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비강내 점적 노출을 통한 산화 알루미늄 나노입자의 폐독성 평가
권정택,서균백,이미미,김현미,심일섭,조은혜,김필제,최경희,Kwon, Jung-Taek,Seo, Gyun-Baek,Lee, Mimi,Kim, Hyun-Mi,Shim, Ilseob,Jo, Eunhye,Kim, Pilje,Choi, Kyunghee 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.1
Objective: The use of nanoparticle products is expected to present a potential harmful effect on consumers. Also, the lack of information regarding inhaled nanoparticles may pose a serious problem. In this study, we addressed this issue by studying pulmonary toxicity after nasal instillation of Al-NPs in SD rats. Methods: The animals were exposed to Al-NPs at 1 mg/kg body weight (low dose), 20 mg/kg body weight (medium dose) and 40 mg/kg body weight (high dose). To determine pulmonary toxicity, bronchoalveolar lavage (ts.AnBAL) fluid analysis and histopathological examination were conducted in rats. In addition, cell viability was investigated at 24 hours after the treatment with Al-NPs. Results: BAL fluid analysis showed that total cells (TC) count and total protein (TP) concentrations increased significantly in all treatment groups, approximately two to three times. Also, lactate dehydrogenase (LDH) and cytokines such as TNF-alpha and IL-6 dose-dependently increased following nasal instillation of Al-NPs. However, polymorphonuclear leukocytes (PMNs) levels showed no significant changes in a dose dependant manner in BAL fluid. In the cytotoxicity analysis, the treatment of Al-NPs significantly and dose-dependently induced cell viability loss (20 to 30%) and damage of cell membrane (5 to 10%) in rat normal lung epithelial cells (L2). Conclusions: Our results suggest that inhaled Al-NPs in the lungs may be removed quickly by alveolar macrophages with minimal inflammatory reaction, but Al-NPs have the potential to affect lung permeability. Therefore, extensive toxicity evaluations of Al-NPs are required prior to their practical application as consumer products.
교모세포종 U-251MG, U-373MG세포주의 Cytokines처리에 의한 세포내 ICAM-1 발현
이종원,권정택,민병국,박승원,김영백,황성남,석종식,최덕영,Lee, Jong-Won,Kwon, Jung-Taek,Min, Byung-Kook,Park, Seung-Won,Kim, Young-Baeg,Hwang, Sung-Nam,Suk, Jong-Sik,Choi, Duck-Young 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.4
Objective : Despite advances in the understanding of tumor biology and the tumor immunology, there has been no effective treatment. The Intercellular adhesion molecule-1(ICAM-1) has been shown to be important in interaction involving cells of the immune system and to be upregulated in a number of cell culture systems by cytokines, including immune interferon($IFN-{\gamma}$) and tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$). ICAM-1 has been identified as one of the ligands for lymphocyte function-associated antigen-1(LFA-1). The effectiveness of various cytokines to ICAM-1 induction on cultured human glioblastoma cell lines and potential efficacy of immunotherapy were studied. Method : Human glioblastoma cell lines, U-251 MG, U-373 MG were trypsinized and suspended at $1{\times}10^5cells/ml$ and grown on 8 well chamber slide, the cells were incubated in 0.3ml medium alone or medium containing $IFN-{\gamma}$(1000U/ml) or $TNF-{\alpha}$(250U/ml) or $IFN-{\gamma}$ plus $TNF-{\alpha}$ for 6, 12, 24, 48 and 72 hours. The coverslip were then removed and stained with a 1/30 dilution of anti-ICAM-1 antibody. Result : Surface antigen expression of ICAM-1 was increased by incubating glioblastoma cell lines with $IFN-{\gamma}$ and $TNF-{\alpha}$. Combined effect of $IFN-{\gamma}$ and $TNF-{\alpha}$ has induced more ICAM-1 expression on glioblastoma cell lines. Upregulation of ICAM-1 expression in an established glioblastoma cell line was of greater magnitude and more rapid following incubation with $IFN-{\gamma}$ plus $TNF-{\alpha}$. Surface antigen expression of ICAM-1 was increased for up to 48 hours after cytokine treatment on both cell lines(p<0.05). There was no difference on both cell lines(p>0.05). Conclusion : The results of the present study indicate that ICAM-1 expression in glioblastoma cell lines, U-251 MG and U-373 MG, are induced and enhanced after treatment with $IFN-{\gamma}$ and $TNF-{\alpha}$. Combined effect of $IFN-{\alpha}$ and $TNF-{\gamma}$ is stronger and more rapid than $IFN-{\gamma}$ or $TNF-{\alpha}$ alone.
교통동맥분절의 내측벽에서 기원한 내경동맥류 치험 2례 - 증례보고 -
이종원,석종식,권정택,민병국,Lee, Jong-Won,Suk, Jong-Sik,Kwon, Jung-Taek,Min, Byung-Kook 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10
Aneurysms of the medial wall of the internal carotid artery(ICA) constitute a rare group of ICA aneurysms arising at locations other than at arterial division. Because these aneurysms usually have thin walls and wide necks associated with arteriosclerosis, neck clipping should be taken into special consideration. The authors report two cases of the aneurysm presented with subarachnoid hemorrhage, in which neck clippings ware performed with impunity.
연구논문 : 마우스 귀부종 시험법과 국소임파절시험법을 병합한 피부감작시험법 개발에 대한 연구
김형아 ( Hyoung Ah Kim ),권정택 ( Jung Taek Kwon ),허용 ( Yong Heo ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
In the present both mouse ear swelling test and mouse local lymph node assay are considered reliable method for determination of chemicals` type IV contact hypersensitivity capability. We developed a skin sensitization method through consolidation of mouse ear swelling test and mouse local lymph node assay. Sensitization of BALB / c mice with potassium dichromate, a well known skin sensitizer, was established through intra-dermal injection of emulsion containing 50 ㎕ of 20 mM potassium dichromate and 50 ㎕ complete Fleund`s adjuvant (CFA) into both flanks. Control mice were treated with CFA only. Thereafter, 10 days later, mice were challenged by injecting 20 ㎕of 3.5 mM potassium dichromate into pinnae of one ear and saline vehicle into that of another ear. Increment of ear thickness was determined using ear thickness guage 48 hour later of the challenge. In vitro BrdU proliferation assay was undertaken using auricular lymph node cells in the presence (1, 10 nM) or absence of potassium dichromate. Number of lymph node cells was significantly elevated in the chrome-sensitized / challenged mice than the other control mice. Ear swelling index, obtained through subtracting ear thickness before challenge from that after the challenge, was also significantly higher in the chrome-sensitized / challenged mice. Furthermore, in vitro auricular lymph node cell proliferation index was nearly two-fold higher at the chrome-sensitized / challenged mice than the other control mice. In order to be evaluated as an alternative skin sensitization test, our method deserves more repetition using various chemical sensitizers and irritants
마우스 귀부종 시험법과 국소임파절시험법을 병합한 피부감작시험법 개발에 대한 연구
김형아 ( Hyoung Ah Kim ),권정택 ( Jung Taek Kwon ),허용 ( Yong Heo ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
In the present both mouse ear swelling test and mouse local lymph node assay are considered reliable method for determination of chemicals` type IV contact hypersensitivity capability. We developed a skin sensitization method through consolidation of mouse ear swelling test and mouse local lymph node assay. Sensitization of BALB / c mice with potassium dichromate, a well known skin sensitizer, was established through intra-dermal injection of emulsion containing 50 ㎕ of 20 mM potassium dichromate and 50 ㎕ complete Fleund`s adjuvant (CFA) into both flanks. Control mice were treated with CFA only. Thereafter, 10 days later, mice were challenged by injecting 20 ㎕of 3.5 mM potassium dichromate into pinnae of one ear and saline vehicle into that of another ear. Increment of ear thickness was determined using ear thickness guage 48 hour later of the challenge. In vitro BrdU proliferation assay was undertaken using auricular lymph node cells in the presence (1, 10 nM) or absence of potassium dichromate. Number of lymph node cells was significantly elevated in the chrome-sensitized / challenged mice than the other control mice. Ear swelling index, obtained through subtracting ear thickness before challenge from that after the challenge, was also significantly higher in the chrome-sensitized / challenged mice. Furthermore, in vitro auricular lymph node cell proliferation index was nearly two-fold higher at the chrome-sensitized / challenged mice than the other control mice. In order to be evaluated as an alternative skin sensitization test, our method deserves more repetition using various chemical sensitizers and irritants
어린이 부비동 엑스선 검사에서 검사자의 갑상선 차폐 효과성에 관한 연구
곽창교(Chang-Kyo Kwak),권정택(Jeong-Taek Kwon),이광제(Kwang-Je Lee),배일환(Il-Hwan Bae),김혜정(Hye-Jung Kim),이소미(So-Mi Lee),이도병(Do-Byung Rhee) 대한방사선과학회(구 대한방사선기술학회) 2024 방사선기술과학 Vol.47 No.3
During paranasal sinus X-ray examinations in children, the radiological technologist’s thyroid shield is often not implemented to shorten the examination time. This study measured the radiation exposure before and after the implementation of thyroid shielding by analyzing the difference in radiation exposure, the radiological technologist’s could receive depending on the actual thyroid shielding. In the left TLD, when thyroid shielding was not performed(N), the radiation exposure dose(mSv) was 2.869 for the depth dose[Hp(10)] and 2.886 for the surface dose[H(3)], and when thyroid shielding was performed(Y), the Hp(10) was 0.033 and the H(3) was 0.034. In the right TLD, when thyroid shielding was not performed(N), the radiation exposure dose was 3.149 for Hp(10) and 3.137 for H(3), and when thyroid shielding was performed, the Hp(10) of (Y) was 0.013 and the H(3) was 0.015. The differences in the overall exposure dose measurement values are all statistically significant (p<0.05). The difference in radiation dose between when thyroid shielding was not performed and when thyroid shielding was performed was more than 99.2% in both cases, indicating a high radiation shielding rate.