[지상 명강의] 시위를 떠난 화살에는 미련을 두지 마라

김수녕 샘터사 2009 월간 샘터 Vol.473 No.-

한국인 침윤성 자궁경부암환자에 있어서의 HLA-A, -B 및 -C 항원 분포에 관한 연구

김수녕,박찬규 연세대학교 대학원 1985 延世論叢 Vol.21 No.5

Abstract It huts been suggested that HLA-linked genes may influence the development of malignant tumors or serve as a genetic tumor marker for come malignant tumors, be the studs of the association between HLA and malignant tumors may make possible more ideal therapeutic approaches to these tumors understanding of their genetic ·causes, and enable more accurate diagnosis. In the present studs, it baa been attempted to survey the assocation of HLA-A, B and -C antigens in Korean patients with invasive carcinoma of the cervix. HLA-A, -B and -C antigen typing was performed on 53 Korean patients with invasive carcinoma of the cervix, and the HLA-A and -B antigen frequencies of patients were compared with 214 healthy controls while the HLA-C antigen frequencies of patients were compared with 72 healthy controls. No statistically significant differences in the frequencies of the HLA-A, -B and -C antigens were observes. However, one of the patients had HLA-Bw21 antigen, which was not found in the controls. Although this data from 53 patients with invasive carcinoma of the cervix is insufficient to give significant conclusions, if the immune response gene is a predisposing factor toward resistance or susceptibility against invasive carcinoma of the cervix, that gene is not strongly associated with any HLA-A, -B or -C antigens.

대한산부인과학회지 게재논문에서 사용된 통계분석 방법에 대한 고찰

김수녕,이철민,최영민,오성택,김재원 대한산부인과학회 2007 대한산부인과학회 학술대회 Vol.93 No.-

근치적 자궁절제술 후 Hemovac 배액술의 효과 및 말단부 세균 배양의 효용성

김수녕,이정필,김진영,박찬규,권혜경,정재은,강성은 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.9

골반임파절 절제술 및 대동맥방임파절 절제술을 포함한 부인암 수술의 주요 합병증으로는 누공, 임파낭종, 골반강내 혈종, 창상감염 및 발열로 인한 사망들을 들 수 있으며 이를 감소시키기 위해 도관을 이용한 배액술, 적절한 항생제의 투여, 수혈, 수술기법 및 마취기술의 개발 등에 대한 연구들이 있어 왔으며 최근에는 수술 기법의 발전 및 적절한 예방적 항생제의 투여가 가장 중요한 요인으로 강조되어 지고 있으며 적절한 항생제 투여시 골반강내 도관 삽입에 의한 배액술의 효과에 대해서는 아직 많은 연구가 필요하며 이에 저자들은 본 연구를 통하여 다음과 같은 결론을 얻었다. 1. Hemovac 제거시 말단부의 균 배양 검사 결과 균의 동정이 관찰되지 않는 경우가 76예(75.5%) 나타났고, Staphycococcus coagulase negetive가 17예(17.0%), Enero coccus faecalis가 4예(3.9%) Pseudomonas 1예(0.9%), Xa nthomonas maltophilia 1예(0.9%), Candida albicans 1예 (0.9%) Klebsiella pneumonia 1예(0.9%)가 각각 동정되었 으며 Staphylococcus coagulase negative균의 동정은 inci dental contamination의 결과라고 여겨지며 합병증의 발생 유무는 Staphylococcus coagulase negative 균의 동정유무 에 따른 두 군간의 유의한 차이는 보이지 않았다. 2. 양측골반임파절 절제술을 포함한 부인암 수술 후 Hemovac suction drain을 삽입하였던 환자 중 합병증이 나타난 예는 총 37예(42.%)였으며, 방광무력증 19예 (17.0%), 창상열개 12예(10.6%), 요로감염 5예(4.5%), 급 성담마진 3예(2.7%),심한 설사 2예(1.8%), 도관삽입부의 감염 1예(0.9%), 호흡곤란 1예(0.9%) 도관삽입부로의 암 전이 1예(0.9%), 외래 추적 관찰중 임파낭종이 발견된 경 우가 3예(2.7%)였다. 대부분의 합병증은 보존적 치료로 호전되었으며 임파낭종 중 1예는 경피적 흡입술을 시행 하였다. 이들 합병증을 균이 자라지 않은 군과 균이 자란 군으로 구분하여 볼 때 각군에 유의한 차이는 없었다 (P=0.0731). 그러므로 부인암 수술 후 적절한 항생제를 투여하는 경우 Hemovac 제거시 말단부의 균배양 검사는 불필요한 것으로 사료된다. In preantibiotic era, pelvic drains had been utilized to decrease the postoperative complications such as febrile morbidity, fistula and lymphocyst formation, wound dehiscence due to pelvic infection. Nowadays, prophylactic antibiotics, transfusion, improved surgical technique and proper anesthesic management are being done for the prevention of postoperative complicatons. In Severance hospital hemovac drains was introduced in the early 1980`s and has been used since then. The purpose of this study was to evaluate the effectiveness of Hemovac tip culture study after radical hysterectomy with pelvic lymphadenectomy by reviewing 102 patients who took radical hysterectomy with pelvic and paraaortic lymphadenectomy at Severance hospital from March 1990 to December 1994. All of those patients had Hemovac drains inserted. Postoperative complications are compared according to the Hemovac tip culture results, and the significance of the tip culture will be studied. The postoperative complications were found as the following: Bladder atony that needed rehabilitation department consultation in 19 cases (17%), wound dehiscence in 12 cases (10.6%), urinary tract infection in 5 cases (4.5%), hemovac insertion site infection in 1 case (0.9%), lymphocyst formation in 3 cases (2.7%), cancer metastasis to hemovac insertion site in 1 case (0.9%). After the removal of hemovac drains, tip culture was routinely performed. In 76 cases (75.5%) no growth was noted, colonization of Staphylococcus coagulase negative growth in 17 cases (17.0%), Enterococcus faecalis growth in 4 cases (3.9%), Pseudomonas growth in 1 case (0.9%), Xanthomonas maltophilia growth in 1 case (0.9%), Candida albicans growth in 1 case (0.9%) and Klebsiella pneumonia growth in 1 case (0.9%). No statistical correlation could be found between the hemovac tip culture positive group and the incidence of ostoperative complication. Therefore as a conclusion, hemovac tip cultures are not mandatory for the purpose of postoperative complication surveillance if proper antibiotics coverage is done after surgery.

LG전자 중국지역 생산법인에 대한 위험 색출훈련에 대한 교육에 즈음하여

김수녕,Kim, Su-Nyeong 대한산업안전협회 2000 안전기술 Vol.30 No.-

자궁경부암에서 PCR기법을 이용한 Human Papillomavirus DNA 검출

김수녕 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

The polymerase chain reaction(PCR) was used to analyze human papillomavirus(HPV) DNA sequences to determine if HPV type 16 or 18 has clinical significance in 18 cases of invasive cervical cancer and 20 controls. Of 18 cases of invasive cervical cancer, 94.4% were HPV 16 positive, and none was HPV 18 positive. Thirty-four percent of controls were HPV 16 positive. HPV 18 was not detected in controls. Age, clinical stage, histologic cell type, lesion size were not related to HPV type. The mean age of HPV 16 group was 46 years, compared to 41 years for the control group. Of 16 squamous carcinomas, HPV 16 was detected in 16 cases. Of 2 adenocarcinomas, HPV 16 was detected in 1 case. Of 11 cervical cancer with lesion < 4㎝, HPV 16 DNA was detected in 9 cases, HPV 16 was detected in 7 cases among 7 cervical cancer with lesion ≥ 4㎝.

부인암 환자 Data Base Management System (DBMS)

김수녕 대한산부인과학회 1990 대한산부인과학회 학술대회 Vol.66 No.-

악성 배세포 난소종양의 임상적 연구

김수녕,최동희,박찬규 대한산부인과학회 1987 대한산부인과학회 학술대회 Vol.60 No.-

자궁경부종양에서 Proliferating Cell Nuclear Antigen(PCNA)을 이용한 세포증식능에 관한 연구

김수녕,박찬규,송건창,김호곤 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.2

Proliferating cell nuclear antigen (FCNA) is a nuclear protein that is syntheaimd in late Gl and S phases of cell cycle and is correlated with the cell proliferative stale. The recent study demonstrated that FCNA functions in 13NA replication. The present study evaluated proliferetive indices (PI) for the assessment of tumor proliferation and for investigating prognostic significancx, in cervical tumors. lmmunohiatoehemical PCNA staining was perfurmed in formalin-fixed paraffin-embedded cervical tissues via the avidin-biotin-complex immunoperoxidase methad. Mean PI was 36.03+-5.14% in normaI controls, as compared to 66.19+-1l.36% in cerviml intraepithelial neoplasia. and 63.19+10.94% in invasive cervical cancer. Our results showed no significant correlation between Pll and histological type. Among invasive cervical cancer (24 cases), PI was 64.43 +-10.94% in squamoua cell carcinoma and 59.00+4.10% in adenocarcinoma. There was no eipiifiant relationship between Fl and clinical etage, and between PI and lesion size. This study suggeste that Pl may not serve as a new prognostie factor in cervical tumors.

포스타 : 종양학 ; 자궁경부 상피내종양의 선별검사로서 질확대경 검사의 임상적 의의

김수녕,박찬규 대한산부인과학회 1996 대한산부인과학회 학술대회 Vol.78 No.-