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李順實,宋世欽,張升銀,安成淑,兪映旭,潘美子,權五名,崔美德,劉胤淑,嚴基和,李內球,李民和 한국병원약사회 1989 병원약사회지 Vol.6 No.3
The present situation of the alternation of dosage forms in dispensing of oral drug products for pediatric patients in Seoul National Univ. Children's Hospital was studied. The total prescriptions in July 1988, were 16,058. The alternations were as follows: tablets and capsules intended for constitution as powders; tablets and powders as capsules; tablets and powders as tablets; tablets, powders and injection as liquids. The kinds of the oral drug products prescribed were 254, including 139 for alternation (57.4%). The total number of dispensing oral drugs was 17,692 and that of dispensing after alternation was 5,311 in it(29.6%). The alternations consisted of 56.5% for grinding tablets for constitution as powders, 16.3% for opening of capsules as powders. The most reason of alternation was that the absence of dosage form equal to the dose prescribed(61.0%). The highest frequency of alternation was showed in the department of thoracic surgery(77.8%) in outpatient's prescriptions and showed in neonate intensive care unit(45.6%) in inpatients'. On the basis of the results of this study, several problems caused by the alternation were discussed, such as changes in bioavailibility, loss in dose, stability and the problem of feeding. It was suggested that the information in alternation must be given by the pharmaceutical manufacturer and the hospital pharmacists must consider these problems in pediatric dispensing. Above all, it was more desirable to develope pediatric dosage forms by the pharmaceutical manufacturer.
$K-BEtest^{\circledR}$, 새로운 생물학적 동등성 시험 통계처리 프로그램의 개발
이영주,최정호,송세흠,서철환,김동섭,박인숙,최기환,나한광,정석재,이민화,심창구,Lee, Young-Joo,Choi, Jung-Ho,Song, Sae-Heum,Seo, Chul-Hwan,Kim, Dong-Sup,Park, In-Sook,Choi, Ki-Hwan,Na, Han-Kwang,Chung, Suk-Jae,Lee, Min-Hwa,Shim, Chang-K 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.4
A computer program for personal computers, $K-BEtest^{\circledR}$, was developed to analyze bioequivalence data in accordance with Korean Guidelines for Bioequivalence Test (KGBT). This program is user-friendly, interactive, Hangul-compatible and supports $2{\times}2$ cross-over design as well as $2{\times}2$ Latin square design with various significance levels. This program is able to calculate AUC, $C_{max}$ and $T_{max}$ parameters from the blood drug concentration-time profile of individual subjects and evaluate the parameters statistically for the bioequivalence by ${\pm}20%$ rule, the F-test, the Non-centrality test and 90% confidence intervals. All procedures are supported with graphic interface, interactive menu and outputs in Korean. In this paper, two experimental data sets were analyzed by the program and detailed process was demonstrated. The $K-BEtest^{\circledR}$ program appears to be very effective for analyzing bioequivalence data and can be widely used with convenience and accuracy.
K-BEtestⓡ , 새로운 생물학적 동등성 시험 통계처리 프로그램의 개발
이영주(Young Joo Lee),최정호(Jung Ho Choi),송세흠(Sae Heum Song),서철환(Chul Hwan Seo),김동섭(Dong Sup Kim),박인숙(In Sook Park),최기환(Ki Hwan Choi),나한광(Han Kwang Na),정석재(Suk Jae Chung),이민화(Min Hwa Lee),심창구(Chang Koo Shi 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.4
N/A A computer program for personal computers, K-BEtest^ⓡ, was developed to analyze bioequivalence data in accordance with Korean Guidelines for Bioequivalence Test (KGBT). This program is user-friendly, interactive, Hangul-compatible and supports 2×2 cross-over design as well as 2×2 Latin square design with various significance levels. This program is able to calculate AUC, C_(max) and T_(max) parameters from the blood drug concentration-time profile of individual subjects and evaluate the parameters statistically for the bioequivalence by ±20% rule, the F-test, the Non-centrality test and 90% confidence intervals. All procedures are supported with graphic interface, interactive menu and outputs in Korean. In this paper, two experimental data sets were analyzed by the program and detailed process was demonstrated. The K-BEtest^ⓡ program appears to be very effective for analyzing bioequivalence data and can be widely used with convenience and accuracy.
Iodin-131I OIH와 99mTc - MAG3의 약물동력학 및 체내 분포에 관한 비교 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),조보연(Bo Youn Cho),이동수(Dong Soo Lee),이범우(Bum Woo Lee),정재민(Jae Min Jeong),염미경(Mi Kyoung Yeom),김문혜(Mun Hye Kim),박경호(Kyung Ho Park),송세흠(Sae Heum 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.1
N/A 99mTc-MAG, was synthesized, and biodistribution and blood clearance rate were compared with those of 131I-OIH in mice and rats respective]y. Finally renal image was obtained from a normal male volunteer before and after prescription of probenecid. The results obtained were as follows: 1) The uptalce of Tc-MAG, by kindey was higher than that of 131I-OIH in mice 10 mins after injection (n=6, p<0.05), but slightly lower uptakes were found in all organs (kindney, blood, stomach, mtestinge and liver) 2 hrs after injection. 2) For ' Tc-MAG, t1/2 a=2.4-+0.0 min, t1/2B=44.3+7.4 min, and blood clearance=3.4+0.5ml/min, and for 131I-OIH t1/2=1.8=0.2 min, t1/2=69.1+9.5 min, and blood clearance=1.3+O.l min were found in rats. 3) From the renogram of normal male volunteer, we could find that tmax=130 sec and t1/2=430sec before probenecid prescriptiori, and tmax 150-170sec and t1/2=810-1,170sec after probenecid prescriprion. From these results we concluded that Tc-MAG, can be used instead of 131I-OIH for obtaining renal irnage.