특발성 파킨슨병 환자의 전침치료 효과

강미경,이상훈,홍장무,박상민,강중원,박히준,임사비나,장대일,이윤호,Kang, Mi-kyung,Lee, Sang-hoon,Hong, Jang-moo,Park, Sang-min,Kang, Jung-won,Park, Hi-joon,Lim, Sabina,Chang, Dae-il,Lee, Yun-ho 대한침구의학회 2004 대한침구의학회지 Vol.21 No.5

Objective : This study was designed to evaluate the effect of electroacupuncture with various scales on symptoms of idiopathic Parkinson's disease. Methods : Subjects were voluntarily recruited by newspapers and internet. All the subjects are confirmed as idiopathic parkinson's disease by a neurologist. The acupuncture therapy was performed twice a week for 8 weeks. Acupuncture points for EA group were GB34, and LR3, electrical stimulation frequency was 120Hz, duration 15 minutes, and intensity is up to pain threshold according to patients. The patient's symptoms were assessed before, after 4 weeks and after 8 weeks treatments by unified Parkinson's disease rating scale(UPDRS), modified Hoehn-Yahr(H-Y) stage, Schwab & England activity of daily living and freezing of gait questionnaire(FOGQ). Results : UPDRS I, II, III, IV and total UPDRS scores were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05) compared to the pre-treatment. The scores of ADL were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05). There were significant changes in H-Y stage after 4 weeks(p<0.05), but There were no significant changes in H-Y stage after 8 weeks. There were significant changes in FOGQ scale after 4 weeks(p<0.05) and after 8 weeks(p<0.05). Conclusion : This study suggests that electroacupuncutre treatments can be applicable to improve symptoms in the patients with idiopathic Parkinson's disease.

다형성 교모세포종의 항생제 내성 종양 줄기세포

강미경,강수경,Kang, Mi-Kyung,Kang, Soo-Kyung 한국생명과학회 2007 생명과학회지 Vol.17 No.8

다형성 교모세포종은 뇌종양 가운데 가장 빈번하게 발병하는 악성종양이다. 다형성 교모세포종에 종양 줄기세포가 존재한다는 보고가 있음에도 불구하고, 항암제 내성과 종양 줄기세포 사이의 상호 연관성에 관한 연구는 아직 미비한 실정이다. 본 연구에서 다형성 교모세포종 세포주 A172 및 뇌종양 환자로부터 확립한 GBM2에 1,3-bis(2 -chloroethyl)-1-nitrosourea (BiCNU)를 처리시 극소량의 세포군만이 생존하며, 이들 생존 세포군은 BiCNU 재처리에 내성을 나타내는 것으로 조사되었다. 또한 이 다형성 교모세포종 유래 BiCNU-내성세포군의 Erk 및 Akt 인산화 활성이 증가되었으며, CD133 줄기세포 표지인자를 발현하는 세포가 다량 존재하였다. 이와 아울러, 다형성 교모세포종 유래 BiCNU-내성세포를 severe combined immuno-deficient (SCID) mouse brain에 이식하였을 때 암이 형성되는 것을 관찰할 수 있었다. 이와 같은 결과는 다형성 교모세포종 유래 BiCNU-내성세포가 종양줄기세포의 능력을 가지는 것으로 생각된다. 따라서 이상의 결과는 다형성 교모세포종에 존재하는 종양줄기세포가 항암제 내성에 관여 한다는 중요한 단서를 제공해줄 수 있을 것으로 사료된다. Glioblastoma multiforme (GBM) is the most frequently occurring brain cancer. Although the existence of cancer stem cells (CSCs) in GBM has been established, there is little evidence to explain the link between CSCs and chemoresistance. In this study, we investigated that only a few cells of A172 and established GBM2 survived after 1,3-bis(2chloroethyl)-1-nitrosourea (BiCNU) exposures and these sur-vived cells resist the subsequent BiCNU treatment. In addition, these BiCNU-resistant small pop-ulations derived from GBM cells increased the phosphorylations of Erk and Akt and highly expressed CD133 stem cell surface marker. Furthermore, we observed that the BiCNU-resistant cancer cells de-rived from GBM have grown tumors when transplanted into severe combined immuno-deficient (SCID) mouse brain. These results demonstrate that BiCNU-resistant subpopulation cells derived from GBM have cancer stem-like cell properties. Therefore, it may provide provide further evidence that CSCs in GBM have chemotherapeutic drug resistance.

골관절염(骨關節炎)의 침구치료(鍼灸治療)에 대한 최신연구경향(最新硏究傾向) - Pubmed 검색을 중심으로 -

강미경,남상수,이윤호,Kang, Mi-kyeong,Nam, Sang-su,Lee, Yun-ho 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2

Objective : To research the trends of study related to osteoarthritis with acupuncture in PubMed, and to establish he hereafter direction of acupuncture for osteoarthritis. Methods : We searthed in PubMed, with osteoarthritis and acupuncture limited by abstract, human, English. Results : 1. The pattern of study was as follow: Review article(2), Clinical Trials(13), randomized controlled trials(13). bee venom acupuncture(1), electroacupuncture(1). We further estimated 15 articles. 2. The lesion of osteoarthritis & kinds of acupuncture were as follows: knee(12), hip(2), cervical vertebral(1), bee venom acupuncture(1), electroacupuncture(1). 3. Most clinical trials are related to decrease of pain, functional improvement. 4. 10 of clinical studies provide affirmative result. And they recommend acupuncture for osteoarthritis. 5. 4 of clinical studies provide negative result. And these studies are designed by sham acupuncture method.

사람의 정상 피부세포 및 폐세포의 발암에 미치는 2,3,7,8-tetrachlorodibenzo-ρ -dioxin의 영향

강미경(Mi Kyung Kang),염태경(Tai Kyung Ryeom),김강련(Kang Ryune Kim),김옥희(Ok Hee Kim),강호일(Hoil Kang) 한국환경성돌연변이발암원학회 2006 한국환경성돌연변이·발암원학회지 Vol.26 No.3

2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) displays high toxicity in animals and has been implicated in human carcinogenesis. Although TCDD is recognized as potent carcinogens, relatively little is known about their role in the tumor promotion and carcinogenesis. It is known that TCDD can increase of cancer risk from various types of tissue by a mechanism possibly involving the aryl hydrocarbon receptor (AhR) activation. In this study, effects of TCDD on cellular proliferation of normal human skin and lung fibroblasts, Detroit551 and WI38 cells were investigated. In addition, to enhance our understanding of TCDD-mediated carcinogenesis, we have investigated process in which expression of Erk1/2, cyclinD1, oncogene such as Ha-ras and c-myc, and their cognate signaling pathway. TCDD that are potent activators of AhR-mediated activity was found to induce significant increase of cytochrome P4501A1 mRNA expression, suggesting a presence of functional AhR. These results support that CYP1A1 enzyme may be involved in the generation of TCDD-induced toxicity. Moreover mitogen-activated protein kinases (MAPKs) phosphorylation and cyclin D1 overexpression are induced by TCDD, which corresponded with the progression of cellular proliferation. However, TCDD did not affected Haras and c-myc mRNA expression. Taken together, it seems that TCDD are could be a part of cellular proliferation in non-tumorigenic normal human cells such as Detroit551 and WI38 cells through the upregulation of MAPKs signaling pathway regulating growth of cell population. Therefore, AhR-activating TCDD could potentially contribute to tumor promotion and Detroit551 and WI38 cells have been used as a detection system of tumorigenic effects of TCDD.

국왕 길들이기: 『스코틀랜드 왕의 권한』(De Jure Regni Apud Scotos)을 중심으로

강미경 ( Kang Mikyung ) 대구사학회 2023 대구사학 Vol.150 No.-

16세기는 인문주의와 종교개혁의 열풍이 전 유럽을 휩쓸던 시기였다. 이 시기 에라스무스(Desiderius Erasmus, 1466-1536)와 같은 인문주의자들은 고대 그리스와 로마의 저서들 속에서 시민의 존엄성과 전제정을 비난할 근거를 찾고자 했다. 그들에게 군주란 공공의 이익을 추구하는 존재이지 자신을 위해 절대 권력을 휘두르는 존재가 아니었다. 그들은 오히려 신민들의 권리를 지키기 위해 전제적인 폭군을 제거할 수 있다고 주장했다. 그리고 이런 주장들은 프랑스 위그노를 비롯한 당대의 많은 신교도에게 차용되었으며 신교 군주들을 교육하는 하나의 배경을 제공하기도 했다. 스코틀랜드에서 이런 주장을 받아들인 대표적 인물이 바로 당시 유명한 인문주의자이자 장로교 이론가였던 조지 뷰캐넌(George Buchanan, 1506-1582)이다. 이 논문은 그의 대표적 저서 『스코틀랜드 왕의 권한』 (De Jure Regni Apud Scotos) 속에 드러난 왕권의 기원과 신민들의 저항권 그리고 이런 내용을 담은 『스코틀랜드 왕의 권한』을 뷰캐넌이 제자 제임스 6세(James Ⅵ, 재위 1567-1625)에게 헌정한 이유가 무엇이었는지를 살펴보려는 논문이다. The 16^th century was when the fever of the Reformation swept Europe. In this period, humanists such as Desiderius Erasmus (1466-1536) tried to find basis to criticize tyranny in books of Ancient Greece and Rome. To them, the monarch was a being that pursues public interest not exerting power for themselves. Their claims especially had a powerful influence on Huguenots of France, who claimed tyrant could be removed to protect rights of people. The claim of humanists was borrowed by many contemporary Protestants including Huguenot and supplied a background to educate monarchies of Protestant. A representative figure who accepted this claim in Scotland was George Buchanan (1506-1582), a famous humanist and Presbyterian theorist. This study is intended to find out the origin of royal authority and people’s rights of resistance in Buchanan’s book De Jure Regni Apud Scotos, along with his intention through the contents.

고준위방사성폐기물 심층처분시설 안전성평가 입력자료 관리를 위한 해외사례 분석

강미경(Mi Kyung Kang),박하나(Hana Park),박선주(Sunju Park),정해식(Hae Sik Jeong),윤운상(Woon Sang Yoon),이정환(Jeonghwan Lee) 대한자원환경지질학회 2023 자원환경지질 Vol.56 No.6

스웨덴, 스위스, 영국 등 폐기물 처분 선도국들은 고준위방사성폐기물 심층처분시설의 계획, 부지선정, 건설, 운영, 폐쇄, 그리고 폐쇄 후 관리 전 단계에서 안전성평가를 수행하고 있다. 안전성평가는 각 단계에서 반복적으로 이루어지며, 장기간에 걸쳐 다양하고 방대한 양의 데이터를 생성하므로, 안전성평가 자료를 위한 데이터베이스를 구축하고 효과적으로 관리하기 위한 자료 관리체계를 구축하는 것이 필수적이다. 본 연구에서는 폐기물 처분 분야에서 선도적인 국가의 안전성평가 자료관리체계를 1) 안전성평가 입력 및 참조자료, 2) 자료관리 지침, 3) 자료관리 조직, 그리고 4) 자료관리 전산시스템으로 구분하여 분석하였다.각 국가는 특정 부분에서는 차이를 보였지만, 안전성평가 입력자료를 처분 시스템 구성 요소를 기반으로 분류하고, 이를 제공, 사용, 관리하는 조직을 설립하며, 지침 및 매뉴얼에 따라 품질관리 체계를 구현하는 등 공통적인 특성을 보이고 있다. 이러한 사례들은 고준위방사성폐기물 처분시설의 안전성을 확보하고 신뢰성을 향상시키기 위해 효과적으로 데이터 관리 시스템과 문서 관리 시스템을 구축하는 것이 중요하다는 것을 시사한다. 이를 위해서는 유연하게 활용 가능한 입력자료의 분류, 입력자료의 일관성과 추적성 보장, 그리고 입력자료와 문서관리를 위한 품질관리 체계를 수립하는 것이 필요하다. Leading waste disposal countries, such as Sweden, Switzerland, and the United Kingdom, conduct safety assessments across all stages of High-Level Radioactive Waste Deep Geological Disposal Facilities-from planning and site selection to construction, operation, closure, and post-closure management. As safety assessments are repeatedly performed at each stage, generating vast amounts of diverse data over extended periods, it is essential to construct a database for safety assessment and establish a data management system. In this study, the safety assessment data management systems of leading countries, were analyzed, categorizing them into 1) input and reference data for safety assessments, 2) guidelines for data management, 3) organizational structures for data management, and 4) computer systems for data management. While each country exhibited differences in specific aspects, commonalities included the classification of safety assessment input data based on disposal system components, the establishment of organizations to supply, use, and manage this data, and the implementation of quality management systems guided by instructions and manuals. These cases highlight the importance of data management systems and document management systems for securing the safety and enhancing the reliability of High-Level Radioactive Waste Disposal Facilities. To achieve this, the classification of input data that can be flexibly and effectively utilized, ensuring the consistency and traceability of input data, and establishing a quality management system for input data and document management are necessary.

수술실 간호사의 병원감염관리에 대한 인지도와 실천정도에 관한 연구

강미경(Kang Mi Kyoung),김경희(Kim Kyoung Hee),최미혜(Choi Mi Hye) 기본간호학회 2004 기본간호학회지 Vol.11 No.3

내관 지압과 심상요법이 방사성요오드 치료를 받는 갑상선암 환자의 오심, 구토, 헛구역질 및 식욕부진에 미치는 효과

강미경(Kang, Mi Kyung),서은영(Suh, Eunyoung, E.) 대한종양간호학회 2013 Asian Oncology Nursing Vol.13 No.4

Purpose: The purpose of this study was to evaluate the effects of P6 acupressure and guided imagery on nausea, vomiting, retching, and anorexia of the patient with thyroid cancer who were undergoing high dose radio-active iodine therapy (HD-RAIT). Methods: Using a randomized control group pretest-posttest study design, the participants were randomly assigned into the control group (C), the experimental group I (E1, P6 acupressure only) and the experimental group II (E2, P6 acupressure and a guided imagery). The patients were recruited from December 2011 to June 2012 in a tertiary hospital in Seoul, South Korea. A total of 82 patients completed the study. The Korean version of the Rhodes INVR and the anorexia scale by Grant (1987) were used. Results: The levels of nausea, vomiting, retching, and anorexia were significantly different among the groups. The levels of nausea and retching especially showed significant group differences over time. Synergic effects of P6 acupressure with guided imagery had significant effects over separate P6 acupressure intervention. Conclusion: Non-pharmacological and nurse-provided P6 acupressure and guided imagery appeared to be effective and safe in reducing nausea, vomiting, retching, and anorexia of the patients with thyroid cancer underwent HD-RAIT.

Poly(N-isopropylacrylamide-co-dimethylamino ethyl methacrylate)가 고정화된 알지네이트 비드 제조 및 방출 특성

강미경(Mi Kyoung Kang),김진철(Jin Chul Kim) 한국고분자학회 2010 폴리머 Vol.34 No.1

여대생의 음주동기, 생활스트레스, 문제음주행위

강미경(Kang, Mi-Kyung),김인경(Kim, In-Kyung) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.8

본 연구의 목적은 여자대학생의 음주동기, 생활스트레스, 문제음주행위의 관계를 알아보고 음주동기와 생활스트레스 가 문제음주행위에 미치는 영향을 확인하기 위함이다. 자료수집은 충북 Y군에 위치한 일개 4년제 대학에 여대생을 대상으로 편의 추출하였다. 대상자는 259명으로 연구목적을 설문에 동의한 자를 대상으로 구조화된 설문지로 조사하였다. 사용한 도구 는 일반적특성, 음주동기, 생활스트레스, 문제음주행위이다. 수집된 자료는 IBMSPSS/WIN 19.0을 이용하여 빈도와 백분율, 평균과 표준편차, t-test, ANOVA, Pearson's correlation, Stepwise regression으로 분석하였다. 연구결과 대상자의 문제음주 행위에 영향을 미치는 요인은 음주동기(t=8.904, p<.001), 주거형태(t=3.624, p<.001), 흡연여부(t=2.065, p=.040) 로 구성되었으 며 35.7%의 설명력을 보였다. 본 연구결과를 통하여 향후 여대생의 문제음주행위를 예방할 수 있는 중재프로그램 개발이 필요할 것을 알 수 있었다. The purpose of this study was to examine the relationship among drinking motivation, daily stress and problem drinking behavior, and to identify the influencing factors of problem drinking behavior in female university students. The participants were 259 female students in university. The data was collected for 1 months from Oct. 28 to Nov. 28, 2013 in a university-located Y city. Questionnaires were used to measure the levels of the drinking motivation, daily stress, and problem drinking behavior. The data was analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation, stepwise regression, and the IBMSPSS/WIN 19.0 program. The predicting factors for problem drinking behavior were drinking motivation, type of residency and smoking. The variables explained the problem drinking behavior by 35.7%. A survey of the various influencing factors of problem drinking behavior will be required and a drinking reduction program for female university students is needed.