Comparison of the Permeability of Stilbene Analogues in Caco-2 Cells

Suna Kim,Jiyun Ahn,Dong-Wha Shon,Ji-Sun Kim,Mi-Hye Kim,Tae-Youl Ha 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.3

Permeability of resveratrol, piceid, rhapontigenin, and rhaponticin in Caco-2 cell assays using high-performance liquid chromatography were compared. Caco-2 cell monolayers were used to evaluate the transport rates of stilbene analogues from the apical to the basolateral sides. All stilbenes experimented in this study were transported to the basolateral side by times. For comparing the permeability of 4 stilbenes, we calculated the slope of the cumulative concentration of each stilbene in basolateral sides over time, resulting in those values of resveratrol, piceid, rhapontigenin, and rhaponticin with 3.766×10^?5, 4.330×10^?6, 5.430×10^?5, and 2.458×10^?5 μM/sec, respectively. Apparent permeability coefficient of resveratrol and rhapontigenin were calculated to 9.994×10^?6 and 1.441×10^?6 cm/sec, respectively, while those of piceid and rhaponticin were to 1.149×10^?7 and 6.523×10^?7 cm/sec, respectively. These results suggest that aglycones would be absorbed more effectively than glycosides in stilbenoids.

Changes in Korean Consumers’ Perception on Food Preservatives by a Risk Communication Booklet

Suna Kim,Ji-Sun Kim,Hee-Jin Kang,Gunyoung Lee,Ho Soo Lim,Sang Soon Yun,Jeong-Weon Kim 한국식품위생안전성학회 2018 한국식품위생안전성학회지 Vol.33 No.6

본 연구는 학부모를 대상으로 식품첨가물 및 보존료에 대한 인식 수준과 정보요구도를 파악하고 이를 바탕으로 학부모의 식품첨가물 및 보존료에 대한 올바른 이해와 안전한 식생활을 위한 교육자료를 개발하고자 하였다. 2014년 서울 경기지역 초등학생을 둔 학부모 381명을 대상으로 식품첨가물 및 보존료에 대한 인식 및 정보요구도에 대한 설문조사를 수행한 결과 응답자 중 가공식품 구입시 안전성을 가장 중요한 요소라고 응답하였으며, 41.5%가 식품 첨가물을 가장 식품안전을 위협하는 것이라고 응답하였으며, 식품 첨가물 중에서는 보존료가 가장 위험하다고 응답하였다. 그러나 응답자의 90.6%가 식품첨가물 및 보존료에 대한 교육 경험이 없다고 응답하였다. 설문결과와 학부모들의 정보요구도에 따라 교육홍보책자인 ‘보존료 바르게 알기’를 개발하였다. ‘보존료 바르게 알기’는 ‘보존료란 어떤 물질인가요?’, ‘보존료는 어떤 종류가 있나요?’, ‘보존료는 안전한가요?’, ‘가공식품, 어떻게 섭취해야 하나요?’, ‘식품첨가물은 식약처가 철저히 관리하고 있어요’ 등의 5장으로 구성하여 소비자인 학부모들이 알고싶어하는 내용들을 알기 쉽고 재미있게 전달할 수 있도록 구성하였다. 개발된 교육홍보책자를 초등학교 학부모에게 시범 적용한 결과, 사전 18.9%만이 보존료가 무엇인지 알고 있다고 응답한 수준에서 사후 90.9%가 그 역할을 이해하고 72.7%가 안전하다고 응답하여 개발된 책자가 보존료에 대한 이해도를 크게 높이고 보존료에 대한 오해를 바로잡을 수 있는 것을 확인할 수 있었다. 따라서 본 연구에서 개발된 교육홍보책자는 학부모를 비롯한 일반소비자들에게 보존료에 대한 이해를 높일 수 있는 효과적인 정보전달매체로 활용될 수 있을 것이다. Food preservatives are very important food additives for the biological and chemical safety of processed foods. The purposes of this study were to investigate Korean consumer’s perception and information needs on food preservatives, to develop an educational booklet as a risk communication material on food preservatives, and to assess the educational effect of the developed booklet. To understand perception on food preservatives, a self-administered questionnaire survey was conducted by 381 parents having elementary school students at Seoul and Geoynggi area in Korea. Based on the survey results, brain storming of the authors along with consultation from the professionals, we developed a risk communication booklet about food preservatives. It was exposed to 35 parents of elementary school children, and their evaluation was collected by using a questionnaire and analyzed statistically. Respondents considered food safety (44.8%) as the most important factor while purchasing processed foods. They still perceived food additives as the most hazardous one (41.5%), and among those, food preservatives were the most concerned (45.9%). Total 67.7% of the respondents considered the consumption of food preservatives as hazardous or very hazardous. However, 90.6% of respondents did not have any educational experience about food additives and food preservatives. Based on their information needs, a science-based booklet consisting of the definition, classification, safety, intake, and management of food preservatives was developed. When the booklet titled as ‘Food preservatives, Just Know Them!’ was exposed to the parents via elementary school teacher, their negative perceptions on food additives and food preservatives were changed positively by increasing the understanding level on preservatives from 18.9% to 90.9% and obtaining 72.7% positive answers on their safety. Therefore, it could be used as an effective risk communication material on food preservatives.

Changes in Korean Consumers' Perception on Food Preservatives by a Risk Communication Booklet

Kim, Suna,Kim, Ji-Sun,Kang, Hee-Jin,Lee, Gunyoung,Lim, Ho Soo,Yun, Sang Soon,Kim, Jeong-Weon The Korean Society of Food Hygiene and Safety 2018 한국식품위생안전성학회지 Vol.33 No.6

본 연구는 학부모를 대상으로 식품첨가물 및 보존료에 대한 인식 수준과 정보요구도를 파악하고 이를 바탕으로 학부모의 식품첨가물 및 보존료에 대한 올바른 이해와 안전한 식생활을 위한 교육자료를 개발하고자 하였다. 2014년 서울 경기지역 초등학생을 둔 학부모 381명을 대상으로 식품첨가물 및 보존료에 대한 인식 및 정보요구도에 대한 설문조사를 수행한 결과 응답자 중 가공식품 구입 시 안전성을 가장 중요한 요소라고 응답하였으며, 41.5%가 식품 첨가물을 가장 식품안전을 위협하는 것이라고 응답하였으며, 식품 첨가물 중에서는 보존료가 가장 위험하다고 응답하였다. 그러나 응답자의 90.6%가 식품첨가물 및 보존료에 대한 교육 경험이 없다고 응답하였다. 설문결과와 학부모들의 정보요구도에 따라 교육홍보책자인 '보존료 바르게 알기'를 개발하였다. '보존료 바르게 알기'는 '보존료란 어떤 물질인가요?', '보존료는 어떤 종류가 있나요?', '보존료는 안전한가요?', '가공식품, 어떻게 섭취해야 하나요?', '식품첨가물은 식약처가 철저히 관리하고 있어요' 등의 5장으로 구성하여 소비자인 학부모들이 알고 싶어하는 내용들을 알기 쉽고 재미있게 전달할 수 있도록 구성하였다. 개발된 교육홍보책자를 초등학교 학부모에게 시범 적용한 결과, 사전 18.9%만이 보존료가 무엇인지 알고 있다고 응답한 수준에서 사후 90.9%가 그 역할을 이해하고 72.7%가 안전하다고 응답하여 개발된 책자가 보존료에 대한 이해도를 크게 높이고 보존료에 대한 오해를 바로잡을 수 있는 것을 확인할 수 있었다. 따라서 본 연구에서 개발된 교육홍보책자는 학부모를 비롯한 일반소비자들에게 보존료에 대한 이해를 높일 수 있는 효과적인 정보전달매체로 활용될 수 있을 것이다. Food preservatives are very important food additives for the biological and chemical safety of processed foods. The purposes of this study were to investigate Korean consumer's perception and information needs on food preservatives, to develop an educational booklet as a risk communication material on food preservatives, and to assess the educational effect of the developed booklet. To understand perception on food preservatives, a self-administered questionnaire survey was conducted by 381 parents having elementary school students at Seoul and Geoynggi area in Korea. Based on the survey results, brain storming of the authors along with consultation from the professionals, we developed a risk communication booklet about food preservatives. It was exposed to 35 parents of elementary school children, and their evaluation was collected by using a questionnaire and analyzed statistically. Respondents considered food safety (44.8%) as the most important factor while purchasing processed foods. They still perceived food additives as the most hazardous one (41.5%), and among those, food preservatives were the most concerned (45.9%). Total 67.7% of the respondents considered the consumption of food preservatives as hazardous or very hazardous. However, 90.6% of respondents did not have any educational experience about food additives and food preservatives. Based on their information needs, a science-based booklet consisting of the definition, classification, safety, intake, and management of food preservatives was developed. When the booklet titled as 'Food preservatives, Just Know Them!' was exposed to the parents via elementary school teacher, their negative perceptions on food additives and food preservatives were changed positively by increasing the understanding level on preservatives from 18.9% to 90.9% and obtaining 72.7% positive answers on their safety. Therefore, it could be used as an effective risk communication material on food preservatives.

A dual gated WSeu₂ field-effect transistors with graphene as the top gate electrode

Taekwang KIM,Hyewon DU,Somyung SHIN,Seonyeong KIM,Minho SONG,Sangmin KIM,Seungjun KIM,Sunae SEO 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

The Converge Effects of the BeHaS Exercise Program on Health Status, Depression and Suicidal Ideation in Female Elderly Who Live Alone in Community

Hyunjoo Kim,Sun Kyung Kim,Jong-Im Kim,Sunae Kim,Young Suk Jun,Keumok Park 한국융합학회 2018 한국융합학회논문지 Vol.9 No.3

본 논문은 베하스 운동프로그램의 지역사회 여성독거노인에 대한 융합적 효과를 알아보고자 시행된 비동등성 대조 군 전후설계의 유사실험연구이다. 실험군 대조군 사전사후 연구이다. 베하스 운동프로그램은 주 2회 시행되어 4주간 총 8회 실시되었고 통증, 어깨유연성, 악력, 우울과 자살생각에 대한 측정이 이루어졌다. 수집된 자료는 Independent t-test, Chi-squre test, paired t-tests, 공분산분석 (ANCOVA)으로 분석되었다. 실험군의 4주의 실험 전후비교결과 통증(t = 4.044, p = .000)과 오른쪽 어깨 유연성(t =2.192, p=.038), 왼쪽어깨유연성(t=2.568, p=.016)의 통계적으로 유의한 향상이 확인되었다. 실험군과 대조군의 그룹간 비교에서는 자살생각의 변화양상에서 통계적으로 유의한 차이가 확인되었다(F=7.32, p =.010). 본 연구를 바탕으로 베하스 운동프로그램의 지역사회 여성 독거노인에서의 신체적 정신적 건강증진에 대한 긍정적인 효과 를 확인하였다. This study was conducted to evaluate the converge effects of the Be Happy and Strong (BeHaS) exercise program on female elders living alone, using a nonequivalent control-group pretest-posttest design. The BeHaS exercise program was conducted twice each week for 4 weeks (total 8 sessions). The outcome measures included pain, shoulder flexibility, grip strength, depression, and suicidal ideation. Independent t-test, Chi-squre test, paired t-tests and ANCOVA were used for the statistical data analysis. A statistically significant improvement emerged in pain (t=4.044, p=.000) and right and left shoulder flexibility (t=2.192, p=.038 and t=2.568, p=.016) 4 weeks later. In a group comparison, a statistically significant difference arose in changed scores of suicidal ideation (F=7.32, p=.010) between groups. The BeHaS exercise program may effectively improve the physical and psychological health of female elders living alone.

한방부인과 영역에 활용되는 수기요법의 국내외 연구 동향

김순아 ( Suna Kim ),김민경 ( Min-kyung Kim ),김수진 ( Su-jin Kim ),경다현 ( Da-hyun Kyung ),백지원 ( Ji-won Baek ),권미리 ( Miri Kwon ) 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.4

Objectives: The purpose of this study is to analyze the research trends using manual therapy in obstetrics and gynecological diseases. Methods: We searched for studies that performed manual therapy on diseases related to obstetrics and gynecology. All relevant papers were selected and extracted to be analyzed. Results: 12 Randomized controlled trials, 8 cases, 3 pilot studies, 3 non-comparative studies, and 1 before-after comparative study were collected. The study subjects, results, techniques of manual therapy used were analyzed. There were studies related to pregnancy-related symptoms, postpartum pain, dysmenorrhea, chronic pelvic pain, abnormal uterine bleeding, sexual dysfunction, and childbirth. Conclusions: It has been found that various manual therapies can be used for obstetrics and gynecological diseases.

Hole carrier enhancement multi-layer MoSe₂ field-effect transistor using rapid-thermal annealing

Seungjun KIM,Taekwang KIM,Hyewon DU,Somyeong SHIN,Seonyeong KIM,Minho SONG,Sangmin KIM,Sunae SEO 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

HTML5 기반의 스마트 TV 플랫폼

김규식(Kyusik Kim),김미경(Mikyoung Kim),김선아(Suna Kim),김진희(Jinhee Kim),남태호(Taeho Nam),김태석(Taeseok Kim) 한국정보과학회 2013 한국정보과학회 학술발표논문집 Vol.2013 No.6

Substance P enhances proliferation and paracrine potential of adipose-derived stem cells <i>in vitro</i>

Kim, Suna,Piao, Jiyuan,Son, Youngsook,Hong, Hyun Sook Elsevier 2017 Biochemical and biophysical research communication Vol.485 No.1

<P><B>Abstract</B></P> <P>Stem cells have tremendous promise to treat intractable diseases. Notably, adipose-derived stem cells (ADSCs) are actively being investigated because of ease of sampling and high repopulation capacity in vitro. ADSCs can exert a therapeutic effect through differentiation and paracrine potential, and these actions have been proven in many diseases, including cutaneous and inflammatory diseases. Transplantation of ADSCs necessitates therapeutic quantities and thus, long term ex vivo culture of ADSCs. However, this procedure can impair the activity of ADSCs and provoke cellular senescence, leading to low efficacy in vivo. Accordingly, strategies to restore cellular activity and inhibit senescence of stem cells during ex vivo culture are needed for stem cell-based therapies. This study evaluated a potential supplementary role of Substance P (SP) in ADSC ex vivo culture. After confirming that the ADSC cell cycle was damaged by passage 6 (p6), ADSCs at p6 were cultured with SP, and their proliferation rates, cumulative cell numbers, cytokine profiles, and impact on T/endothelial cells were assessed. Long-term culture weakened proliferation ability and secretion of the cytokines, transforming growth factor-beta 1 (TGF-beta1), vascular endothelial growth factor (VEGF), and stromal cell derived factor-1 alpha (SDF-1alpha) in ADSCs. However, SP treatment reduced the population doubling time (PDT), enabling gain of a sufficient number of ADSCs at early passages. In addition, SP restored cytokine secretion, enhancing the ADSC-mediated paracrine effect on T cell and human umbilical vein endothelial cells (HUVECs).</P> <P>Taken together, these results suggest that SP can retain the therapeutic effect of ADSCs by elevating their proliferative and paracrine potential in ex vivo culture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Long-term culture of ADSCs leads to cell senescence. </LI> <LI> Paracrine potential of ADSC decreases as passage number increases. </LI> <LI> SP enhances the weakened proliferation capacity of ADSCs. </LI> <LI> SP stimulates cytokine secretion from ADSC with impaired paracrine potential. </LI> </UL> </P>

A Study on the Application of Internal Compliance Programs to South Korea’s Nuclear Export Control

Suna Heo,Su-jeong Kim,Su-hyeon Kim,Seung-hyo Yang 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1

The Internal Compliance Program (ICP) is a framework for promoting compliance with laws and regulations and minimizing violations. It aims to prevent law breaches, by raising awareness of the compliance within the organization, which leads to enhance the credibility of the organization, and to prepare for audits. From the perspective of nuclear export control, ICP can be used to verify the company’s credibility by following NSG Guidelines and is expected to contribute to preventing the vertical and horizontal proliferation of nuclear weapons in the international community. However, ICP system is not globally established, and the NSG does not provide official guidelines for ICP. Therefore, this study aims to analyze the “Good Practices for Internal Compliance Programs for Nuclear and Nuclear-Related Exports” provided by the Pacific Northwest National Laboratory to find ways to apply and activate ICPs for domestic exporters. The form of ICP could vary depending on company’s size and internal environments, but it should be organized as follows. First, an internal department should be established so as to implement the ICP, and an executive who has export control knowledge should be assigned as the Chief Export Control Officer (CECO). The CECO, establish and revise ICP operating procedures and manual, organize contact point to communicate internally and externally. Second, measures should be established minimize risks in the export process, including business development transaction screening, supply chain, research and development, human resource, and intangible technology transfer risks. Third, internal control system should be established for export control compliance. The CECO should conduct regular assessments to ensure compliance and strengthen the organization’s internal export compliance processes. Fourth, an export-related training program should be periodically conducted for employees. In addition, as soon as the CECO becomes aware of, CECO should review the matter, take corrective action, and report to the relevant national authorities, when a violation of domestic export control laws or suspicious circumstances are captured. Nuclear export control plays an important role in ensuring nuclear nonproliferation. Republic of Korea has been implementing the ICP system for Dual-Use Items under the Foreign Trade Act, but not for Trigger List Items. Therefore, introduction of ICP for Trigger List Items is expected significantly contribute to nuclear nonproliferation. The subjects of ICP will be initially targeted to major nuclear enterprises, then gradually expanded to all nuclear enterprises. Further researches are needed to introduce on ICP for Trigger List Items.