Dislocation Density-Based Constitutive Model and Processing Map for T2 Copper During Isothermal and Time-Variant Deformation

Gang Chen,Yu Jin,Jing Wang,Cheng Zhang,Qiang Chen,Hongming Zhang,Xingjian Zhao,Zhiyong Li,Changhai Xie,Zhiming Du 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9

Isothermal compression tests were carried out to study the hot deformation behavior of T2 copper under various conditions. The deformation parameters, such as temperature and strain rate, have strong influence on flow stress and microstructureevolution of the alloy. A unified dislocation density-based model considering dynamic recovery and recrystallization wasestablished. And material parameters of the developed model were optimized by genetic algorithm. Comparisons betweenthe experimental and model data demonstrates that the developed model can precisely describe the flow behavior at quitewide range of deformation conditions. Meanwhile, the designed iterative procedure allows the model to be applied in timevariantdeformation conditions. Processing map and microstructure examination were constructed to optimize the processingwindow of the studied alloy. According to the processing maps, flow instability mainly appeared at low temperatures of500–650 °C and strain rates higher than 0.1 s−1. The optimum deformation parameters of T2 copper was concluded as thetemperature range of 700–800 °C and the strain rate of 0.1–1 s−1.

Sofosbuvir/velpatasvir plus ribavirin for Child-Pugh B and Child-Pugh C hepatitis C virus-related cirrhosis

( Chen-hua Liu ),( Chi-yi Chen ),( Wei-wen Su ),( Chun-jen Liu ),( Ching-chu Lo ),( Ke-jhang Huang ),( Jyh-jou Chen ),( Kuo-chih Tseng ),( Chi-yang Chang ),( Cheng-yuan Peng ),( Yu-lueng Shih ),( Chia 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4

Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR₁₂) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR₁₂ rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5-94.2%), 94.1% (95% CI, 87.8-97.3%), and 100% (95% CI, 96.2-100%). Number of patients who failed to achieve SVR₁₂ were attributed to virologic failures. The SVR₁₂ rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR₁₂, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16-14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 ㎡/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 ㎡/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis. (Clin Mol Hepatol 2021;27:575-588)

A study on Safe Pork Consumption Behavior in Taiwan

( Cheng-wei Chen ),( Yu-ping Fan ),( Cheng-hsing Yeh ) 한국농업경제학회 2009 농업경제연구 Vol.50 No.3

Pork is the most popular meat in Taiwan, that makes hog industry an important agriculture industry. The government had lauched the traceability system of agricultural products from 2004. It is needed to appreciate the policy affecting consumers’ willingness to buy safe pork for hog industry to separate market. This research use consumer decision process model and market segmentation to separate four respective factors as age group, educational background, family income, and the population element as family structure to find out the habit of safe pork consumption. This study was based on household as its unit, and had conducted questionnaire survey upon the primary purchasers of pork, which were then analyzed with descriptive statistics, Chi-square test, and the logit model so as to differentiate the preference of demographic characteristics among consumers with various features. This research indicated consumers with more members of household, older, less educated,less income, less cognitive about pork risk would have higher possibility to buy warm pork. Consumers with female, more educated, more income, more cognitive about pork risk would have higher willingness to pork with traceability system.However consumers in Taiwan still prefer buy warm body pork, little perception about pork marketing risk. The government should improve pork safety by more inspecting hog farms, processing factories and markets and educating consumers the knowledge of safe pork by television broadcasting and other mass media.

Translational Investigation of Non-Alcoholic Fatty Liv-er Disease in a Rat Model

( Cheng-maw Ho ),( Shih-jer Hsu ),( Ya-hui Chen ),( Hung-yen Chen ),( Chun-hsien Yu ),( Hui-ling Chen ),( Rey-heng Hu ),( Po-huang Lee ) 대한간학회 2023 춘·추계 학술대회 (The Liver Week) Vol.2023 No.1

Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses

Chen, Yu-Chih,Baac, Hyoung Won,Lee, Kyu-Tae,Fouladdel, Shamileh,Teichert, Kendall,Ok, Jong G.,Cheng, Yu-Heng,Ingram, Patrick N.,Hart, A. John,Azizi, Ebrahim,Guo, L. Jay,Wicha, Max S.,Yoon, Euisik American Chemical Society 2017 ACS NANO Vol.11 No.5

<P>Considerable evidence suggests that self-renewal and differentiation of cancer stem-like cells, a key cell population in tumorgenesis, can determine the outcome of disease. Though the development of microfluidics has enhanced the study of cellular lineage, it remains challenging to retrieve sister cells separately inside enclosed microfluidics for further analyses. In this work, we developed a photomechanical method to selectively detach and reliably retrieve target cells from enclosed microfluidic chambers. Cells cultured on carbon nanotube polydimethylsiloxane composite surfaces can be detached using shear force induced through irradiation of a nanosecond-pulsed laser. This retrieval process has been verified to preserve cell viability, membrane proteins, and mRNA expression levels. Using the presented method, we have successfully performed 96-plex single-cell transcriptome analysis on sister cells in order to identify the genes altered during self-renewal and differentiation, demonstrating phenomenal resolution in the study of cellular lineage.</P>

A study on Safe Pork Consumption Behavior in Taiwan

( Cheng-wei Chen ),( Yu-ping Fan ),( Cheng-hsing Yeh ) 한국농업경제학회 2009 KOREAN JOURNAL OF AGRICULTURAL ECONOMICS(KJAT) Vol.50 No.3

Pork is the most popular meat in Taiwan, that makes hog industry an important agriculture industry. The government had lauched the traceability system of agricultural products from 2004. It is needed to appreciate the policy affecting consumers’ willingness to buy safe pork for hog industry to separate market. This research use consumer decision process model and market segmentation to separate four respective factors as age group, educational background, family income, and the population element as family structure to find out the habit of safe pork consumption. This study was based on household as its unit, and had conducted questionnaire survey upon the primary purchasers of pork, which were then analyzed with descriptive statistics, Chi-square test, and the logit model so as to differentiate the preference of demographic characteristics among consumers with various features. This research indicated consumers with more members of household, older, less educated,less income, less cognitive about pork risk would have higher possibility to buy warm pork. Consumers with female, more educated, more income, more cognitive about pork risk would have higher willingness to pork with traceability system.However consumers in Taiwan still prefer buy warm body pork, little perception about pork marketing risk. The government should improve pork safety by more inspecting hog farms, processing factories and markets and educating consumers the knowledge of safe pork by television broadcasting and other mass media.

Construction of Z-scheme W18O49/NiAl-LDH heterojunction with photothermal effect for photocatalytic reduction of CO2

Cheng Xia,Rui-Tang Guo,Zhen-rui Zhang,Chen-yuan Fan,Yu-zhe Liu,Yu-cheng Lin,Chu-fan Li,Wei-Guo Pan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Recently, the photocatalytic CO2 reduction technology is an effective solution to remit the energy crisis. Inorder to improve the photocatalytic performance, Z-scheme W18O49/NiAl-LDH composite catalysts wereprepared by hydrothermal method. Fortunately, the prepared catalysts revealed excellent photocatalyticperformance under the simulated sunlight, and CO and CH4 could be detected in the reduction products. WO/LDH-0.5 catalyst possessed the optimal activity, with CO and CH4 yield of 37.09 and 8.01 lmol g-1h1separately, which were 7.9 and 3.6 times that of NiAl-LDH monomer. In addition, W18O49 endowedW18O49/NiAl-LDH catalysts with photothermal effect, which raised the surface temperature andfacilitated the catalytic reaction. Meanwhile, the Z-scheme heterojunction composed of flower-likeNiAl-LDH and urchin-like W18O49 accelerated the separation of photoexcited carriers and enhanced theredox ability. Through a series of characterizations and investigations, this work is promising to breaknew ground for the design of photocatalysts with photothermal effect.

Influence of FeSe doping on superconducting properties of MgB2 by hybrid microwave method

Cheng Cheng,Zhenjie Feng,Qing Li,Xu Wang,Chuan Yu,Hao Chu,Ya Yang,Changqin Liu,Yiming Cao,Zhe Li,Jingzhe Chen,Chao Jing,Shixun Cao,Jincang Zhang 한국물리학회 2017 Current Applied Physics Vol.17 No.11

The effect of FeSe doping on the physical properties of MgB2 is studied. Bulk samples of the FeSe doped MgB2 with weight ratio x ðFeSe : MgB2Þ ¼ 0%; 3%; 7% and 10% were prepared by hybrid microwave method. It is proved that FeSe is not stable together with MgB2. Fe2þ enters into MgB2 lattice, some Mg2þ and Se2『 are combined into the new impurity compound MgSe. The superconducting transition temperature (Tc) slightly decreased with increasing doping content of FeSe from R-T and M-T curves, which results from the substitution of Mg2þ by Fe2þ in the MgB2 lattice. The Jc increase slightly with the FeSe doping content increasing from 3 wt % to 10 wt %, which results from the increasing MgSe impurity pinning centers.

Sublimation and high-temperature stability of SnO2-doped Bi2O3 ionic materials in controlled atmosphere

Yu-Hung Cheng,Yen-Yu Chen,Wen-Cheng J. Wei 한양대학교 세라믹연구소 2018 Journal of Ceramic Processing Research Vol.19 No.5

Sublimation of Bi2O3-based materials is an important degradation issue for the long-term applications of many electronicdevices. A series of SnO2-doped Bi2O3 materials (SBO), was synthesized, densified, and then tested in air or strong reducingatmosphere. The SnO2-doping effects and sublimation kinetics of the SBO materials were studied by X-ray diffraction (XRD),scanning electron microscope (SEM) and precise mass loss measurement. The results show that formation of Bi2Sn2O7 phasegreatly retards the mass loss of SBO. The SBO samples show a surface sublimation in an energy of 52.6 kJ.mol−1. However,the sublimation is also controlled by surface microstructure as the amount of vaporizing species (the Bi or gaseous Bi-oxides)is more than 0.1 mass%. The evaporation is retarded on the rough surface and the mechanism of surface evaporation ischanged to diffusional control.

The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings

Cheng-Chang Chang,Hui-Chen Wang,Yu-Ping Liao,Yu-Chih Chen,Yu-Chun Weng,Mu-Hsien Yu,Hung-Cheng Lai 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1

Objective: We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. Methods: We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verified in training set using cervical scrapings of 10 EC/10 OC patients and 10 controls, and further validated in the testing set using independent cervical scrapings in 30 EC/30 OC patients and 30 controls. We generated cutoff values of methylation index (M-index) from cervical scrapings to distinguish between cancer patients and control. Sensitivity/specificity of DNA methylation biomarkers in detecting EC and OC was calculated. Results: Of 14 genes, 4 (PTGDR, HS3ST2, POU4F3, MAGI2) showed hypermethylation in EC and OC tissues, and were verified in training set. POU4F3 and MAGI2 exhibited hypermethylation in training set were validated in independent cases. The mean M-index of POU4F3 is 78.28 in EC and 20.36 in OC, which are higher than that in controls (6.59; p<0.001 and p=0.100, respectively), and that of MAGI2 is 246.0 in EC and 12.2 in OC, which is significantly higher that than in controls (2.85; p<0.001 and p=0.480, respectively). Sensitivity and specificity of POU4F3/MAGI2 were 83%–90% and 69%–75% for detection of EC, and 61% and 62%–69% for the detection of OC. Conclusion: The findings demonstrate the potential of EC/OC detection through testing for DNA methylation in cervical scrapings.