후순환계 뇌동맥류의 임상양상과 치료예후 - 전순환계 동맥류와의 비교분석을 중심으로 -

정제훈,김국기,고준석,임영진,김태성,임언,이봉암,Jeong, Je Hoon,Kim, Gook Ki,Koh, Jun Seok,Lim, Young Jin,Kim, Tae Sung,Leem, Won,Rhee, Bong Arm 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.9

Object : With the recent variable treatment modalities and the development of microsurgical techniques, outcomes of surgical and medical management of aneurysm have shown much progress in the last 10 years. However, the management of posterior circulation aneurysm is still a debatable due to its difficulty in limited surgical approach, complicated anatomical structure and many small perforators to vital structure. The purpose of this study is to compare the results of clinical manifestation and outcome of surgery with respect to anterior and posterior circulation aneurysms. Material and Methods : We evaluated the 33 patients with PCAs(posterior circulation aneurysm) and 359 patients with ACAs(anterior circulation aneurysm) treated between 1994 and 1999, retrospectively. Results : Posterior circulation aneurysms showed higher tendency(5 cases, 14.7%) to have unusual shapes, such as dissecting or fusiform compared with anterior circulation aneurysm(15 cases, 4.2%). There were more multiple aneurysms in posterior circulation aneurysm(8 cases, 26.5%) than anterior circulation aneurysm(59 cases, 16.2%). The number of patients with Hunt-Hess grade III or IV on admission were 91(25.3%) in anterior circulation aneurysms, and 14(42.4%) in posterior circulation aneurysms. There were higher incidences of vasospasm and acute hydrocephalus in patients with posterior circulation aneurysm. In cases of anterior circulation aneurysm, neck clipping was possible in 97%. But, in posterior circulation aneurysm, neck clipping was possible only in 67.7% of each. Two hundred forty four cases(85.0%) of all anterior circulation aneurysms and 22 cases(78.6%) of all posterior circulation aneurysms showed good recovery(GR) or moderate disability(MD). The postoperative mortality rates of anterior and posterior circulation aneurysms were 4.9% and 10.7%, respectively. Conclusion : These results indicate that there exist substantial differences with respect to that there were few difference in the aspect of surgery and management outcome between posterior circulation aneurysms and anterior circulation aneurysms.

LNG/극저온용 펌프 및 밸브 성능 시험 설비 구축

박성제(Seong-Je Park),고준석(Jun-Seok Ko),홍용주(Yong-Ju Hong),김효봉(Hyobong-Bong Kim),고득용(Deuk-Yong Koh),염한길(Han-Kil Yeom),김기덕 대한설비공학회 2013 대한설비공학회 학술발표대회논문집 Vol.2013 No.11

The natural gas industry began in the early 1900s and is still evolving. Liquid processing occurs whenever natural gas is a product. Baseload plants exist to provide the industrial world with gas from stranded reserves in remote places. Stranded gas reserves are located where no economic use for the natural gas exists at the point of origin and where transportation of the gas by pipeline to a point of end use is not feasible. This paper describes some of the issues associated with LNG & cryogenic equipment test and evaluation center. The natural gas is stored and transported in a liquid state because its liquid density is 600 times greater than gas density. The storage and transportation of LNG (Liquified Natural Gas) are accompanied with cryogenic cooling processes which require various cryogenic equipments including compressor, pump, valve, heat exchanger and auxiliary components. LNG & cryogenic equipment test and evaluation center will be designed and established by KIMM (Korea Institute of Machinery & Materials) in cooperation with Gyeongnam Technopark, Gimhae city and Gyeongsangnam-do.

증례 : 전이성 뇌종양에 의한 악성 경막하 삼출 및 경막하 혈종

전재균 ( Jae Kyun Jun ),이봉압 ( Bong Arm Rhee ),고준석 ( Jun Seok Koh ),임영진 ( Young Jin Lim ),김국기 ( Gook Ki Kim ),김태성 ( Tae Sung Kim ) 경희대학교 경희의료원 2004 慶熙醫學 Vol.20 No.1

특발성 및 이차성 삼차 신경통에 대한 감마나이프 방사선수술의 역할 - 수술적 치료와의 비교 -

김상현,임영진,임언,이봉암,고준석,김태성,김국기,Keem, Sang Hyun,Lim, Young Jin,Leem, Won,Rhee, Bong Arm,Koh, Jun Seok,Kim, Tae Sung,Kim, Gook Ki 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.5

Objective : To evaluate the role of Gamma Knife radiosurgery in essential and tumor-related(secondary) trigeminal neuralgia, outcomes of radiosurgery and microsurgery were compared each other. Methods : Five patients with essential trigeminal neuralgia underwent stereotactic radiosurgical treatment with Leksell Gamma Knife and twenty five patients were treated with microsurgery during the same period(1994. 1-1997. 6). A 4-mm collimator was used and REZ or proximal portion of trigeminal nerve was targeted with maximal dose of 60-72Gy. The mean follow-up after radiosurgery was 39.4 months and that after microsurgery was 47.9 months. Results : At the last follow-up, four patients(80%) had excellent(pain free) or good(50-90% pain relief) outcomes, one(20%) had poor control after radiosurgical treatment. Twenty-three patients(92%) had excellent or good outcomes and two(8%) had poor results after microsurgery. Postoperative complications occurred in ten(40%) with microsurgery, but there were no complications in patients with Gamma Knife radiosurgery. Six patients with secondary trigeminal neuralgia received radiosurgical treatment directed at their tumors, and three patients were surgically treated. Three of six(50%) patients treated with Gamma Knife had pain relief while two of three patients with surgical treatment showed immediate pain relief. Post-treatment complications were developed in two of six radiosurgical patients and in one of three surgical patients. Conclusion : Gamma Knife stereotactic radiosurgery may be considered as a useful and alternative option for the treatment of essential and secondary trigeminal neuralgia owing to of its safety and less complications. The preliminary results obtained in our series appear encouraging, although the outcome is not so good as that of surgery.

Dual acting 방식 1 kW급 스털링 엔진/발전기 설계 기술

박성제(Seong-Je Park),고준석(Jun-Seok Ko),홍용주(Yong-Ju Hong),김효봉(Hyobong-Bong Kim),염한길(Han-Kil Yeom),고득용(Deuk-Yong Koh),이청수(Cheong-Soo Lee),강인수(In-Soo Kang) 대한설비공학회 2013 대한설비공학회 학술발표대회논문집 Vol.2013 No.11

In small distributed generation applications, Stirling engine have competition from fuel cells, microturbine and etc.. In order to be economical in the application, a long system life with minimum maintenance is generally required. Free-piston Stirling engine(FPSE) have no crank and rotating parts to generate lateral forces and require lubrication. The FPSE is typically comprised of two oscillating pistons contained in a common cylinder. The temperature difference across the displacer maintains the oscillations, and the FPSE operate at natural frequency of the mass-spring system. The power is generated from a linear alternator. This paper describes the design, fabrication and performance characteristics of the 1 kW class dual acting type Stirling engine/alternater.

종양내 출혈을 동반한 뇌수막종 - 증례보고 -

천세명,김태성,이기택,고준석,임영진,김국기,임언,이봉암,Chun, Sae Myoung,Kim, Tae Sung,Yee, Gi Taek,Koh, Jun Seok,Lim, Young Jin,Kim, Gook Ki,Leem, Won,Rhee, Bong Arm 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.9

Meningioma associated with intratumoral hemorrhage is rarely reported. We present two patients with intratumoral hemorrhage. One 70-year-old man was admitted to our department with a decreased level of consciousness and left hemiparesis. CT scan and MRI scan revealed huge tumor with intratumoral hemorrhage in the frontal lobe. After surgical removal of the tumor, histopathological diagnosis was a meningotheliomatous meningioma. The other seemed patients was 56-year-old woman with headache and vomiting. She showed no specific neurological deficit. CT and MRI scan revealed large size tumor with intratumoral hemorrhage that looks like meningioma. The patient died suddenly before surgery. We reviewed the relevant literature and discussed the possible mechanism of hemorrhage in the meningioma.

유즙 호르몬 과분비 선종에 대한 감마 나이프 수술의 역할

허진우,임영진,임언,양재영,고준석,김태성,이봉암,김국기,Hur, Jin Woo,Lim, Young Jin,Leem, Won,Yang, Jae Young,Koh, Jun Seok,Kim, Tae Sung,Rhee, Bong Arm,Kim, Gook Ki 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.3

Objective : The treatment for prolactin secreting pituitary adenoma(prolactinoma) include pharmacology, surgery, radiation therapy or radiosurgery. The recent development of radiological imaging and microsurgery has made transsphenoidal microsurgery the treatment of choice for most prolactin secreting pituitary adenoma. Despite its low morbidity and mortality, relatively high recurrence and failure rate have been reported. Recent advances in neuroimaging provide a precise targeting in radiosurgery for treatment of prolactin secreting pituitary adenoma. In this regard, Gamma knife radiosurgery has been proposed as an alternative primary treatment modality or adjuvant therapy. Patients and Methods : Twenty three patients with prolactin secreting pituitary adenoma have been treated with Gamma knife radiosurgery in our institute from March 1992 to September 1998. We analyzed clinical, radiological and endocrinological changes in 21 patients who were followed up for an average of 35.7 months. Results : The mean age was 34.9 years and 16 patients were treated with Gamma knife radiosurgery as primary treatment and 5 patients underwent Gamma knife radiosurgery for residual tumors after microsurgery. The margin of the tumor was incorporated within the 40 to 80% and the mean marginal dose was 24.5 Gy. Clinical improvement in the last follow-up were present in 17 cases(81.0%) and 3 of 5 infertility patients became pregnant after Gamma knife radiosurgery. Tumor control rate after Gamma knife radiosurgery was 100%. Endocrinological normalization in the last follow-up were obtained in 12 cases(57.1%). In three cases, hormonal normalizations were present in early period(3-32 months) but serum hormone levels were elevated subsequently. Conclusion : We conclude that the Gamma knife radiosurgery for prolactin secreting pituitary adenoma seems to be safe and effective as adjuvant therapy after microsurgery and primary treatment modality in selective patients.

성장호르몬 분비 뇌하수체선종에 대한 감마나이프 방사선수술의 치료결과

임영진,최영호,임언,이기택,고준석,김태성,김국기,이봉암,Lim, Young Jin,Choi, Yeong Ho,Leem, Won,Lee, Ki Taek,Koh, Jun Seok,Kim, Tae Sung,Kim, Gook Ki,Rhee, Bong Arm 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5

Objective : As for growth hormone(GH) secreting pituitary adenoma, it's remission should be declared on the basis of satisfactory controlling of the tumor, normalization of hormonal level, and symptomatic improvement of the patient. Several modalities of treatment have been applied and administered, and yet, this disease still remains as inveterate one to be fully treated. The purpose of this study is to evaluate the outcome of gamma knife radiosurgery(GKRS) for GH secreting pituitary adenoma, and to identify various factors affecting the outcome of the treatment. Method : A group of 24 out of 35 patients, treated by Leksell gamma knife unit during the period of March of 1992 through October of 1997, had been observed for more than two years. The mean target volume of microadenoma was $449.3mm^3(range 216-880mm^3)$, and that of macroadenoma was $3183.1mm^3(range 1456-13125mm^3)$. The tumor margin was covered with 50% isodose profile, and mean marginal dose was 25.2Gy(range 15-32.4Gy). The mean number of isocenter was 4.3(range 1-6). The exposed dose to the optic apparatus was less than 8Gy. The mean follow-up period was 37.8months(range 24-102months). Result : No patients showed any increase in the tumor volume during the follow-up period. And definite shrinkage of tumor volume(tumor volume reduction rate, TVRR : more than 50%) was obtained in 10 patients(41.7%). Twenty one patients(87.5%) had reduced hormonal level compared than pre-treatment level. Among them, normalization of the hormonal level was achieved in 12 patients(50%). Clinicoendocrinological remission was seen in 3 patients (12.5%). According to the results of statistical analysis, tumor volume(p=0.016),duration of symptoms(p=0.046), initial GH level(p=0.017), and the invasion of cavernous sinus(p=0.036) were significantly favorable to post-radiosurgical outcome. The TVRR was significantly related to post-radiosurgical reduction of serum GH level. Permanent complication was not seen. Conclusion : The authors concluded that GKRS is a safe and effective treatment modality for acromegaly. To otain the better outcome of GKRS in GH secreting pituitary adenoma, more careful and sophisticated treatment-planning is recommended.

초소형 일체형 스터링 극저온냉동기 개발

홍용주,박성제,김효봉,고준석,고득용,Hong, Yong-Ju,Park, Seong-Je,Kim, Hyo-Bong,Ko, Jun-Seok,Koh, Deuk-Yong 재료연구소 2010 機械와 材料 Vol.22 No.3

획기적으로 선명한 영상의 구현, 휴대 용이성 및 정확한 온도분포의 구현이 가능한 초점면 배열 방식의 적외선 검출기는 탐지도 및 분해능 향상을 위해 액체질소 온도수준의 극저온냉각을 요구한다. 냉동기의 저온부에 적외선 검출기를 직접 부착하는 일체형 스터링 극저온냉동기는 효율적인 적외선 검출기의 냉각이 가능할 뿐 만 아니라, 소형/경량화가 용이하여, 기동 및 휴대용 열상장비용 극저온냉각을 위해 많이 활용되고 있다. 적외선 검출기 냉각용 즉저온냉동기는 다양한 열/진동/충격/전자파 등의 운용환경조건에서 검출기를 액체질소 온도수준으로 냉각/유지할 수 있어야 하며, 안정적인 시스템의 운용을 위한 충분한 신뢰성이 확보되어야 한다. 본 고에서는 민군 겸용기술사업을 통해 국내에서 개발된 열상장비 냉각용 일체형 스터링냉동기의 기술적 특징 및 환경/신뢰성 시험 결과를 소개하고자 한다.

2단 밸브 구동형 맥동관 냉동기를 이용한 크라이오펌프 기술 개발

박성제(Seong-Je Park),고준석(Jun-Seok Ko),홍용주(Yong-Ju Hong),김효봉(Hyobong-Bong Kim),염한길(Han-Kil Yeom),고득용(Deuk-Yong Koh),이청수(Cheong-Soo Lee),강인수(In-Soo Kang) 대한설비공학회 2013 대한설비공학회 학술발표대회논문집 Vol.2013 No.11

A pulse tube refrigerator (PTR) is a small scale cryocooler which was invented by Gifford and Longsworth in 1963. It has the advantages of high reliability and low vibration because it has no moving part in the cold part. In this paper, research is focused on the cryopump using the valve driving 2 stage Gifford–McMahon type pulse tube refrigerator with 5 kW input power compressor. Generally, pulse tube refrigerator for cryopump operates at 80 K (1<SUP>st</SUP> stage) and 20 K (2nd stage). Design of the 2 stage PTR is conducted by FZKPTR(Forschungs Zentrum Karlsruhe Pulse Tube Refrigerator) program for the design of pulse tube refrigerators. The fabricated PTR has U-type configuration and incorporates orifice valve, double-inlet valve and reservoir as phase control mechanism. Rotary valve is used to make pulsating pressure and is directly connected to inlet of 1st stage regenerator. Experimental results show the best cooling performance with 2 Hz operation in spite of small pressure amplitude. The lowest temperatures of the 2 stage PTR were 8.68 K at the second stage and 42.53 K at the first stage. The cooling capacities achieved were 40.0 W at 82.9 K, the first stage and 10.0 W at 20.5 K, the second stage. And the pumping speed and vacuum pressure of the cryopump were 4,4,00 L/s and 7.3 ×10<SUP>-10</SUP> mbar, respectively.