Chang Woo Nam),김규열(Gyu Yeol Kim),박건춘(Kun Choon Park) 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.62 No.6

시대별 아파트 평면계획에 관한 연구

김양원(Kim, Yang-Won),김기수(Kim, Gi-Soo) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.2

신기능 강재를 활용한 합리화 강교량의 최신동향

김양원(Yang Won Kim) 한국강구조학회 2001 韓國鋼構造學會誌 Vol.13 No.1

대전역사 공간구성특성 및 이용자평가에 관한 연구

김양원(Kim, Yang-Won),김기수(Kim, Gi-Soo) 대한건축학회 2018 대한건축학회 학술발표대회 논문집 Vol.38 No.1

With the economic growth of our country, railway transportation has been established and the railway station has been newly constructed and reconstructed actively. In the meantime, railway transportation has dealt with passenger and cargo transportation. However, as the number of express train passengers increases, passenger handling services are increased, and in order to build a railway station, A customer satisfaction survey was conducted to make the data. The station to be surveyed was selected as Daejeon Station on the express train. Passenger and station staff using Daejeon station were analyzed for the satisfaction of Daejeon station space configuration, passenger facilities and passenger traffic.

멀티콥터 풍동시험 모델 및 장치 개발

김양원(Kim Yang Won),조태환(Tae Hwang Cho) 한국항공우주학회 2017 한국항공우주학회 학술발표회 논문집 Vol.2017 No.11

공동주택 층간소음 저감을 위한 일체화공법에 관한 연구

김양원(Kim, Yang-Won),김기수(Kim, Gi Soo) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.1

The social problems caused by the floor noise in the apartment complex are at a serious level, and the floor noise dispute lawsuits are increasing rapidly every year. So we defined the legal standard of floor noise, and compared the existing sound insulation structure of apartment house and the integration method of aero con"c which is applied to it. As a result of the study, it was found that it is impossible to solve the problems caused by the construction of the existing flooring type sound insulation panel. In order to overcome this problem, it is necessary to apply the method which can integrate the sound insulation material and slabs with liquid-type sound insulation performance.

상행 결장에 발생한 양성 신경초종 1예

민양원 ( Yang Won Min ),김영호 ( Young Ho Kim ),윤환식 ( Hwan Sic Yun ),길재숙 ( Jae Sook Kil ),김영찬 ( Young Chan Kim ),윤성현 ( Seong Hyeon Yun ),김경미 ( Kyoung Mee Kim ),김재준 ( Jae J Kim ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.6

Schwannomas are rare tumors derived from the cells of Schwann which form the neural sheath. Some patients with gastrointestinal schwannoma have been previously reported in the literature. However, schwannomas of the colon are extremely rare. We herein describe a case of schwannoma of the colon. A 49-year-old woman was admitted with complaint of abdominal pain and investigations revealed the presence of a 4 cm sized mass in the ascending colon. Following right hemicolectomy, histopathology and immunohistochemistry confirmed the colonic lesion to be a benign schwannoma. There was no evidence of specific complication or recurrence until now. (Korean J Gastroenterol 2007;50:398-401)

사람의 복막중피세포에서 Interleukin-1β 자극에 의한 Fibronectin 생성의 세포내 신호전달에 있어 Atypical Protein Kinase C의 역할

양원석 ( Yang Won Seog ),김병식 ( Kim Byeong Sig ),김순배 ( Kim Sun Bae ),박수길 ( Park Su Gil ),박정식 ( Park Jeong Sig ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.4

배 경 : Protein kinase C (PKC)에는 diacylglycerol (DAG)에 의해 활성화되는 conventional type (PKC-α, -βⅠ, -βⅡ, -γ )과 novel type (PKC-δ, -ε, -θ, -η)외에 DAG에 의해 활성화되지 않는 atypical type (PKC-ζ, -ι)이 있다. Glucose 자극에 의한 fibronectin 생성 과정에 관여하는 PKC isoenzyme은 DAG에 의해 활성화되는 PKC로 알려져 있다. 본 실험에서는 사람의 복막중피세포에서 IL-1β자극에 의한 fibronectin 생성의 신호전달 과정에 PKC가 관여하는 지와 그 isoenzyme에 대해 알아보고자 하였다. 방 법 : Fibronectin mRNA양은 northern blot assay로 측정하였고, 세포내 phosphorylated PKC ζ/ι 단백질 양은 western blot으로 비교하였다. 결 과 : 복막중피세포를 PKC억제제인 calphostin C (500, 750, 1000 nM)로 전처치 한 다음 IL-1β (1 ng/mL)로 자극하였을 때 fibronectin mRNA 발현은 calphostin C 용량에 비례하여 억제되었다. 다른 PKC억제제인 GF109203X (1, 5, 10 μM)도 IL-1β 자극에 의한 fibronectin mRNA 발현을 용량에 비례하여 억제시켰다. 반면에, conventional 및 novel PKC 자극제인 phorbol 12-myristate 13-acetate (PMA)는 fibronectin mRNA 발현을 증가시켰다. PMA를 72시간 작용시켜 PKC를 소모시킨 상태에서 PMA를 다시 투여해도 fibronectin mRNA 발현이 자극되지 않는 반면, IL-1β(1 ng/mL)는 fibronectin mRNA 발현을 자극하였다. Myristoylated PKC ζ/ι pseudosubstrate (5, 10, 15, 20 μM)는 IL-1β자극에 의한 fibronectin mRNA 발현을 용량에 비례하여 억제시켰고, 20 μM에서는 IL-1β자극에 의한 fibronectin mRNA 발현을 완전히 억제하였다. 대조군으로 투여한 myristoylated PKC [19-27] pseudosubstrate (20 μM)는 IL-1β자극에 의한 fibronectin mRNA 발현에 영향을 주지 않았다. IL-1β 자극에 의해 PKC ζ/ι가 활성화되는 지를 보기 위해 시행한 western blot에서는 IL-1β자극에 의해 PKC ζ/ι의 활성화된 형태인 phosphorylated PKC ζ/ι가 증가하였다. 결 론 : 이상의 결과는 복막중피세포에서 IL-1β에 의한 fibronectin 생성이 atypical PKC인 PKC ζ/ι 활성화를 통해 일어남을 시사한다. Background : Protein kinase C (PKC)s consist of three groups of isoenzyme; conventional, novel and atypical PKCs. Diacylglycerol (DAG) activates both conventional and novel PKCs, but not atypical PKCs. High glucose-induced fibronection production was shown to be mediated by activation of DAG-sensitive PKCs. In this study, we investigated whether PKC mediates IL-1β-induced fibronectin mRNA expression, and the subtypes of PKC involved in the process. Methods : Fibronection mRNA level and phosphorylated PKC ζ/ι in total cell lysate were measured by Northern blot and Western blot, respectively. Results : Pretreatment of HPMCs with calphostin C, a pan-PKC inhibitor, at doses of 500, 750 and 1,000 nM caused dose-dependent inhibition of IL-1β (1 ng.mL)-induced fibronection mRNA level. GF109203X, another pan-PKC inhibitor, at doses of 1, 5 and 10 ㎛ also downregulated IL-1β (1 ng/mL)-induced fibornectin mRNA level in a dose-de-pendent manner. Phorbol 12-myristate 13-acetate(PMA), an activator of conventional and novel PKCs, stimulated fibornectin mRNA level at doses of 1, 10 and 100nM. After prolonged treatment of the cells for 72 hr with PMA, another dose of PMA did not increase fibronectin mRNA level, while IL-1β (1 ng/mL) still stimulated it. Pretreatment of the cells with 5, 10, 15 and 20 ㎛ of myristoylated PKC ζ/ι pseudosubstrate inhibited IL-1β (1 ng/mL)-in-duced fibronectin mRNA level in a dose-dependent manner, while 20 ㎛ of myristoylated PKC [19-27] pseudosubstrate, given as a control, had no effect. Stimulation of fibronectin mRNA level by IL-1β (1 ng/mL) was completely prevented by 20 ㎛of myristoylated PKC ζ/ιpseudosubstrate. IL-1β (1 ng/mL) increased phosphorylated PKC ζ/ι, an active form of the enzyme. Conclusion : IL-1β-induced fibronectin production in HPMCs occurs by way of activation of atypical PKCs (PKC ζ/ι). (Korean J Nephrol 2003;22(4):340-348)

山菜의 成分에 關한 硏究

김용두(Kim Young-Doo),양원모(Yang Won-Mo) 한국식품영양과학회 1986 한국식품영양과학회지 Vol.15 No.4

우리 나라에서 일반적으로 채취 이용되고 있는 13가지의 山菜에 대한 영양가 조성을 평가하기 위하여 실험을 수행하였는데 수분함량은 다른 채소류보다 약간 낮았으며, 조단백질은 모두 2% 이상으로서 배추, 무우, 시금치, 당근 등의 채소보다 높았고, 조회분도 같은 경향이었다. 조지방, 조섬유는 종류간 큰 차이가 없었으며, 더덕의 조섬유는 다른 山菜에 비해 3배 정도 높았다.<br/> 무기성분 중 K의 함량은 山菜間에 비슷하였으나 더덕만은 매우 낮았고 Ca와 P는 산채의 종류에 따라 심한 차이를 보였다. Mg은 가죽 4.3㎎%, 원추리 1.92㎎%, 잔대뿌리 4.13㎎%, 두릅 7.68㎎%, 고사리 8.99㎎%였고, 그 이외에는 16㎎% 내외로서 비슷하였다.<br/> 총 아미노산 함량은 두릅; 3072.4㎎%>더덕; 2709.4㎎%>고사리, 가죽, 창출, 우산나물; 2350㎎%내외>곤달비, 머위, 잔대잎, 엉겅퀴, 옥잠; 1400㎎%내외>원추리, 참취, 잔대뿌리; 600㎎%내외 순이었으며, 일반적으로 Asp와 Glu가 가장 많아 총 아미노산 함량의 46%를 차지하였으며, 더덕은 Arg가 가장 많았는데 다른 山菜의 Arg에 비해 6배 정도가 높았다.<br/> 가죽, 옥잠, 창출의 Vitamin C 함량은 각각 45.9㎎%, 36.8㎎%, 30.2㎎%로서 비교적 높았고 배당체 함량은 곤달비, 더덕이 각각 4.1%, 3.5%로서 가장 높았으나, 머위와 고사리가 다음으로서 2.2%, 2.0%로 나타났고 이들 배당체는 山菜의 쓴맛에 관여하고 있는 것으로 생각되었다. To evaluate the nutritive value, 13 Wild vegetables which commonly used for side dish were analyzed.<br/> Their Moisture are lower than that of other vegetables. Crude Protein content of these Wild vegetables is more than 2%, which is higher than that of other vegetables and these tendencies were also shown in the content of Crude Ash. The content of Crude Fat and of Crude Fiber are similar in the Wild vegetables, but Crude Fiber of C. lanceolata TRAUTV is three times higher than that of other Wild vegetables. In all Wild vegetables, the K content of Mineral is similar, but that of C. lanceolata TRAUTV is very low. The content of Ca and P are quite different among Wild vegetables. The content of Mg is also similar each other, about 16㎎%, but that of P.agwilinum var. latiusculum UNDERW, A. elata SEEM, A.altissima SWINGLE, root of A. triphylla (Thunb.)A. DC., H. Thunbergii BAK. is 8.99, 7.68, 4.30, 4.13 and 1.92㎎% respectively.<br/> Total Amino acids were contained in order of A.elata; 3072.4㎎%>C.lanceolata TRAUTV; 2709.4㎎%>P.agwilinum var. latiusculum UNDERW, A. altissima SWINGLE, A. Japonica KOIDZ, S.palmata MAX. ; about 2350㎎%>L.Jaluensis KOM., P.Caponicus MAX., leaf of A. triphylla(Thunb.)A.DC., C. Japonicum var. ussuriense, H. plantaginea ASCHERS; about 1400 ㎎%>H. Thunbergii BAK., A. scaber THUNB, root of A. triphylla(Thunb.) A. DC. ; about 600 ㎎%. Asp.A.A. and Glu.A.A. content, 46% of Total A.A. is higher than other Amino acids and the content of Arg. A.A. in C.lanceolata TRAUTV which is higher than that of other Amino acids is 6 times highly than that of other Wild vegetables.<br/> A. altissima SWINGLE, H. plantaginea ASCHERS, A. Japonica KOIDZ contain Vitamin C a little avobe, 45.9㎎%, 36.8㎎%, 30.2㎎% respectively.<br/> Glucoside content of L. Jaluensis KOM., C.lanceolata TRAUTV which are 4.1%, 3.5%, were highest of all and that of P.Caponicus MAX., P.agwilinum var. latiusculum UNDERW, 2.2%, 2.0% is in the second, which seems to be the cause of bitter taste.

체외순환이 보체활성화화 백혈구의 폐내 정체에 미치는 영향에 관한 연구

김양원,최석철,조광현,Kim, Yang-Won,Choe, Seok-Cheol,Jo, Gwang-Hyeon 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.7

From December 1993 to April 1994, to investigate complement activation and pulmonary leukostasis, thirty adult patients were studied during cardiopulmonary bypass[CPB for cardiac surgery in Department of Cardiovascular & Thoracic Surgery, Pusan Paik Hospital, Inje University. Total patients were divided into group I and II according to the purpose of study ; Group I was 15 patients undergoing CPB with bubble oxygenator, Group II was 15 patients undergoing CPB with membrane oxygenator. The results of study were summarized as follows.1. The decrease of C3 and C4 levels were observed within few minutes of beginning of CPB in all patients[P<0.05 , and this decrease was proved to be due to complement activation, not by the influence of hemodilution.2. In the correlation between the change of C3 and C4, group I showed linear correlation each other suggesting complement activation occurred through the classical pathway, group II showed a correlation at only partial sampling times suggesting complement activation via both classical and alternative pathway, however there was no significant statistical difference at the change of C3 and C4 concentrations in two groups[P>0.05 .3. After switching to partial CPB, a few difference between right atrial and left atrial WBC count was observed, but statistically not significant and median cell count difference between group I and II was not significant, too [P>0.05 . With the above result, we concluded that CPB itself contributes to the activation of complement system, but bubble oxygenator does not activate always complement system more than membrane oxygenator.