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아토피 피부염의 임상연구병행 경제성평가 프로토콜 개발을 위한 체계적 문헌고찰연구
권지예,선지혜,윤화정,김남권,Gwon, Ji-Yae,Seon, Ji-Hye,Yun, Hwa-Jeong,Kim, Nam-Kwen 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.1
Objectives : The aim of this study is reviewing the literature to extracting the key parameter and finding the calibration parameter for the clinical study with economical assessment protocol on atopic dermatitis. Methods : Literature search is performed using PUBMED for literature published from Janurary 2000 to December 2016. We included randomized controlled trials(RCTs) with economic assessment in which human participants. Results : Among the articles published from January 2000 to December 2016, The 1464 articles were found. After reviewing the title, abstract and full text, the five articles were selected. Selected articles are classified 3 CEA(cost effective analysis)study, 1 CMA(cost minimizing analysis)study and 1 cost analysis study. Conclusions : We found highly reliable key parameters and calibration parameters, which might be necessary factors for developing research protocol of economic evaluation alongside clinical trial about atopic dermatitis patients.
권지예,이승훈,전주연,최정원,정경아,조근형,김석중,양철우,박성환,조미라 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.4
Osteoarthritis (OA), a degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Probiotic complex, rosavin, and zinc have been used as dietary supplements that exhibit anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergic effect in OA. This study aims to determine whether combination with probiotic complex, rosavin, and zinc decreases progression of monosodium iodoacetate (MIA)-induced OA rat model. The combination improved pain levels by preventing cartilage damage. The expression of proinflammatory cytokines and catabolic factors was reduced by the combination within the joint tissue. However, the combination increased anti-inflammatory cytokines as well as the anabolic factor production. The gene level of catabolic factors was decreased with treatment of the combination in chondrocytes isolated from OA patients. These results suggest that the combination can improve MIA development through the inhibition of proinflammatory cytokines and cartilage destruction, thus playing a key role as a therapeutic candidate for OA treatment.
협동적 읽기, 쓰기 통합학습이 영어 독해력과 독해 메타 인지에 미치는 영향
정길정,권지예 학습자중심교과교육학회 2006 학습자중심교과교육연구 Vol.6 No.1
본 연구는 협동적 읽기․쓰기 통합학습(Cooperative Integrated Reading and Composition: CIRC)을 통해 읽기와 쓰기를 통합하고 학습자 중심의 협동학습을 실시하여, CIRC가 영어독해력과 독해메타인지에 미치는 영향을 규명하는데 그 목적이 있었다. 위와 같은 목적을 달성하기 위하여 선행연구물을 기초로 다음과 같은 가설을 설정하였다. <가설 1> CIRC는 독해력 향상에 영향을 미칠 것이다. <가설 2> CIRC는 독해메타인지에 긍정적인 영향을 미칠 것이다. 가설검증 결과는 다음과 같다. <가설 1>은 긍정되어 영어독해력 향상에 영향을 미쳤다. 즉 사전검사 O3와 사후검사 O4, O5, O6와의 평균치의 차이검증을 실시한 결과 모두 p<.05 수준에서 의의있는 차이를 나타내었다. <가설 2>도 긍정되어 CIRC는 영어독해메타인지에 긍정적인 영향을 미쳤다. 즉 사전검사와 사후검사의 평균치는 p<.01 수준에서 의의있는 차이를 나타냈다. 결론적으로 CIRC 프로그램은 학습자의 독해력을 신장시키고, 메타인지 수준을 향상시킨다는 사실이 밝혀졌다. 그러나 본 연구에서는 기간 및 학생수 등의 제한점으로 그 효과 정도를 일반화시키기에는 무리가 있으므로 후속되는 연구에서는 장기간에 걸쳐 다수의 학생을 대상으로 하는 연구가 이루어져야 하겠다. The purpose of this study was to identify the effects of CIRC on English Reading Comprehension & Reading Metacognition for the accomplishment of the purpose. The following hypotheses were formulated on the basis of previous studies and relevant literatures. The CIRC would make a positive effects on English reading comprehension. The CIRC would make a positive effects on metacognition of English reading comprehension. The results of this study were as follows. The hypothesis 1 was accepted. That is to say, there was significant difference on reading comprehension between pre-tests groups and post-tests groups(P<.05). In other words, the CIRC made a positive effects on increasing English reading comprehension. The hypothesis 2 was also accepted. That is to say, there was significant difference on reading meacognition between pre-tests groups and post-tests groups(P<.01). In conclusion, the CIRC as effective in increasing English reading comprehension and reading metacognition even in EFL classroom situation. However, this study had some limitations to generalize the results to other situations. Therefore, further studies should be required for generalizing with inclusion of more samples and long term period for the studies.
박진실,최정원,전주연,권지예,이보인,양철우,박성환,조미라 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.3
Disruption of the balance among the microbiota, epithelial cells, and resident immune cells in the intestine is involved in the pathogenesis of inflammatory bowel disease (IBD). Probiotics exert protective effects against IBD, and probiotic commensal Lactobacillus species are common inhabitants of the natural microbiota, especially in the gut. To investigate the effects of Lactobacillus acidophilus on the development of IBD, L. acidophilus was administered orally in mice with dextran sodium sulfate (DSS)-induced colitis. DSS-induced damage and the therapeutic effect of L. acidophilus were investigated. Treatment with L. acidophilus attenuated the severity of DSS-induced colitis. Specifically, it suppressed proinflammatory cytokines such as interleukin (IL)-6, tumor necrosis factor-α, IL-1β, and IL-17 in the colon tissues, which are produced by T helper (Th) 17 cells. Moreover, in vitro L. acidophilus treatment directly induced T regulatory (Treg) cells and the production of IL-10, whereas the production of IL-17 was suppressed in splenocytes. In addition, we found that L. acidophilus treatment decreased the levels of α-smooth muscle actin, a marker of activated myofibroblasts, and type I collagen compared with control mice. These results suggest that L. acidophilus may be a novel treatment for IBD by modulating the balance between Th17 and Treg cells, as well as fibrosis development.