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김성철,이원혁,김송희,Abdumadjidov Alisher Abdulkhayevich,박정우,김영민,문경현,이상훈,박성찬 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.4
Purpose: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel-induced apoptosis and to determine whether prostate cancer responses to docetaxel treatment differ with DRG2 expression. Materials and Methods: PC3, DU145, and LNCaP prostate cancer cell lines were used. The MTT assay was used to determine cell viability. Western blotting analysis was performed using anti-DRG2 antibodies. Cells were transfected with 50 nmol DRG2 siRNA using an siRNA transfection reagent for DRG2 knockdown. The cell cycle was analyzed by using flow cytometry, and apoptosis was detected by using the Annexin V cell death assay. Results: DRG2 expression differed in each prostate cancer cell line. Docetaxel reduced DRG2 expression in a dose-dependent manner. Upon DRG2 knockdown in prostate cancer cells, an increase in the sub-G1 phase was observed without a change in the G1 or G2/M phases. When 4 nM docetaxel was administered to DRG2 knockdown prostate cancer cell lines, an increase in the sub-G1 phase was observed without increasing the G2/M phase, which was similar to that in DU145 cells before DRG2 knockdown. In PC3 and DU145 cell lines, DRG2 knockdown increased docetaxel-induced Annexin V (+) apoptosis by 8.7 and 2.7 times, respectively. Conclusions: In prostate cancer cells, DRG2 regulates G2/M arrest after docetaxel treatment. In prostate cancer cells with DRG2 knockdown, apoptosis increases without G2/M arrest in response to docetaxel treatment. These results show that inhibition of DRG2 expression can be useful to enhance docetaxel-induced apoptosis despite low-dose administration in castration-resistant prostate cancer.
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김성철,김인구,Kim, Seong-Chul,Kim, In-Koo 대한소아외과학회 1997 소아외과 Vol.3 No.1
One case of primary omental torsion in a 10 year-old, 43 kg boy is presented. He presented with a history of acute, continuous pain in the upper abdomen, aggravated by changes of position. Physical examination of his abdomen showed board-like rigidity. tenderness and rebound tenderness over the entire abdomen. The preoperative diagnosis was perforated peptic ulcer. Exploratory laparatomy revealed torsion of the greater omentum. The torsed omentum was excised and the outcome was good. Omental torsion is a rare surgical condition and is difficult to diagnose prior to operation. Therefore, in case of negative exploration for acute abdomen, the omentum should be included among the organs examined. In addition, careful search for an inflammatory focus should be made, because secondary omental torsion with intraabdominal sepsis is much more common than primary torsion.
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지진력에 의한 고층건물의 병진 및 비틀림 거동에 관한 연구
홍창국,김기봉,조미라,김성철 中央大學校 建設環境硏究所 1991 環境科學硏究 Vol.2 No.-
Although the lateral motion of structures subjected to earthquake excitations has been an active research topic for the past twenty years, very few investigators have considered the torsional motion of the structures. Torsional motion, if not considered in design, could result in overstressing of columns at the periphery of the structure. Thus, the coupled lateral-torsional motion is considered in this paper. The random mature of earthquake excitations is accounted for and the problem is formulated in terms of transfer matrix method instead of the normal mode approach. Numerical examples are presented for illustrative purposes.
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김성철 韓日經商學會 1997 韓日經商論集 Vol.14 No.-
Both empirical and theoretical literature on intra-industry trade have developed rapidly. During the past decade, there has been growing interest in the phenomenon of intra-industry trade(IIT), whereby countries export to each other hoods which are broadly similar in nature, or even identical. IIT occurs when countries simultaneously export andimport goods produced by thesame industries or adjacent countries. This phenomenon is not envisaged by the standard comparative advantage theory of international trade and requires explanations based upon factors such as economies of scale, product differentiation, imperfect markets and consumer's taste for variety, which arenot condidered in theworld of perfect competition of the standard theory. This intra-industry trade will certainly occur when the economies are absolutely identical in all respects and can persist under conditions of comparative advantage. However, asufficiently great difference incomparative advantage,either becauseof technological or factor endowment differences,can eliminate thetwo-way trade in manufactures. Thus, intra-industry trade not only may occur between similar economies, it is most likely to occur between such economies and the volume may be much higher than trade based on comparative advantage. If exports and imports tend to match each other in each industry, the index approaches zero. According to Balassa, this signifies a low degree of inter-industry specialization(with a correspondingly high degree of intra-industry specialization). On the other hand, if exports and imports differ widely, theindex approaches unity, indicating high inter-industry specialization(and low intra-industry specialization). This paper explains the analysis of intra-industry trade between Korea and Japan. The verified results of the important contents with respect to thepromotion of intra-industry trade between Korea and Japan and their indications can be summarized as follows. The fact that intra-industry trade between Korea and Japan was unable to take root is attributable to not only to thedifferences in the pattern of economic development and industrial structure, but also to thelack of opportunities for international industrial cooperation. However, Japan is now showingsigns of expanding intra-industry trade to offset the weakening price ocmpetitiveness of Japanese products resulting from thestrong yen and the collapse of thebubble economy. An expansion of intra-industry trade among adjacent countries enables the countries concerned to make full use of the complementary nature of each other's comparative advantage. Under these circumstances, it is becoming increasingly important to find ways to expandtheintra-industry trade between Korea and Japan. To this end, the following steps must be taken; First, Korea should focus on import substitution by stepping up technological cooperation and strategic alliance with Japan in the supporting industry, a field in which Korea is at a comparative disadvantage. Second, Korea should pursue intra-industry trade that relies on product differentiation, especially in the high value-added industries. It must also diversify its export items and promote industries of high income elasticity as major export industries. Third, Inter-Industry Trade of progress of work should be expanded in the manufacturing of machinery and transportation equipment as well as electrical machinery or appliances that rely heavily on trade nad economies of scale. Fourth, in order to make use of Japan's competitive advantage in high developed industries, Korea should utilize to a variety of measures including the use of Japanese techincians, the joint development of technology, and strategic alliance. Fifth, in order to facilitate industrial coordination between Korea and Japan in the information age,, an information and telecommunications network should be established between the two countries. Through this network, the two nations will be able to exchange precise information oneach other's industries of comparative advantage and disadvantage. This inturn, will lay the basis for establishing appropriate strategies for technology development and industrial restructuring with regard to intra-industry trade. For industries where domestic production is possible, inter progress of work should be promoted within the industry. For industries where low technological standards hinder product differentiation, interm progress of work should be promoted within the firm.
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