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구보음(九寶飮)과 가미구보음(加味九寶飮)이 폐혈전색전(肺血栓塞栓) 및 즉시형(卽時型) Allergy반응(反應)에 미치는 영향(影響)
김경민,강병령,박동일,정광식,Kim, Gyoung-Min,Gang, Byoung-Ryoung,Park, Dong-Il,Jeong, Gwang-Sik 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4
Objective : Experimental studies were done to research the effects of Gubo-eum(Jiubao-yin) and Kamigubo-eum(Jiameijiubao-yin) on the pulmonary thromboembolism and the immediately type hypersensitivity. Methods : For measuring the response about the pulmonary thromboembolism, we investigated a survival rate after the intravenous injection of sodium arachidonate and adenocine diphophate(ADP). For measuring the response about the immediately type hypersensitivity, we did the intravenous injection of histamin and serotonin, and phlebotomized and excoriated skin and investigated the amount of escaped pigment. Results : The each solid extract of Gubo-eum(Jiubao-yin) and Kamigubo-eum(Jiameijiubao-yin) revealed significant decrease effect on viscosity of mucin solution. The each solid extract of Gubo-eum(Jiubao-yin) and Kamigubo-eum(Jiameijiubao-yin) revealed significant effect on the pulmonary thromboembolism induced by sodium arachidonate and adenocine diphophate(ADP). The each solid extract of Guboeum(Jiubao-yin) and Kamigubo-eum(Jiameijiubao-yin) revealed significant on vascular permeability responses to intradenmal histamine and serotonine. conclusions : The each solid extract of Gubo-eum(Jiubao-yin) and Kamigubo-eum(Jiameijiubao-yin) revealed significant effect on the immediately type hypersensitivity and the pulmonary thromboembolism.
瀉白散 추출물에 의한 인체 폐암세포의 Apoptosis 유도 기전에 관한 연구
이재훈,강병령,감철우,박동일,최영현 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2
We investigated the effects of Sabaek-san (SBS) water extract on the growth of human lung carcinoma A549 cells. Upon treatment with SBS extract, a concentration-dependent inhibition of cell viability was observed and cells developed many of the hallmark features of apoptosis, including condensation of chromatin. Flow cytometry analysis confirmed that SBS treatment increased populations of apoptotic-sub Gl phase. In addition, proteolytic cleavages of poly(ADP-ribose) polymerase and β-catenin protein were observed after treatment of SBS extract. These apoptotic effects of SBS in A549 cells were associated with marked inhibition of Bcl-2 and Bcl-xL mRNA in a dose-dependent manner, however the levels of Bax expression were not affected. SBS treatment also induced a proteolytic activation of caspase-3, which is believed to play a central role in the apoptotic signaling pathway. The previous and present results indicated that SBS-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1/S progression and the induction of apoptosis.