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사람 망막아세포종 세포에 발현된 니코틴성 수용체의 특성
김대란,차승규,공인덕,정세환,라상훈.Dae-Ran Kim. Ph.D.. Seung-Kyu Cha. Ph.D.. In-Deok Kong. M.D.. Se-Hwan Jung. M.D. Sang Hoon Rah. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To identify the characteristics and physiological function of the nicotinic receptor expressed in human retinoblastoma cells. Methods: We measured possible nicotinic signaling in WERI-Rb-1 cells using the Ca2+ imaging technique and the patch clamp method. Results: 1) Nicotine-induced [Ca2+]i rise arose entirely through Ca2+ influx, which was completely abolished by hexamethonium (100 μM). 2) Nicotine also induced remarkable depolarization from -56.6±3.7 mV to -29.6±3.6 mV (n=4) under current clamp mode, but it failed to directly activate the T-type Ca2+ channel expressed in retinoblastoma cells. Conclusions: Nicotinic activation can increase the intracellular calcium level through calcium influx in the undifferentiated retinoblastoma cells, which may play important roles in cell proliferation, differentiation, and cell death.
사람 망막아세포종 세포에 발현된 니코틴성 수용성의 특성
김대란,차승규,공인덕,정세환,라상훈 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To identify the characteristics and physiological function of the nicotinic receptor expressed in human retinoblastoma cells. Methods: We measured possible nicotinic signaling in WERI-Rb-1 cells using the Ca2+ imaging technique and the patch clamp method. Results: 1) Nicotine-induced [Ca2+]i rise arose entirely through Ca2+ influx, which was completely abolished by hexamethonium (100 μM). 2) Nicotine also induced remarkable depolarization from -56.6±3.7 mV to -29.6±3.6 mV (n=4) under current clamp mode, but it failed to directly activate the T-type Ca2+ channel expressed in retinoblastoma cells. Conclusions: Nicotinic activation can increase the intracellular calcium level through calcium influx in the undifferentiated retinoblastoma cells, which may play important roles in cell proliferation, differentiation, and cell death. 목적 : 사람의 망막아세포종 세포에 발현되어 있을 것으로 예상되는 니코틴성 수용체의 특성과 그 생리적 기능의 일부를 규명하고자 하였다. 대상과 방법 : 니코틴성 수용체의 활성화를 확인하기 위해 망막아세포종 세포주의 하나인 WERI-Rb-1 세포를 대상으로 칼슘 이미징(imaging) 기법을 이용하여 세포내 칼슘농도([Ca2+]i)를 측정하였으며, patch clamp 기법으로 세포막을 통한 이온전류를 측정하였다. 결과 : 1) 니코틴에 의한 [Ca2+]i 증가는 모두 세포막을 통한 Ca2+ 유입에 의한 것으로 나타났다. 2) 니코틴 투여시 내향성 전류를 유발하였으며, 막전압의 뚜렷한 탈분극(대조군: -56.6±3.7 mV, 니코틴 투여군: -29.6±3.6 mV, n=4)을 초래하였다. 이와 같은 변화는 니코틴 수용체 차단제(hexamethoniun, 100 μM)에 의해 완전히 억제되었다. 3) 니코틴 투여가 망막아세포종 세포에 이미 발현되어 있는 T-형 칼슘 전류에는 직접적인 영향을 주지 않았다. 결론 : 망막아세포종 세포에는 니코틴성 수용체가 발현되어 있으며, 세포막에 발현된 니코틴성 수용체를 통한 Ca2+ 유입 및 탈분극에 따른 세포내 칼슘유입은 세포분화, 증식, 세포사멸 등의 조절기전에 관여하리라 사료된다.
비알코올성 지방간질환에 대한 이해와 비약물적 중재 및 측정지표에 대한 문헌분석
김대란 기초간호학회 2013 Journal of korean biological nursing science Vol.15 No.2
Purpose: This study was intended to analyze the types and measurement parameters of non-pharmacological interventional studies for nonalcoholic fatty liver disease (NAFLD). Methods: NAFLD related literatures were systematically reviewed. The existing literatures were searched electronically using the data base of PubMed, a Medline data base of the National Library of Medicine with the key words of nonalcoholic fatty liver disease, NAFLD, nonalcoholic steatohepatitis, and NASH. The criteria for inclusion in this review were 1) non-pharmacological intervention, 2) human, 3) English. Finally, 20 articles were included in the review. Results: The major findings of this study were as follows: 1) the types of non-pharmacological intervention were exercise (35%), caloric restriction (30%), and lifestyle modification with combination both of exercise and caloric restriction (35%), 2) Almost all studies adopted various measurement parameters derived from pathophysiological mechanism-based biomarkers such as anthropometric indices, biochemical parameters,body fat mass, and liver biopsy results. Conclusion: Non-pharmacological interventions have been reported to be effective to improve NAFLD status, and many objective biomarkers confirmed supported these findings. Therefore, the development of nursing interventions for NAFLD subjects is needed and the consideration of using mechanism-based biomarkers is suggested to verify nursing outcomes objectively.
중년후기 유방암 생존 여성과 건강한 여성의 성공적 노화인식 비교
김은자,김대란 한국노인간호학회 2017 노인간호학회지 Vol.19 No.1
Purpose: The study was done to compare the perception of successful aging for late middle-aged breast cancer survivors and healthy women. Methods: A descriptive research design was used and data were collected from April to August 2014. Participants were 75 women breast cancer survivors and 71 healthy women. A questionnaire was used to collect data. Data analysis was performed using descriptive statistics, t-test, ANOVA, ANCOVA. Results: The study results showed that late middle-aged breast cancer survivors scored higher than healthy women in perception of successful aging and also on the sub-items of the perception of successful aging such as personal growth, pursuing meaning, and moderation. There were significant differences in perceptions of successful aging for late middle-aged breast cancer survivors according to education level and job, but for late middle-aged healthy women, the significant difference in perception of successful aging was related to religion. Conclusion: Based on these results, to plan a successful aging program and increase the perception of successful aging for late middle-aged healthy women, intervention strategies should be developed considering these items that are important to successful aging.
사람 망막아세포종 세포에 발현된 P2Y11 수용체의 확인
김윤희,김대란,전고이,이종혁,공인덕,Yoon Hee Kim,Dae Ran Kim,Ko I Chun,Jong Hyuck Lee,In Deok Kong 대한안과학회 2007 대한안과학회지 Vol.48 No.8
Purpose: The present study aimed to identify the characteristics and physiological function of the P2Y11 receptor, a receptor likely expressed in human retinoblastoma cells. Methods: We measured possible P2Y11 signaling in WERI-Rb-1 cells using a Ca2+ imaging technique and RT-PCR. Results: 1) 10 ?M ATP elicited a strong but transient increase in Ca2+ in the WERI-Rb-1 cells, and this Ca2+ rise was well maintained after external Ca2+-depletion. 2) ATP-induced Ca2+ response arose entirely through Ca2+ mobilization. 3) P2Y11 agonist (BzATP, 100 ?M) increased Ca2+ by 31.2±3.7 % of ATP effect. 4) mRNA for P2Y11 subtype was identified using RT-PCR. Conclusions: P2Y11 purinergic activation can increase the intracellular calcium level through calcium mobilization in undifferentiated retinoblastoma cells, which may play an important role in cell proliferation, differentiation, and even pathologic processes.