악성 흉수, 결핵성 흉수 및 부폐렴 삼출액과 농흉에서 Interferon-gamma, Interleukin-2 Receptor, Interleukin-6, Interleukin-10 농도의 비교

김명훈,김승준,박용근,김석찬,이숙영,김영균,김관형,문화식,송정섭,박성학,Kim, Myung-Hoon,Kim, Seung-Joon,Park, Yong-Keun,Kim, Seok-Chan,Lee, Sook-Young,Kim, Young-Kyoon,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Sung-Hak 대한결핵및호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.5

연구배경 : Cytokine은 주요한 염증 매개 물질로서 질환에 따라 다른 양상을 보일 수 있어, 흉수를 일으키는 다양한 원인 질환의 감별에 이용되어 왔다. 이 중에서 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 INF-${\gamma}$, IL-2R, IL-6, IL-1를 동사에 측정하여 비교한 연구는 많지 않아 본 연구를 시행하게 되었다. 방법 : 흉수를 주소로 내원한 환자 중에서 흉수 천자로 삼출액이 확인된 환자들을 대상으로 흉수를 채취하여, ELISA kit를 이용하여 INF-${\gamma}$, IL-2R, IL-6, IL-10 농도를 측정하였다. 결과 : 악성 흉수, 결핵성 흉수, 부폐렴 삼출액 및 농흉에서 흉수 내의 cytokine의 순서대로, INF-${\gamma}$는 $16.7{\pm}50$, $295.5{\pm}585.5$, $10.0{\pm}0$ pg/ml, IL-2R은 $3247.4{\pm}1713.3$, $7423.5{\pm}3752.8$, $3790.2{\pm}3201.1$ pg/ml, IL-6는 $600{\pm}12.8$, $556.4{\pm}161.7$, $514.4{\pm}224.8$ pg/ml, IL-10은 $28.2{\pm}55.5$, $11.3{\pm}11.7$, $98.4{\pm}141.7$ pg/ml로 각각 측정되어, 결핵성 흉수가 다른 원인의 흉수에 비해 IL-2R 농도가 의 있게 높았으며, IFN-${\gamma}$ 농도도 높은 경향을 나타내었으며, 부폐렴 삼출액에서는 IL-10농도가 다른 원인의 흉수에 비해 의미있게 높았다. 결론 : 결론적으로 흉수 내의 IL-2R농도 측정은 결핵성 흉수와 다른 원인의 흉수를 감별하는데 어느 정도 도움이 될 것으로 사료되며, IL-10 측정은 부폐렴 삼출액과 다른 원인의 흉수를 감별하는데 어느 정도 도움을 줄 것으로 생각된다. Background : Cytokines are chemical mediators that control and modulate many inflammatory processes. They work in different fashions in a variety of diseases. Discriminating between malignant effusion, tuberculous effusion, and parapneumonic effusion are crucial from the clinical view-point in Korea. In the current study, interferon-gamma (IFN-${\gamma}$), soluble interleukin-2 receptor (IL-2R), interleukin-6 (IL-6) and interleukin-10 (IL-10) were measured for this purpose. Methods : Pleural fluids from patients with malignant disease, tuberculosis, parapneumonic effusion and lung empysema were collected and gauged using commercial ELISA kits. Results : 34 patients were enrolled in this study. Among these 15 cases were malignant effusions, 12 were tuberculosis pleurisy and 7 were parapneumonic effusion and lung empyema. The levels of cytokines measured in this study were as follows, in order of frequency, malignant effusion, tuberculous effusion, parapneumonic effusion and lung empyema. The levels of INF-${\gamma}$ were higher in tuberculous effusion than in malignant or parapneumonic effusion ($295.5{\pm}585.5$ vs. $16.7{\pm}50$ vs. $10.0{\pm}0$ pg/ml, p>0.05). The levels of IL-2R were higher in tuberculous effusion than in malignant or parapneumoruc effusion ($7423.5{\pm}3752.8$ vs. $3247.4{\pm}1713.3$ vs. $3790.2{\pm}3201.1$ pg/ml, p<0.05). No significant differences were found in the levels of IL-6 between the groups ($600{\pm}12.8$ pg/ml in malignant effusion, $556.4{\pm}161.7$ pg/ml in tuberculous effusion, $514.4{\pm}224.8$ pg/ml in parapneumoruc effusion). IL-10 levels were higher in parapneumoruc effusion than in malignant or tuberculous effusions ($98.4{\pm}141.7$ vs. $28.2{\pm}55.5$ vs. $11.3{\pm}11.7$ pg/ml, p<0.05). Conclusion : These results suggest that the measurement of IL-2R levels in pleural fluids may be a useful means of differentiating between tuberculous effusion and pleural effusions of other origins, and that the measurement of IL-10 levels in pleural fluids may be useful to differentiate between parapneumonic effusion and pleural effusions of other origins.

정상근과 근막 유발점이 활성화된 근육의 초음파 영상의 비교

김명훈,김수현,김현진,Kim, Myung-Hoon,Kim, Su-Hyon,Kim, Hyun-Jin 대한물리치료학회 2013 대한물리치료학회지 Vol.25 No.2

Purpose: The objective of this study was to offer primary clinical data examining whether change of imaging structure and quantitative evaluation of muscle activity on myofascial trigger points can lead to implementation of an analytical technique for evaluation of myofascial pain diagnoses. In addition, we examined the effect of a variety of mediation techniques, in order to examine neuromuscular physiological characteristics of myofascial trigger points muscle by comparing differences in pressure pain threshold and ultrasound imaging. Methods: Participants in the study included 30 adults in their twenties. The subjects were divided into the normal and myofascial trigger points groups. Clinical outcomes were evaluated by pressure pain threshold for pain and ultrasound imaging was performed for evaluation of the structural characteristics of muscle. Independent t-test was used for statistical analysis. Results: The two groups showed statistical significance in the change in pressure pain threshold (p<0.05). Findings of ultrasound imaging analysis showed no significant differences, increased muscle thickness was observed (p>0.05). Findings of ultrasound imaging analysis showed significant differences, increased muscle echodensity was observed (p<0.05). Findings on ultrasound imaging analysis showed significant differences, increased muscle white area index was observed (p<0.05). Conclusion: From these results, active myofascial trigger points muscle showed quality deterioration on ultrasound imaging. Thorough evaluation of imaging structure and physiological characteristics can be useful quantitative analytical techniques for diagnosis of myofascial pain syndrome and a primary factor reflected in physical therapy intervention.

의료계의 사회공헌활동 현주소와 개선방안

김명훈,Kim, Myeong-Hun 대한병원협회 2008 대한병원협회지 Vol.37 No.5

스크리닝(Screening)을 통한 문제환자의 관리

김명훈,Kim, Myeong-Hun 대한병원협회 1988 대한병원협회지 Vol.17 No.11

사진 디지털아카이브 구축에 관한 연구 : 민주화운동 사진기록을 중심으로

김명훈,현종철,Kim, Myoung-Hun,Hyun, Jong-Chul 한국과학기술정보연구원 과학기술정보센터 2006 Journal of Information Science Theory and Practice Vol.37 No.3

본 연구에서는 민주화운동 관련 사진들을 기반으로 한 사진 디지털아카이브 구축 프로세스를 분석하였다. 사진 디지털아카이브를 디지털 객체를 대상으로 수집, 분류, 기술, 저장, 활용시키는 통합적 시스템으로 규정한 후, 사진의 고유성을 반영한 메타데이터의 도출 및 분류체계 수립 사례를 제시하였다. 특히 사진 디지털아카이브의 분류체계 수립 시, 기존의 기본분류체계 외에 다양한 검색어를 활용한 다원분류체계를 설계함으로써, 문자화된 의미전달이 부재한 사진들 간의 통합성 및 상호연계성을 창출시켜 활용성을 극대화시킬 수 있는 방안을 제시하고자 하였다. This article analyze a constructing process of photographic digital archive based on photographs of korean democratization movements. After photographic digital archive defines as integrated systems in which photographic digital objects collect, classify, describe, preserve and access, this article explains metadata elements and classification schema reflecting a special quality of photograph. Especially, this article presents dynamic classification structure using subject keywords. After all, this method provides integrity and interrelationship with photographes which promote usability of photographic digital objects.

척수 손상 환자에 관한 실태 조사

김명훈,Kim, Myung-Hoon 대한물리치료과학회 1996 대한물리치료과학회지 Vol.3 No.2

The incidence of spinal cord injury increase due to traffic accident, industrial accident and leisure sports. Spinal cord injury damages motor and sensory function below the injury level, also affects autonomic functions associated with voiding and defecation. Sexual dysfunction and psychosocial, vocational maladaptations are also some of the unwanted consequences of injury. The purpose of this study is look for means to prevent and to manage complications in spinal cord injury through investigation and analysis. The subjects of this study in spinal cord injured patients were admitted to the department of physical therapy, Kwangju christian Hospital, Nam Kwang Hospital, Chun Nam university Hospital and Cho Sun university Hospital, from April, 1, 1995 to March, 31, 1996. The results are as follows: 1. The subjects comprised 96 cases of spinal cord injury, ranging from 17 to 85(mean-40.8 yrs) and included 72 males and 24 females. Among these patients, 58 were cervical injury, 20 were thoracic injury and 18 were lumbar injury. 2. As for a major causative of spinal cord injury were traffic accident(59.4%), fall down (27.1 %), and motocycle(4.2%).. 3. The bladder control were taken by indwelling cathetar(41.7%), Crede maneuver(37.5%) and self voiding(16.7%). The bowel control were taken by all aid(61.5%), assitance(32.3%) and self defecation(6.2%). 4. Possible of sexual function were 35 cases (47.9%). 5. The device of transfer used wheel chair(69.8%) and bed(16.7%). 6. The patients with higher cord lesion got more serious pain than lower cord lesion. Also the patients with higher cord lesion got a serious spasticity. 7. The incidence of decubitus ulcer among 96 patients were in case 46(47.9%). The largest group of the pressure sore sites were sacral portion(82.0%), less than 1 month of onset occured a large numbers(50%). Incidence of pressure sore by spasticity occured many patients in case of mild or moderate. Incidence of pressure sore by pain occured many patients in case of severe pain.

키네시오 테이핑과 발목관절 근력 운동이 균형지수에 미치는 변화

김명훈,이정훈,김찬규,Kim, Myung-Hoon,Lee, Jeong-Hun,Kim, Chan-Kyu 대한물리치료학회 2009 대한물리치료학회지 Vol.21 No.3

Purpose: This study examined that effect of a change in balance index on ankle Kinesio taping, muscle strength exercises and taping after muscle strength exercises in 30 healthy adult subjects. Methods: The Sway Index of the left, right, front and back on stable, toes up and linear were compared using a Balance System, a balance experimental instrument. Results: The pre and post experimental balance index regarding stable, toes up, and linear were taken for the Kinesio taping group, lower extremities muscle strengthening group, and muscle strengthening with the Kinesio taping group. Statistically significant decreases were observed in all variables except for the left and right pre and post experiment results under stable conditions. Conclusion: The balance index of exercise with taping was lower than that of exercise only. There is a need for objective research on the long-term applications and post-exercise. The body balance appears to be influenced by ankle stabilization using taping.

요통환자에 관한 통계적고찰

김명훈,Kim, Myong-Hoon 대한물리치료사협회 1985 대한물리치료사협회지 Vol.6 No.1

재활원의 물리치료대상 뇌성마비아의 임상적 고찰

김명훈,김상엽,Kim, Myung-Hoon,Kim, Sang-Yeob 대한물리치료과학회 1999 대한물리치료과학회지 Vol.6 No.3

The prognosis and result of treatment are influenced by associated cerebral handicaps. 38 cerebral palsied children in rehabilitation center were analized and neuromotor type severity associated defects, and their correlation were studied. The results were follows: 1. neuromotor type distribution was 65.78% of spasticity, 21.05% of athetoid, 2.63% of Ataxia, Tremor, and Rigidity, 5.26% of mixed type. 2. Mean values of I.Q, S.Q and M.Q were 84.3, 63.0 and 26.6 respectively, and percentages of strabismus, speech disturbance, shoulder abnormality, spine abnormality and hip abnormality were 26.3%, 81.5%, 5.2%, 52.6% and 15.9% respectively. 3. Significant differences were noted between each group of mild, moderate, and severe in S. Q, M. Q, and spine abnormality and between moderate and severe group in speech disturbance.

허리 및 하지 근력운동 후 스트레칭이 20대 남성 허리 유연성에 미치는 효과

김명훈,김현진,Kim, Myung-hoon,Kim, Hyun-jin 대한물리치료과학회 2019 대한물리치료과학회지 Vol.26 No.1

Background: The purpose of this study was to the effects of stretching on lumbar flexibility after lumbar and lower muscle strengthening exercise. Design: Randomized Controlled Trial. Methods: 24 subjects without back pain in their twenties were divided into 12 experimental groups and 12 control groups. The experimental group performed a stretching program after muscle strength exercise. In the control group, only muscle strength exercise was performed, and total exercise was performed 24 times a week for 8 weeks to compare and analyze before and after experiment. Results: The results of this study are as follows: 1) There was no statistically significant difference in both before and after weight of experimental group and control group. 2) There was no statistically significant difference in both before and after skeletal muscle levels of experimental group and control group. 3) There was no statistically significant difference in both before and after fat mass of experimental group and control group. 4) There was a statistically significant difference in both before and after trunk forward flexion of experimental group and control group. Conclusion: This research showed a positive affect on increasing flexibility, which is expected to have a great effect on improvement of flexibility in the future.