백서 주령에 따른 carboxyhemoglobin의 해리양상에 관한 실험적 연구

김선민,김헌,조수헌,Kim, Sun-Min,Kim, Heon,Cho, Soo-Hun 대한예방의학회 1991 예방의학회지 Vol.24 No.4

One, two, six and ten week old Sprague-Dawley rats were exposed to carbon monoxide at 3,700 ppm for 30 minutes, and carboxyhemoglobin was measured immediateley. 5, 30, 60, 90, 120 minutes after the exposure. In each time after the exposure, the means of the carboxyhemoglobin levels were compared among the week age groups. The regression analysis was done using the natural logarithm of the carboxyhemoglobin concentration as a dependent variable and the time after the exposure as an independent vaiable. From the regression equation, the half lives of the carboxyhemoglobin were calculated. The one week old rats showed significantly higher carboxyhemoglobin level than other week age rats in the entire time after the exposure. The corrected carboxyhemoglobin concentration calculated by subtracting the normal carboxyhemoglobin level from the measured carboxyhemoglobin at each age group, showed no uniform differences. 백서 주령이 일산화탄소(CO) 폭로후 carboxyhemoglobin (HbCO) 형성 및 해리에 미치는 영향을 관찰하기 위하여 주령 1주, 2주, 6주 및 10주의 Sprague-Dawley계 백서에 일산화탄소를 폭로시킨 후 HbCO를 측정하여 다음과 같은 결론을 얻었다. 1. CO에 급성으로 폭로된 후 형성되는 HbCO의 농도는 백서 주령에 따라 유의한 차이를 보였으며, 이는 1주군에서 현저히 높았고, 폭로후 120분이 경과되어도 다른 주령군에 비하여 유의하게 높았다. 2. CO에 폭로되지 않은 백서에서의 HbCO농도는 각 주령군마다 유의한 차이를 보였으며, 비폭로군에서 얻어진 주령별 평균 HbCO농도를 CO폭로후 얻어진 개개의 관측치에서 뺀 후 이를 비교한 결과 1.에서와 같은 차이를 보이지 않았다. 3. CO폭로후 경과시간과 HbCO 농도와의 관계를 알아보는 회귀분석에서 폭로후 경과시간은 HbCO농도에 유의한 영향을 미치며, HbCO가 해리되는 속도는 주령 1주군에서 유의하게 높았다.

창출(蒼朮) 에탄올 추출물이 비만세포 매개 염증반응에 미치는 영향

김선민,김경준,Kim, Sun-Min,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.1

Objective : Atractyloides Chinensis Rhizome (ACR) is widely used in oriental medicine as a remedy for an inflammation and an allergic disease. However, as yet there is no clear explanation of how ACR affects the production of inflammatory cytokine. This study was to determine the effects of ACR on the mast cell-mediated inflammatory responses. Method : The amount of inflammatory cytokine production induced by the phorbol myristate acetate (PMA) plus calcium ionophore(A23187) in the human mast cell line (HMC-1) incubated with various concentrations of ACR was measured. The TNF-${\alpha}$ protein levels were analysised by Western blots. The TNF-${\alpha}$, IL-6 and IL-8 secreted protein levels were measured by the ELISA assay. The TNF-${\alpha}$, IL-6 and IL-8 mRNA levels were measured by the RT-PCR analysis. NF-${\kappa}$B, phospho-I${\kappa}$B and MAPKs were examined by Western blot analysis. The NF-${\kappa}$B promoter activity was examined by a luciferase assay. Results : 1. The expressions of TNF-${\alpha}$ and TNF-${\alpha}$ mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$. 2. The expressions of IL-6 and IL-6 mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$. 3. The expressions of IL-8 and IL-8 mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$ specially. 4. The expressions of Phosphorylated-JNK were decreased, not p38, ERK 5. The expressions of NF-${\kappa}$B were decreased dose-dependently at 0.1-0.2mg/$m\ell$ of ACR. The expressions of Phosphorylated I${\kappa}$B were significantly decreased at 0.2mg/$m\ell$. In addition, ACR suppressed PMA plus A23187-induced NF-${\kappa}$B promoting activity. Conclusion : It is suggested that ACR should suppress through inhibition of NF-${\kappa}$B activity and cytokine production.

포중익기탕(補中益氣湯)이 알레르기 비염(鼻炎) 유발 마우스에 미치는 효과(效果)

김선민,심성용,변학성,김경준,Kim, Sun-Min,Sim, Sung-Youn,Byun, Hak-Sung,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objectives: Maier symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. When exposed to certain allergens, the IgE covered mast cells degranulate and release inflammatory mediators and cytokines which result in a local inflammatory reaction. In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of allergic rhinitis. This experimental study was done to reveal the effects of the Bojungikgi-tang on the allergic rhinitis. We have studied effect of mice on OVA-induced production of IL-4, IL-5, $INF-{\gamma}$ by murine splenocytes and effect of OVA-induced Total IgE and OVA-specific IgE Meterial and Metheds: 21 BALB/c rats were divided into three groups: normal group, control group, experimental group. To induce the allergic rhinitis in control group and experimental group, rats were sentitized intraperitioneally with 0.1% ovalbumin solution 3 times at intervals of 2 weeks. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin solution 3 times at intervals of 2 days for a week. After that time, rats in experimental group were oral administration treated by the Bojuogikgi-tang fer 28 days. We observed changes of IL-4, IL-5, $INF-{\gamma}$, Total IgE and OVA-specific IgE. We used independent-test statistically. Results: 1. In IL-4 study, Bojungikgi-tang treated group didn't show significant differences. 2. In IL-5 study, Bojungikgi-tang treated group shows significant differences. 3. In $INF-{\gamma}$ study, Bojungikgi-tang treated group shows significant differences. 4. In Total IgE, Bojungikgi-tang treated group shows significant differences. 5. In OVA-specific IgE, Bojungikgi-tang treated group didn't show significant differences. According to this result, Bojungikgi-tang was concluded to be effective on lowering the total IgE. Through this. Bojungikgi tang seems to reduce the symptoms of allergic rhinitis. More studies are required to know exact mechanism of Bojungikgi tang to show the anti allergenic effect.

양극산화법에 의한 TiO₂ 나노튜브 어레이의 제조와 성장거동

김선민,김기원,류광선,김유영,조권구,Kim, Seon-Min,Kim, Ki-Won,Ryu, Kwang-Sun,Kim, Yoo-Young,Cho, Kwon-Koo 한국분말야금학회 2011 한국분말재료학회지 (KPMI) Vol.18 No.1

Recently, $TiO_2$ nanotubes have considerably researched because of their novel application about photocatalysis, dye-sensitized solar cells (DSSCs), lithium ion battery, etc. In this work, self-standing $TiO_2$ nanotube arrays were fabricated by anodic oxidation method using pure Ti foil as a working electrode in ethylene glycole with 0.3M $NH_4F$ + $2%H_2O$. Growth behavior of $TiO_2$ nanotube arrays was compared according to temperature, voltage and time. The morphology, structure and crystalline of anodized $TiO_2$ nanotube arrays were observed by FE-SEM (field emission scanning electron microscope) and XRD (X-ray diffraction).

체감의이인탕(體感薏苡仁湯) 복용(服用)과 전침시술(電鍼施術)이 체지방(體脂肪) 감소(減少)에 미치는 효과(效果) (한방치료((韓方治療)의 부분비만(部分肥滿) 개선(改善) 효과(效果))

김선민,김길수,Kim, Sun-Min,Kim, Kil-Soo 한방비만학회 2002 한방비만학회지 Vol.2 No.1

Background & Methods: In order to study the effect of electro-lipolysis-acupuncture, 57 outpatients who have had herbal medication in Kirin Oriental Hospital were devided to two groups; acupuncture-treated group(46) vs non-acupuncture-treated group(11) Acupuncture-treated group was given electro-lipolysis-acupuncture at least two times a week and administered with herbal diet medication, whereas non-acupuncture-treated group was administered only with herbal diet medication. Results: Mean age, body weight and BMI of these two group at the start point of the treatment were $27.22({\pm}7.64)\;vs \;29.09({\pm}8.73),\;67.76({\pm}9.34)\;vs\;67.00({\pm}10.69),\;and\;26.20({\pm}3.02)\;vs\;26.14({\pm}4.10)$ in the order of acupuncture-treated and non-acupuncture groups. After one month of treatment, change rate of body weight, BMI, total fat, percentage of fat was significantly higher in acupuncture-treated group. Also the change rate of arm circumference, hip circumference and thigh circumference was significantly higher in acupuncture-treated group. The change rate of abdominal circumference and WHR of acupuncture-treated group was higher than that of non-acupuncture-treated group with no statistical significance. The circumference reduction rate according to herbal dieting program was higher in this order, abdomen, arms, chest, thighs and hips. On the other hand, chest circumference change rate over weight loss rate, which is the portion no acupuncture treatment was given to, and AMC change rate was higher in non-acupuncture-treated group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body fat, size reduction of localized obesity and preservation of muscle than herbal prescription only dieting program.

양극산화법에 의한 TiO₂ 나노튜브 어레이의 제조 및 광전기화학적 특성에 관한 연구

김선민,조권구,최영진,김기원,류광선,Kim, Seon-Min,Cho, Kwon-Koo,Choe, Yeong-Jin,Kim, Ki-Won,Ryu, Kwang-Sun 한국분말야금학회 2010 한국분말재료학회지 (KPMI) Vol.17 No.3

Self-standing $TiO_2$ nanotube arrays were fabricated by potentiostatic anodic oxidation method using pure Ti foil as a working electrode and ethylene glycol solution as electrolytes with small addition of $NH_4F$ and $H_2O$. The influences of anodization temperature and time on the morphology and formation of $TiO_2$ nanotube arrays were investigated. The fabricated $TiO_2$ nanotube arrays were applied as a photoelectrode to dye-sensitized solar cells. Regardless of anodizing temperature and time, the average diameter and wall thickness of $TiO_2$ nanotube show a similar value, whereas the thickness show a different trend with reaction temperature. The thickness of $TiO_2$ nanotube arrays anodized at $20^{\circ}C$ and $30^{\circ}C$ was time-dependent, but on the other hand its at $10^{\circ}C$ are independent of anodization time. The conversion efficiency is low, which is due to a morphology breaking of the $TiO_2$ nanotube arrays in manufacturing process of photoelectrode.

오픈신경망 포맷을 이용한 기계학습 모델 변환 및 추론

김선민,한병현,허준영,Kim, Seon-Min,Han, Byunghyun,Heo, Junyeong 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.3

최근 다양한 분야에 인공지능 기술이 도입되고, 학계 관심이 늘어남에 따라 다양한 기계학습 모델들이 여러 프레임워크에서 운용되고 있다. 하지만 이러한 프레임워크들은 서로 다른 데이터 포맷을 가지고 있어, 상호운용성이 부족하며 이를 극복하기 위해 오픈 신경망 교환 포맷인 ONNX가 제안되었다. 본 논문에서는 여러 기계학습 모델을 ONNX로 변환하는 방법을 설명하고, 통합된 ONNX 포맷에서 기계학습 기법을 판별할 수 있는 알고리즘 및 추론 시스템을 제안한다. 또한, ONNX 변환 전·후 모델의 추론 성능을 비교하여 ONNX 변환 간 학습 결과의 손실이나 성능 저하가 없음을 보인다. Recently artificial intelligence technology has been introduced in various fields and various machine learning models have been operated in various frameworks as academic interest has increased. However, these frameworks have different data formats, which lack interoperability, and to overcome this, the open neural network exchange format, ONNX, has been proposed. In this paper we describe how to transform multiple machine learning models to ONNX, and propose algorithms and inference systems that can determine machine learning techniques in an integrated ONNX format. Furthermore we compare the inference results of the models before and after the ONNX transformation, showing that there is no loss or performance degradation of the learning results between the ONNX transformation.

브로거 운동을 병행한 산전운동프로그램이 임산부의 허리 통증 및 균형에 미치는 영향 단일 사례 연구

김선민,장상훈,Kim, Sun Min,Jang, Sang Hun 대한물리치료과학회 2021 대한물리치료과학회지 Vol.28 No.1

Background: The purpose of this study was to effect of prenatal exercise program combined with Brugger's exercise on low back pain and balance in pregnant women. Design: A Single-Subject Study. Methods: This study was applied to 28 weeks of pregnant women who complained of low back pain for a total of 4 weeks. A total of 10 prenatal exercise programs in this study consists of sessions, and each session was applied with a Bruger exercise for 1 minute before the start. For the fatigue and safety of pregnant women, a break for 1 minute was provided for each session and was conducted under the supervision of the therapist The visual analogue scale (VAS), Oswestry disability index (ODI), and static balance (BT-4) were measured to evaluate the pregnant women's low back pain and balance ability before and after the intervention Results: The change in back pain after the intervention was VAS 5 before the intervention, but the VAS gradually decreased at 4 weeks after the intervention. Reduced to VAS 2 after 4 weeks of intervention. The Oswestry Disability Index (ODI) was 54%, which was at the level of severe disability, but the dysfunction index gradually decreased 4 weeks after intervention, reaching 19% in 4 weeks, and there were no problems with daily life. As for the static balance ability, the sway area and the sway distance values gradually decreased after the intervention in both the eyes open and closed state, showing an improvement in the static balance ability of pregnant women after the intervention than before the intervention. Conclusion: The prenatal exercise program combined with Brugger's exercise was effective to improve low back pain and static balance in pregnant women. The result of this study may helpful as basic data for obstetric physical therapy.

악관절 환자에서 Bite block을 이용한 역동적 자기공명 영상의 유용성

김선민,이평재,권영호,Kim Sun Min,Lee Pyeong Jae,Kwon Young Ho 대한방사선사협회 2004 대한방사선사협회지 Vol.30 No.1

Purpose : When wish to confirm form of purpose temporomandibularl joint negative plate and degree of displacement, application of own fairness reflex can supply much diagnostic data. Market wished to search usefulness of own fairness roller retroaction en

우리나리 보건복지 사업의 전망과 과제

김선민,Kim, Seon-Min 한국가톨릭의료협회 2002 한국가톨릭병원협회지 Vol.32 No.-