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      • KCI등재

        Resistive switching characteristic of Ce0.9Y0.1O2/ TiO2 bi‑layer structure by photochemical metal‑organic deposition

        Sung‑Eun Kim,Jin-Gyu Lee,In-Young Choi,Ha-Eun Kim,Hong-Sub Lee 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.1

        Sneak current is one of the main bottlenecks for dense crossbar array resistive random access memory. This study reports highly non-linear resistive switching characteristic from Ce0.9Y0.1O2/ TiO2 bi-layer (1S/1R device) structure, fabricated by photochemical metal-organic deposition, as a solution for sneak current issue. Ce0.9Y0.1O2 material, possessing oxygen vacancies, was used as a potential barrier as well as oxygen reservoir which rectified the current of low resistance state without an electrical breakdown in 1S/1R device. TiO2 was adopted for resistive switching property, and TiO2 layer having mixed phase (anatase and brookite) showed typical diode switching behavior. The photochemical reaction of photochemical metal-organic deposition process and phase formation were monitored and established using by Fourier-transform infrared spectroscopy and X-ray diffraction, respectively. The 1S/1R device showed highly non-linear resistive switching characteristic, large on/ off ratio of above three orders of magnitude with low operating current.

      • KCI등재
      • KCI등재

        이상정 장군의 육필 유고 『표박기(飄泊記)』 분석

        이상규(Lee, Sang-gyu) 동아인문학회 2017 동아인문학 Vol.39 No.-

        글은 이상정의 생애와 업적을 살펴보고, 그가 남긴 유고집의 의미와 사료적 가치를 조망하는 것을 목적으로 한다. 자료의 한계로 인해 그 전모 전체를 밝히기에는 어려움이 있지만 본 논의의 의미는 다음과 같이 정리할 수 있다. 이상정의 조국 독립군으로서의 활동을 살펴볼 수 있었고, 우리나라 최초의 여유 비행사였던 권기옥의 독립투쟁사를 밝힐 수 있었다. 뿐만 아니라 동북아시아 특히 한・중의 과거 관계를 알 수 있는 역사 사료로서의 가치를 발견할 수 있었다. 우리나라 고대사의 흐름을 제대로 이해하기 위해서는 동북 지역사에 대한 새로운 인식이 필요하다. 책의 내용을 보면 중국 동북삼성뿐만 아니라 곳곳의 유적지를 답사하며 고적과 유물의 역사와 유래에 대한 글을 남기고 있기 때문이다. 또한 『개벽(開闢)』 잡지 등에 그가 남긴 여러 편의 시조를 살펴보면 문예가로서의 면모도 발견할 수 있는데, 유고집에 남긴 이러한 글들은 문예집으로서도 가치를 지닌다고 할 수 있다. The purpose of this paper is to examine the life and achievements of General Lee Sang-jeong and identify the meaning and historical value of posthumous collection he left. Although there are difficulties in clarifying the full account due to the limitations of data, the significance of this paper can be summarized as follows. It could examine the activities of General Lee Sang-jeong as an army for national independence, and clarify the struggles for independence by Kwon Ki-ok, the first female pilot in Korea. Moreover, this paper could discover values as a historical record to know the past relationship in Northeast Asia, especially Korea and China. It is necessary to have a new recognition of the regional history of Northeast Asia to properly understand the flow of the ancient Korean history. By exploring historical sites in the 3 provinces of Northeast China as well as various places, the book leaves many writings about the history and origins of historical remains and sites, whose quality surpasses that of the writings by renowned, excellent historical scholars. Also, several sijo (Korean traditional three-verse Korean poems) in magazines such as ‘Gaebyeok’ show General Lee Sang-jeong’s talent as a literary artist, indicating the significant value of the pieces he left in his posthumous collection as a literary collection.

      • Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

        ( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

        Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

      • KCI등재

        Explanatory Power and Prognostic Implications of Factors Associated with Troponin Elevation in Acute Ischemic Stroke

        Sung-Ho Ahn,Ji-Sung Lee,Mi-Sook Yun,Jung-Hee Han,Soo-Young Kim,Young-Hak Kim,Sang-Hyun Lee,Min-Gyu Park,Kyung-Pil Park,Dong-Wha Kang,Jong S. Kim,Sun U. Kwon 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1

        Background and Purpose We investigated the impact of comorbidity burden on troponin elevation, with separate consideration of neurological conditions, in patients with acute ischemic stroke (AIS). Methods This prospective, observational cohort study consecutively enrolled patients with AIS for 2 years. Serum cardiac troponin I was repeatedly measured, and disease-related biomarkers were collected for diagnosis of preassigned comorbidities, including atrial fibrillation (AF), ischemic heart disease (IHD), myocardial hypertrophy (MH), heart failure (HF), renal insufficiency (RI), and active cancer. The severity of neurological deficits and insular cortical ischemic lesions were assessed as neurological conditions. Adjusted associations between these factors and troponin elevation were determined using a multivariate ordinal logistic regression model and area under the receiver operating characteristic curve (AUC). Cox proportional hazards model was used to determine the prognostic significance of comorbidity beyond neurological conditions. Results Among 1,092 patients (66.5±12.4 years, 63.3% male), 145 (13.3%) and 335 (30.7%) had elevated (≥0.040 ng/mL) and minimally-elevated (0.040–0.010 ng/mL) troponin, respectively. In the adjusted analysis, AF, MH, HF, RI, active cancer, and neurological deficits were associated with troponin elevation. The multivariate model with six comorbidities and two neurological conditions exhibited an AUC of 0.729 (95% confidence interval [CI], 0.698–0.759). In Cox regression, AF, IHD, and HF were associated with adverse cardio-cerebrovascular events, whereas HF and active cancer were associated with mortality. Conclusion Troponin elevation in patients with AIS can be explained by the burden of comorbidities in combination with neurological status, which explains the prognostic significance of troponin assay.

      • KCI등재후보
      • Screening for Highly Susceptible Soybean Genotypes to Agrobacterium tumefaciens

        LEE, SUNG HO,LIM, CHAE HO,CHUNG, GYU HWA,WON, JONG LAC,PARK, JOONG SUK,KIM, ZHOO HYEON 경상대학교 유전공학연구소 1989 遺傳工學硏究所報 Vol.8 No.-

        This experiment was conducted to screen the highly susceptible soybean genotypes to Agrobacterium tumefaciens. Plants from 703 lines and 20 cultivars were inoculated with Agrobacteriun tumefaciens Nopaline type strain c58 and Octopine type strain 15955. About 97% of tested lines were infected by Agrobacteriun tumefaciens strain c58, which only two lines, B678 and B679 responded to Agrobacteriun tumefaciens strain 15955. The number of highly susceptible lines with higher than 50% tumorigenesis and greater than 1 mm tumor size was 53, while 20 lines were not infected at all. Among the highly susceptible group, the lines 53, 79, 463, 551, 674, 675, 677, 678, and 679 could be used for transformation studies due to their high tuomrigenesis and large tumor size. The lines selected in the field test according to the degree of susceptibility showed the same responses to Agrobacterium infection in vitro.

      • Chemical ecology meets molecular biology: the plant defense system against Trichobaris weevil attacks

        Sang-Gyu Kim,Gisuk Lee,Youngsung Joo,Ian T. Baldwin 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04

        Herbivorous insects use plant metabolites to inform their host plant selection for oviposition. These host-selection behaviors are often consistent with the preference-performance hypothesis; females oviposit on hosts that maximize the performance of their offspring. However, the metabolites used for these oviposition choices and those responsible for differences in offspring performance remain unknown for ecologically-relevant interactions. In this time, I will talk about the host-selection behaviors of two sympatric weevils, the Datura (Trichobaris compacta) and tobacco (T. mucorea) weevils in field- and glasshouse-experiments with transgenic host plants specifically altered indifferent components of their secondary metabolism. In addition, I will show that adult females are able to choose the best host plant for their offspring and use chemicals different from those that influence larval performance to inform their oviposition decisions.

      • Tenofovir-Based Combination Therapy or Monotherapy for Multi-Drug Resistant Chronic Hepatitis B; Five Year Follow-Up Data of Multicenter Prospective Cohort Study (Final Results)

        ( Sang Jun Suh ),( Hyung Joon Yim ),( Young Kul Jung ),( Seong Gyu Hwang ),( Hana Park ),( Yeon Seok Seo ),( Soon Ho Um ),( Sae Hwan Lee ),( Young Seok Kim ),( Jae Young Jang ),( In Hee Kim ),( Hyoung 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Background/Aims: Recommendation of management of multidrug resistant (MDR) chronic hepatitis B (CHB) is still not uniform. Although current guidelines recommend tenofovir plus entecavir (ETV) or tenofovir monotherapy for MDR CHB, real-life data comparing combinations based TDF versus (vs.) TDF monotherapy are sparse. Herein, we report a multicenter cohort study for the evaluation of TDF-based therapy for MDR CHB. Methods: The inclusion criteria were CHB patients with resistance to more than 2 nucleos(t)ide analogues and hepatitis B virus (HBV) DNA level over 200 IU/mL. Patients with decompensated cirrhosis or hepatocellular carcinoma were excluded. Primary end point was cumulative virologic response defined by undetectable HBV DNA (<20 IU/mL) until month 60. Results: A total of 256 patients were enrolled and 236 patients were included for analysis. Mean age of patients were 49 years and 77.5 % were male. Mean baseline HBV DNA level was 4.2±1.6 log IU/mL. Genotypic resistance to L-nucleoside analogues (L-NA)+adefovir (ADV) (79 patients), L-NA+ETV (106 patients), L-NA+ADV+ETV (51 patients) were confirmed at enrollment. Initial treatments for MDR CHB were TDF+ETV 1 mg (171, 72.5 %), TDF+ETV 0.5 mg (7, 3.0 %), TDF+L-NA (6, 3.0 %), and TDF monotherapy (52, 22.0%). Virologic response rates of the whole cohort at year 1, year 2, year 3, year 4, and year 5 were 77.2%, 86.9 %, 89.9 %, 90.1 %, and 92.5 %, respectively. At year 5, virologic response rate was not significantly different between the TDF monotherapy group and TDF-based combination group (87.5 % vs. 93.0 %, respectively, P=0.493 by Fisher’s exact test). The cumulative virologic response rate of TDF monotherapy was not significantly different at year 3 (92.3 % vs. 94.0%, respectively, P=0.893) and at year 5 (96.2 % vs. 97.8 %, respectively, P=0.910), and was not inferior to combination therapies considering that 95% confidence interval (-9.2% ~ 5.8% at year 3; -6.5% ~ 3.2% at year 5) did not include the 10% of non-inferiority margin. Conclusions: TDF based therapy was effective for the treatment of MDR CHB for during 5 years of follow-up. The efficacy of TDF monotherapy was not inferior to the TDF based combination therapy.

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