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불균일 분포 특성을 갖는 공간 데이타를 위한 색인 구조
김덕윤(Deok Yun Kim),이윤준(Yoon Joon Lee),김명호(Myoung Ho Kim) 한국정보과학회 1995 한국정보과학회 학술발표논문집 Vol.22 No.2A
새로운 공간 색인 기법인 BR-tree를 제안한다. BR-tree는 불균일 데이타 분포에서 높은 페이지 사용율을 유지할 수 있으며 공간 조인과 영역 질의 처리에 효과적이다. BR-tree는 Quad-tree, Grid-tree, Buddy-tree와 같이 영역을 동일 크기로 분할하는 방법을 사용하며 이들의 문제점들을 분할 갯수를 늘려서 해결한다. 본 논문에서는 BR-tree의 이러한 특성을 지원하기 위하여, 밀집 영역 관리 방법과 희소 영역 관리 방법을 제안한다. 또한 실험을 통하여 Quad-tree, Buddy-tree 등과 페이지 사용율, 영역 질의 비용을 비교한다.
Islet Cell Surface Antibody ( ICSA ) 양성인 인슐린 비의존성 당뇨병 환자의 임상적인 특징과 ICSA 의 인슐린 분비억제에 대한 기전
우정택(Jeong Taek Woo),김덕윤(Deok Yoon Kim),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi) 대한내과학회 1993 대한내과학회지 Vol.45 No.1
N/A glycemic control and significantly reduced insulin secretory response. 3) Inhibitory effect of serum immunoglobulins from the diabetics with ICSA on insulin secretion of p-cells induced by glucose stimulation was confirmed by the perifusion system. 4) The suggested mechanisms of ICSA on insulin secretion are ① inhibition of glucokinase and glucose transporter 2 mRNA expression ② inhibition of phosphoinositide hydrolysis metabolic pathway Conclusion: There is a certain group of adult onset diabetes still unclassified but characterized by appearance of ICSA, marked weight loss and markedly reduced insulin secretion and finally becoming insulin dependent. The ICSA detected in this group of adult onset diabetics may also play a role in an effect on multiple steps of signal transduction pathways related to insulin secretory mechanism.
HIT 세포에서의 Dexmethasone 이 글루코키나제와 글루코기나제 mRNA 발현에 미치는 영향
안규정(Kyu Jeong Ahn),김덕윤(Deok Yoon Kim),우정택(Jeong Taek Woo),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi) 대한내과학회 1994 대한내과학회지 Vol.46 No.4
N/A Objectives: The glucokinase-glucose sensor concept of physiological glucose recognition by pancreatic beta- cells has developed progressively since the presence of this enzyme in beta-cells was first reported in 1968. It is well known that HIT cells have glucokinase activity and then insulin secretory response according to glucose stimulation, but there are few data about the effect of hormone on insulin secretion and glucokinase in HIT cells. Therefore, we studied the effect of dexamethasone on glucokinase activity, mRNA expression and insulin secretion in HIT cells. Methods: HIT cells were cultured for 24 hours in medium containing 0, 50, or 500 nM dexamethasone, and then the activities of glucokinase was quantitiated using pyridine uncleotide-dependent fluorometric assays. Northern blot analysis of glucokinase mRNS was done. Results: 1) The Vmax and Km of glucokinase in HIT cells were 3.5 μ mol/min/mg protein, 0.77 mM in HIT cells exposed to 7 mM glucose, respectively and the Vmax and Km of hexokinase in HIT cells were 2.64 μmol/ min/mg protein, 0.06 mM, respectively. 2) 24 hours after incubation of HIT cell with dexamethasone 0, 50, 500 mM, the glucokinase activity and insulin secretion were observed: the glucokinase activities were 1.4±0.45(control), 0.87±0.43(50nmol dexarnethasone), 0.13±0.52 uU/mg protein(500 nmol dexamethasone), and insulin secretion were 44.57±4.1(control), 35.50±1.72(50 nmol dexamethasone), 31.62±1.07 ng/mg protein(500 nmol dexamethasone), respectively. 3) Northern analysis revealed that dexamethaxone increase glucokinase mRNA expression according to dexamethasone concentrations 24 hours after incubation of HIT cells with dexamethasone 50 or 500 nM. Conclusion: Our data showed that dexamethasone tended to increase glucokinase mRNS expression, but decrease glucokinase activity and insulin secretion in HIT cells. Thease data suggested that dexamethasone may have an variable effect on transcriptional or posttranslational levels of glucokinase.
한방음악치료가 사상체질에 따라 분류된 뇌경색환자에 마치는 효과에 관한 연구
이승현,김덕윤,고병희,이수경,김상복,Lee, Seung-Hyun,Kim, Deok-Yoon,Koh, Byung-Hee,Lee, Soo-Kyung,Kim, Sang-Bok 사상체질의학회 2006 사상체질의학회지 Vol.18 No.2
1. Objectives The purpose of this study was to examine the regional cerebral blood-flow(r-CBF) difference between OMT(Oriental Music Therapy) group and control group using brain SPECT, to evaluate the effect of OMT in ischemic stroke patients Classified by Sasang Constitutional. 2. Methods We selected 10 ischemic storke patients, classified groups into OMT group or control group. r-CBF of two groups were examined by brain SPECT. in all group we applied SCM(Sasang constitutional medicine)treatment for 4-5 weaks, and additionally in OMT group We applied OMT for 4-5 weaks. after that all the r-CBF of two groups took brain SPECT again. r-CBF difference and change before and after SCM treatment and OMT were quantified and analyzed using SPM. 3. Results r-CBF of OMT groups were increased compared to control groups. 4. Conclusions This study demonstrated that Sasang Constitutional OMT increased regional cerebral blood perfusion to the corresponding brain areas in ischemic stroke patients.
EV Frame Body 유효성 검증 및 성능 개선에 대한 해석적 연구
김정훈(Jeong-Hun Kim),장우정(Woo-Jeong Jang),김덕윤(Deok-Yoon Kim) 한국자동차공학회 2021 한국자동차공학회 지부 학술대회 논문집 Vol.2021 No.5
Products in modern society have issues such as light weight, quality problems, performance improvement, and environmental problems depending on the increasing consumer sentiment and level of environmental problems. Accordingly, the industry is constantly striving to produce high-quality products that are parallel to cost reduction and environmental issues. The automobile industry is also actively conducting research to solve environmental problems through light weighting and quality improvement. This study is an analysis of the validation and performance improvement of EV (Electronic Vehicle) frame body applying aluminum material, a non-ferrous metal suitable for modern society issues and trends. Through research, we conducted a study to secure analytical technology and reliability for the Electronic Vehicle (EV) Frame Body single product and derived a valid analytical performance improvement plan through relative comparative analysis by CASE. We focus on establishing valid analytical techniques for structural features of Electronic Vehicle (EV) Frame Body, and work on CASE Study to secure performance improvements. Analytical validation of EV (Electronic Vehicle) frame body single product was completed by securing improvement measures through CASE Study, analyzing the impact of improvement plans, and establishing interpretation techniques. This is a prior analytical study to flexibly cope with RFQ of future active Electronic Vehicle (EV) Frame Body single product analysis.
인슐린 비의존형 당뇨병에서 글류코키나제 유전자 변이에 대한 연구
오승준(Seung Joon Oh),우정택(Jeong Taek Woo),김덕윤(Deok Yoon Kim),양인명(In Myung Yang),김성운(Sung Woon Kim),김진우(Jin Woo Kim),김영설(Young Seol Kim),최영길(Young Kil Choi),팽정령(Jeong Ryung Paeng) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives : Considerable evidences suggest that genetic factors are of crucial importance in the pathogenesis of NIDDM. As glucokinase is a major enzyme of glucose homeostasis, the glucokinase gene has been proposed as one of candidate genes that confer genetic susceptibility to NIDDM. Although recent studies suggest that mutations of the glucokinase gene related to MODY, a possible relationship between this gene mutation and other subtypes of N1DDM has not investigated. Methods: To investigate the possible relationship between the mutations and NIDDM in Koreans, we screened mutation over all 12 exons of glucokinase gene in 30 normal controls (group 1) and 103 NIDDM patients, 34 patients without family history (group 2) and 69 patients with family history (group 3), by PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism). Results : Eighteen of 133 subjects (13.5%) had mutations which were found in exon 10β, 1L, 1V, and 5, Four different types of polymorphisms were found in exon 10β, 3 types in exon 1L, 1 in both exon 1V and exon 5. Seventeen of 103 NIDDM patients (16.5%) and 1 of 30 normal control (3.3%) had mutations, which suggests that the mutations are related to NIDDM. The frequency of mutations was not different between group 2 and 3. However, the frequency of mutations was higher in the patients with low 24 hour urine C-peptide excretion than those who not. Serum glucose concentration was significantly higher and serum insulin level tended to decrease at 60 min after oral glucose loading in the patients with mutations. Conclusion: These data suggest that the mutations of glucokinase gene are related to NIDDM in Koreans, especially who have low insulin secretory capacity. Further studies are needed to clarify how the mutations relate to NIDDM.
SPECT를 이용한 뇌경색환자의 건측 합곡-곡지 전침치료가 뇌관류에 미치는 영향
문상관,김영석,박성욱,정우상,고창남,조기호,배형섭,이재동,김덕윤,Moon, Sang-kwan,Kim, Young-suk,Park, Sung-uk,Jung, Woo-sang,Ko, Chang-nam,Cho, Ki-ho,Bae, Hyung-sup,Lee, Jae-dong,Kim, Deok-yoon 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1
Background and purpose: Opposing-needling technique involves selecting acupoints at unaffected limb. The aim of this study was to evaluate the effect of LI4-LI11 electrical acupuncture at unaffected limb on the cerebral blood flow in ischemic stroke patients using SPECT Methods: We selected 9 ischemic stroke patients. Baseline brain SPECT was done with triple head gamma camera(MultiSPECT3, Siemens, USA) after intravenous administration of 925 MBq of Tc-99m ECD). Fifteen-minute electro-acupuncture at Hapgok(LI 4) and Gokji(LI 11) were applied on unaffected upper limb of subjects. The same dose of Tc-99m ECD was injected during the electro-acupuncture, and the second SPECT images were obtained. Using the computer software(ICON 7.1, Siemens, USA), 3 SPECT slices(upper, middle, lower) surrounding the brain lesion were selected and each slice was divided by 10-16 brain regions. Asymmetry indexes were analyzed in each brain region. We regarded$\geq$10% changes of asymmetry index between before and after electro-acupuncture as significance. Results: Seven Patients(77.8%) had significantly increased perfusion and 2(22.2%) didn't show increased perfusion in post-acupuncture scans compared to pre-acupuncture scans(baseline). The regions of CBF improvement were mostly frontal lobes and anterior temporal lobes. Conclusions: This study demonstrated that LI4-LI11 electro-acupuncture at unaffected limb increased regional cerebral blood perfusion to the corresponding brain areas in ischemic stroke patients.