다형성 교모세포종의 항생제 내성 종양 줄기세포

강미경,강수경,Kang, Mi-Kyung,Kang, Soo-Kyung 한국생명과학회 2007 생명과학회지 Vol.17 No.8

다형성 교모세포종은 뇌종양 가운데 가장 빈번하게 발병하는 악성종양이다. 다형성 교모세포종에 종양 줄기세포가 존재한다는 보고가 있음에도 불구하고, 항암제 내성과 종양 줄기세포 사이의 상호 연관성에 관한 연구는 아직 미비한 실정이다. 본 연구에서 다형성 교모세포종 세포주 A172 및 뇌종양 환자로부터 확립한 GBM2에 1,3-bis(2 -chloroethyl)-1-nitrosourea (BiCNU)를 처리시 극소량의 세포군만이 생존하며, 이들 생존 세포군은 BiCNU 재처리에 내성을 나타내는 것으로 조사되었다. 또한 이 다형성 교모세포종 유래 BiCNU-내성세포군의 Erk 및 Akt 인산화 활성이 증가되었으며, CD133 줄기세포 표지인자를 발현하는 세포가 다량 존재하였다. 이와 아울러, 다형성 교모세포종 유래 BiCNU-내성세포를 severe combined immuno-deficient (SCID) mouse brain에 이식하였을 때 암이 형성되는 것을 관찰할 수 있었다. 이와 같은 결과는 다형성 교모세포종 유래 BiCNU-내성세포가 종양줄기세포의 능력을 가지는 것으로 생각된다. 따라서 이상의 결과는 다형성 교모세포종에 존재하는 종양줄기세포가 항암제 내성에 관여 한다는 중요한 단서를 제공해줄 수 있을 것으로 사료된다. Glioblastoma multiforme (GBM) is the most frequently occurring brain cancer. Although the existence of cancer stem cells (CSCs) in GBM has been established, there is little evidence to explain the link between CSCs and chemoresistance. In this study, we investigated that only a few cells of A172 and established GBM2 survived after 1,3-bis(2chloroethyl)-1-nitrosourea (BiCNU) exposures and these sur-vived cells resist the subsequent BiCNU treatment. In addition, these BiCNU-resistant small pop-ulations derived from GBM cells increased the phosphorylations of Erk and Akt and highly expressed CD133 stem cell surface marker. Furthermore, we observed that the BiCNU-resistant cancer cells de-rived from GBM have grown tumors when transplanted into severe combined immuno-deficient (SCID) mouse brain. These results demonstrate that BiCNU-resistant subpopulation cells derived from GBM have cancer stem-like cell properties. Therefore, it may provide provide further evidence that CSCs in GBM have chemotherapeutic drug resistance.

특발성 파킨슨병 환자의 전침치료 효과

강미경,이상훈,홍장무,박상민,강중원,박히준,임사비나,장대일,이윤호,Kang, Mi-kyung,Lee, Sang-hoon,Hong, Jang-moo,Park, Sang-min,Kang, Jung-won,Park, Hi-joon,Lim, Sabina,Chang, Dae-il,Lee, Yun-ho 대한침구의학회 2004 대한침구의학회지 Vol.21 No.5

Objective : This study was designed to evaluate the effect of electroacupuncture with various scales on symptoms of idiopathic Parkinson's disease. Methods : Subjects were voluntarily recruited by newspapers and internet. All the subjects are confirmed as idiopathic parkinson's disease by a neurologist. The acupuncture therapy was performed twice a week for 8 weeks. Acupuncture points for EA group were GB34, and LR3, electrical stimulation frequency was 120Hz, duration 15 minutes, and intensity is up to pain threshold according to patients. The patient's symptoms were assessed before, after 4 weeks and after 8 weeks treatments by unified Parkinson's disease rating scale(UPDRS), modified Hoehn-Yahr(H-Y) stage, Schwab & England activity of daily living and freezing of gait questionnaire(FOGQ). Results : UPDRS I, II, III, IV and total UPDRS scores were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05) compared to the pre-treatment. The scores of ADL were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05). There were significant changes in H-Y stage after 4 weeks(p<0.05), but There were no significant changes in H-Y stage after 8 weeks. There were significant changes in FOGQ scale after 4 weeks(p<0.05) and after 8 weeks(p<0.05). Conclusion : This study suggests that electroacupuncutre treatments can be applicable to improve symptoms in the patients with idiopathic Parkinson's disease.

제임스 1세의 청교도 정책

강미경 ( Mi Kyung Kang ) 대구사학회 2012 대구사학 Vol.108 No.-

It is very important to analyze the relation of globalization phenomena and educational system in the era of globalization. Virtually all aspects of modern life-jobs, culture, education, relationship with one another-are being transformed by the profound forces of globalization. Not only has globalization become the central issue of our time, but it will define the world the next inherit. This study tries to make a comprehensive framework to deal with the problems of globalization in history education and also reviewed history educational reform in accordance with globalization phenomena in historical perspectives. The purpose of this study is to construct the theoretical survey for a new paradigm of history education in the age of globalization. A new paradigm should be beyond Eurocentrism and Nationalism. The historical background has changed very rapidly after World War II with the decline of Historicism. Korea has also reformed history educational curriculum periodically in the meet of changing political and historical circumstances since 1954. The most epochal reform of history education has occurred in the 7th National Curriculum and the History Revised Curriculum in 2007. The globalization has reflected more directly and extensively since the 7th Revised Curricurum. This article reflects the transformation of history and history education starting for the globalization phenomena in 1980`s. It is necessary to analysis and criticize modernity in meeting of post-modern era in order to pursuit a new World History Paradigm. I believe that to make a new history paradigm will contribute to the enhancement of history education.

서평 : 우리는 지금 관용의 시대에 살고 있는가? : 김응종, 『관용의 역사, 르네상스에서 계몽주의까지』

강미경 ( Mi Kyung Kang ) 한국서양사학회 2014 西洋史論 Vol.0 No.123

내관 지압과 심상요법이 방사성요오드 치료를 받는 갑상선암 환자의 오심, 구토, 헛구역질 및 식욕부진에 미치는 효과

강미경(Kang, Mi Kyung),서은영(Suh, Eunyoung, E.) 대한종양간호학회 2013 Asian Oncology Nursing Vol.13 No.4

Purpose: The purpose of this study was to evaluate the effects of P6 acupressure and guided imagery on nausea, vomiting, retching, and anorexia of the patient with thyroid cancer who were undergoing high dose radio-active iodine therapy (HD-RAIT). Methods: Using a randomized control group pretest-posttest study design, the participants were randomly assigned into the control group (C), the experimental group I (E1, P6 acupressure only) and the experimental group II (E2, P6 acupressure and a guided imagery). The patients were recruited from December 2011 to June 2012 in a tertiary hospital in Seoul, South Korea. A total of 82 patients completed the study. The Korean version of the Rhodes INVR and the anorexia scale by Grant (1987) were used. Results: The levels of nausea, vomiting, retching, and anorexia were significantly different among the groups. The levels of nausea and retching especially showed significant group differences over time. Synergic effects of P6 acupressure with guided imagery had significant effects over separate P6 acupressure intervention. Conclusion: Non-pharmacological and nurse-provided P6 acupressure and guided imagery appeared to be effective and safe in reducing nausea, vomiting, retching, and anorexia of the patients with thyroid cancer underwent HD-RAIT.

왕권에 대한 조언 : Basilikon Doron을 중심으로

강미경 ( Kang Mi-kyung ) 대구사학회 2021 대구사학 Vol.145 No.-

Marcus Tullius Cicero (BC 106-BC 43), a famous politician and philosopher of Rome, wrote letters of advice to his son who went to Athens to study even though he was very busy. The publication of these letters in three volumes had a great effect on modern Western thinkers, and this is De Officiis (BC 44). As the ancient culture was revived and regenerated after Renaissance, the British Islands saw re-illumination of classical books, and especially De Officiis was widely spread in English and Scotland both in the original version and in English-translated version of 1534. There was a trend to publish letters of advice to sons or daughters by being modeled after De Officiis, and the representative work of the tendency was Basilikon Doron (1599) by James Ⅵ (1567-1625), King of Scotland. Basilikon Doron is a Greek word meaning ‘the royal gift’, and it is a conduct book in the form of letters written to Prince Henry (1594-1612). At first, this conduct book was printed for private purpose, so there were only seven books in secret. However, by the time King James succeeded to the king of English after Queen Elizabeth Ι (1533-1603), the attention of this book was spread not only in Scotland but also England and European continent. Even fabricated copies and abridged editions were popular. Finally, Basilikon Doron was officially published in London for general public and translated into Latin, French and German, being distributed throughout English and Europe as a bestseller of the time. Why do we need to read Basilikon Doron now? What is the significance of the book? As Basilikon Doron appeared as a conduct book from the king to his son, this book can help to understand king’s education and ideal king in those days. In addition, it is an important resource to find out how King James, who was a king and intellectual, recognized his era and kingship. It also gives an opportunity to see a device to express the ideal about his kingship during the period of the conflicts among Divine Right of Kings, the theory of social contract and authority to depose the King. This study is intended to focus on political and religious backgrounds and contents of the advent of Basilikon Doron, and the publication and distribution of Basilikon Doron around 1603 when King James succeeded to throne. (Kyungpook National University / james-1603@knu.ac.kr)

여대생의 음주동기, 생활스트레스, 문제음주행위

강미경(Kang, Mi-Kyung),김인경(Kim, In-Kyung) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.8

본 연구의 목적은 여자대학생의 음주동기, 생활스트레스, 문제음주행위의 관계를 알아보고 음주동기와 생활스트레스 가 문제음주행위에 미치는 영향을 확인하기 위함이다. 자료수집은 충북 Y군에 위치한 일개 4년제 대학에 여대생을 대상으로 편의 추출하였다. 대상자는 259명으로 연구목적을 설문에 동의한 자를 대상으로 구조화된 설문지로 조사하였다. 사용한 도구 는 일반적특성, 음주동기, 생활스트레스, 문제음주행위이다. 수집된 자료는 IBMSPSS/WIN 19.0을 이용하여 빈도와 백분율, 평균과 표준편차, t-test, ANOVA, Pearson's correlation, Stepwise regression으로 분석하였다. 연구결과 대상자의 문제음주 행위에 영향을 미치는 요인은 음주동기(t=8.904, p<.001), 주거형태(t=3.624, p<.001), 흡연여부(t=2.065, p=.040) 로 구성되었으 며 35.7%의 설명력을 보였다. 본 연구결과를 통하여 향후 여대생의 문제음주행위를 예방할 수 있는 중재프로그램 개발이 필요할 것을 알 수 있었다. The purpose of this study was to examine the relationship among drinking motivation, daily stress and problem drinking behavior, and to identify the influencing factors of problem drinking behavior in female university students. The participants were 259 female students in university. The data was collected for 1 months from Oct. 28 to Nov. 28, 2013 in a university-located Y city. Questionnaires were used to measure the levels of the drinking motivation, daily stress, and problem drinking behavior. The data was analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation, stepwise regression, and the IBMSPSS/WIN 19.0 program. The predicting factors for problem drinking behavior were drinking motivation, type of residency and smoking. The variables explained the problem drinking behavior by 35.7%. A survey of the various influencing factors of problem drinking behavior will be required and a drinking reduction program for female university students is needed.

모바일 앱 접근성에 대한 연구

강미경(Kang, Mi Kyung) 한국디자인리서치학회 2017 한국디자인리서치 Vol.2 No.3

As the Disability Discrimination Act was enacted on April 11, 2008, the environment for web accessibility improved through increased awareness of web accessibility. In recent years, web environment has shifted from PC to mobile system and also the latter has gained more importance as domestic smartphone devices are more used. According to the report The Trend of Accessibility to Mobile Applications , which was released by Ministry of Science, ICT and Future Planning, however, the rate is still 78.1% as of 2015, which is not satisfactory. The main reason for the low accessibility is attributed to the development of mobile applications targeting for non-disabled people only. According to the survey Current Conditions of Mobile Shopping , more people do shopping on a mobile device than on PC due to purchasing and shipping benefits. In this study, we examine the compliance rate with the guideline for the mobile app Mobile Application Contents Accessibility Guideline 2.0 . In addition, we attempt to know the effect of applying the guideline on mobile application and its users from a design point of view. We expect the findings of this study to provide a theoretical background for the compliance with app accessibility.

아동학대 행위 중단과정에 관한 질적연구

강미경(Mi Kyung Kang) 한국아동복지학회 2009 한국아동복지학 Vol.- No.29

본 연구는 아동학대 한 경험을 갖고 있는 부모 또는 양육자들이 어떻게 학대 행위를 중단하게 되며 그 과정에서 어떤 요인들이 영향을 미치며 상호 작용하는지 탐색함으로써 아동학대 행위 중단 과정을 설명하고, 궁극적으로는 아동보호 분야에 적용할 수 있는 실천 지식과 방안을 제공하려는 목적으로 수행되었다. 이러한 연구목적을 위한 중심 질문은 "아동학대 경험을 갖고 있는 부모 또는 양육자가 학대 행위를 중단해 가는 경우, 그 과정에서 어떤 경험을 하는가?"였다. 본 연구 참여자는 아동학대 행동을 중단한 부모 9명이었다. 연구 자료는 연구 참여자 심층개별면접을 통해 수집하였다. 근거이론방법에 의한 분석결과 개방코딩에서는 93개의 개념, 32개의 하위범주, 12개의 범주가 도출되었다. 아동학대 행위 중단과정은 부모 자신의 `통찰`로부터 시작되는 것으로 나타났다. 이러한 통찰은 부모의 개인적 경험이나 인식의 전환만이 아니라 외부로부터의 자극과 상호작용을 통해 자신을 객관화시키게 되면서 더욱 촉진되었으며 학대 행위 중단의 전 과정을 통해 나타나는 현상이었다. 아동학대 행위에 대한 통찰이 일어나면서 참여자들은 적응적 양육방법을 찾아가게 되는데 이때 중재적 조건인 `사회적 지지 체계의 구축`과 `변화 매개체로서 사회복지 서비스 활용`이 아동학대 행위 중단에 중요한 조건으로 작용하는 것으로 나타났다. 적응적 양육방법으로의 변화 노력의 결과를 통해 자녀, 참여자 자신, 가족관계의 변화를 이끌어내는 성공적 경험이 축적되고 이러한 경험은 참여자의 변화 노력을 지속하게 하는 요인으로 작용하고 있었다. This study was conducted with the aim to explain the process of desistance from child abuse, by exploring how the parents who had abused their children in the past could desist from child abuse and what factors affected the process. The ultimate aim of this study was to provide knowledge and meanings applicable to child welfare practice. The main question of this study was "What experiences did parents have in the process of desisting from child abuse? The participants of the study were 9 parents who desisted from child abusive behavior. The study data were collected through in-depth interviews. At the result of the data analysis using the grounded theory, 93 concepts, 32 sub-categories, and 12 categories were induced in open coding. The process of desistance from child abusive behaviors began with the parent`s `insight.` This insight was facilitated not only by the parent`s personal experience or change of consciousness but also by the outer stimuli and interaction. The insight was through the whole process of desistance from abuse behavior. With the insight, participants looked for an adaptive ways of child rearing. The intervening conditions such as `the using of social welfare service as a change agency` and `the establishment of social support system` were discovered as important conditions to desistance from child abusive behaviors. As the result of endeavors for change to an adaptive child rearing, the successful experiences of changing of the child, participant, and family relationship were accumulated, which became the factor enabling the participant to keep the endeavor. A theory unifying the process and types of desistance from child abusive behaviors were suggested from the study result.

하지 인공관절 치환술 환자의 건강 관련 삶의 질 영향요인

강미경(Kang, Mi Kyung),김근진(Kim, Geun Jin),김혜영(Kim, Hye Young) 기본간호학회 2017 기본간호학회지 Vol.24 No.3

Purpose: The purpose of this research was to identify factors that influence health-related quality of life of patients who have had knee or hip arthroplasty. Factors included sleep disorders, pain, activities of daily living, and depression. Methods: The participants in this research were 97 patients within one year after receiving knee or hip arthroplasty surgery and who regularly visited a hospital outpatient department. Data were analyzed using descriptive statistics, t-test, ANOVA, and stepwise regression analysis with the SPSS program. Results: Sleep disorders, pain, activities of daily living, and depression had significant correlations with health related quality of life. Factors influencing health-related quality of life among arthroplasty patients were the length of time since surgery, sleep disorders, activities of daily living, and depression. These factors explained 58% of the participants" health-related quality of life. Conclusion: The results show that various factors can affect patients" health-related quality of life following joint replacement surgery. The findings indicate that sleep disorders and depression should receive continued attention after the arthroplasty. It is also necessary to develop appropriate nursing intervention programs to lower depression and increase patient participation in daily living activities.