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      • 痢疾 A 群菌의 R Plasmid 의 非適合性

        趙晟龍,薛盛用,全燾基 慶北大學校 醫科大學 1981 慶北醫大誌 Vol.22 No.1

        1978年과 1979年에 大邱地方에서 分離한 Shigella는 大部分이 chloramphenicol(Cm), tetracycline(Tc), streptomycin(Sm) 및 sulfisomidine(Sa) 또는 ampicillin, trimethoprin 또는 nalidixic acid(Na) 등에 多藥劑耐性이었으며 이들 耐性菌의 80% 以上이 Na를 除外한 全耐性을 接合에 의하여 E. coli에 傳達시킬 수 있어 이들 耐性은 R plasmid에 由來하는 것임을 알 수 있었다. 任意로 選擇한 各 耐性樣相을 가진 菌의 R plasmid에 對하여 表面排除를 實驗한바 A 群由來의 Cm, Tc, Sm 및 Sa 耐性 plasmid를 除外한 全供試 plasmid는 相互間에 導入排除가 强하여 이들은 같은 非適合性群에 屬하는 것으로 思料되며 各 非適合性群의 標準 plasmid와의 反應에서는 FⅣ 非適合性群 plasmid와의 表面排除가 强하여 이 群 또는 이와 關係가 깊은 群의 plasmid로 推測되었다. Cm, Tc, Sm 및 Sa 耐性 plasmid를 갖은 A群(S. dysenteriae)菌이 4株 있었는데 그 중 1株의 R plasmid만이 O非適合性群임이 導入實驗에 의하여 判明되었고 殘餘 3株의 plasmid는 O群과의 適合性이며 FⅣ 또는 이와 關係가 깊은 非適合性群임을 알 수 있었다. The majority of Shigella strains isolated in 1978 and 1979 in Taegu area were found resistant to four or more drugs of chloramphenicol (Cm), tetracycline (Tc), streptomycin (Sm), sulfisomidine (Sa), ampicillin, trimethoprim, and nalidixic acid (Na). Approximately 80% of multiply drug-resistant strains transferred by conjugation the complete resistance to drugs except Na to E. coli K12 substrains, and the resistance was determined as plasmid-mediated. Plasmids encoding various patterns of drug resistance were transferred to E. coli and the mutual surface exclusion was studied on randomly selected plasmids in Shigella of various patterns of resistance. All plasmids except one from S. dysenteriae were found to be mutually incompatible. The surface exclusion test of these plasmids with standard R plasmids of known incompatibility group showed that all these plasmids were strongly excluded when introduced in Inc FⅣ, while well accepted by other incompatibility group plasmids. One plasmid from S. dysenteriae conferring resistance to Cm, Tc, Sm, and Sa was confirmed belong to Inc group 0 by surface exclusion and colony tests. There were four strains resistant to Cm, Tc, Sm, and Sa in S. dysenteriae, and the other three plasmids were suspectcd belong to Inc FⅣ or related group.

      • 스마트폰 부재와 분실을 대비한 어플리케이션

        조시현;문상수;김기환;도민균;서재현;김태공 인제대학교 2012 仁濟論叢 Vol.27 No.1

        Recently, as the Smart Phone is rapidly disseminated worldwide, it is emerging as an important digital communication media changing the communication types of users. We use the Smart Phone in all aspect of daily life besides communication. The Smart Phone is indispensible tool that has a great ripple effect on our daily life. Therefore, if the Smart Phone users lose or do not bring their phones, they were troubled. In this paper, we make users available to use the Smart Phone, even if they lose or do not bring their phones. To do this end, we develop features that search the phone in case of not knowing where it is, that contact another phone in case of not bringing their phone, that lock the phone in case of losing it. We expect these features promote a expansion and a vitality of the Smart Phone market.

      • 비·부비동 종양의 신생혈관 형성에서 COX-2 및 VEGF의 역할

        도남용,박성용,조성일,윤혁수,박선홍,박영균,권대승,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

        Background and Objectives : COX-2, the inducible form of cyclooxygenase(COX), is upregulated in transformed cells and in malignant cells, which have important roles in promotion of colorectal carcinogenesis, invasiveness and angiogenesis. Vascular endothelial growth factor(VEGF) may act as endothelial cell mitogen in various cancer tissues. It will increase tumor growth and angiogenesis. Aims of this study were to asses COX-2/VEGF expression and it's clinical correlation in sinonasal tumors and to investigate the effects on angiogenesis also. Materials and Method : The study samples were obtained from surgical removal of 27 cases of inverted papilloma(IPs), 5 cases of IP with malignant transformation(IP-MT), 16 cases of Squamous cell carcinoma(SCC) in sinonasal cavity COX-2 and VEGF expressions were assessed by immunohistochemical staining. Synchronism of COX-2/VEGF expression in one tumor cell was demonstrated with double immunofluorescence technique. Results : The expression rates of COX-2 were 37% in IP, 80% in IP-MT and 100% in SCC. The positive rates of VEGF were 29 6% in IP, 100% in IP-MT and SCC. COX-2 and VEGF expressions were increased as tumor progressed, and there is a positive correlation between COX-2 &EGF expressions. All clinical features which were compared are not associated with COX-2 &EGF expressions except malignant change in IP(p=0 028). Synchronism of COX-2/VEGF expressions was noted in all positive immunostaining samples. Conclusion : These findings suggest the role of COX-2 pathway could be involved in sinonasal tumor angiogenesis, which is modulated by VEGF COX-2 may act as autocrine factor in VEGF expression. There is a potential role for selective COX-2 inhibitors in the treatment of these lesions.

      • 우리나라 初等敎員의 外國語 解得能力에 關한 調査硏究

        趙性度 서울 敎育大學校 1978 論文集 Vol.11 No.-

        The aim of this study is to ivestigate the Korean Primary school teachers' comprehensive ability of foreign language and to examine the problem of early education of foreign language. One thousand teachers abstracted among the primary school teachers in every province of Korea were the subject of this study. By the result of the vestigation through questionaire and interview, we knew the fact that 80.8% of them felt keenly the necessity of the comprehensive ability of foreign language, while 90% of them were below the level. As a way of finding out the cause of this actual circumstances, the curriculums of teachers training institutes in Japan and China wore compared with those of Korea. As to the necessity of the early education of foreign language, the advisability of it could not be decided definitely, but actually many a children are being taught English by the private teachers outside their schools, nevertheless the time is not yet ripe for the early education of foreign language. According to the above mentioned conclusion, several proposals are brought in as follows : 1. Junior teachers college should be raised to -senior college and students should get at least 12 credits of foreign language for 4 years. 2. Students should get at least 8 credits of foreign language even under the system of Junior college. 3. In the curriculum of the primary school teachers inservice training., more than 18 hours for foreign language should be contained. 4. In case when early education of foreign language will be inforced, special institute for the training of English teachers should be set up.

      • 일측성 악하선 무형성증 2예

        도남용,조성일 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

        Aplasia or agenesis of the salivary gland is an uncommon disorder. Unilateral aplasia of the submandibular gland is an extremely rare disorder. Salivary gland aplasia may occur either in isolation or in association with other developmental anomalities, such as atresia of the lacrimal pucta, mandibulofacial dysostosis or congenital malformations of the temporomandibular component. Clinically, patients may be asymptomatic or may present with dryness of the mouth, difficulty in swallowing, and dental caries. The authors experienced two cases of incidentally detected unilateral aplasia of the submandibular gland demonstrated by computed tomography. So we present this cases with review of literatures.

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