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Modulation of affinity peptide for improvement of electrochemical sensor performance
조채환,김지홍,신재환,박종필 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Colorectal cancer(CRC) which occurs in the intestine is considered one of the most common cancers and is the fourth leading cause of death. The transition of adenoma to carcinoma is difficult to predict cancer progress in conventional methods, early and accurate detection of colon cancer. Thus, CRC has attracted the interest to reduce high mortality. Recently, we reported unique affinity peptides by phage display and their potential binding affinity and the use as peptide receptor for the development of electrochemical sensor. From our observations, we conclude that peptide-assisted electrochemical sensor will be needed to be more optimized for enhancement of sensor performance. Therefore, we attempted to modulate synthetic peptide sequence using molecular docking and simulation, and applied to the sensor system for point-of-care testing. More detail will be presenting on a poster.
전기중합 분자 각인기술을 활용한 전기화학 바이오센서 개발
조채환,김지홍,신재환,양효정,박종필 한국생물공학회 2021 KSBB Journal Vol.36 No.4
Biosensors have been widely studied and developed as a tool in various fields, including pharmaceutical, food safety, environmental and medical applications. Antibodybased immunosensors are considered as gold standard method, however, more advanced biosensor without need of antibody as receptor is needed. Molecularly imprinted polymers (MIPs) are synthetic receptors obtained by polymerization of functional monomers in the presence of the target molecule and can form high specific binding sites to the target molecules depending on shape, size, and functionality. One of the most synthesis of MIPs is electropolymerization that use electrochemical method. This method can easily manipulate the desired morphology and thickness of the polymer films. Various EMIPs (electropolymerized molecular imprinted polymers) based biosensors have been developed for detection of small molecule such as chemicals, drugs, and toxins. In this review, we summarize the synthetic methods and characteristics of EMIPs-based biosensor for various targets.
조채환,박태정,박종필 한국생물공학회 2022 Biotechnology and Bioprocess Engineering Vol.27 No.4
Bovine diarrhea is a major concern in the global bovine industry because it can cause significant financial damage. Of the many potential infectious agents that can lead to bovine diarrhea, bovine rotavirus (BRV) is a particular problem due to its high transmissibility and infectivity. Therefore, it is important to prevent the proliferation of BRV using an early detection system. This study developed an affinity peptide-based electrochemical method for use as a rapid detection system for BRV. A BRV-specific peptide was identified via the phage display technique and chemically synthesized. The synthetic peptide was immobilized on a gold electrode through thiol–gold interactions. The performance of the BRV specific binding peptides was evaluated using square wave voltammetry. The developed detection system exhibited a low detection limit (5 copies/mL) and limit of quantitation (2.14 × 102 copies/mL), indicating that it is a promising sensor platform for the monitoring of BRV.
양효정,조채환,김지홍,신재환,박종필 한국생물공학회 2021 KSBB Journal Vol.36 No.4
A biosensor is an analytic microsystem in which a biological component is coupled with a transducer to convert biological signal into an electrical out. Utilization of biosensors has been considered the importance in the field of drug discovery, biomedicine, food safety, biodefense with security, and environmental monitoring. Recently, interest in biosensor is still increasing, and it needs to develop more advanced biosensor that capable of any of targets with high sensitivity and selectivity. Therefore, it is necessary to discover new bioreceptors with high sensitivity and selectivity. Bacteriophage, especially M13 bacteriophages, are emerging as new biological receptors. The peptide-displayed M13 bacteriophage not only could specifically and selectively bind to desired target molecules but also easily manipulate genetical and/or chemical modification in biosensor applications. Therefore, we summarize recent advances and the possibilities of biosensor development utilizing M13 bacteriophages.
김지홍,조채환,신재환,박종필 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
Hemagglutinin (HA) which derived from influenza virus H5N1 is a glycoprotein on surface of the virus. It has been used as antigen for diagnosis of influenza which causes seasonal epidemics of disease with high mortality rate. In this study, we isolated HA specific peptide motif (GHPHYNNPSLQL) by biopanning of random M13 phage library. After bipanning, we observed its binding affinity to HA by ELISA. Then, a series of synthetic peptides (IFA BP1 ~ IFA BP6) was chemically synthesized and immobilized on functionalized gold chips for detection of HA. The sensor performance was monitored by square wave voltammetry (SWV). Among six synthetic affinity peptides, IFA BP6 coated gold electrode had relatively high decreasing in current compared to other peptides. More details about the result will be talk in presentation.
무선 통신 기술 활용 SK텔레콤 Location 기술/서비스 동향
강석연,조채환,윤종필 한국통신학회 2015 정보와 통신 Vol.32 No.8
이동 통신 사업자는 위성 및 이동통신망을 활용하여 Location 기술 및 서비스를 제공하여 왔다. 최근 스마트폰 보급에 따라 Wi-Fi, Bluetooth 등 근거리 통신망 신호를 활용하여, 실내에서 보다 정확한 위치 파악이 가능해지고 있다. 또한, UWB(Ultra Wide Band)신호를 활용한 초정밀 위치 확인 기술, BLE(Bluetooth Low Energy) 및 센서 활용 기술 등 저전력/비용 효율적인 서비스 제공을 위한 다양한 시도가 진행 중에 있다.
pCell Network 기반 솔루션을 이용한 측위 성능 향상에 대한 연구
김긍태,조채환,한규영 에스케이텔레콤 (주) 2008 Telecommunications Review Vol.18 No.2
현재 서비스되고 있는 위치측위 방식은 주로 기지국 수신 신호를 이용하는 네트워크 기반 방식과 GPS 신호를 이용하는 핸드셋 기반 방식 2 가지를 모두 동시에 이용하여 서비스를 제공한다. 즉, GPS 단말기가 건물 내에 있어서 GPS 신호를 이용한 측위가 불가능할 때에는 정확도가 떨어지는 네트워크 기반 방식을 이용하는 것이다. 통상적으로 GPS단말의 측위 통계를 분석하여 보면 전체 Traffic의 약 25%정도는 GPS측위 이고, 나머지 75%는 네트워크 기반 방식을 이용한 측위를 할 정도로 네트워크 기반 방식 측위의 중요성이 대두 되고 있다. 또한 네트워크 기반 방식 측위의 경우에도 단 1개 기지국 신호를 받아서 측위를 할 경우가 상당히 많아서 이에 대한 측위 정확도를 올리는 방법에 대한 연구를 진행하였다. 본 논문은 pCell DB를 이용한 Non GPS단말의 위치 측위 방법에 관한 것으로, pCell방식을 이용하여 기존의 Cell ID 측위 방식 대비 새로운 측위 방식의 개선효과 정도를 파악하고 그 결과를 분석하였다.