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      • KCI등재

        군 방호시설에 자철석 콘크리트 적용 시 감마선 차폐효과 분석

        이상규,이호찬,이건우,한다희,박영준,Lee, Sang-Kyu,Lee, Ho-Chan,Lee, Gun-Woo,Han, Da-Hee,Park, Young-Jun 한국건축시공학회 2020 한국건축시공학회지 Vol.20 No.2

        핵 및 방사능전 상황에서 방사선에 의한 인명피해를 줄이기 위한 방안으로서 유개호에 자철석이 포함된 중량 콘크리트의 적용 가능성을 확인해보았다. 이에 본 연구에서는 자철광 콘크리트의 방사선 차폐효과를 분석하기 위하여 감마선원을 사용하여 차폐실험을 진행하였고 실험조건과 동일한 몬테칼로 모델링도 하였다. 그 결과 자철광의 함량이 증가할수록 감마선에 대한 차폐효과가 향상됨을 확인할 수 있었다. 향후 자철광 콘크리트가 군사적 목적의 시설물에 적용될 경우 방사선 차폐 측면에서 효과를 얻을 수 있을 것이라 기대한다. The purpose of this research is to analyze the gamma ray shielding effect of heavy concrete containing magnetic aggregate and to confirm the applicability to the military protective facilities. In general, a military concrete structure protects combatants from bullets, and also it provides some radiation shielding. In this research, experiments were conducted using a Cs-137 source to check the gamma ray shielding effect. In addition, the Monte Carlo N-Particle(MCNP) modeling was applied to evaluate the gamma ray shielding effect of a military structure. As a result, as the concrete thickness increased, the shielding performance improved according th the linear attenuation law. With that, as the ratio of magnetic aggregate was increased, gamma ray shielding performance was also improved. Therefore, this research verified that the application of magnetic aggregate concrete to military facilities for radiation shielding purposes would be useful.

      • SCOPUSKCI등재

        전라북도(全羅北道) 공무원(公務員)의 체격(體格)에 관(關)한 연구(硏究)

        이상규,Lee, Sang-Kyu 대한예방의학회 1976 Journal of Preventive Medicine and Public Health Vol.9 No.1

        A study was conducted on 2,210 officials in Jeonbug Province to check out their physical growth, development and nutritional state during the period June 1st 1975 to August 31, 1915. As the results of this study, the following conclusions were reached: 1. Physical measurement a. Body height: The mean body height of male was $166.8{\pm}4.6cm$ and that of female was $156.3{\pm}4.9cm$. The highest value of mean body height was $167.1{\pm}3.9cm$, showing by male of administrative job. The lowest valthe of that was $165.7{\pm}5.2cm$, showing by the male functional job, while the difference of body height was not significant in female. b. Body weight: The mean body weight of male was $61.5{\pm}4.6kg$ and that of female was $51.2{\pm}3.9kg$. The administrative job heavier than functional job of male by type of job, while that of female of functional job heavier than administrative job. c. Chest-girth: The mean chest-girth of male was $90.8{\pm}3.2cm$ and that of female was $83.6{\pm}3.6cm$. 2. Physical growth and developmental state a. The relative body weight was normal in male except the young man under 25 years, while that of female was under the level of standard. b. The relative chest-girth was showed standard values by all age group of officals. c. The Rohrer and Kaup indices were showed standard values except under 19 years officials and 30 to 34 years female officials. 3. Vervaeck index for nutritional status was appeared normal in male but under the values of standard in female.

      • KCI등재

        Hepatotoxic Effect of 1-Bromopropane and its Conjugation with Glutathione in Male ICR Mice

        이상규,Sang Wook Jo,Tae Won Jeon,In Hye Jun,Chun Hua Jin,Ghee Hwan Kim,Dong Ju Lee,Tae-Oh Kim,이응석,정태천 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.10

        The hepatotoxic effects of 1-bromopropane (1-BP) and its conjugation with glutathione were investigated in male ICR mice. A single dose (1000 mg/kg, po) of 1-BP in corn oil to mice significantly increased serum activities of alanine aminotransferase and aspartate aminotransferase. Glutathione (GSH) content was dose-dependently reduced in liver homogenates 12 h after 1-BP treatment. In addition, 1-BP treatment dose-dependently increased levels of S-propyl GSH conjugate at 12 h after treatment, as measured by liquid chromatography-electrospray ionization tandem mass spectrometry. The GSH conjugate was maximally increased in liver at 6 h after 1-BP treatment (1000 mg/kg), with a parallel depletion of hepatic GSH content. Finally, 1-BP induced the production of malondialdehyde in liver. The present results suggest that 1-BP might cause hepatotoxicity, including lipid peroxidation via the depletion of GSH, due to the formation of GSH conjugates in male ICR mice.

      • KCI등재

        Identification of Glutathione Conjugates of 2, 3-Dibromopropene in Male ICR Mice

        이상규,백서연,전태원,전인혜,김기환,진전화,Dong Ju Lee,김준규,염영나,정태천 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.2

        Hepatotoxic potential of 2, 3-dibromopropene (2, 3-DBPE) and its conjugation with glutathione (GSH) were investigated in male ICR mice. Treatment of mice with 20, 50, and 100 mg/kg of 2, 3-DBPE for 24 h caused elevation of serum alanine aminotransferase and aspartate aminotransferase activities. The hepatic content of GSH was not changed by 2, 3-DBPE. Meanwhile, the GSH content was slightly reduced when mice were treated with 2, 3-DBPE for 6 h and significantly increased 12 h after the treatment. Subsequently, a possible formation of GSH conjugate of 2, 3-DBPE was investigated in vivo. After the animals were treated orally with 20, 50, and 100 mg/kg of 2, 3-DBPE, the animals were subjected to necropsy 6, 12, and 24 h later. A conjugate of S-2-bromopropenyl GSH was identified in liver and serum treated with 100 mg/kg of 2, 3-DBPE by using liquid chromatography-electrospray ionization tandem mass spectrometry. The protonated molecular ions [M+H]+ of S-2-bromopropenyl GSH were observed at m/z 425.9 and 428.1 in the positive ESI spectrum with a retention time of 6.35 and 6.39 min, respectively. In a time-course study in livers following an oral treatment of mice with 100 mg/kg of 2, 3-DBPE for 6, 12, and 24 h, the 2, 3-DBPE GSH conjugate was detected maximally 6 h after the treatment. The present results suggested that 2, 3-DBPE-induced hepatotoxicity might be related with the production of its GSH conjugate.

      • KCI등재

        온도와 $CO_{2}C$ 농도에 따른 배추의 광합성특성 및 세포조직의 변화

        이상규,문지혜,장윤아,이우문,조일환,김승유,고관달,Lee, Sang-Gyu,Moon, Ji-Hye,Jang, Yoon-Ah,Lee, Woo-Moon,Cho, Ill-Hwan,Kim, Seung-Yu,Ko, Kwan-Dal 한국생물환경조절학회 2009 생물환경조절학회지 Vol.18 No.2

        본 연구는 배추 재배시 기후변화에 대비하여 고온과 고농도의 이산화탄소 조건에서 생육반응과 세포조직의 변화를 알아보고자 수행하였다. 처리는 '대기중 온도+대기중 $CO_{2}$ 농도(Control)', '대기중 온도+대기보다 $CO_{2}$ 2배 상승(Elevated $CO_{2}$)' '(대기온도보다 4$^{\circ}C$ 상승+대기중 $CO_{2}$ 농도(Elevated temp.)', '대기온도보다 4$^{\circ}C$ 상승+대기보다 $CO_{2}$ 2배 상승(Elevated temp.+$CO_{2}$)'의 4가지 조건으로 처리하였다. 그 결과, 대기조건보다 온도만 높아지게 되면 배추의 생체중이 현저하게 저하되어 수량이 떨어지는 것으로 나타났고, 온도가 높아지고 $CO_{2}$ 농도가 동시에 올라가게 되면 생육이 어느정도 회복되는 것으로 나타났다. 또한 칼륨과 인산함량은 처리별로 차이가 없었지만 칼슘과 총질소함량은 온도만 높인 처리에서 높았고, 마그네슘 함량은 온도와 $CO_{2}$ 농도를 동시에 높인 처리에서 높게 나타났다. 배추잎의 세포 관찰결과 $CO_{2}$ 농도를 2배 정도 높인 처리에서 잎내의 전분함량이 증가하는 것으로 나타났고, 온도만 높인 처리에서 전분 함량이 가장 낮았다. Numerous studies have presented evidence that global atmospheric carbon dioxide ($CO_{2}$ ) concentration and temperature is increasing every year. Both of the $CO_{2}$ and temperature are important components for photosynthesis activity of plants and thusgrowth and yield. However, little information is available in terms of the reaction of vegetable plants to increased $CO_{2}$ concentration and temperature, and also the reaction to a complex condition of both increased $CO_{2}$ concentration and temperature. The aim of this research was therefore to investigate changes in growth, photosynthetic activity and ultra-cellular structure of leaf tissue of Chinese cabbage. Plants were grown under either of elevated $CO_{2}$ concentration (elevated $CO_{2}$, 2-fold higher than atmospheric $CO_{2}$ ) or elevated temperature (elevated temp, 4$^{\circ}C$ higher than atmospheric temperature), under both of elevated $CO_{2}$ concentration and elevated temperature (elevated temp+$CO_{2}$), and under atmospheric $CO_{2}$ concentration and temperature (control). The treatment of 'elevated temp' negatively affected leaf area, fresh weight, chlorophyll and starch content. However, when the treatment of 'elevated temp' was applied coincidently with the treatment of 'elevated $CO_{2}$', growth and photosynthetic performance of plants were as good as those in the treatment of 'elevated $CO_{2}$', Microscopic study resulted that the highest starch content and density of cells were observed in the leaf tissue grown at the treatment of 'elevated $CO_{2}$', whereas the lowest ones were observed in the leaf tissue grown at the treatment of 'elevated temp'. These results suggest that when Chinese cabbage grows under a high-temperature condition, supplement of $CO_{2}$ would improve the growth and yield. In our knowledge, it is the first time to determine the effect of a complex relationship between the increased $CO_{2}$ concentration and temperature on the growth of Chinese cabbage.

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