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- 저자 : ( Yu Lei ) (검색결과 411 건)
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Yu-yan Zhao,Lei Guo,Xiao-juan Zhao,Hong Liu,Tian Lei,Dong-jie Ma,Xiao-yu Gao 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.7
Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation through an estrogen- responsive gene in target cells, we investigated the effects of estrogen on IGFBP-6 expression in the human osteoblastic-like cell line SaOS-2. Expressions of IGFBP-6 protein and mRNA increased 2.8 and 2-fold, respectively, in the presence of 17-β-estradiol (E2) (0.01 to 1 μM) and estrogen receptor (ER) in SaOS-2 cells. On the other hand, E2 induced a 2-fold increase in SaOS-2 cell proliferation. To identify genomic sequences associated with estrogen responsiveness, the 5'-promoter region (-44 to +118) of the IGFBP-6 gene was cloned into a chloramphenicol acetyltransferase (CAT) reporter vector. E2 induced a 3-fold increase in CAT activity in SaOS-2 cells transiently transfected with this construct. Identification of the estrogen- responsive element (ERE) [5'-CCTTCA CCTG-3'] (-9 to +1) in this IGFBP-6 gene promoter region was confirmed using electromobility shift assays and deletion analysis. This functional ERE was important for E2-induced trans-activation of the IGFBP-6 gene. These results demonstrate that E2 exhibits a positive effect on IGFBP-6 gene transcription through estrogen- liganded ER binding to the functional ERE in the IGFBP-6 gene promoter in SaOS-2 cells. Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation through an estrogen- responsive gene in target cells, we investigated the effects of estrogen on IGFBP-6 expression in the human osteoblastic-like cell line SaOS-2. Expressions of IGFBP-6 protein and mRNA increased 2.8 and 2-fold, respectively, in the presence of 17-β-estradiol (E2) (0.01 to 1 μM) and estrogen receptor (ER) in SaOS-2 cells. On the other hand, E2 induced a 2-fold increase in SaOS-2 cell proliferation. To identify genomic sequences associated with estrogen responsiveness, the 5'-promoter region (-44 to +118) of the IGFBP-6 gene was cloned into a chloramphenicol acetyltransferase (CAT) reporter vector. E2 induced a 3-fold increase in CAT activity in SaOS-2 cells transiently transfected with this construct. Identification of the estrogen- responsive element (ERE) [5'-CCTTCA CCTG-3'] (-9 to +1) in this IGFBP-6 gene promoter region was confirmed using electromobility shift assays and deletion analysis. This functional ERE was important for E2-induced trans-activation of the IGFBP-6 gene. These results demonstrate that E2 exhibits a positive effect on IGFBP-6 gene transcription through estrogen- liganded ER binding to the functional ERE in the IGFBP-6 gene promoter in SaOS-2 cells.
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( Yu Lei ),( Kwanghyun Yu ),( Sungchul Bang ) 아시아.유럽미래학회 2013 유라시아연구 Vol.10 No.1
With China’s accession to the World Trade Organization (WTO), many foreign banks have started to enter into China while Chinese banking and insurance industries have been deepening and opening up. Commercial banks will pay more attention to profit and abandon appropriate liquidity in order to survive in fierce competition. Particularly in recent years, liquidity risk caused by the US sub-prime mortgage crisis has lead banks and many financial institutions to collapse and has also been bringing the devastating impact on the global economy. In 1978, Chinese government began to implement the reform and opening up, and in the meanwhile began to reform the banking sector, which interrupted the banking monopoly and led in competition system into banking sector. During the Asian financial crisis in 1997, China’s banking sector experienced liquidity crises due to over competition, leading to the bankruptcy of Hainan Development Bank because of exhausted liquidity. The bankruptcy of Hainan Development Bank resulted in the loss of nearly 4 billion yuan of People’s Bank of China, which had a graveness influence on China’s banking sector. In addition, China’s long-term trade surplus and a large inflow of foreign capital lead to the excess liquidity in the banking sector. In the pressure of such excess liquidity, banks will blindly decrease lending rates to get inter-bank rate lower than bank-deposit rate appearing interest rate inversion phenomenon to decrease bank returns. In the long term, this will probably accelerate the accumulation of non-performing loan of bank. When the economy changes, asset bubbles of bank will quickly be shattered, which will directly result in the systematic financial crisis in the banking sector. Meanwhile, China as a largest trading partner of South Korea has been a key factor on its economy. However, South Korea is lacking of understanding of potential various uncertainties and liquidity risk in China’s Economy, which bases on banking. In this case, South Korea will be significantly influenced due to its highly dependence on China’s Economy if Chinese commercial banks suffer from liquidity risk. Especially, Korean companies already invested in China and global financial companies constantly attempting to expand all over of China should be directly affected. Therefore, this paper is to analyze the determinants of the bank’s liquidity risk in Chinese commercial banks and what difference between large commercial banks and small-medium commercial banks. The banking data used in this paper were extracted from the database BankScope IBCA-Fitch, the People’s Bank of China and China Statistical Yearbook. We used panel data of 25 commercial banks over the period from 2004 to 2011 to estimate the determinants of liquidity risk by panel OLS, the fixed effects and random effects regression. The results of the empirical analysis are as follows: first, internal factors in banks did not affect the liquidity of the commercial banks in China, but it was affected by macro-economic factors negatively. It implies that the People’s Bank of China will be able to adjust liquidity and manage liquidity risk in commercial banks in China using monetary policy. Second, in terms of asset size of banks, both internal factors in banks and macro-economic factors have influence on the liquidity of large commercial banks in China, however, small-medium commercial banks have only been affected by non-performance loans ratio and macro-economic factors.
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Image Tracking Algorithm Improvement Based on TLD Frame
Lei Yu,Tao Zheng,Qiyun Shi 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.5
Image target tracking is an important part in computer vision field, and has a broad application prospect in modern society. Lack of online learning function, the traditional target tracking algorithm was based on the single track as long as possible. The target deformation and occlusion will lead to target tracking lost. TLD (tracking-learning-detection) is the long-term effective algorithm in tracking single target proposed. The algorithm requires less prior knowledge and can achieve long-term tracking, but when target encounter obstacles, there will be drift phenomenon in the short term. In order to overcome this shortcoming, the paper improve the tracking module of TLD. A method is proposed by using Harris feature point instead of the original Grid sampling method. The experimental results show that this method can effectively suppress the tracking drift, and improve tracking precision.
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Yu, Min,Liu, Lei,Zhang, Bing-Lan,Chen, Qi,Ma, Xue-Lei,Wu, Yu-Ke,Liang, Chun-Shui,Niu, Zhi-Min,Qin, Xin,Niu, Ting Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.
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Lei-Chen Lin,Wan-Rou Lin,Yu-Chen Hsu,Hung-Yu Pan 한국원예학회 2020 원예과학기술지 Vol.38 No.5
Rhododendron kanehirae Wilson is an endemic species of Taiwan that is listed as extinct in the wild by the Red List of Vascular Plants of Taiwan. R. kanehirae seedlings can form mycorrhizae with the ericoid mycobiont Oidiodendron maius. A completely randomized experimental design was conducted to investigate the effects of three different O. maius isolates (strains CBS110450, RhYM3, and RooDK1) as well as nitrate and ammonium (inorganic nitrogen) on the growth of R. kanehirae by evaluating height and shoot, root, and total fresh weight. Three isolates of O. maius showed different colony morphology and growth rate, which was further verified by molecular analysis. The results showed that application of ammonium fertilizer improved the height and shoot, root, and total fresh weight of all of the R. kanehirae seedlings. Among them, seedlings inoculated with RhYM3 had the highest fresh weights and heights. By applying an appropriate amount of nitrogen combined with RhYM3 inoculation, the rhizome of R. kanehirae grew well. The information provided here is crucial for the conservation of R. kanehirae, as this species is on the verge of extinction.
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Yu Lei,Sui Sophia 한국학술연구원 2022 Korea Observer Vol.53 No.2
This paper finds that Pyongyang's nuclear issue is by no means China's "primary contradiction (top priority)" in its international relations. Chinese priority on the Korean peninsula is to keep stability and the status quo of a divided Korea rather than rush to find a resolution to the nuclear issue, which may result in a military imbalance on the Peninsula, or the collapse of the Pyongyang regime and hurt China's interest. To this end, China has adopted the strategy of making a delicate balance between pressuring and sustaining the Pyongyang regime. The paper concludes that from Chinese perspectives, a North Korea at the nuclear threshold contributes to counterbalancing US military presence in the region, maintaining a status quo of divided Koreas and helping China overcome US containment. China aspires to achieve three interconnected objectives with this strategy. This first is to sustain China's economic growth, the second to counterattack US containment, and the third to propel China's rise at the systemic (global) level.
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