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- 저자 : ( Tong Zhou ) (검색결과 112 건)
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Zhou Yi-Tong,Zhang Pei-Jie,Wang Shu-Ping,Li Chang-Hao,Zhang Jia-Qing,Zhang Wei-Xin,Zhao Yuan-Di,Cao Yuan-Cheng,Fan Jin-Xuan 한국독성학회 2024 Toxicological Research Vol.40 No.3
The Internet Data Center (IDC) is one of the most important infrastructures in the field of information technology. The cooling system for heat dissipation of IDC is indispensable due to it generates a large amount of heat during its calculation process, which may potentially harm its normal operation. Electronic fluorinated fluids have been widely used in cooling systems of IDC with stable physical and chemical properties. However, the biological toxicity of electronic fluorinated fluids has not been fully evaluated and there is a lack of unified safety standards, which may pose potential risks to the environment and human health. Here, hexafluoropropylene terpolymer (HFPT) as an example has been systematically studied, fully considering the application scenarios of data centers. Also, the emergency effects of fluorinated coolants in mammalian models from the perspectives of inhalation, skin contact, accidental entry into eyes, accidental ingestion, and chronic toxicity, are evaluated. Multiple in vivo experiments have proven that HFPT not only has stable physical and chemical properties, that can maintain the safe operation of IDC, but also has low physiological toxicity to mammals and can provide health benefits to data center staff and the assurance of surrounding environment. This study proves the good biological safety of electronic fluorinated fluids and provides a reference for environmental assessment and risk management of liquid cooling technology in IDC.
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Stochastic Modeling and Synthesis of Near-Fault Forward-Directivity Ground Motions
Tong Zhou,Ai-QunLi 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.2
The stochastic modeling and synthesis of near-fault forward-directivity ground motions for the prescribed seismic scenario is presented in this study. This stochastic model, which is established in the orientation of the strongest pulse, combines the directivity pulse component represented by the Gabor wavelet pulse model and the high-frequency component characterized by the modulated filtered white noise model. In this regard, the pulse feature, evolutionary intensity and frequency contents are reasonably considered. Then, the empirical predictive equations that relate the parameters of the proposed stochastic model to the variables that describe earthquake source, path, site conditions, and near-fault rupture-to-source geometry are developed based on both regression and correlation analysis. The basic procedure for the synthesis of possible forward-directivity ground motions under the prescribed seismic scenario is provided as well. The efficacy of the stochastic model and the simulation procedure is confirmed by comparing the simulated motions with the recorded ones in terms of time-series and response spectra values, which indicate that the synthetic ground motions are capable of reproducing the salient characteristics, as well as the natural variability, of the recorded ones. Therefore, the proposed stochastic modeling and simulation method is expected to be a desirable alternative and complement for recorded ground motions in the near-fault seismic risk assessment.
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Zhou, Tong,Hu, Yanbo,Yan, Xuecui,Cui, Jing,Wang, Yibing,Luo, Feng,Yuan, Ye,Yu, Zhenxiang,Zhou, Yifa The Korean Society for Microbiology and Biotechnol 2022 Journal of microbiology and biotechnology Vol.32 No.8
Arabinogalactans have diverse biological properties and can be used as pharmaceutical agents. Most arabinogalactans are composed of β-(1→3)-galactan, so it is particularly important to identify β-1,3-galactanases that can selectively degrade them. In this study, a novel exo-β-1,3-galactanase, named PoGal3, was screened from Penicillium oxalicum sp. 68, and hetero-expressed in P. pastoris GS115 as a soluble protein. PoGal3 belongs to glycoside hydrolase family 43 (GH43) and has a 1,356-bp gene length that encodes 451 amino acids residues. To study the enzymatic properties and substrate selectivity of PoGal3, β-1,3-galactan (AG-P-I) from larch wood arabinogalactan (LWAG) was prepared and characterized by HPLC and NMR. Using AG-P-I as substrate, purified PoGal3 exhibited an optimal pH of 5.0 and temperature of 40℃. We also discovered that Zn<sup>2+</sup> had the strongest promoting effect on enzyme activity, increasing it by 28.6%. Substrate specificity suggests that PoGal3 functions as an exo-β-1,3-galactanase, with its greatest catalytic activity observed on AG-P-I. Hydrolytic products of AG-P-I are mainly composed of galactose and β-1,6-galactobiose. In addition, PoGal3 can catalyze hydrolysis of LWAG to produce galacto-oligomers. PoGal3 is the first enzyme identified as an exo-β-1,3-galactanase that can be used in building glycan blocks of crucial glycoconjugates to assess their biological functions.
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Tong Zhou,Yi-Feng Wu,AiQun Li 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.9
Predicting the ultimate behavior of elastomeric bearings subjected to combined compression-shear loading is an indispensable part of quantitatively evaluating the performance of seismic isolated structures during earthquakes. In this paper, the initial critical load derived from three different approximations for bending modulus are analyzed and evaluated by existing experimental data. Then, Finite Element (FE) models of bearings are developed and validated by critical load results. Based on that, a parametric FE study is performed to investigate the failure mode of bearings under this combined loading. It is demonstrated that the bending modulus based on the pressure solution and further simplification provides a more reasonable estimate of initial critical load. The predicting capacity of the overlapping area method for the general trend of critical load is improved with the increasing of external diameter. The dividing line between stability limit and shear failure is dominated by the second shape factor. Furthermore, as the first shape factor increases, the ultimate shear deformation corresponding to shear failure slightly increases.
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Tong Zhou,Haiyang Tang,Ying Han,Dustin Fraidenburg,김영원,이동희,최정윤,고재홍,방효원 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology. First, we identified the genes differentially expressed between wild-type and Vdac1 knockout mouse embryonic fibroblasts in hypoxic conditions. These genes were deemed to be influenced by VDAC1 deficiency. Gene ontology analysis indicates that the VDAC1 influenced genes are significantly associated with PAH pathobiology. Second, a molecular signature derived from the VDAC1 influenced genes was developed. We suggest that, VDAC1 has a protective role in PAH and the gene expression signature of VDAC1 influenced genes can be used to i) predict severity of pulmonary hypertension secondary to pulmonary diseases, ii) differentiate idiopathic pulmonary artery hypertension (IPAH) patients from controls, and iii) differentiate IPAH from connective tissue disease associated PAH.
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Zhou, Tong,Tang, Haiyang,Han, Ying,Fraidenburg, Dustin,Kim, Young-Won,Lee, Donghee,Choi, Jeongyoon,Bang, Hyoweon,Ko, Jae-Hong The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis. Recent studies suggest that VDAC1 may interact with endothelium-dependent nitric oxide synthase (eNOS). Decreased VDAC1 expression may limit the physical interaction between VDAC1 and eNOS and thus impair nitric oxide production, leading to cardiovascular diseases, including pulmonary arterial hypertension (PAH). In this report, we conducted meta-analysis of genome-wide expression data to identify VDAC1 influenced genes implicated in PAH pathobiology. First, we identified the genes differentially expressed between wild-type and Vdac1 knockout mouse embryonic fibroblasts in hypoxic conditions. These genes were deemed to be influenced by VDAC1 deficiency. Gene ontology analysis indicates that the VDAC1 influenced genes are significantly associated with PAH pathobiology. Second, a molecular signature derived from the VDAC1 influenced genes was developed. We suggest that, VDAC1 has a protective role in PAH and the gene expression signature of VDAC1 influenced genes can be used to i) predict severity of pulmonary hypertension secondary to pulmonary diseases, ii) differentiate idiopathic pulmonary artery hypertension (IPAH) patients from controls, and iii) differentiate IPAH from connective tissue disease associated PAH.
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Hao-tong Zhou,Chang-qing Liu,Gui-he Wang,Kai Kang,Yu-hong Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.5
Given the hazards caused by drilling ground collapse (DGC) due to groundwater flow in the processes of geotechnical engineering investigation, a coupled computational fluid dynamics and discrete element method (CFD-DEM) method is adopted to numerically simulate the development of hazards. An improved coupling program is employed to realize the two-way coupling between open-source CFD code OpenFOAM and commercial DEM software PFC3D. The coupling program allows complex meshes generated by ANSYS ICEM to be imported into PFC3D. The feasibility and accuracy of the CFD-DEM method are first verified by simulating a single spherical particle settling in hydrostatic water and the formation of the repose angle of sandpiles. Then, this method is adopted to investigate the patterns of stratum deformation and foundation loss, typical particle flow processes, and characteristics of drilling rig toppling. Finally, measures for prevention of DGC induced by groundwater flow are discussed in detail. Two typical strata, including a water-rich sand stratum and a water-rich sand-clay compound stratum, are considered. The research results show that for the water-rich sand stratum, DGC induces a “bowl”-shaped settlement trough, and the maximum value of ground surface settlement is proportional to the foundation loss rate. For the water-rich sand-clay compound stratum, a “jar”-shaped settlement trough is created. Four typical particle flow processes are involved in DGC. The drilling rig topples toward the center of the settlement trough. The maximum displacement appears at the top of the tower and has an approximate linear correlation with the groundwater flow velocity. The measures and methods of DGC prevention are also summarized in detail. The results of this research provide a reference for hazard prevention and delicacy control of DGC induced by groundwater flow.
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Dongbing Tong,Liping Zhang,Wuneng Zhou,Jun Zhou,Yuhua Xu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.3
In this paper, the problem of the adaptive synchronization control is considered for neural networkswith uncertainty and stochastic noise. Via utilizing stochastic analysis method and linear matrix inequality (LMI)approach, several sufficient conditions to ensure the adaptive synchronization for neural networks are derived. Bythe adaptive feedback methods, some suitable parameters update laws are found. Finally, a simulation result isprovided to substantiate the effectiveness of the proposed approach.
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