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Safety and Efficacy of Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Sang Jun Ko,In Choel Shin,Dae Won Kim,Si Sung Choi,Yun Sik Yang 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.4
Purpose: The purpose of this study was to determine the efficacy and safety of selective intra-arterial thrombolysis in patients with central retinal artery occlusion (CRAO). Methods: Medical records for 44 eyes of 44 patients diagnosed with acute non-arteritic CRAO and thrombolysis between October 2010 and February 2019 were analyzed retrospectively. Based on visual acuity, fundoscopic findings, and fluorescein angiography, the patients were classified into three stages: incomplete, subtotal, and total. The perfusion state using the best-corrected visual acuity (BCVA), arm to retina time, and arteriovenous passage times, after 1 month, 6 months, and at the final visit after the procedure, were compared with baseline readings. Results: Improvement of visual acuity was confirmed in 31 out of 44 patients (70.45%). The mean BCVA of 44 patients changed from 1.65 ± 0.78 logarithmic minimum angle of resolution (logMAR) at the first visit to 1.18 ± 0.91 logMAR at the last visit (p = 0.114). The BCVA according to CRAO stage was 0.08 ± 0.11 logMAR for the incomplete stage at the first visit, 0.06 ± 0.05 logMAR (p = 0.933) 1 month after the procedure, and 0.05 ± 0.07 logMAR (p = 0.933) at the last visit. In the subtotal stage, the results were 1.81 ± 0.54 logMAR at the first visit, 1.63 ± 0.76 logMAR (p = 0.035) 1 month after the procedure, and 1.36 ± 0.85 logMAR (p = 0.014) at the last visit. For the total stage of BCVA, the result at the first visit was 2.36 ± 0.25 logMAR, and it was 2.30 ± 0.30 logMAR (p = 0.510) 1 month after the procedure, and 2.42 ± 0.30 logMAR (p = 0.642) at the last visit. Reperfusion was observed in 40 patients out of the 44 (90.91%). Conclusions: Selective intra-arterial thrombolysis can be helpful in patients with subtotal CRAO in terms of visual improvement and retinal arterial reperfusion.
( Sung Jun Ko ),( Sun Mi Choi ),( Jin Woo Lee ),( Young Sik Park ),( Chang Hoon Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Young Whan Kim ),( Sung Koo Han ),( Sang Min Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.0
Background: Adipose tissue is recently recognized as not only energy reservoir but also endocrine organ producing proinflammatory cytokines. Especially the impact of visceral adipose tissue(VAT) in critical illnesses has been proposed, but researches on the association between VAT and sepsis were scarce and quantitative measurement of VAT had not been used. Methods: In this retrospective cohort study, we enrolled patients with sepsis who examined abdominal computed tomography( A-CT) within 1 month of occurrence of sepsis, among the patients admitted to intensive care unit(ICU). Age, sex, anthropometric values, comorbidities and APACHE II score were reviewed. The areas of VAT and total adipose tissue(TAT) on the section of A-CT image of the umbilicus level were measured by calculating pixels presenting fat density. Results: Among 287 patients admitted to ICU due to sepsis, 178 patients were included for this study. Median age was 65 and 59.0% were men. In-hospital mortality rate was 57.9%. Women had higher TAT and subcutaneous adipose tissue, lower VAT/TAT ratio compared to men. The amount of VAT and VAT/TAT ratio were higher in in-hospital mortality group than in survivor group(90.41cm2 vs. 63.83cm2 and 45.88% vs. 32.79%, p=0.001 and <0.001, respectively). After adjusting age, sex, APACHE II score and comorbidities, multivariate logistic regression analysis revealed that the amount of VAT and VAT/TAT ratio were independent prognostic factors of sepsis with obvious dose-dependent relationship(VAT/TAT ratio quartile 3: OR 8.832, p<0.001 and quartile 4: OR 29.477, p<0.001, compared to quartile 1 respectively). Conclusion: The amount of VAT and VAT/TAT ratio quantitatively measured by A-CT were positively correlated with mortality in sepsis, and this association was dose-dependent. Visceral obesity should be considered as the poor prognostic factor of sepsis.
A relationship between Stroke and Sasang Constitution in Korean
Ko, Ho-Yeon,Jun, Chan-Yong,Park, Jong-Hyeong,Yoon, Yoo-Sik,Lee, Sun-Dong,Han, Chang-Ho,Jung, Woo-Sang,Moon, Sang-Kwan,Cho, Ki-Ho,Ko, Seong-Gyu Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.4
Experts of Sasang Constitution Medicine of Traditional Korean Medicine have classified stroke patients with four types of Sasang constitutions in their clinical practice and some types of Sasang constitutions have been regarded as risk factors of stroke, but this is uncertain because there were no evidences by large scale of prospective studies. The purpose of this was to study the association between strokes and Sasang constitutions. Case-control study has been conducted to the patients admitted to the research hospitals. The patients were confirmed stroke by brain MRI or CT scans and recruited from May 2003 to August 2005. The subjects who met the requirement of inclusion and exclusion criteria were 108 patients as the cases and 107 as healthy controls. Data collection has been performed by the trained specialists majoring neurologists through interviews, physical examinations, and laboratory testes. No statistical significance was obtained between the strokes and Sasang constitutions, yet Taeumin, and Soyangin types showed a trend of increase in the incidence of strokes as compared with Soeumin. To acquire more concrete data on this theme, we need further and large scale of prospective researches.
Maximum Torque Control of IPMSM Drive with Multi-MFC
Sung-Jun Kang,Jae-Sub Ko,Jung-Sik Choi,Jung-Woo Baek,Dong-Hwa Chung 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
This paper proposes maximum torque control of IPMSM drive using multi model reference adaptive fuzzy controller (Multi-MFC) and artificial neural network (ANN). This control method is applicable over the entire speed range which considered the limits of the inverter"s current and voltage rated value. For each control mode, a condition that determines the optimal -axis current for maximum torque operation is derived. This paper considers the design and implementation of novel technique of high performance speed control for IPMSM using Multi-MFC and ANN controller. The hybrid combination of adaptive and fuzzy control will produce a powerful representation flexibility and numerical processing capability. Also, this paper proposes speed and current control of IPMSM using MFC and estimation of speed using ANN controller. The back propagation neural network technique is used to provide a real time adaptive estimation of the motor speed. The proposed control algorithm is applied to IPMSM drive system and the operating characteristics controlled by maximum torque control are examined in detail. Also, this paper proposes the analysis results to verify the effectiveness of the Multi-MFC and ANN controller.
( Sang Yoon Ko ),( Hyung Eun Lee ),( Se Jin Park ),( Se Jin Jeon ),( Bo Seong Kim ),( Qing Tao Gao ),( Dae Sik Jang ),( Jong Hoon Ryu ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.2
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var. spinosa, on memory impairment or the pathological changes induced through amyloid-b1-42 oligomer (AbO) in mice. Memory impairment was induced by intracerebroventricular injection of AbO (50 μM) and spinosin (5, 10, and 20 mg/kg) was administered for 7 days. In the behavioral tasks, the subchronic administration of spinosin (20 mg/kg, p.o.) significantly ameliorated AbO-induced cognitive impairment in the passive avoidance task or the Y-maze task. To identify the effects of spinosin on the pathological changes induced through AbO, immunohistochemistry and Western blot analyses were performed. Spinosin treatment also reduced the number of activated microglia and astrocytes observed after AbO injection. In addition, spinosin rescued the AbO-induced decrease in choline acetyltransferase expression levels. These results suggest that spinosin ameliorated memory impairment induced through AbO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of spinosin. Therefore, spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients.
( Sung Sik Ko ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1
Purpose: The purpose of this study was to investigated the effects of lower limb functional exercise in an unstable ground on lower limb strength and the balance ability of encephalopathy teenagers. Method: The lower limb functional exercise was applied once every 50 minutes twice a week during 12 weeks in the experimental group, meanwhile control group did not receive any treatment except daily life. In order to evaluate the lower limb strength and the balance ability of the study subjects from exercise before and after exercise, the lower limb strength test using thera bands, static balance ability test(standing by one leg, FRT) and dynamic balance ability test(TUG, walking 10m, walking 3m) were used. Result: First, the measured results of the lower limb strength using thera bands was that the bending force and new force of a hip joint increased significantly(p=.000), also the bending force and new force of the knee joint increased significantly(p=.000). Second, in the static balance ability, standing by one leg with opened eyes and functional arm stretching(FRT) increased significantly( p=.000, p.002) respectively. Third, in the dynamic balance ability, in standing up and walking(TUG) and in walking straight 3m(Tandem Gait Test) decreased significantly(p=.000, p=.000), in walking straight 10m(Straight Walking Test) appeared no change. Conclusion: These suggest that the lower limb functional exercise in an unstable ground during 12 weeks is believed to improve the lower limb strength and also static and dynamic balance ability of encephalopathy teenagers.