안지오텐신 II의 적출심근 및 대동맥 평활근에 대한 작용기전

김규찬,김기환,엄융의,Kim, Kyu-Chan,Kim, Ki-Whan,Earm, Yung-E 대한생리학회 1983 대한생리학회지 Vol.17 No.1

Contractile responses of myocardium and vascular smooth muscle to angiotensin II were studied in isolated rabbit papillary muscles and aortic helical strips, with respect to the sensitivity and the mechanism of action. All experiments were performed in $HCO-_3\;-buffered Tyrode solution which was aerated with $3%\;CO_2-97%\;O_2$ and kept pH 7.35 at $35^{\circ}C$. Action potentials were measured by conventional microelectrode technique in the papillary muscles. Helical strips of vascular smooth muscle were prepared from the descending thoracic aorta of the rabbit. Angiotensin II elicited a positive inotropic effect in doses from $10^{-8}$ to $10^{-6}\;M$, and this effect was dose-dependent and characterized by a symmetrical increase of maximum dP/dt during contraction and relaxation phase. Slow responses (or slow action potentials) were induced by A. II $(10^{-6}\;M)$ in the papillary muscle hypopolarized by 27 mM $K^+$. These A. II-induced slow action potentials were eliminated by verapamil (2 mg/l), but not affected by propranolol $(10^{-5}\;M)$. In aortic helical strips, contractile force was increased dose-dependently in the range of $10^{-10}{\sim}10^{-7}\;M$ A. II. $ED_{50}$ in aorta was $3{\times}10^{-9}\;M$ A. II, whereas that in paillary muscle was $2.5{\times}10^{-7}\;M$ A. II. A. II contracted vascular smooth muscle in depolarizing concentration of $K^+$ (100 mM $K^+$), and also produced a sustained contraction even in the presence of verapamil and regitine. The results of this experiment suggest that the primarily important physiological role of A. II is the action on the blood vessel, and the positive inotropic effect of A. II in papillary muscle results from the increase of slow inward $Ca^{++}$ current, and that A. II-induced contraction of aorta is independent of transmembrane potential and associated with promoting bet transmembrane $Ca^{++}\;-influx$ and the mobilization of cellular $Ca^{++}$.

인공지능 기반 차량 인포테인먼트시스템

김규찬(Kyu-chan Kim),김지섭(Ji-seob Kim),김정무(Jung-mu Kim),이창민(Chang-min Lee),박준형(Jun-hyeong Park),김태원(Tae-won Kim),박준호(Joon-ho Park) 한국컴퓨터정보학회 2023 한국컴퓨터정보학회 학술발표논문집 Vol.31 No.2

블랙박스형 AI 기반의 보행자 위험 알림 시스템

김현우(Hyun-Woo Kim),김지섭(Ji-Seob Kim),양성모(Seong-Mo Yang),김규찬(Kyu-Chan Kim),박철우(Chul-Woo Park),박준호(Joon-Ho Park) 한국컴퓨터정보학회 2023 한국컴퓨터정보학회 학술발표논문집 Vol.31 No.1

다매체 수용자의 장르 선호와 장르 이용에 따른 정치사회적 영향에 대한 연구

조성동(Sung-Dong Cho),김규찬(Kyu Chan Kim),강남준(Nam-Jun Kang) 한국언론학회 2010 한국언론학보 Vol.54 No.1

Audience’s media using patterns are more complicated than ever with the changes in the media environment, and they can select genre according to their content preferences whenever they want. This is especially the case for multi-channel TV(cable & satellite, IPTV, DMB) and Internet hypertext, which multi-media functions offer varied options to us. Given that, over those media and channels, program choice has increased rapidly in the last decade, audience’s polarized program consumption means that they can avoid some contents whenever they wish not to watch them. Here, much of the concern about audience’s political and social problems stems from in this new media environment. The purpose of this study is to examine how genre preference and usage contributed to increase political knowledge and political efficacy, and to determine the disparities of political knowledge and political efficacy between two groups(news-social and drama-entertainment preference groups). This study analyses 1,353 individual’s panel of one source data(ID ordering) which was collected by TNS Korea(people-meter rating data & telephone survey data) using descriptive, t-test, hierarchical regression of SPSS package. The results suggest that the increased gap in the political knowledge and political efficacy according to the genre preference has disparities in a significant level. And genre usage as a predictor related to the effects on political knowledge in spite of controled demographic and media usage variables, but not political efficacy.

기사 제목에 포함된 직접인용부호 사용의 문제점과 원인

이준웅(June Woong Rhe),양승목(Seung-Mock Yang),김규찬(Kyu Chan Kim),송현주(Hyun Joo Song) 한국언론학회 2007 한국언론학보 Vol.51 No.3

This study explored the ways in which direct quotations were employed in newspaper headlines of the coverage of the Local Election on May 31, 2006. Even though critics and journalism academics have expressed worries about the frequent uses of direct quotations in the headlines of the Korean dailies, no systematic attempts have been made to examine the extent to which, and the reason for which, direct quotations were extensively utilized. Content analysis, conducted on a systematic sample of 448 news stories in the coverage of the election, revealed that about 60% of the headlines with direct quotations contained the phrases that one could not find in the content of the main stories. It was also found that the direct quotations were more about the intentions and emotions of the politicians than events and policies. Based upon the results from a series of in-depth interviews with six journalists, this study discussed the implications of the findings for the journalism norms and ethics regarding direct quoting.

식음료 상품의 고객만족과 재구매의도에 관한 연구

박호표,김규찬 한국관광정책학회 1999 觀光政策學硏究 Vol.5 No.1

This study aims to indicate what are the factors of consumer satisfaction and to find whether there's any changes on consumer's action according to satisfaction and dissatisfaction. The specific purpose of this study are as follows 1) develop the theoretical base though analysis previous studies on consumer satisfaction and intention of repurchasing of food and beverage products. 2) develop the instrument for empirical study through the literature and evaluate the effect of expectation size. 3) and to propose the result of this study for the marketing strategy of restaurants. The results of this study are as follows. First, the expectation formed by experience of consumption and words of mouth is indicated very high. Second, the importance of satisfaction factors of food and beverage goods are in orders of accuracy of payment, cleanness, response of order, friendliness, positiveness of employees and quality of foods. Third, the satisfaction factors were evaluated higher by male than female and married people than unmarried people. Forth, it is indicated that the more visits, age and higher income level, the higher expectation and satisfaction. And last, it is shown through regression analysis that the higher expectation and satisfaction, the higher intention of repurchasing.

四鹽化炭素 誘發 肝纖維症 白鼠의 肝膠原質 分劃에 대한 Colchicine의 作用

金圭讚,徐大圭 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.1

Colchicine is a putative antifibrotic agent as it inhibits collagen synthesis and secretion and, also enhances collagenase activity in vitro. This study was undertaken to investigate the therapeutic effect of colchicine on hepatic fibrosis and the effect of it on collagen fractions in fibrotic liver. In addition, serum N-acetyl-β-D-glucosaminidase (NAG) activity as a possible marker reflecting fibrotic activity and therapeutic efficiency of colchicine were also studied. Colchicine and carbon tetrachloride-treated group had significantly lower liver collagen content, higher serum albumin level and lower NAG activity than those in carbon tetrachloride-treated group. Inhibitory effect of colchicine on collagen accumulation appeared to be mainly on insoluble fraction of collagen, since collagen content was decreased in insoluble fraction, but unchanged in soluble fraction in the group treated with both carbon tetrachloride and colchincine as compared to the group receiving carbon tetrachloride only. The fact that correlation coefficient value between serum NAG activity and liver collagen content was 0.86 (P<0.001) indicated that serum NAG activity might well be reflecting the fibrotic activity in liver. These results suggest that colchicine has a beneficial effect on hepatic fibrosis by inhibiting accumulation of collagen, mainly on insoluble fraction.

Primrose系 種子油의 有效成分 分析

申仁澈,金圭讚,徐大圭 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.2

Many medicinal products have been obtained in natural source. Recently, Primrose seed oil is suggested to the richest natural source of valuable biologically active polyunsaturates, especially gamma-linolenic acid (GLA), which is concerned to the treatment of various uncontrolled disease related to the disorders of fatty acid metabolism. Thus this study was investigated firstly to confirm the presence of GLA and its content in Primrose seed oil in Korea, and the following results were obtained. 1. 0.16 gm of seed oil were extracted from 1.0 gm of its seed. 2. In the compositions of seed oil tested cis-linoleic acid (66.0%) and GLA (12.3%) were main components. 3. Minute contents of metals identified in seed oil tested were not exceed its limited value. It can concluded that Primrose seed oil in Korea are abundant in cis-linoleic acid especially GLA in regard to other vegetable oil, thus it is valuable for control of variable disease related to the fatty acids.

삼출성 중이염에서 RT-Nested PCR 법으로 RS Virus의 검출

전병훈,박재영,나우진,김규찬 인제대학교 1995 仁濟醫學 Vol.16 No.4

유소아 상기도 감염의 가장 중요한 원인이며 삼출성 중이염 환자의 중이 저류액과 비인강에서 가장 많이 검출되는 바이러스인 respiratory syncytial virus(RSV)를 중이 저류액 내에서 검출하기 위하여 약물치료로 호전되지 않는 3-9세의 소아 12례를 대상으로 reverse transcriptase-polymerase chain reaction (RT-PCR)과 nested polymerase chain reaction(nested-PCR) 법을 이용하여 RSV의 염기서열을 검출해 보았다. 그 결과 1례(8.3%)에서만 RSV의 염기서열을 발견할 수 있었으므로 RSV는 삼출성 중이염의 병인으로 작용하는 것으로 생각되며, 삼출성 중이염의 만성화에는 다른 요인들이 관여할 것으로 추정된다. College of Medicine, Inje University, Paik Hospital, Seoul Otitis media with effusion (OME) is the most common cause of acquired hearing loss in childhood. The pathogenesis still remains unclear, though it is closely relaxed to viral upper respiratory infections. It is known that respiratory syncytial virus (RSV) is one of the most common virus isolated from middle ear effusions. The reverse transcriptase-polymerase chain reaction (RT-PCR) and the nested polymerase chain reaction (nested PCR) were used for detection of RSV sequences in middle ear effusions collected from children with intractable OME. These samples were collected from June 1, to December 31, 1994, and the sequences of RSV were detected in 1 of 12 samples tested (8.3%). This observation suggests RSV as a factor in the pathogenesis of OME, but some other factors may be involved in the disease processes of prolonged OME