間按正犯에 關한 小考

金容培 청주대학교 법학연구소 1967 法學論考 Vol.7 No.-

Minoxidil과 Griseofulvin을 이용한 섬유모세포 억제기전에 대한 실험적 연구

김용배 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

이 연구는 임상에서 사용할 수 있는 상용약으로서 창상의 구축 과정을 약화 내지는 억제시키는데 그 목적을 두었다. 실험결과 minoxidil은 griseofulvin보다 더 강력하게 섬유모세포의 증식을 억제하였다. 또한 농도가 증가함에 따라서 세포의 모양도 방추형에서 원형에 가깝게 변화하였으며 원혈질돌기가 현저히 감소함이 관찰 되었다. 이러한 결과로 섬유모세포의 파괴없이 구축을 억제할수있는 방법을 모색 할 수 있었으며 나아가서는 이러한 약제의 정확한 기전을 파악하여 임상적으로 과섬유소증이나 창상치유를 조절하는데 활용시킬 수 있으리라고 생각된다. Fibroblasts are known as the key cells for wound contraction. In the plastic surgical field, wound contraction is one of the main concerns. Many drugs and treatment modalities have been tried to reduce the action of the fibroblasts. To investigate the effects of minoxidil and griseofulvin on fibroblasts, fetal human fibroblasts were isolated from the anterior chest of normal individual. Minoxidil, in addition to its effect on hypertention and hair growth and griseofulvin which has been used as antifungal agent were added on cultured fibroblasts. The morphological changes and numerical changes of the fibroblatsts were obseved by phase contrast microscopy. In low concentration, minoxidil do not affect the fibroblast proliferation but in high concentration, it inhibt fibroblast proliferation and changes morphology of fibroblasts. Griseofulvin affects the fibroblasts but not so significant as minoxidil. The significance of present findings is possible usage of this drugs to treat clinical fibrosis, hypertrophic scars. Futher studies are planned to learn more about a possible role for minoxidil and griseofulvin in prevention of wound contraction.

Long-Term Clinical and Angiographic Outcomes of Wrap- Clipping Strategies for Unclippable Cerebral Aneurysm

김용배,허승곤,홍창기,정준호,주진양 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.2

Purpose: To evaluate the efficacy and stability of the wrap-clipping methods as a reconstructive strategy in the treatment of unclippable cerebral aneurysms. Materialsand Methods: Twenty four patients who had undergone wrap-clipping microsurgerywere retrospectively reviewed. Type and morphology of the treated aneurysm,utilized technique for wrap-clip procedure, and clinical outcome with angiographic results at their last follow-up were evaluated. Results: Of 24 patients,eleven patients had internal carotid artery (ICA) blister-like aneurysms, three had dissecting type aneurysms, and ten had fusiform aneurysms. The follow-up period for the late clinical and angiographic results ranged from 10 to 75 months (mean 35 months). Wrap-clipping was performed in eleven, wrap-holding clipping was in ten, and combination of wrap-clip and wrap-holding clip was in three cases. At the last angiographic follow-up study, twelve aneurysms (50%) were found to have completely healed, and nine aneurysms (38%) were at least stable. However, wrap-holding clip for the elongated blister type of ICA aneurysm was found failed, leading to fatal rebleeding in one case, and two cases of combinationof wrap-clip-wrap-holding clip revealed delayed branch occlusion and marked regrowing, respectively. Conclusion: Wrap-clipping strategy could be an easy and safe alternative for unclippable aneurysms. The wrapped aneurysm mostlydisappeared, or at least remained stationary, after a long-term period. However, surgeons should be aware of that the wrapped aneurysm might become worse. Therefore, follow-up surveillance for an extended period should be mandatory.

연취급 근로자들의 혈중 ZPP 농도 선별기준에 따른 정확도의 변화

김용배,안현철,황보영,리갑수,이성수,안규동,이병국,Kim, Yong-Bae,Ahn, Hyun-Cheol,HwangBo, Young,Lee, Gap-Soo,Lee, Sung-Soo,Ahn, Kyu-Dong,Lee, Byung-Kook 대한예방의학회 1997 예방의학회지 Vol.30 No.4

Measurement of blood lead (PbB) and blood zinc protoporphyrin (ZPP) are most common biological indices to identify the individual at risk for excess or the health sequences by lead exposure. Because PbB is known most important and reliable index of lead exposure, PbB is often regarded as a gold standard to detect lead exposure. But in Korea PbB is a secondary test item of detailed health check-up with positive finding of screening test in most occasion. Our lead standard requires all lead workers to take annual heath-check twice a year for investigation of their health effect due to lead exposure. Blood ZPP is one of most important index to detect high lead absorption in lead workers as a screening test. Measurement of blood ZPP is known ,well to correlate with PbB in steady state of exposure in most lead workers and is often used as a primary screening test to detect high lead absorption of lead workers with the advantage of simplicity, easiness, portability and low cost. The current cut-off criteria of blood ZPP for further detailed health check-up is $100{\mu}g/d\ell$ which is supposed to match the level of $40{\mu}g/d\ell$ of PbB according to our standard. Authors tried to investigate the validity of current criteria of cut-off level $(100{\mu}g/d\ell)$ of blood ZPP and possible another better cut-off level of it to detect the lead workers whose PbB level over $40{\mu}g/d\ell$. The subjects in our study were 212 male workers in three small scale storage battery industries. Blood ZPP, PbB and hemoglobin (Hb) were selected as the indices of lead exposure. The results were as follows. 1. The mean of blood ZPP, PbB and Hb in lead workers were $79.5{\pm}46.7{\mu}g/d\ell,\;38.7{\pm}15.1{\mu}g/d\ell,\;and\;14.8{\pm}1.2g/d\ell$, respectively. There were significant differences in blood ZPP, PbB and Hb by industry (P<0.01). 2. The percents of lead workers whose blood ZPP were above $100{\mu}g/d\ell$ in the group of work duration below 1, 1-4, 5-9 and above 10 years were 8.6%, 17.2%, 47.6%, and 50.0%, respectively. The percents of lead workers whose PbB were above $40{\mu}g/d\ell$ in those were 31.4%, 40.4%, 71.4%, and 86.4%, respectively. 3. The percents of lead workers whose PbB were below $40{\mu}g/d\ell$, $40-59{\mu}g/d\ell$ and above $60{\mu}g/d\ell$ were 54.7%, 34.9% and 10.4%, respectively. Those of lead workers whose blood ZPP were below $100{\mu}g/d\ell$, $100-149{\mu}g/d\ell$ and above $150{\mu}g/d\ell$ were 79.2%, 13.7% and 7.1%, respectively. 4. Simple linear regression of PbB on blood ZPP was statistically significant (P<0.01) and as PbB was $40{\mu}g/d\ell$, blood ZPP was $82.1{\mu}g/d\ell$. 5. While the highest sensitivity and specificity of blood ZPP test to detect lead workers with PbB eve. $40{\mu}g/d\ell$ were observed in the cut-off level of $50{\mu}g/d\ell$ and $100{\mu}g/d\ell$ of blood ZPP, respectively, the highest validity (sensitivity+specificity) of blood ZPP to detect lead workers with PbB over $40{\mu}g/d\ell$ was observed in the cut-off level of around $70{\mu}g/d\ell$ of blood ZPP. But even with optimal cut-off level of around $70{\mu}g/d\ell$ of blood ZPP, still 25.0% of false negative and 20.7% false positive lead workers were found. As the result of this study, it was suggested that reconsideration of current blood ZPP cut-off of our lead standard from $100{\mu}g/d\ell$ to somewhat lower level such as around $70{\mu}g/d\ell$ and the inclusion of PbB measurement as a primary screening test for lead workers was highly recommended for the effective prevention of lead workers.

정신교육교재문제와 강좌운영 : 통일연수소의 사례를 중심으로

김용배,최봉기 한국국민윤리학회 1982 倫理硏究 Vol.13 No.1

소화효소제(消化酵素劑)의 제조(製造)에 관(關)한 연구(硏究) 제4보(第4報)

김용배,김완회,이병국,신현종,Kim, Yong-Bae,Kim, Whan-Hoe,Yi, Pyong-Kuk,Shin, Hyun-Jong 한국약제학회 1978 Journal of Pharmaceutical Investigation Vol.8 No.4

Since the active center of digestive enzymetic preparations, while under storage, lose their activity and potency by the exposure to moisture, colorization, solidifying and other physical changes. It is more important than beautiful package form that protected packaging form from moisture to get a pharmaceutical safety preparations and to maintain a definite potency. Then, in order to get a desirable conditions of storage and packaging, we used shellac and $AEA^{\circledR}$ as a coating base, and blister package, foil and bottle container as a packaging material. Temperature were set on room temperature and $37^{\circ}C$, moisture was adjusted to 40% RH and 80 % RH as a accelerated conditions. Accelerated test was carried out 6 times. The results are as follows: 1) The effect of packaging conditions give great influence on the maintenace of the stable potency. 2) Best result was produced with bottle container package. 3) $AEA^{\circledR}$ is more useful than shellac as a coating base of prevention from moisture. 4) Absorption of moisture gave considerable effects on potency and it has a limited point. 5) Difference in potency between optimal and worst condition is 472 u/2T, and difference in effective period is about 44 months.

특수재질을 이용한 부표류 계류시설 개발

김용배,이호진,조영선 한국항해항만학회 2011 한국항해항만학회 학술대회논문집 Vol.2011 No.춘계

SIMS: Circuit Interconnect Modeling Environment for VLSI Design

김용배,백준호,김춘경,차건업,정원영 대한전자공학회 1994 대한전자공학회 학술대회 Vol.1994 No.7

전력 빅데이터 플랫폼 구축 및 활용 사례

김용배,최준석,정재훈,장민영 한국에너지학회 2018 한국에너지공학회 학술발표회 Vol.2018 No.04

특집/방사선치료의 진화: 고정밀방사선치료

김용배,서창옥 대한의사협회 2008 대한의사협회지 Vol.51 No.7

Technological advances that have been achieved over the last two decades in the area of treatment planning and sophisticated and complicated hardware capabilities, such as computer-controlled treatments, multileaf collimators, and incorporating imaging devices into treatment machines, enable clinical implementation of high-precision radiotherapy in field of radiation oncology. High-precision radiotherapy allows the delivery of increased tumor doses with relative sparing of normal tissues compared to 3 -dimensional radiotherapy and conventional techniques. Preliminary clinical experiences of high precision radiation therapy have been encouraging by high rates of local control and decrease of toxicity. This article provides an overview of high precision radiotherapy such as intensity-modulated radiotherapy, stereotactic radiation therapy, image-guided radiotherapy, and charged particle therapy.