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Polychlorinated Biophenyl類의 毒性에 대한 數種 抽出液의 解毒效果에 關한 硏究
오호정,장판섭 德成女子大學校 藥學硏究所 1990 藥學論文誌 Vol.1 No.1
The effect of the water extracts and ethanol extracts from picrorrhiza kurroa, Gentiana scabra and Lycium chinense on the toxicity of polychlorinated biphenyls (PCBs) were examined and following results were obtained. 1. In the PCBs control group, the body weights were decreased while the weight of liver was increased in comparison with that of normal control group. However, by the administration of these extracts, PCBs intoxicated rats showed the increase in body weight but did not show marked recovery of liver weight. 2. By the administration of these extracts, the hematological parameters of red blood cell and white blood cell, hemoglobin content and hematocrit value which were decreased by the administration of PCBs were shown to be increased. Among these extracts, the extracts of Lycium chinense were especially effective. 3. Cholesterol and total lipids levels in serum were significantly increased in the group fed PCBs. These extracts ameliorated the elevated levels but the recovery was not completed. 4. The activities of s-GOT, s-GPT and alkaline phosphatase were significantly stimulated by PCBs and their stimulation was inhibited by the adminstration of these extracts. Furthermore, the extracts of Picrorrhiza kurroa showed the normalizing tendency in s-GOT, s-GPT and alkaline phosphatase.
사람 폐암세포주에서의 bcl-2 안티센스 처리에 의한 효과
김선미,정자영,오호정,손여원 한국독성학회 2002 Toxicological Research Vol.18 No.4
Apoptosis, or programmed cell death, is a genetically regulated pathway that is altered in many cancers. Overexpression of bcl-2 leads to resistance to apoptosis and promotes tumorigenesis. To determine the effects of bcl-2 antisense treatment in human lung cancer cell lines, a 20 mer full phosphorothioate oligonucleotide (ODN) targeted at the coding region of the bcl-2 mRNA was synthesized. Western blot analyses were used to examine bcl-2 protein level in five human non-small cell lung cancer (NSCLC) cell lines (NCI-H226, SK-MES-1, NCI-H358, NCI-H522 and NCI-H1299) and four human small cell lung cancer (SCLC) cell lines (NCI-H69, NCI-H417, HCC-2108 and SW2). Three out of five NSCLC (NCI-H226, KS-MES-1 and NCI-H1299) and all of SCLC cell lines expressed Bcl-2 protein. Treatment of these cells with antisense ODN for 48 hours reduced their viability and Bcl-2 protein levels. As a conclusion, bcl-2 antisense treatment appears reduction of the Bcl-2 protein levels and cytotoxic effect including apoptosis in human lung cacer cell lines.