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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
Acetylcholinesterase Inhibitory Effect of Lignans Isolated from Schizandra chinensis
Hung, Tran Manh,Na, Min-Kyun,Min, Byung-Sun,Ngoc, Tran Minh,Lee, Ik-Soo,Zhang, XinFeng,Bae, Ki-Hwan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A(13), entirely inhibited AChE in dose dependent manners, with IC$_{50}$ values of 6.71 ${\pm}$ 0.53, 6.55 ${\pm}$ 0.31, 7.84 ${\pm}$ 0.62, 12.57 ${\pm}$ 1.07 and 13.28 ${\pm}$ 1.68 ${\mu}$M, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
Development of Population Pharmacokinetic Model for Ethambutol in Korean Patients with Tuberculosis
( Tran Minh Hung ),( Nguyen Phuoc Long ),( Pham Quang Hoa ),( Tae-won Jang ),( Jusang Kim ),( Jee Youn Oh ),( Hyun Kuk Kim ),( Ji Joung Kang ),( Yong-soon Cho ),( Jae-gook Shin ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Ethambutol (EMB) is one of the four drugs to treat drug-susceptibility tuberculosis (TB). Therapeutic drug monitoring (TDM) is suggested to establish the safe and effective dosing of drugs in TB treatment. The population pharmacokinetic (PK) model provides a helpful tool for individualizing the treatment to minimize therapeutic failure and toxicity. This study was designed to evaluate the EMB PK parameters, characterize the interindividual variability of EMB PK parameters in Korean patients. Methods Data were collected from patients in the prospective cohort from the Center for Personalized Precision Medicine of Tuberculosis research center. The data were randomly divided into training and test sets with a ratio of 4:1. The model was developed using NONMEM version 4.7.1. Non-parametric bootstrapping and prediction-corrected visual predictive checks were used to validate the final model. Additionally, the model performance was evaluated on the test set. Results A model with two-compartment, one transit compartment prior to first-order absorption and elimination adequately described the PK profile of EMB. The estimates were 69.3 L/h for apparent clearance (CL/F), 154 L/h for apparent intercompartment clearance (Q/F), 98.8 L for apparent volume of central compartment (Vc/F), 849 L for apparent volume of peripheral compartment (Vp/F), 0.446 h-1 for rate constant of first-order absorption (Ka) and 0.719 h for mean transit time (MTT). Body weight significantly influenced CL/F and Q/F, and eGFR markedly affected CL/F. The internal and external validations indicated a satisfactory descriptive and predictive performance of the model, respectively. Conclusions We successfully established a population PK model to predict EMB concentrations for Korean TB patients. Internal and external validation confirmed that our model showed a good performance. Our model may be a valuable tool to support dose optimization according to individual patients' body weight and renal function in clinical management.
The Role of Zn Doping on the Catalytic Activity of the Nanoparticle Perovskite La0.7Sr0.3MnO3
Tran Thi Minh Nguyet,Nguyen Quang Huan,Tran Que Chi,Do The Chan,Nguyen Doan Thai,Nguyen Cong Trang,Luu Tien Hung,Le Van Tiep,Nguyen Van Qui 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.5
The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃ The nanometer complex oxide La0:7Sr0.3Mn0.6Zn0.₄O₃ was prepared by using a Sol-Gel method with citric acid as a ligand. The in uence of Zn doping of La0.7Sr0.₃MnO₃ on the structure, the morphology, the surface properties and on the catalytic activity of material was studied by using X-ray diraction (XRD), transmission electron microscopy (TEM), a high-resolution images and selected area electron diraction (SAED), physical adsorption and temperature programmed surface reaction (TPSR) methods. The results showed that perovskite La0:7Sr0:3Mn0:6. Zn0.₄O₃ could well catalyse propene oxidation in the temperature range 190 { 280 ℃, which was reduced to 100 { 120 ℃ for catalyst La1-χSrχMnO₃
Experiment on Nearest Level Modulation algorithm for FPGA based Modular Multilevel Converters
Tran Hung Cuong,Pham Viet Phuong,Tran Van Phuong,Tran Trong Minh 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Modular Multilevel Converters (MMC) have many advantages in comparison with conventional multilevel converters in application to high voltage system. However, the control system of MMC requires a large amount of I/O signal ports which cannot be generated by a single digital signal processor (DSP) with maximum I/O port of 24. This paper fucuses on the experimental results of aMMC that uses a Field Programmable Gate Array (FPGA) in which embedge the Nearest Level Modulation (NLM) method and capacitor voltage balancing algorithm. The MMC consists of 12 Sub-Modules (SM) in each phase to generate a 13-level ac output voltage. Applying the NLM method and capacitor voltage balancing algorithm have significantly reduced the switching frequency and produced an ac output voltage with very low harmonic distortion. The experimental results have verified by a laboratory-scale prototype and compared with the simulation results.
Acetylcholinesterase Inhibitory Effect of Lignans Isolated from Schizandra chinensis
Tran Manh Hung,나민균,민병선,Tran Minh Ngoc,IkSoo Lee,XinFeng Zhang,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. The compounds having both aromatic methylenedioxy and hydroxyl groups on their cyclooctadiene ring, such as gomisin C (6), gomisin G (7), gomisin D (8), schisandrol B (11) and gomisin A (13), entirely inhibited AChE in dose dependent manners, with IC50 values of 6.71 ± 0.53, 6.55 ± 0.31, 7.84 ± 0.62, 12.57 ± 1.07 and 13.28 ± 1.68 µM, respectively. These results indicate that the lignans could potentially be a potent class of AChE inhibitors.
Lipoxygenase Inhibitory Constituents from Rhubarb
Tran Minh Ngoc,Pham Thi Hong Minh,Tran Manh Hung,IkSoo Lee,민병선,Phuong Thien Thuong,배기환 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
Phytochemical study on the ethanol extract of rhubarb led to the isolation of fifteen compounds, including five anthraquinones: chrysophanol (1), physcion (2), emodin (7), chrysophanol- 8-O-β-D-glucopyranoside (9) and emodin-8-O-β-D-glucopyranoside (15), and ten stilbenes: desoxyrhaponticin (3), rhaponticin (4), resveratrol (5), desoxyrhapotigenin (6), rhapontigenin (8), piceatannol-3'-O-β-D-glucopyranoside (10), piceid (11), ε -viniferin (12), ampelopsin B (13) and isorhaponticin (14). Their structures were identified by comparing the physicochemical data with those of published papers. Among the isolated compounds, stilbene derivatives (3-6, 8 and 10-14) showed remarkable inhibitory effect on lipoxygenase with IC50 values ranging from 6.7 to 74.1 μM. The inhibition kinetics analyzed by Lineweaver-Burk plots found that they were competitive inhibitors with the linoleic acid at the active site of lipoxygenase. In addition, stilbenes exhibited significantly free radical scavenging activity against ABTS•+ with trolox equivalent activity capacity (TEAC) values ranging from 1.16 to 4.64. Whereas, anthraquinone derivatives (1-2, 7, 9 and 15) neither inhibited lipoxygenase nor scavenged free radical ABTS•+. These results indicated that stilbene derivatives were considerate to be mainly lipoxygenase inhibitor and free radical scavenger constituents of rhubarb.