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Case Reports : A rare case of primary adenosquamous carcinoma arising from ovary
( Ji Yun Lee ),( Song Mi Noo ),( Nam Hun Cho ),( Young Mi Choi ),( Ga Won Yim ),( Maria Lee ),( Jiheum Paek ),( San Hee Lee ),( Eun Ji Nam ),( Sang Wun Kim ),( Young Tae Kim ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.3
Primary adenosquamous carcinoma of ovary is extremely rare malignancy. We report a case of primary adenosquamous carcinoma of the ovary which has not been reported in Korea before. The case of a 32 year old woman, evaluated for palpable abdominal mass is presented. Ultrasonography, abdomino-pelvic MRI, PET-CT were suggestive of a malignant neoplastic process. Surgical debulking operation including total abdominal hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, para-aortic lymph node biopsy, total omentectomy, incidental appendectomy and low anterior resection of rectum were performed. Histopathology demonstrated primary adenosquamous carcinoma arising from the left ovary to the myometrium, serosa, rectal wall mass and omentum. The staging for ovarian tumor was consistent with FIGO stage IV. We present a case of this rare malignancy
심성실,김진희,김누리,서영선,최명임,김지영,김명현,최정화,이관,정해관 東國大學校醫學硏究所 2003 東國醫學 Vol.10 No.1
목적 : 최근 학생들 사이에서 교복을 줄여서 꽉 끼게 입는 현상을 흔히 관찰 할 수 있다. 일반적으로 ‘쫄’ 교복 착용이 건강재해를 유발할 것이라는 생각은 많지만 관련된 연구는 드물다. 본 연구는 ‘쫄’ 교복 착용이 소화기계에 어떤 영향을 미치는지 알아보고자 시행하게 되었다. 대상 및 방법: ‘쫄’ 교복 착용에 의한 행동의 부자유도와 옆터짐 정도를 본 연구진이 개발한 INDEX 조사를 통하여 측정하였다. 00여고 2학년 198명에 대해 ‘쫄 교복 착용군 89명, 미착용군 109명을 설문조사하였다. 결과 : 일개 여고생들에게 ‘쫄’ 교복 착용률은 44.9%이었으며 조기 포만감과 상복부 이물감 호소율이 ‘쫄’ 교보 착용군에서 미착용군 보다 유의하게 높았다(P<0.05). 소화기계 증상 발생의 위험 요인에 대한 다중 로지스틱회귀분석에서 줄여 입은 군의 줄여 이비 않은 군에 대한 교차비는 2.01(95% CI 1.05-3.83), 아침을 먹은 군이 먹지 않은 군에 대한 교차비는 0.32(95% CI 0.10-0.99), 스트레스가 있는 군이 없는 군에 대한 교차비는 2.65(95% CI 1.31-5.38)로 조사되었다. 결론 : 여고생에서 ‘쫄’ 착용은 소화기계의 건강장해를 유발한다고 조사되었다. 단순한 유행의 하나로 '쫄‘ 교복을 착용할 수는 있지만 이로 인한 건강장해가 발생한다면 이는 청소년들에서 중요한 문제를 유발할 수 있다. ’쫄‘ 교복착용의 부작용에 대한 다양하고 심도있는 연구가 필요하며 일선 학교에서도 홍보와 계도가 필요하다. Objectives : This study was carried out to evaluate the health effects of a tight school uniform in high school girls. Of the health effects, we focused gastrointestinal disorders. Methods : We conducted a questionnaire survey of 198 students at a girls' high school in Gyeongju. One hundred ninety eight students were divided into two groups by wearing on a tight school uniform(TSU) and a loose school uniform(LSU). We have measured the extent of discomfort related to motion and a garment rips through tightness INDEX developed by the authors. Results : The proportion of students wearing TSU was 44.9%. TSU group complained significantly more early gastric satiety and epigastric foreign body sensation than LSU group (P<0.05). Multiple logistic regression, TSU(OR=2.01, 95% CI:1.05-3.83), regular breakfast(OR=0.32, 95% CI:0.10-0.99), and stress (OR=2.65, 95% CI:1.31-5.38) were significantly associated with gastrointestinal symptoms. Conclusions : The results of this study indicate that the clothing pressure from a tight school uniform has some effects on the gastrointestinal disorder. More extensive epidemiological studies and public activities for adverse effects of a TSU is needed.
( Noo Ri Lee ),( Na Young Yoon ),( Minyoung Jung ),( Ji Yun Kim ),( Seong Jun Seo ),( Hye Young Wang ),( Hye Young Lee ),( Young Bae Sohn ),( Eung Ho Choi ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
X-linked recessive ichthyosis (RXLI) is an inherited ichthyosis characterized by generalized dryness and scales, and is caused by deficiency of steroid sulfatase (STS) which results in an accumulation of cholesterol sulfate in the intercorneocyte lipids. The STS gene is located on the distal tip of the short arm of X chromosome, locus Xp22.3. RXLI must be differentiated from ichthyosis vulgaris (IV) showing very similar clinical manifestations. We evaluated clinical manifestations and skin barrier function of 16 Korean male RXLI patients, who were diagnosed by fluorescence in situ hybridization (FISH) and array CGH analysis. We evaluated their past histories and family histories, skin barrier properties, cytokine expression levels in the stratum corneum and gene mutations. The clinical manifestations showed quite different from the already reported features, as most of the patients showed uninvolved flexural skin and 10 patients (62.5%) had past history or family history of atopic diseases. Four patients showed elevated serum IgE level. Histopathology of ichthyosis lesions showed normal or slightly increased granular layers in all patients. In the functional study on skin barrier, all patients showed significantly lower stratum corneum hydration compared to normal controls, but no difference in basal transepidermal water loss (TEWL). Skin surface pH of measured from lesional skin or the patients did not show any significant difference compared to the uninvolved skin. We measured various cytokine expression levels including Th1, Th2, Treg, and proinflammatory cytokines in the stratum corneum taken from lesional skin and non-lesional of the patients to compare with normal control group. As results, interferon-γ, interleukin-4 and 5 showed significantly lower level in the lesional skin of the patients compared to control group. By evaluating for gene mutations in filaggrin, kallikrein 7 and SPINK 5 genes, surprisingly, 12 patients (75%) showed mutations in kallikrein 7 gene. We believe that this is the first report on RXLI patients in Korea diagnosed by FISH and array analysis as the most definite diagnosis. Here we have found the novel features of RXLI that it usually does not involve the flexures of extremities, frequently correlate with atopic diseases like IV, and does not accompany changes in basal TEWL.
Lee, Noo Ri,Yoon, Na Young,Jung, Minyoung,Kim, Ji-Yun,Seo, Seong Jun,Wang, Hye-young,Lee, Hyeyoung,Sohn, Young Bae,Choi, Eung Ho The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.8
<P>X-linked ichthyosis (XLI) is a recessively inherited ichthyosis. Skin barrier function of XLI patients reported in Western countries presented minimally abnormal or normal. Here, we evaluated the skin barrier properties and a skin barrier-related gene mutation in 16 Korean XLI patients who were diagnosed by fluorescence in situ hybridization and array comparative genomic hybridization analysis. Skin barrier properties were measured, cytokine expression levels in the stratum corneum (SC) were evaluated with the tape stripped specimen from skin surface, and a genetic test was done on blood. XLI patients showed significantly lower SC hydration, but normal basal trans-epidermal water loss and skin surface pH as compared to a healthy control group. Histopathology of ichthyosis epidermis showed no acanthosis, and levels of the pro-inflammatory cytokines in the corneal layer did not differ between control and lesional/non-lesional skin of XLI patients. Among the mutations in <I>filaggrin</I> (<I>FLG</I>), <I>kallikrein</I> 7 (<I>KLK7</I>), and <I>SPINK5</I> genes, the prevalence of <I>KLK7</I> gene mutations was significantly higher in XLI patients (50%) than in controls (0%), whereas <I>FLG</I> and <I>SPINK5</I> prevalence was comparable. Korean XLI patients exhibited unimpaired skin barrier function and frequent association with the <I>KLK7</I> gene polymorphism, which may differentiate them from Western XLI patients.</P>