확장성 심근증의 임상적 특성에 대한 연구

정상만,문언수,정시전 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Dilated cardiomyopathy is a heart muscle disease in which one or both ventricles are dilated, resulting in decreasing left ventricular contractility and pump failure. Complex arrhythmias are frequent in this disorder and are often associated with poor prognosis. We analysis the clinical parameter, electrocardiographic and echocardiographic findings of the 15 patients who were diagnosed as dilated cardiomyopathy between Aug. 1978 and Dec. 1992 in Kon-Kuk University Minjoog Hospital. The results were as follows: 1) 9 male and 6 female patients with mean age of 56.6 were included in this study. 2) In decreasing order of frequency, the clinical findings were dyspnea on exertion(93.3%) ; fatigue or weakness(46.7%) ; orthopnea(26.7%) ; cough(26.7%) ; edema(20.0%) ; chest pain(20.0%) and palpitation(13.3%). 3) In decreasing order of frequency, the findings of physical examination were apical systolic murmur(53.3%) ; hepatomegaly(33.3%) ; S3 gallop(26.7%) : pretibial pitting edema(7%) ; rales or wheezing(20.0%) and peripheral cyanosis (20.0%). 4) The most common finding of electrocardiography was LVH(33.3%) and atrial fibrillation(33.3%). NSIVCD(26.7%), PVC(20.0%), LBBB(6.7%), atrial flutter(6.7%) were also noted in this study. 5)The echocardiographic study showed markedly increased LVEDD(65.3±11.1mm), LVESD(56.8±10.7mm), LAD(42.9±7.4mm), EPSS(23.3±6.1mm) and decreased EF(28.8±11.0%), IVST(7.6±1.1mm) and LVPWT(7.5±1.3mm). This data showed that congestive heart failure was the major clinical feature and the left ventricular performance was markedly decreased in the patients with dilated cardiomyopathy. Electrocardiographic abnormalities were frequently associated with this disorder. Adequate therapeutic modality and proper follow up were necessary to improve the prognosis of the patients with dilated cardiomyopathy.

검사시간의 경과에 따른 컴퓨터 신경행동검사 수행기능의 변화양상

정성태,전만중,사공준 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 컴퓨터 신경행동검사에서 검사시간의 경과에 따른 측정치들의 타당도 변화양상과 타당도에 영향을 미치는 요인들을 평가하고 수용할 만한 타당도가 나타나는 최소한의 검사시간을 제시하여 컴퓨터 선경행동검사의 결과 해석의 정확성을 높이고 검사시간 설정의 기준으로 활용 하고자 수행되었다. 방법: 자동차공장 근로자 중 혼합 유기용제에 만성적으로 노출되는 도장공 118명과 연령을 짝지은 대조군 113명으로 총 231명을 대상으로 하였다. 대상자 전원은 고등학교졸업의 학력을 가진 남자 근로자였으며,연령,작업부서,근무년수,주야간 교대작업 여부,음주 및 흡연 습관을 자기기입식 설문지를 통하여 조사하고 SPES를 이용한 컴퓨터 신경행동검사를 시행하였다. 신경행동검사는 연습수행을 포함하여 단순반응시간 6분,부호숫자짝짓기 10회,손가락두드리기 5회를 수행하였다. 단순반응시간은 1분 단위로, 부호숫자짝짓기와 손가락두드리기는 수행단위(session)마다의 평균반응시간,표준편차 및 두드린 횟수에 대한 검사시간의 경과에 따른 변화양상을 관찰하고 t 통계량과 반복측정분산분석을 이용하여 타당도의 변화양상을 관찰하였다. 결과: 단순반응시간은 도장공과 대조군 모두에서 검사에 대한 미숙함은 적은 반면 시도가 반복됨에 따라 학습 효과에 비해 지루함 혹은 흥미의 감소 등의 영향이 더 큰 것으로 나타났다. 도장공과 대조군의 평균반응시간 차이의 타당도는 연습수행 후 1분의 검사시간에서 높았다. 부호숫자짝짓기의 초기에는 검사에 대한 미숙함 등이 많이 개입되며,시도의 횟수가 증가함에 따라 학습효과의 개입이 증가하였다. 5∼7번째 시도의 평균반응시간에 대한 t 동계량이 가장 컸다 손가락두드리기의 경우 우수는 학습 효과에 의해 시도가 반복될수록 두드린 횟수가 증가하는 경향이 있었고 열수는 피로에 의해 두드린 횟수가 점차 감소하는 경향이 있었다. 결론: 따라서 단순반응시간은 연습수행 1회 후 1분(1회째)의 검사를 분석에 이용하고,부호숫자짝짓기는 검사 시작 후 4번의 시도들을 연습수행으로 하며 ,이후 연속적인 3번의 시도에 대한 평균반응시간을 대표값으로 이용하고,손가락두드리기는 연습수행 1회 후 1,2번째 시도의 평균 두드린 횟수를 분석에 이용하면 타당도를 높이고 시간을 절약할 수 있을 것이다. Objective: A cross-sectional study was performed to assess changes in computerized neurobehavioral performance across multiple test sessions for developing a valid performance level and reducing test time. Methods: The study was conducted on 118 male car painters exposed to low-dose, mixed organic solvents. The study controls were 113 unexposed reference workers matched for age and educational year from different sections of the same factory. Each worker completed a medical and occupational exam and questionnaire. Three tests of the Swedish Performance Evaluation System (5 minutes of Simple Reaction Time, 9 sessions of Symbol Digit, and 4 sessions of Finger Tapping Speed) were administered to each group. Results: The mean age, mean duration of employment, and mean years of education were 33 years, 6.7 years, and 12 years in both groups, respectively. The mean reaction times of the Simple Reaction Time increased with the lapse of time. The known group difference between the exposed and control groups was larger for the first minute than for the successive 3 minutes. Both groups showed improved performance across the first to the seventh sessions on Symbol Digit. Following the seventh session, the performance levels of Symbol Digit had worsened. The t statistic of the two groups was the largest when the two mean reaction times were calculated from the sessions of the fifth to the seventh, In the dominant and non-dominant hands, the number of taps increased and decreased, respectively, across the sessions on Finger Tapping Speed. The known group difference was the largest when comparing the performances from the first to the second sessions. Conclusions: For valid interpretation and timesaving in computerized neurobehavioral tests, the following is recommended: one practice and one test session for Simple Reaction Time, four practice and three test sessions for Symbol Digit, and one practice and two test sessions for Finger Tapping Speed.

연마된 단일 모드 광 섬유에서 외피 두께의 측정에 관한 연구

정만영,윤성현 동아대학교 공과대학 부설 한국자원개발연구소 1989 硏究報告 Vol.13 No.1

This paper studied cladding thickness that is the most important parameter when optical divices are fabricated with polished single mode optical fiber. When a drop of liquid with appropriate index oil is placed on the polished surface of the single mode optical fiber, guided mode of optical fiber is coupled in the liquid index oil. This coupling induces additional loss of the guided mode. These losses vary with the evanescent field in the cladding, and it is proportioned to thickness of polished cladding, so we can get cladding thickness by the measurement of loss, during optical fiber is polished.

유한 저크(Finite Jerk)를 이용한 수직 MC(machining center)의 가속도 최적화에 대한 연구

정원지,조영덕,이춘만,윤상환 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

By the reason of increased demand of high productivity and quality, the manufacturer have an effort in many directions of a machine tool industries. Among there, we proposed method of decreasing displacement in MC(machining center). In other words, Quality related with vibration of a tool cutting products. For decreasing it, improved by optimizing a shape of the column-part and acceleration curves of motors In this paper we could find design factors has much influence on decreasing the displacement using the DOE(Design of Experiments) and optimized the level of the factors using ADAMS^(R) and MINITAB^(R). And we suggest optimized a acceleration curve using Matlab^(R).

후천성 이중 유문 1예

정규성,조기섭,정재용,조영호,민영돈,박찬국,김만우 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Double pyrolus, one of the relatively rare anomalies of the gastrointestinal tract, is a fistulous communication between the gastric antrum and the duodenal bulb. The first case of a double Pylorus was reported in 1969 by Smith, since then several cases have been reported. Recently, as the frequency of examining upper gastrointestinal series and endoscopy increases, it occurs more frequently and a few cases have been described in our country. According to the reports previously published, it resulted only from cysts, diverticla, atresia, band, membrane malformation of the pylorus, however, it might be also caused by penetration, complication of peptic ulcer. We report a case of double pylorus in a 67-year old man with prolonged administration of corticostetoids due to lumbago who has complained epigastric pain which was confirmed by endoscopy and biopsy.

탈회동결건조골에 혼합한 형질 변형 성장인자(TGF-β1)가 골조직 재생에 미치는 효과

정성민,이만섭,박준봉 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.1

The purpose of ss this study was to observe the effect of TGF-Rl on the regeneration of bone in guided bore regeneration. Four adult dogs aged 12 to 24 months were used in this study. Experimental bone defects were created surgically with surgical bur and chisel on the 3th. premolars. In experimental group; bone defect were grafted with DFDB and TGF-R1. In control groups, bone defects were grafted with only Dl-.DB. At 1, 2, 3 and 4 weeks, dogs were serially sacrificed and specimens were prepared with Hematoxylin-Eosin stain and Goldner`s stain for light microscopic evaluation. The results of this study were as follows 1. The infiltration of inflammatory cells was prominent in control groups at 1, 2 and 3 weeks. 2. The lining of osteoblast was observed at 2 weeks in control group, but at 1 week in experimental group. 3. In both groups, osteoid was formed at 2 weeks. In control groups, osteoid was fromed on only bone surface. but in experimental groups, osteoid were formed on both bone & DFDB surfaces. 4. In only experimental groups, The fusion of new bone & DFDB was only observed at 3 weeks. and the fusion of new bone & DFDG was more prominent at 4 weeks. But in control groups, No fusion of new bone & DFDB was oberved at 3 and 4weeks From the above result, the TGF-01 was effective in bone formation and increased inductive effect of DFDB guided bone regeneration technique. Inductive effect of DFDB was increased with TGF-131.

Bacillus lkicheniformis IAM 11054가 生産하는 耐熱性 α- Amylase의 特性과 分解産物에 關한 硏究

鄭萬在,南相烈,申敬娥 충북대학교 농업과학기술연구소 1987 農業科學硏究 Vol.5 No.2

These experiments were performed to investigate the purification, the characteristics and the hydrolysis products on various Polysaccharides and oligosaccharides of thermophilic α-amylase produced by Bacillus licheniformis IAM 11054. The optimum culture time, the optimum initial pH and the optimum culture temperature for the production of α-amylase were 72hrs, pH 6.5 and 40℃, respectively. The crude enzyme was purified to 568- fold by starch adsorption, ammonium sulfate fractionation, DEAE-cellulose column chromatography and CM cellulose column chromatography. The specific activity of the purified enzyme was 312.5u /mg ㆍ protein and the yield of enzyme activity was 13.0%. The purified enzyme showed a single band (relative mobility 0.25) on polyacrylamide gel electrophoresis and the molecular weight was estimated to be approximately 145,000 by SDS-polyacrylamide gel electrophoresis, and isoelectric point was pH6.0. The optimum pH, the stable pH range, the optimum temperature and the stable temperature of the purified enzyme were pH6.0∼7.5, pH6.0∼10.5. 80℃ and below 75℃, respectively. The purified enzyme was greatly inhibited by Hg++ Ag+ and I2, and the thermostability of it was greatly increased by Ca++. The purified enzyme hydrolyzed soluble starch, corn starch, glutinous rice starch, green banana starch, arrow root starch, potato starch, yam starch, oyster glycogen, maltopentaose and maltohexaose, but did not hydrloyze α, β, γ -cyclodextrin, pullulan, maltose, maltotriose, maltotetraose, raffinose, lactose and sucrose. The purified enzyme hydrolyzed various starch to G1, G2, G3, G4, G5, G6 and others, and G5 to G2 and G3 and G6 to G1, G2, G3, G4 and G5. Among various gelatinized starches, potato starch and green banana starch were favorably hydrolyzed by the purified enzyme.

급성 심근경색증에 동반된 승모판 폐쇄부전증의 임상적 특징

정상만,조영일,조화상,유광하,송기호,인행환 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.- No.7

HPLC 시스템을 이용한 大氣中 多核芳香族 炭化水素의 定量에 關한 硏究

정재필,황승만,박철용,백성옥 嶺南大學校 工業技術硏究所 1991 연구보고 Vol.19 No.1

In this study, an analytical procedure was evaluated for the determination of atmospheric PAH, both in gaseous and particulate phases. The method involves Soxhlet extraction of the filters and Tenax adsorbent, followed by a clean-up stage using a silica mini column prior to analysis by reversephase HPLC with wavelength programmable fluorescence and UV detection. A total of 18 PAH were identified and quantified, all of which have been of environmental concern. In order to validate the methodology and to ensure compatibility of the results, the analytical method used for the determination of PAH was evaluatd with respect to the efficiencies of extraction and clean-up procedure, HPLC separation, and lower limits of detection. In addition, substrate dependency of PAH recovery was also investigated for the two type of filter(glass fiber and PTEF filters) and Tenax adsorbent.

급성 심근경색증에 동반된 승모판 폐쇄부전증의 임상적 특징

정상만,조영일,조화상,유광하,송기호,인행환 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-

The early detection and proper management of mitral regurgitation(MR) associated with acute myocardial infarction(MI) is very important to improve the clinical course and outcome of disease. The change of left ventricular shape and regional function, papillary muscle rupture are major determinant of the existence and severity of MR. We performed 2D and M mode echocardiography of 28 patients at the early stage of acute MI to evaluate the existance and degree of MR and its pathogenetic factor. Significant MR occured in 12 (42.9%) patients. In the group of MI with MR, the inferior MI was frequent (7 case) than anterior MI (5 case) comparing to the patient group of MI without MR (inferior MI : 6 case, anterior MI : 10 case) (p<0.01).The left ventricular end diastolic dimension(LVEDD), end systolic dimension (LVESD) and left atrial dimension (LAD) were significantly increased in MI with MR than MI without MR (LVEDD : 57.3 ±8.6 vs 46.4 ±9.2, p<0.05 ; LVESD : 52.9 ±9.2 vs 38.3 ±7.4, p<0.01 ; LAD : 45.4 ±3.8 vs 37.7 ±3.7, p<0.05).However, the ejection fraction was not different between two group two groups. These datas showed that MR was more frequent in inferior MI and the hemodynamic derangement was more serious in acute MI with MR.