玉蜀黍毛 水性엑기스의 賢臟作用

羅漢光,李漢九,高錫太 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1

Stigma Maydis Water Extract (SWE), when given intravenously, produced the diuretic action accompanied with the increased amounts of sodium (E_Na) and potassium (E_K) excreted in urine, and the decreased reabsorption rates of sodium (R_Na) and potassium (R_K) in renal tubules, and then glomerular filtration rate (GFR) and renal plasma flow (RPF) were not changed, osmolar clearance (Cosm) was augmented, but free water clearance (??) was diminished. SWE, when given into a renal artery, or into carotid artery, elicited the decreased urine flow, GFR, RPF, E_Na the unchanged R_Na, E_K and R_K in both kidney. Above results suggest that SWE exhibit the central antidiuretrc action, and diuretic action by inhibition of electrolytes in renal tubules through humoral natriurectic agent.

발표회장 : 20. Bacampicillin 정제의 생물학적 동등성시험 ( BE )

나한광(H . K . Na),이선희(S . H . Lee),최광식(K . S . Choi),최철희(C . H . Choi),문화희(H . H . Moon) 한국약제학회 1989 한국약제학회 총회 및 학술대회 요지집 Vol.- No.19

Bacampicillin 정제의 생물학적 동등성시험 ( BE )

나한광 ( H K Na ),이선희 ( S H Lee ),최광식 ( K S Choi ),최철희 ( C H Choi ),문화희 ( H H Moon ) 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.4

N/A

클로르프로마진의 클로르프로마진 설폭시드로의 대사동태

정숙진,나한광,이용복 전남대학교 약품개발연구소 1998 약품개발연구지 Vol.7 No.1

In order to elucidate the fraction of sulfoxidation in the over all in vivo metabolism of chlorpromazine (CPZ), the sulfoxidation of CPZ to chlorpromazine sulfoxide (CPZSO) was studied in rats. CPZ (10 ㎎/㎏) and CPZSO (1 ㎎/㎏) were injected into the rat femoral vein. respectively. Md the pharmacokinetic parameters were obtained from the plasma concentration-time pro5les of CPZ and CPZSO determined by the simultaneous analysis using high-performance liquid chromatography. It was supposed that these drugs were almost metabolized in vivo because the total excreted amounts of CPZ and CPZSO via urinary and biliary route were lower than 1.4% and 10.61% of the administered dose, respectively. And also. it was found that the fraction of systemic clearance of CPZ which formed CPZSO (F_(mi)) was 0.115. These results showed that CPZ was sulfoxized by 11.5% in rats and the residue would be metabolized via the other mutes.

5-Hydroxytryptamine(5-HT)이 개의 신장기능에 미치는 영향

고석태,나한광,최인 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2

5-Hydroxytryptamine(5-HT, serotonin), when given into the vein, produced antidiuretic action accompanied with reduction of glomerular filtration(GFR), renal plasma flow(RPF). osmolar clearance(Cosm) and amounts of sodium or potassium excreted in urine(E_Na, E_K), with the augmented reabsorption rates of sodium and potassium in renal tutbules. 5-HT, when infused into a renal artery, exhibited diuretic action accompained with the augmented RPF and increased E_Na and E_K in only infused kidney. Antidiuretic action of 5-HT infused into the vein was not influenced by ketanserin, 5-HT₂receptor blockade, given into a renal artery, vein or carotid artery, by methysergide, 5-HT₁receptor blockade, given into a renal artery, whereas above antidiyretic action was inhibited by methysergide given into vein or carotide artery. Diuretic action og 5-HT infused into a renal artery in only experimental kidney was blocked by ketanserin injected into a renal artery, was not influenced by methysergide ad inidtered into a renal artery. Above results suggest that 5-Hydroxytryptamine(5-HT) produced the antidiuretic action through central 5-HT₁receptor and the diuretic action through 5-HT₂receptor located in renal tubules of kidney.

Dopamine의 家兎腸作用에 對한 烏梅水性 엑기스의 影響

李漢九,羅漢光,高錫太 朝鮮大學校 1991 藥學硏究誌 Vol.13 No.1

Dopamine elicited the decrease of spontanevus movements and suppression of tension in the strips of small intestine, and longitudinal and circular muscle of large intestine isolated from rabbit. Mume fructus water extracts(MW) blocked the dopamine action(spontaneous movement and tension) in small lntestinal strips. In longitudinal muscle strips of large intestine, MW potentiated the decrease of spontaneous movements but diminished the suppression of tension induced by dopamine, and then in circular muscle strips of large intestine, MW did not influence on the spontaneous movements and blocked the suppression of tension caused by dopamine. Effect of metoclopropamide, dopamine antagonist, on dopamine action in intestinal strips performed at the same time in this experiment was the same to that of MW.

PBPK(생리학적약동력) 방법을 이용한 화학물질의 체내동태에 관한 연구

김동섭,나한광,박인숙,서수경,최기환,김학림,황인영 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-

PBPK model은 물질을 투여한 후 시간에 따른 각 조직내의 농도를 예측하는데 생리학적 인자(체중,조직의 체적,켤류량, 심박동수, 체포순환 둥f, 물질의 분배계수 및 생화학적 상수(분포.율. 대사율, 단백질결합상수 둥)를 사용하는 것으로 이 방법은 고롱도에서 저농도로의 변화에 따른 조직의 농도추정, 투여경로에 따른 농도의 변화 그리고 실험동울을 통하여 얻어진 실험값의 잃체로의 적용에 매우 유용한 방법이다. 또한 여러물질의 약동력 기전에 대한 정보를 규명하기에 용이한 장점이 있어 국태에서도 PBPK model의 확립이 필요하다. 이에 사용빈도it 높은 진통소염제인 케토로락의 모델을 확립 후, 그 if!확성을 밉증하고 향후 이 약물들과 병통하는 타 약물과의 상호작용 예측에 필요한 기초를 화립하고자 하였다. A physiologically-based pharrnacokinetic (PBPK) model for a target chemical baa the tissue dosirRetry and PBPK approach (or the tissue dosimetry has several advantages against data-based mathem,ttical pharmacokinetics. Main issue to build and use a PBPK model is to carry out route-to-route aBd high-to-low dose extrapolations as welt as species extrapolation. Kineticfelg HLtn;naf frnw, #vnDr;mpnlt wrrp f;flpf wifh n nrim iliup PTPf mnApl nnd in vivo kinetic COnEtantsconstants and biochemical parameters calculated from experimental results for estiraating distributionrnt n rhpm irnl iT farrpl liTTllrl Kefnrotnr has been shown to be effective for moderate to severe Pain 『☞lief such as postpartum and postoperative pain. We investigated PBPK modet of ketorolac and thenup PBPK modeling/ACSL si3uulation.

Methoxyverapamil이 血厭에 關與하는 藥物의 作用에 미치는 影響

高錫太,李漢九,羅漢光 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1

Methoxyverapamil, Ca^2+ chamnel blocker, inhibited the pressor actions of norepinephrine and angiotensin Ⅱ, and the depressor action of isoproterenol, while did not influence the pressor actions of tyramine and epinephrine. and the depressor actions of acetylcholine, pilocarphine, histamine and serotonin in rabbit.

5-Hydroxytryptamine (5-HT) 이 개의 신장기능에 미치는 영향

고석태(Suk Tai Ko),나한광(Han Kwang Na),최인(In Choe) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.1

5-Hydroxytryptamine(5-HT, serotonin), when given into the vein, produced antidiuretic action accompanied with reduction of glomerular filtration(GFR), renal plasma flow(RPF), osmolar clearance(Cosm) and amounts of sodium or potassium excreted in urine(E_(Na), E_K), with the augmented reabsorption rates of sodium and potassium in renal tubules. 5-HT, when infused into a renal artery, exhibited diuretic action accompanied with the augmented RPF and increased E_(Na), and E_K in only infused kidney. Antidiuretic action of 5-HT infused into the vein was not influenced by ketanserin, 5-HT₂ receptor blockade, given into a renal artery, vein or carotid artery, by methysergide, 5-HT₁ receptor blockade, given into a renal artery, whereas above antidiuretic action was inhibited by methysergide given into vein or carotid artery. Diuretic action of 5-HT infused into a renal artery in only experimental kidney was blocked by ketanserin injected into a renal artery, was not influenced by methysergide administered into a renal artery. Above results suggest that 5-hydroxytryptamine(5-HT) produced the antidiuretic action through central 5-HT₁ receptor and the diuretic action through 5-HT₂ receptor located in renal tubules of kidney.

베나제프릴의 장곽막 투과도와 흡수 클리어런스에 미치는 아목시실린의 영향

김영만,이용복,주은희,고형석,나한광 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.1

Intestinal absorption of β-lactam antibiotics and angiotensin converting enzyme(ACE) inhibitors has been shown to use the carrier-mediated transport system. In vitro experiments have established that the efficacy of uptake by enterocytes depends on an inwardly directed proton gradient. It was suggested that benazepril was mediated by tripeptide transport system and that amoxicillin was transported by dipeptide transport carrier. The aim of this study is to assess the influence of amoxicillin on the intestinal absorption of benazepril using in vitro diffusion chamber and in situ single pass perfusion technique in the rat in order to elucidate whether the above transport systems are competitive or not. We obtained the gastrointestinal pemeability coefficient of amoxicillin, benazepril and both of them using in vitro diffusion chamber. And also the gastrointestinal absorption clearance of amoxicillin, benazepril and both of them using in situ single-pass perfusion method at steady state were calculated. Amoxicillin and benazepril were analyzed by HPLC. The results by the use of diffusion chamber in vitro indicated that the apparent intestinal permeability coefficient of benazepril was significantly(p<0.01) decreased by amoxicillin(45.2%) and vice versa significantly(p<0.01) decreased(89.1%). The results by the in situ gastrointestinal single-pass perfusion method indicated that the intestinal absorption clearance of benazepril was significantly(p<0.05) decreased by amoxicillin (40.2%) and vice versa significantly(p<0.05) decreased(54.8%). These results might suggest that they share the same peptide carrier pathway for oral absorption.