Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

혈액 및 비장조직에서 일산화탄소 헤모글로빈 농도에 관한 연구 : A Comparison of CO-Hb in Blood and Spleen Specimens

이진훈,오세진,김유나,이진숙,유재훈,장성길 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

Chromium picolinate가 고지방, 고설탕 식이를 섭취한 흰쥐의 체내 포도당, 지질 농도에 미치는 영향

오유진,진윤경,장유경 漢陽大學校 韓國生活科學硏究所 2001 韓國 生活 科學 硏究 Vol.- No.19

This study was carried out to investigate the effect of chromium picolinate supplementation on the metabolism of rats. Male Sprague-Dawley rats were divided into 3 groups and each group had 16 rats. Three experimental diets of CT(control), HS(high sucrose) and HF(high fat) were fed for 10 weeks and then chromium picolinate were supplemented to HS and HF groups for 6 weeks. Eight rats from each group were sacrificed after 10 weeks and another 8 rats from each group were sacrificed after 16 weeks. The results from this experiment were summarized as follows: The change of calorie intake and body weight was not significantly different among three groups after chromium picolinate supplementation. The plasma glucose and insulin concentration in CT group tended to increase after 16 weeks but those in HS and HF groups tended to decrease after chromium picolinate supplementation. The plasma triglyceride and cholesterol concentration of CT group tended to be higher than those of HS and HF groups which were supplemented by chromium picolinate. Our results indicate that chromium picolinate tend to reduce blood glucose, insulin, triglyceride, and cholesterol level but increase HDL-cholesterol level.

임진택의 오월광주 에 나타난5.18 민주화운동의 형상화 방식

부유진 ( Boo Yu Jin ) 전남대학교 호남학연구원 2014 호남학 Vol.0 No.55

본고에서는 사설의 구성방식, 음악적인 특징, 연행의 의의 등을 망라하여 임진택의 <오월광주>에 접근하고자 하였다. 이를 통해 <오월광주>에서 기억되는 5·18의 모습이 어떠한 방식으로 형상화되는 지 살펴볼 수 있었다. 먼저, <오월광주> 사설은 사건 중심의 전개를 취하는 것이 특징 이다. 동시에 ‘학생’에서 ‘시민공동체’로 다시 ‘노동 민중’으로 변화 해 나가는 항쟁 주체 세력의 변모에 주목할 수 있다. 이는 1980년, 공 수대원으로 상징되는 국가권력의 폭력이 어떻게 증폭되는가를 반증 한다고 볼 수 있다. 음악적인 특징 면에서는 계면조와 우조의 적절한 배치를 통해 청 중의 몰입과 이완을 돕는다. 몰입을 통한 치유의 효과는 물론이고, 객관적 사실을 전달해 내기도 한다. 더불어 곳곳에 웃음의 요소를 배 치하여 분위기를 환기시키기도 한다. <오월광주>를 통해 5·18의 기억을 직접적으로 보유하는 이들은 물론이고, 기록물을 통한 간접적인 기억을 보유한 이들, 혹은 전혀 관련이 없는 이라도 <오월광주>의 연행현장에서 넘나들 수 있게 된 다. 그리고 이들 모두가 5·18을 망각하지 않고 기억해나갈 수 있게 한다. This study approched Lim Jin-teak`s newly created Pansori <May 18th of Gwangju> the way contains organizing Pansori song story, musical feature, and meaning of performance. This helps could go through Gwangju DemocratizationMovement is being remembered as <May 18th of Gwangju>. First, Pansori song story of <May 18th of Gwangju> is centers on the episode. Also remakable thing about the leading group change from ‘Student’ to ‘civic community’, and to ‘working class people’. The fact disprovied that power of the state`s violence how is getting worse. Resarching the musical feature aspects, Gyemyon-jo and Woo-jo were appropriate arranged. And it is possible that audience be immersed and relaxed. Through the immersion not only healing effect but also giving the fact. Moreover, for awaken atmosphere, using the element of laugh. Even if we don`t have any information of Gwangju Democratization Movement, we can play with the performance of <May 18th of Gwangju>. We must don`t forget the history of Gwangju Democratization Movement and keep remembering this fact.

과학적 근거 중심 평가를 도입한 마늘의 콜레스테롤 조절 기능성 평가

김인혜;조강진;김진영;황경아;황유진;채유진;엄애선 한양대학교 2010 韓國 生活 科學 硏究 Vol.30 No.1

Garlic (Allium sativum) is used a flavouring agent and a traditional medicine in human history. Numerous studies support the fact that garlic intake may have effect on cholesetrol-lowering. No claims currently have been made about garlic intake and cholesterol-lowering effect with respect to health claim in Korea. The aim of this study was to evaluate the scientific evidence on garlic intake and cholesterol-lowering effect by the scientific evidence-based rating system of Korean Food and Drug Administration for health claim. We carried out a comprehensive search of the Pubmed, EMBASE, Cochrane Library and manual searches of relevant journals for studies between 1955-2009. The search terms were garlic and Allium sativum in combination with cholesterol. Eighteen clinical stidies were included and reviewed to evaluate the strength of evidence that supports a relation between garlic intake and cholesterol-lowering effect. Our results suggests that level of scientific evidence on garlic intake and cholesterol-lowering effect is "other function (II) probable".

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

바닥공조시스템과 천장공조시스템의 실내환경 비교 평가

유기형,조동우,유지용,이진영,이상엽 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5

The purpose of this study was to evaluate the indoor environment of office building with underfloor air distribution system and ceiling based air conditioning system. The underfloor air distribution system was introduced to use access floor and aim to economical motive such as reducing floor to height level. Researches were not sufficient to preserve the characteristics between ceiling based air conditioning system and underfloor air distribution system. Experiments have been carried out to indoor environment in the summer and winter. As the result, thermal environment of the underfloor air distribution system is better than ceiling based air conditioning system in the winter. Ventilation effectiveness of the underfloor air distribution system is bigger than ceiling based air conditioning system.

외과적 정출술을 통한 치은 하방 치경부 파절선이 있는 상악 전치부의 심미 보철 치료

이소진,김유진,박영범,조규성,정문규 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Surgical extrusion, immediate extrusion following tooth luxation, is a method to preserve one's natural tooth and achieve esthetic restoration without additional periodontal surgery when subgingival dental caries or crown fracture occurs. A 16-year-old male was referred to the clinic from the department of operative dentistry for the esthetic restoration of maxillary left lateral incisor. Due to the crown to root fracture, the tooth was endodontically treated with a buccal crown length of 4 mm. When the palatal flap was elevated, the mesiopalatal cervical fracture area was situated 3 - 4 mm subgingivally. Crown lengthening was achieved through surgical extrusion. After 3 months of clinical observation and provisional restoration, the maxillary left central incisor was restored with all ceramic crown and obtained a satisfactory clinical result. 치은연 하방에 치아 우식증이나 치아 파절이 발생했을 때, 치아를 탈구시켜 즉시 정출시키는 외과적 정출술을 이용한 치관 연장술은 자연치를 보존하고 추가적인 치주적 수술 없이 단기간에 심미적인 보철 치료를 가능하게 한다. 본 환자는 16세 남환으로 본원 보존과로부터 상악 좌측 중절치의 심미 수복을 위해 본원 보철과로 의뢰되었다. 상악 좌측 중절치는 근관치료가 되어 있었으며 치관-치근 파절로 인해 협측 치관 길이는 4 mm였으며 구개측 판막을 열었을 때 근심 구개측 치경부 파절 범위는 치은 하방 3 - 4 mm에 위치하였다. 외과적 정출술을 통한 치관연장술을 시행하였으며 경과 관찰 및 임시 치아의 단계를 거쳐 3개월 후에 전부 도재관으로 수복하여 만족할 만한 임상 결과를 얻을 수 있었다.