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Keum, Sam-Rok,Roh, Se-Jung,Kim, Young-Nan,Im, Do-Hyuck,Ma, So-Young Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.11
The unequivocal solid-state structure and stereochemistry of the hetaryl leuco-TAM dye, 2,2’-(2-phenyl propane- 1,3-diylidene) bis(1,3,3- trimethylindoline) derivatives were established using X-ray single crystal analysis. The X-ray crystal analysis showed that the (Z, E)-isomers only formed stereoselectively, with a so-called “threebladed propeller” conformation, from the reaction of a Fischer base and benzaldehyde derivatives. These isomers were stacked in a juxtaposition to form a dimer or a double dimer, adopting either a triclinic, with P-1, or monoclinic crystal system with a space group P21/n in the unit cell of the crystal.
Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes
( Young Sam Keum ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.2
The molecular mechanisms by which a variety of naturally-occurring dietary compounds exert chemopreventive effects have been a subject of intense scientifl c investigations. Induction of phase II detoxifl cation and anti-oxidant enzymes through activation of Nrf2/ ARE-dependent gene is recognized as one of the major cellular defense mechanisms against oxidative or xenobiotic stresses and currently represents a critical chemopreventive mechanism of action. In the present review, the functional signifl cance of Keap1/ Nrf2 protein module in regulating ARE-dependent phase II detoxifl cation and anti-oxidant gene expression is discussed. The biochemical mechanisms underlying the phosphorylation and expression of Keap1/Nrf2 proteins that are controlled by the intracellular signaling kinases and ubiquitin-mediated E3 ligase system as well as control of nucleocytoplasmic translocation of Nrf2 by its innate nuclear export signal (NES) are described.
( Young-sam Keum ),( Bu Young Choi ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.5
Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors. [BMB Reports 2015; 48(5): 266-270]
( Sam Sung Eun ),( Tae Hun An ),( Ki Tae Jung ),( Jong Dal Jung ),( Keum Young So ),( Byung Sik Yu ),( Kyung Joon Lim ),( Sang Hun Kim ),( Hyun Young Lee ),( Chang Hoon Song ),( Hong Lin Shi ),( Ji Li 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.6
Background: Intravenous hypnotics are used in pregnancy, labor and delivery. The aim of the present study was to investigate and compare the relaxant effects of propofol, thiopental, ketamine, and etomidate on isolated rat uterine smooth muscles. Methods: Uterine smooth muscle preparations were obtained from non-pregnant female rats. The uterus of the rat was dissected and cut into 10 mm strips. The muscle strips were bathed in Krebs solution. After spontaneous uterine contractile activity had been accomplished, propofol, ketamine, thiopental, and etomidate in various concentrations were added cumulatively to the baths and resting tension, active tension, and frequency of contration were recorded at each concentration of agents. EC5, EC25, EC50, EC75, and EC95 of each drug on active tension and frequency of contraction were calculated using a probit model. Results: Propofol, thiopental, and etomidate reduced uterine contractions in a concentration-dependent manner. Ketamine concentrations of 10(-7) to 10(-5) M augmented uterine contractions but ketamine concentrations of 10(-4) to 10(-3) M attenuated uterine contractions. The EC50`s of propofol, thiopental, ketamine, and etomidate on active tension were 1.56 × 10(-5) M, 4.97 × 10(-5) M, 3.52 × 10(-4) M, and 2.73 × 10(-5) M, respectively. Conclusions: All four intravenous hypnotics relaxed the uterine smooth muscle of rats except for ketamine in low concentrations (10(-7) to 10(-5) M). Propofol had the greatest relaxant effects on isolated rat uterine smooth muscle among these hypnotics. It seems that ketamine is a suitable obstetric hypnotic agent for hypovolemic parturients and propofol is a useful hypnotic agent for uterine relaxation during pregnancy. (Korean J Anesthesiol 2008; 55: 723~30)
Keum, Sam-Rok,Ma, So-Young,Lim, Hyun-Woo,Han, Tae-Hwi,Choi, Kyu-Hyun Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
The position of the thermodynamic equilibrium for reverse thermochromic spiropyran 6-carboxylates (SP-COOHs) was easily determined in aqueous binary mixtures, such as water-methanol, water-acetonitrile and water-dimethyl sulfoxide. The existence of more than one type of interconvertible species of the ring-opened form of SP-COOH in aqueous binary solvents enables us to evaluate the molar extinction coefficients of the ring-opened species of SP-COOH and to obtain the thermodynamic parameters.
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
지삼룡 ( Sam Ryong Jee ),최석렬 ( Seok Reyol Choi ),김광진 ( Kwang Jin Kim ),금동주 ( Dong Joo Keum ),홍기봉 ( Ki Bong Hong ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최필조 ( Pill Jo Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 식도절제술은 식도암에 있어서 장기생존 및 증상의 호전을 위하여 치료원칙이 되며, 증상의 호전을 위한 고식적 수술로도 시행된다. 또한, 식도의 양성 협착 질환이나 식도 천공의 치료법으로도 행해진다. 그러나, 식도절제술후의 식도 운동기능의 양상과 위배출능에 대한 국내문헌은 찾아보기 힘든 실정이다, 이에 저자들은 식도절제술후 호소하는 증상과 식도내압 및 위배출시간과의 연관성을 알아보고자 하였다. 〈방법〉 1994년 10월부터 1998년 11월 사이에