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- 저자 : ( Xing-jing Luo ) (검색결과 14 건)
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Luo Xiao-Jing,He Ming-Ming,Liu Jia,Zheng Jia-Bo,Wu Qi-Nian,Chen Yan-Xing,Meng Qi,Luo Kong-Jia,Chen Dong-Liang,Xu Rui-Hua,Zeng Zhao-Lei,Liu Ze-Xian,Luo Hui-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Esophageal squamous cell carcinoma (ESCC) is one of the most life- and health-threatening malignant diseases worldwide, especially in China. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and tumor progression. However, the roles and mechanisms of lncRNAs in ESCC require further exploration. Here, in combination with a small interfering RNA (siRNA) library targeting specific lncRNAs, we performed MTS and Transwell assays to screen functional lncRNAs that were overexpressed in ESCC. TMPO-AS1 expression was significantly upregulated in ESCC tumor samples, with higher TMPOAS1 expression positively correlated with shorter overall survival times. In vitro and in vivo functional experiments revealed that TMPO-AS1 promotes the proliferation and metastasis of ESCC cells. Mechanistically, TMPO-AS1 bound to fused in sarcoma (FUS) and recruited p300 to the TMPO promoter, forming biomolecular condensates in situ to activate TMPO transcription in cis by increasing the acetylation of histone H3 lysine 27 (H3K27ac). Targeting TMPO-AS1 led to impaired ESCC tumor growth in a patient-derived xenograft (PDX) model. We found that TMPO-AS1 is required for cell proliferation and metastasis in ESCC by promoting the expression of TMPO, and both TMPO-AS1 and TMPO might be potential biomarkers and therapeutic targets in ESCC.
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A Novel Method of Reducing the Cogging Torque in SPM Machine with Segmented Stator
Jing, Li-Bing,Liu, Lin,Qu, Rong-Hai,Gao, Qi-Xing,Luo, Zheng-Hao The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
The method of stator segmentation is generally taken to enhance the electromagnetic performance of surface-mounted permanent magnet (SPM) machine and reduce its production cost. Based on the model with single slot, the expressions of cogging torque in machine with uniform or non-uniform segmentations are deduced and the optimal combination is given. Moreover, this paper discusses a structured skewing method and put forward a novel stator structure model to reduce the cogging torque in segmented permanent magnet machine. The model can reduce the cogging torque amplitude by shifting a proper angle of slot-opening. The shifting angle formula for analysis can also be suitable for other permanent machine with segmented stator. Finally the results of finite element simulation are given to prove that the method is effective and feasible.
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Branched polymeric prodrug/programmed cell death 4 complexes for combinational cancer therapy
Yu‑Jing He,Lei Xing,Peng‑Fei Cui,Jia‑Liang Zhang,Jian‑Bin Qiao,Cheng‑Qiong Luo,Ge Jiang,Hu‑Lin Jiang 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.2
Here, we demonstrate a co-delivery system constructed by integrating chemotherapeutic molecules into branched polymeric prodrug which can condense nucleic acids. Demethylcantharidate (DCA) was chosen as a model drug and premodified through nucleophilic substitution reaction by its two carboxylic groups with allyl chloride. The synthesized intermediate (DCA-dially) was then used to polymerize with tris (2-aminoethyl) amine (TAEA) through progressively ammonolysis reaction. The obtained poly (DCA-alt-TAEA) (DCAT) was used to pack PDCD4 into spherical-like nanoparticles through electrostatic interaction. Gel retardation assays implied that DCAT could integrate DNA at the weight ratio of 1 and protect it from digestion by nuclease. Acid-base titration experiments showed that DCAT obtained preferable buffering capability which was beneficial for the endosomal escape of DCAT/PDCD4 complexes. Cellular tests involving gene transfection efficiency and cytotoxicity indicated that DCA and PDCD4 co-delivered by the complexes significantly and synergistically suppressed the viability of SMMC-7721 cells. These results suggest that integrating chemotherapeutic molecules into nucleic acid-packing polymeric prodrug as cationic polymer/PDCD4 complexes is a highly efficient way to co-deliver chemotherapeutic drugs and nucleic acids for cancer therapy.
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Wang Jing,Xing Haijun,Wang Huaxin,Xie Baojiang,Luo Yangfan 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.5
In order to further improve the energy consumption potential and system energy utilization effi ciency on the demand side of regional integrated energy system (RIES), taking into account economy and energy effi ciency, a RIES optimal operation model and strategy considering integrated demand response (IDR) and exergy effi ciency are proposed. Firstly, the IDR is modeled, the exergy effi ciency of RIES is analyzed, and an exergy effi ciency model considering IDR is established. Secondly the RIES multi-objective optimization model is established with the goal of the lowest economic cost and the highest exergy effi ciency. In order to obtain a series of Pareto frontier solutions with uniform distribution, the normal boundary intersection is used to solve the multi-objective. Finally, the system economic cost and exergy effi ciency under four diff erent scenarios are analyzed. A practical example is used to verify the proposed model. The results show that considering the comprehensive demand response in RIES can eff ectively reduce the system cost. Through multi-objective analysis, it is verifi ed that the reasonable addition of comprehensive demand response can further improve the system exergy effi ciency and stimulate the exergy consumption potential on the demand side.
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A Novel Method of Reducing the Cogging Torque in SPM Machine with Segmented Stator
Li-Bing Jing,Lin Liu,Rong-Hai Qu,Qi-Xing Gao,Zheng-Hao Luo 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
The method of stator segmentation is generally taken to enhance the electromagnetic performance of surface-mounted permanent magnet (SPM) machine and reduce its production cost. Based on the model with single slot, the expressions of cogging torque in machine with uniform or non-uniform segmentations are deduced and the optimal combination is given. Moreover, this paper discusses a structured skewing method and put forward a novel stator structure model to reduce the cogging torque in segmented permanent magnet machine. The model can reduce the cogging torque amplitude by shifting a proper angle of slot-opening. The shifting angle formula for analysis can also be suitable for other permanent machine with segmented stator. Finally the results of finite element simulation are given to prove that the method is effective and feasible.
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Optimization Design of Magnetic Gear Based on Genetic Algorithm Toolbox of Matlab
Li-Bing Jing,Zheng-Hao Luo,Lin Liu,Qi-Xing Gao 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.5
Concentric magnetic gear (CMG) is a transmission gear with a novel structure and a promising prospect. However, the calculation of its electromagnetic field is more complicated. In this paper, an exact analytical method is used to calculate the magnetic field distribution and electromagnetic torque. The genetic algorithm optimization toolbox of matlab (GAOT) provides a good tool for its optimization design. The optimization results show that the genetic algorithm is practicable and effective, and provide a new approach for the analysis and design of the concentric magnetic gear. It is significant for the research and application of the concentric magnetic gear.
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Zhuang-hao Zheng,Jing-ting Luo,Feng Li,Guang-xing Liang,Ping Fan 한국물리학회 2019 Current Applied Physics Vol.19 No.4
In this work, a new idea of organic-inorganic hybridization was proposed to fabricate flexible p-type - Sb2Te3/ CH3NH3I thin films. The CH3NH3I has a strong adsorption which can promote the growth of organic molecules, improve the crystallization, and finally increase electrical conductivity. Post-annealing of the fabricated films increased the phonon scattering, thus resulting in a reduction of thermal conductivity and an increased ZT value. The annealed hybrid-composite film showed a significant enhancement in thermoelectric performance, with a maximum ZT value of 0.94 at a temperature of 413 K, which is twice as large as that of the as-deposited film.
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Triterpenoid saponins from Clinopodium chinense (Benth.) O. Kuntze and their biological activity
Yin-Di Zhu,Jing-Yi Hong,Feng-Da Bao,Na Xing,Ling-Tian Wang,Zhong-Hao Sun,Yun Luo,Hai Jiang,Xudong Xu,Nai-Liang Zhu,Hai-Feng Wu,Gui-Bo Sun,Jun-Shan Yang 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Four new ursane-type triterpenoid saponins, clinopoursaponins A–D (1–4), six new oleanane-type triterpenoid saponins, clinopodiside VII–XII (5–10), as well as eight known triterpene analogues (11–18), were isolated from the aerial parts of Clinopodium chinense (Benth.) O. Kuntze. The structures of the new compounds were determined based on extensive spectral analyses, including 1D (1H and 13C) and 2D NMR experiments (COSY, NOESY, HSQC, 2D TOCSY, HSQC-TOCSY and HMBC), HR-ESI-MS and chemical methods. Compounds 1–18 were evaluated for their protective effects against anoxia/reoxygenation-induced apoptosis in H9c2 cells and cytotoxicities against murine mammary carcinoma cell line 4T1. Compounds 8, 9 and 18 exhibited significant protective effects, while compound 1 exhibited cytotoxic activity with IC50 value of 7.4 μm compared to 7.6 μm for the positive control 10-hydroxycamptothecin.
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Zhao, Tai-Yun,Tu, Jing,Wang, Yin,Cheng, Da-Wei,Gao, Xian-Kui,Luo, Hao,Yan, Bi-Chun,Xu, Xiao-Li,Zhang, Hong-Ling,Lu, Xing-Jun,Wang, Yao-Jun Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: Through search the possible randomized control trials, we make a renewed meta-analysis in order to assess the impact of aspirin in preventing the recurrence of colorectal adenoma. Materials and Methods: The Medicine/PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Chinese biomedical literature service system (SinoMed) databases were searched for the related randomized controlled trials until to the April 2016. Three different authors respectively evaluated the quality of studies and extracted data, and we used the STATA software to analyze, investigate heterogeneity between the data, using the fixed-effects model to calculate and merge data. Results: 7 papers were included the renewed meta-analysis, among these studies, two pairs were identified as representing the same study population, with the only difference being the duration of follow-up. Thus there were only five papers included our meta-analysis, and one Chinese paper were also included the work. Results were categorized by the length of follow-up, different kinds of people, varied dose of oral aspirin. The relative of adenoma in patients taking aspirin vs placebo were 0.73 (95% CI 0.55-0.98, P=0.039) with 1 year follow up; 0.84 (95% CI 0.72-0.98, P=0.484) with greater than 1 year follow up; for the advanced adenoma, the RR 0.68 (95% CI 0.49-0.94, P=0.582),for one year; RR=0.75 (95% CI 0.52-1.07, P=0.552) for greater one year. Furthermore the white population could divided into two subgroups according to the different length of follow-up time. When the length of follow-up time less than 3-year, The RR of two subgroups respective were RR=0.86 (95% CI 0.76-0.98, P=0.332), $I^2=0%$, RR=0.68 (95% CI 0.47-0.98, P=0.552), $I^2=64.6%$, But with the extension of follow-up time greater than 2-year, with the white, oral aspirin without considering dose had no efficacy on preventing the recurrence of any adenoma, the RR was 0.86 (95% CI 0.71-1.05, P=0.302), $I^2=16.4%$. Conclusions: This meta-analysis indicated that oral aspirin is associated with a remarkable decrease in the recurrence of any adenoma and advanced adenomas in patients follow-up for 1 year without concerning the dose of aspirin, but with the extension of follow-up time for greater than 1 year, oral aspirin can be effective on preventing the recurrence of any adenoma, but for the advanced adenoma, the result indicated that oral aspirin had no efficacy, According to the inclusion of ethnic groups, we also divided relevant papers into two subgroups as the yellow and white group. Then the follow-up time was less than 3 years, oral aspirin without considering the dose, had an significant efficacy on preventing the recurrence of any adenoma. But with the follow-up greater than 2 years, oral aspirin had no effect in the white.
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