말기신부전증 환자의 성생활에 관한 연구

전진석,장재영,이영창,홍세용,양동호,황산,함정식 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.1

Sexual dysfunction is a common problem in patients with end stage renal disease. The pathogenesis of this problem is complex, and includes psychological factors, vascular, and neurological disorders, drug therapy, uremic intoxication and hormo- nal disturbances. However, we don't have any valid report because pathogenesis and physiologic significance is not proved clearly. With the questionnaire that we provided to our patients, we evaluated the sexual dysfunction in patients with end stage renal disease, and we treated our patient with antidepressants for males and estrogen for females. The results are as follows: 1) Sixty patients among 70 answered the sexual question. Among these, 46 patients (76%) complained of sexual dysfunction, 75% of male patients and 58% of female patients complained of impotence and mensturation disturbance, respectively. Especially, female patients complained of loss of libido as a whole. Also they said that they never tried to do anything to recover their sexual dysfunction, 2) After starting dialysis, 57% of patients showed decrease in coital frequency than before. 58% of patients showed no significant change in subjective sezual symptoms after dialysis. 18% of patients showed significant change in sexual function after anemia treatment. 3) Eighty-eight percents of males and one hundred percents of females treated with antidepressants and estrogen, respectively showed no effect. Finally, we found that sexual dysfunction is a common problem in chronic renal failure, but they never try to recover their conditions. Our therapeutic approach was not effective, but dialysis in CRF patient must be used for lifting the value of life, not by way of life extension. Ln addition we can make more effective treatment through objective study and psychological examination.

프로배구 타이틀 스폰서 기업의 마케팅활동이 브랜드자산과 브랜드확장제품 구매의도에 미치는 영향

전진석,강동완,김재필 한국스포츠학회 2013 한국스포츠학회지 Vol.11 No.2

포스터 발표 : 투석 중단에 대한 신장내과 의사의 태도조사

전진석,이선영,박은경,오현숙,한동철 대한신장학회 2006 춘계학술대회 초록집 Vol.25 No.1

200kW 인산형 연료전지 발전시스템의 엑서지-열경제학적 해석 ( Exergetic and Thermoeconomic Analysis of a 200kW Phosphoric Acid Fuel Cell Plant )

전진석,곽호영,이현수,최동수,박달령,조영아 대한기계학회 2001 대한기계학회 춘추학술대회 Vol.1 No.4

출혈위험이 높은 혈액투석 환자에서 저분자량 헤파린의 유용성

전진석,박민선,정성희,이희발,황승덕,황산,황보권,소인임,임애숙 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.1

Anticoagulation is vital in hemodialysis (HD) to maintain adequate dialysis. The use of anticoagulating agent is, however, limited in patients with high risk of bleeding. To evaluate the effect of Fractionated heparin(FH) in HD patients with high risk of bleeding, 19 patients(10 major surgery, 7 gastric bleeding, 1 each of renal cyst bleeding and pericardial effusion) were included in this study. Four consecutive HD sessions using single intravenous injection of FH(0.2ml in patients with body weight 40-70kg and 0.3ml for over 70kg) followed by 4 consecutive HD sessions with low dose or no heparin(LH) were performed in 9 patients and in reverse order in 10 patients. Major hemorrhagic episodes were recorded and pre and post HD body weight, blood pressure, activated partial thromboplastin time(APTT), hemoglobin(Hb), hematocrit (Hct), and platelet count(Plt) were obtained. Clots in venous air trap and/or artificial kidney was given scores: 0, none,' 1, fibrin ring', 2, fibrin ring requiring saline flush; 3, complete obstruction. The color of dialyser after completion of dialysis was given the following scores' 0, pale', 1, pale pink; 2, pink. Time of compressing needling site to prevent vascular access bleeding was recorded. Hypotensive episode was not observed during HD. Recurrence of gastric bleeding in 3 patients(5 episodes with FH and 4 episodes with Control) and renal cyst bleeding(1 episode with FH) were observed during the study period. No bleeding complications were observed in the other 15 patients. No significant differences in pre-and post APTT, Hb, Hct, and Plt were observed between FH and Contro!. Significantly fewer coagulation episodes in venous air traps and/or artificial kidneys was observed during HD with FH than Control(0.07?0.19 vs. 0.79?0.91). No significant difference was observed in hemodialyser color at the end of dialysis and time of compressing needling site between FH and Control. Tubing system was changed due to complete obstruction of extracorporeal system in 4 episodes in 3 patien in Control group, but not in FH group. In conclusion, Fraxiparine was effective in preventing coagulation in the extracorporeal circulation and did not increase bleeding complications during HD in high risk patients and is recommended for use in HD patients with high risk of bleeding.

의약분업 정책변화에 대한 연구 : 정책옹호연합모형을 적용하여

전진석 한국정책학회 2003 韓國政策學會報 Vol.12 No.2

장기간 동안에 걸쳐서 일어나고 있는 정책의 변화를 이해하기 위하여 정책옹오연합모형(advocacy coalition framework : ACF)이 많은 정책사례에 적용되고 있다. 본 논문에서는 1963년 약사법 개정으로 의약분업을 처음 법제화한 이후에 지금까지의 의약분업 정책변화 연구에 정책옹호연합모형을 적용하였다. 정책옹호연합 접근방법에서 강조되는 기본적 전제들이 의약분업정책사례에도 나타나고 있는 것으로 파악되었다. 수 십년 동안의 장기간에 걸쳐서 나타나는 의약분업정책의 변화는 정책옹호연합들의 상호작용이며, 그리고 정책하위체제에 영향을 주는 안정적인 변수와 역동적인 외적변수들도 확인되었다. 또한 정책옹호연합들의 믿음체계(belief systems)의 수정을 의미하느 정책지향적 학습(policy-oriented learning)도 장기적이고 점증적인 의약분업정책변화에 주요한 요인이 되는 것으로 나타났다. 본 연구에서느 전통적인 정책분석방법(heuristic stages)에 대안으로서 제기된 정책옹호연합모형이 의약분업정책의 변화를 설명하는 데 매우 유용한 모형인 것으로 나타났다. The Advocacy Coalition Framework(ACF) have been applied to many foreign policy cases to analyze the process of policy change over several decades. This study used the ACF approach to analyze the policy change of prescription/pharmacy separation (PPB) to the present since the PPS had first been inserted into the Drugs. Cosmetics and Medical Instruments Law in 1963. The basic premises in the ACF model are perceived in this PPS policy case :1) the change of PPS policy is an interaction of policy advocacy coalitions, 2) relatively stable parameters and dynamic external perturbations affecting policy subsystems are explored, 3) policy-oriented learning across belief systems of different coalitions is understood as one of important factors bringing about incremental policy change over several decades in PPS. The ACF model as an alternative approach to the traditional policy analysis method (the stages model) is confirmed as the very useful framework in explaining policy change of PPS.

전자부품의 액침냉각을 위한 수로에서의 비등 열전달의 실험적 연구

전진석,강상우,김익생,곽호영 대한기계학회 1988 대한기계학회 춘추학술대회 Vol.- No.-

Transepithelial transport and dynamic changes on apical membrane area of turtle bladder

전진석,Jeon, Jin-Seok Korean Society of Electron Microscopy 1993 Applied microscopy Vol.23 No.1

The present study was carried out to analyze the evidence of membrane recycling, and the regulation of cellular transport by dynamic changes in apical membrane area that functionally interacts with the number of cytoplasmic vesicles. Under scanning electron micrographs, turtle bladder mucosa contain three main type of cells; granular cells and carbonic anhydrase (CA)-rich cells, deviding into a and b type of epithelial cell. The granular cell is the majority cell type of the mucosa comprising 80% of the total cell number. The remaining 20% of the cells are characteristically rich in carbonic anhydrase. Uptake of HRP was detected in the most vacuoles or tubulovesicles in both type of CA-rich cells in the turtle bladder, indicating that the part of plasma membrane was internalized in the apical cytoplasmic vacuoles. It seems quite likely that CA-rich cells possess intracellular vesicles carrying proton pumps which are recycling back to the apical plasma membrane. In turtle bladder, the granular cells actively secrete large quantities of mucin and other proteins by an exocytotic mechanism in an apparently constitutive fashion. The possibility that bladder epithelial cells secrete mucin via a regulated secretory pathway has not been rigorously examined and much is still to be determined about these issues from this cell type. 본 연구는 세포질 액포의 수와 기능적으로 상호작용하는 정단세포막(丁端細胞膜)의 역동적(力動的) 변화로 인한 세포수송의 조절과 세포막의 재순환(再循環) 과정의 증거를 분석(分析)하였다. 주사전자현미경(走査電子顯微鏡) 관찰에 의하면 Turtle bladder 점막(粘膜)에는 다음 세 증류의 주요세포가 있다. 과립성세포(顆粒性細胞)는 방광점막(膀胱粘膜) 세포의 대다수를 차지하는 것으로서 총 세포수의 80%에 해당하며, 나머지 20%의 세포는 탄산탈수효소가 풍부한 A 및 B형으로 분류되는 상피세포(上皮細胞)가 특징이다. 탄산탈수효소가 풍부한 두 종류의 세포내의 관상액포(管狀液胞)나 대부분의 액포에서 horseradish peroxidase의 흡수를 조사한 결과, 세포막부분이 정단세포질(丁端細胞質) 액포에 내화(內化)되어 있었다. 마치 탄산탈수효소를 함유한 세포가 세포내(細胞內) 액포(液胞)를 소유하고 있는것 같으며 이 세포내 액포는 정단세포막으로 재순환(再循環)하는 proton 펌프를 지니는 것으로 생각된다. Turtle bladder에서 과립상세포는 두렷한 세포외분필(細胞外分泌) 기작에 의하여 다량의 mucin과 기타 단백질을 능동적으로 분비하는 constitutive pathway로서 믿어지며. 조절된 분비경로를 통해 방광상피세포(膀胱上皮細胞)가 mucin을 분비하는 가능성에 대해서는 엄밀하게 규명되어있지 않으므로 이러한 vesicular transport 상당부분이 미결상태로 남아있다.

Tight epithelia의 세포특성과 수송체계에 관한 전자현미경적 연구

전진석,Jeon, Jin-Seok 한국현미경학회 1996 Applied microscopy Vol.26 No.1

This study analysed the transport properties of bladder mucosa known as the typical system of 'tight epithelia' by using TEM observation with both rapid freeze-fracture electron microscopy and thin-section method and mainly analysed the cellular characteristics of turtle bladder epithelial cells. The bladder epithelium, like other tight epithelia, consists of a heterogenous population of cells. The majority of the mucosal cells are the granular cells and may function primarily in the process of active $Na^+$ reabsorption in turtle bladder. The remaining two types of cells are rich in mitochondria and is believed to be res-ponsible for a single major transport system, namely, $H^+$ transport by A-type of cell and urinary $HCO_{3}^-$ secretion by B-type of cell. As viewed in freeze-fracture electron micrograph, the tight junctions form a continuous tight seal around the epithelial cells, thus restricting diffusion in tight epithelia. In addition, the apical surface membranes have a population of rod-shaped intramembranous particles (IMPs). It is believed that these IMPs probably represent the components of the proton pump. However, it is likely that these characteristics of the apical transporter remain to be clarified in tight epithelial cells.

코로나19로 인한 학교현장의 변화와 상담지원 정책 방향

전진석 한국상담학회 2020 한국상담학회 학술대회 논문집 Vol.2020 No.8