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Application of Botulinum Toxin in Pain Management
Sim, Woo-Seog The Korean Pain Society 2011 The Korean Journal of Pain Vol.24 No.1
Botulinum toxin has been used for the treatment of many clinical disorders by producing temporary skeletal muscle relaxation. In pain management, botulinum toxin has demonstrated an analgesic effect by reducing muscular hyperactivity, but recent studies suggest this neurotoxin could have direct analgesic mechanisms different from its neuromuscular actions. At the moment, botulinum toxin is widely investigated and used in many painful diseases such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Further studies are needed to understand the exact analgesic mechanisms, efficacy and complications of botulinum toxin in chronic pain disorders.
( Woo Seog Sim ),( Jun Geol Lee ),( Sang Chul Lee ),( Yong Chul Kim ),( Young Jin Lim ),( Jae Hyuck Shin ),( Jae Hun Kim ),( Sang Hyun Park ),( Yun Ra Choi ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.4
Background: Postlaminectomy peridural fibrosis is inevitable. Some studies have compared and identified the effects of high molecular weight hyaluronic acids (HMWHA) and low molecular weight hyaluronic acids (LMWHA) on peridural fibrosis in postlaminectomy animal models. However, no studies have been found that compare pain behaviors between hyaluronic acids or among hyaluronic acids and other solid materials. The purpose of this study was to examine the correlation between pain-related behaviors and histopathologic changes in laminectomized rats using various peridurally administered materials. Methods: Forty male Sprague-Dawley rats, laminectomized at the L5 and L6 levels, were divided into four groups: group C, laminectomy only; group L, laminectomy and LMWHA application; group H, laminectomy and HMWHA application; group F, laminectomy and fat interposition. Pain behaviors were checked before, 3 days, 1 week, and 3 weeks after surgery. Histopathological changes were checked at the L5 level 3 weeks after the surgery. Results: The 50% withdrawal thresholds in groups L and H were higher than that in groups C and F three days after laminectomy (P < 0.05). The paw withdrawal time did not change among the groups and in each group during the study period. Peridural fibrosis in group F was significantly lower than in the other groups (P < 0.05). Conclusions: Hyaluronic acids significantly reduced mechanical allodynia but not thermal hyperalgesia. Peridural fibrosis did not show any correlation with pain behaviors. There have been limited studies on the correlation between peridural fibrosis and pain behavioral change, which should be verified by further studies.
Review Article : Application of Botulinum Toxin in Pain Management
( Woo Seog Sim ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.1
Botulinum toxin has been used for the treatment of many clinical disorders by producing temporary skeletal muscle relaxation. In pain management, botulinum toxin has demonstrated an analgesic effect by reducing muscular hyperactivity, but recent studies suggest this neurotoxin could have direct analgesic mechanisms different from its neuromuscular actions. At the moment, botulinum toxin is widely investigated and used in many painful diseases such as myofascial syndrome, headaches, arthritis, and neuropathic pain. Further studies are needed to understand the exact analgesic mechanisms, efficacy and complications of botulinum toxin in chronic pain disorders. (Korean J Pain 2011; 24: 1-6)
( Jae-woo Jung ),( Hae-sim Park ),( Choon-sik Park ),( Sang-heon Cho ),( Inseon S. Choi ),( Hee-bom Moon ),( Soon Seog Kwon ),( Ho Joo Yoon ),( Jung Won Park ),( Jong-myung Lee ),( Dong-chull Choi ),( 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.4
Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma. Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement in the quality of life with the additional administration of omalizumab for 24 weeks in Korean patients with severe persistent allergic asthma. Results: Of the 44 patients, 31.8% were men and the mean age was 49.8 ± 11.8 years. A score improvement of 0.5 points or more in the Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) was noted in 50.0% (22/44) of the patinets. In the improved group, the baseline total immunoglobulin E (IgE) level and the amount of omalizumab used were higher, and the day and night asthma symptoms were more severe, compared to those in the non-improved group. According to the Global Evaluation of Treatment Effectiveness, favorable outcomes were found in 78.6% of patients. The Korean asthma control test (p < 0.005) and forced expiratory volume in 1 second % predicted (FEV1%; p < 0.01) improved significantly in patients who received omalizumab treatment, compared to that at week 0, and the total dose of rescue systemic corticosteroids significantly decreased (p < 0.05). The improved group on KAQLQ showed a significant improvement in FEV1% (p < 0.001). Conclusions: Omalizumab can be considered a biological treatment for Korean patients with severe allergic asthma. It is recommended to consider omalizumab as add-on therapy in patients with high baseline total IgE levels and severe asthma symptoms.
자궁선근증에서 혈청 CA-125치와 월경곤란증 정도의 병변 깊이와의 관계
장석현 ( Seog Hyun Jang ),안태순 ( Tae Soon Ann ),오은성 ( En Sung Oh ),심재학 ( Jae Hag Sim ),백애란 ( Ae Lan Paik ),원종천 ( Jong Cheon Weon ),정강우 ( Kang Woo Jung ),김용필 ( Yong Pil Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Objective : To evaluate the association of level of CA-125 and severity of dysmenorrhea with lesion depth in adenomyosis. Methods : Sixty-eight women who had undergone hysterectomy and were found to have pure adenomyosis on histopathologic examination wer
이진영,Woo Seog Sim,Duk-Kyung Kim,박휴정,Min Seok Oh,Jieun Lee 대한마취통증의학회 2014 Anesthesia and pain medicine Vol.9 No.2
Pulsed radiofrequency treatment has an analgesic effect byneuromodulation of the central pain pathway without neural injury. However, lack of knowledge regarding the exact mechanism onneuropathic pain makes the use of pulsed radiofrequency treatmentcontroversial. Here, we describe a case of satisfactory pain reliefafter ultrasound-guided pulsed radiofrequency treatment in a patientwith supraorbital herpetic pain refractory to medication. This caseindicates the potential of ultrasound-guided pulsed radiofrequencytreatment in patients with postherpetic supraorbital neuralgia.
김원석(Won Seog Kim),정흠(Heum Jung),장흥문(Heung Moon Chang),정경해(Keong Hae Jung),우인숙(In Sook Woo),허대석(Dae Suck Heo),방영주(Yung Jue Bang),심영수(Yung Soo Sim),김노경(Noe Kyeong Kim) 대한내과학회 1995 대한내과학회지 Vol.48 No.3
The cancer-associated retinopathy (CAR) is a very rare paraneoplastic syndrome. Most of the cases are associated with the lung cancer, especially small cell lung cancer. The triad of CAR is described as photosensitivity, scotomatous peripheral visual field loss, and attenuated retinal arterial caliver. The pathogenesis is suggested that anti-retinal antibody induced by malignat tumors causes the degeneration of photoreceptors in the retina through the cross reaction. The titer of these antibodies can be used as an index of disease activity and treatment response. The CAR antigen is not clearly determined yet, but 26 kD proteins located in cone and rod photoreceptor cells are considered as that antigen. Consequently, the destructioon of the photoreceptors by immune mechanism results in visual changes even complete blindness. If no treatment is done, the visual loss progresses to complete blindness. Many authors recommanded prednisone as a treatment. This can reduce the antibody titer even to normal range, and stop the disease progress through the immunosuppression. With a brief review of literature, we report a case of cancer-associated retinopathy in 54-year old female patient who has a small cell lung cancer in the stage of limited disease, Her initial symptomes were peritpheral visual loss and sparkling in front of her eys. We treated her with the combination chemotherapy of cisplatin and etoposide (VP-16) and radiation therapy. The gastrointestinal symptom made her stop prednisone medication. The outcome of teatments was complete remission and her visual symptoms were not progressed. We have a good result in this patient. So we report this case.
( Ji Won Choi ),( Hyung Woo Lim ),( Jin Young Lee ),( Won Il Lee ),( Eun Kyung Lee ),( Choo Hoon Chang ),( Jae Young Yang ),( Woo Seog Sim ) 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.2
Background: It is widely accepted that cervical interlaminar steroid injection (CIESI) is more effective in treating radicular pain than axial neck pain, but without direct comparison. And the differences of effect after CIESI according to MRI findings are inconsistent. In this retrospective study, we evaluated the therapeutic response of CIESI according to pain sites, durations, MRI findings, and other predictive factors altogether, unlike previous studies, which evaluated them separately. Methods: The medical records of 128 patients who received fluoroscopy guided CIESI were analyzed. We evaluated the therapeutic response (more than a 50% reduction on the visual analog scale [VAS] by their second visit) after CIESI by (1) pain site; neck pain without radicular pain/radicular pain with or without neck pain, (2) pain duration; acute/chronic (more than 6 month), and (3) findings of MRI; herniated intervertebral disc (HIVD)/spinal stenosis, respectively and altogether. Results: Eighty-eight patients (68%) responded to CIESI, and there were no significant differences in demographic data, initial VAS score, or laboratory findings. And there were no significant differences in the response rate relating to pain site, pain duration, or MRI findings, respectively. In additional analysis, acute radicular pain with HIVD patients showed significantly better response than chronic neck pain with spinal stenosis (P = 0.04). Conclusions: We cannot find any sole predictive factor of therapeutic response to the CIESI. But the patients having acute radicular pain with HIVD showed the best response, and those having other chronic neck pain showed the worst response to CIESI. (Korean J Pain 2016; 29: 96-102)