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No Association between PIK3CA Polymorphism and Lung Cancer Risk in the Korean Population
Sung, Jae-Sook,Park, Kyong-Hwa,Kim, Seung-Tae,Seo, Jae-Hong,Shin, Sang-Won,Kim, Jun-Suk,Kim, Yeul-Hong Korea Genome Organization 2010 Genomics & informatics Vol.8 No.4
The PIK3CA gene, oncogenic gene located on human chromosome 3q26.3, is an important regulator of cell proliferation, death, motility and invasion. To evaluate the role of PIK3CA gene in the risk of Korean lung cancer, genotypes of the PIK3CA polymorphisms (rs11709323, rs2699895, rs3729679, rs17849074 and rs1356413) were determined in 423 lung cancer patients and 443 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the PIK3CA gene were not significantly associated with the risk of lung cancer in the Korean population, suggesting that these PIK3CA polymorphisms do not contribute to the genetic susceptibility to lung cancer in the Korean population.
Development of an Efficient Microbial Process Using Non-edible Biomass by Engineering Vibrio sp. dhg
Sung Hwa WOO,Hyun Gyu LIM,Dong Hun KWAK,Yong Hee HAN,Sungwoo PARK,Sang Woo SEO,Gyoo Yeol JUNG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Most microorganisms including industrial host strains were not able to efficiently utilize non-preferred carbon sources contained in non-edible biomass, such as alginate, xylose, and arabinose. Therefore, choosing an appropriate host strain would determine the efficiency of the entire bioprocess. In this regard, due to a broad spectrum of sugar utilization and genetic tractability of Vibrio sp. dhg, it was studied as a platform strain for the processes using non-edible biomass as a feedstock; brown-macroalgae and lignocellulose in this study. In order to efficiently utilize brown macroalgae as a feedstock, Vibrio sp. dhg capable of catabolizing alginate was isolated. After genome sequencing, genetic engineering tools were established. The production strains for ethanol, 2,3-butanediol, and lycopene demonstrated unprecedent productivities from brown macroalgae-derived carbon sources (alginate and mannitol). In order to efficiently utilize lignocellulose as a feedstock, Vibrio sp. dhg was rationally and evolutionary engineered for improved xylose catabolism and removal of carbon catabolite repression (CCR). Lactate-producing strain was constructed based on previously engineered strain and showed high productivity from lignocellulose-derived sugars (glucose, arabinose, and xylose).
Outcomes of pelvic exenteration for recurrent or primary locally advanced colorectal cancer
Hwa Yeon Yang,Sung Chan Park,Jong Hee Hyun,Ho Kyung Seo,Jae Hwan Oh 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.89 No.3
Purpose: The objective of this study was to assess the clinical outcomes of pelvic exenteration for patients with primary locally advanced colorectal cancer (LACRC) or locally recurrent colorectal cancer (LRCRC), and to identify clinically relevant prognostic factors. Methods: Between January 2001 and December 2010, 40 consecutive patients with primary LACRC or LRCRC underwent pelvic exenteration at the National Cancer Center, Republic of Korea. We retrospectively reviewed their medical records. Results: The median age was 59 years and the median follow-up time was 26 months (range, 1?117 months). The overall complication and in-hospital mortality rates were 70% (28/40) and 7.5% (3/40), respectively. The complication rates were similar between patients with primary LACRC (69.6%) and those with LRCRC (70.6%). The overall recurrence rate was 50% (17/34), and was lower in patients with primary LACRC than in patients with LRCRC (33.3% vs. 76.9%, P = 0.032). The 5-year overall survival was significantly different between primary LACRC and patients with LRCRC (58.7% vs. 11.8%, P = 0.022). Multivariate analysis revealed that radicality (R0 vs. R1/R2) was an independent prognostic factor for overall survival (P = 0.020). Conclusion: The complication and operative mortality rates of pelvic exenteration remained high, but pelvic exenteration might provide an opportunity for long-term survival and good local control. Complete (R0) resection was the only independent prognostic factor for overall survival.
Seo, Sung-Man,Kim, Ghyung-Hwa,Lee, Seok-Hee,Bae, Jun-Seok,Lim, Woo-Taik Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
Large single crystals of zeolite, |$Na_{75}$|[$Si_{117}Al_{75}O_{384}$]-FAU (Na-Y, Si/Al = 1.56), were synthesized from gels with composition of 3.58Si$O_2$ : 2.08NaAl$O_2$ : 7.59NaOH : 455$H_2$O : 5.06TEA : 2.23TCl. One of these, a colorless single-crystal was ion exchanged by allowing aqueous 0.02 M CsOH to flow past the crystal at 293 K for 3 days, followed by dehydration at 673 K and 1 ${\times}\;10^{-6}$ Torr for 2 days. The crystal structure of fully dehydrated partially $Cs^+$-exchanged zeolite Y, |$Cs_{45}Na_{30}$|[$Si_{117}Al_{75}O_{384}$]-FAU per unit cell (a = 24.9080(10) $\AA$) was determined by single-crystal X-ray diffraction technique in the cubic space group Fd $\overline{3}$ m at 294(1) K. The structure was refined using all intensities to the final error indices (using only the 877 reflections with $F_o\;>\;4{\sigma}(F_o))\;R_1$ = 0.0966 (Based on F) and $R_2\;=\;0.2641\;(Based\;on\;F^2$). About forty-five $Cs^+$ ions per unit cell are found at six different crystallographic sites. The 2 $Cs^+$ ions occupied at site I, at the centers of double 6-ring (D6Rs, Cs-O = 2.774(10) $\AA$ and O-Cs-O = 88.9(3) and 91.1(3)$^o$). Two $Cs^+$ ions are found at site I’ in the sodalite cavity; the $Cs^+$ ions were recessed 2.05 $\AA$ into the sodalite cavity from their 3-oxygen plane (Cs-O = 3.05(3) $\AA$ and O-Cs-O = 77.4(13)$^o$). Site-II’ positions (opposite single 6-rings in the sodalite cage) are occupied by 7 $Cs^+$ ions, each of which extends 2.04 $\AA$ into the sodalite cage from its 3-oxygen plane (Cs-O = 3.067(11) $\AA$ and O-Cs-O = 80.1(3)$^o$). The 26 $Cs^+$ ions are nearly three-quarters filled at site II in the supercage, being recessed 2.34 $\AA$ into the supercage (Cs-O = 3.273(8) $\AA$ and O-Cs-O = 74.3(3)$^o$). The 4 $Cs^+$ ions are found at site III deep in the supercage (Cs-O = 3.321(19) and 3.08(3) $\AA$), and 4 $Cs^+$ ions at another site III’ (Cs-O = 2.87(4) and 3.38(4) $\AA$). About 30 $Na^+$ ions per unit cell are found at one crystallographic site; The $Na^+$ ions are located at site I’ in the sodalite cavity opposite double 6-rings (Na-O = 2.578(11) $\AA$ and O-Na-O = 97.8(4)$^o$).
Design and Analysis of Sub-10 nm Junctionless Fin-Shaped Field-Effect Transistors
Sung Yoon Kim,Jae Hwa Seo,Young Jun Yoon,Gwan Min Yoo,Young Jae Kim,Hye Rim Eun,Hye Su Kang,Jungjoon Kim,Seongjae Cho,Jung-Hee Lee,In Man Kang 대한전자공학회 2014 Journal of semiconductor technology and science Vol.14 No.5
We design and analyze the n-channel junctionless fin-shaped field-effect transistor (JL FinFET) with 10-nm gate length and compare its performances with those of the conventional bulktype fin-shaped FET (conventional bulk FinFET). A three-dimensional (3-D) device simulations were performed to optimize the device design parameters including the width (Wfin) and height (Hfin) of the fin as well as the channel doping concentration (Nch). Based on the design optimization, the two devices were compared in terms of direct-current (DC) and radio-frequency (RF) characteristics. The results reveal that the JL FinFET has better subthreshold swing, and more effectively suppresses short-channel effects (SCEs) than the conventional bulk FinFET.
Hwa-Jeong Yeom,Jaesoon Kang,Sung-Woong Kim,Seon-Mi Seo,Yoon-Mi Jeon,Il-KwonPark 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Fumigant and contact toxicities of 11 Myrtaceae plant essential oils and their constituents against adult male and female Blattella germanica were evaluated. Of 11 Myrtaceae plant essential oils, Eucalyptus polybractea, E. smithii, E. radiata, E. dives, E. globulus, and Melaleuca uncinata, showed 100% fumigant toxicity against adult male German cockroaches at a concentration of 7.5 mg/liter air concentration. In contact toxicity tests, E. polybractea, E. smithii, E. radiata, E. dives, E. globulus, M. dissitiflora, and M. uncinata produced strong insecticidal activity against adult male and female German cockroaches. Of the essential oil constituents, terpinolene, α-terpinene, and terpinen-4-ol demonstrated strong fumigant toxicity against adult male and female B. germanica. Eugenol, isoeugenol, methyl eugenol, and terpinen-4-ol showed strong contact toxicity against adult male B. germanica. The toxicity of the constituent blends identified from M. dissitiflora essential oils indicated that terpinen-4-ol were major contributor to the fumigant activity or contact toxicity of the artificial blend. Only isoeugenol exhibited inhibition activity against male acetylcholinesterase. IC50values of isoeugenol were 0.22 mg/mL against male acetylcholinesterase.