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( Jee Hye Kwon ),( Won Kim ),( Donghee Kim ),( Yong Jin Jung ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Initial alpha-fetoprotein (AFP) response might affect clinical outcomes after systemic chemotherapy for advanced HCC. In this study, we aimed to find the correlation between initial AFP response and intrahepatic recurrence of hepatitis B-related HCC after RFA. Methods: A total of 615 consecutive patients underwent RFA for HBV-related HCC at Seoul National University Hospital from January 2005 to June 2010. We retrospectively collected and reviewed clinical data from electronic medical records. Patients with no available AFP data at baseline or initial serum AFP <20 ng/mL were excluded from analysis. AFP response was defined as >50% decline from baseline 1 month after RFA. Results: A total of 255 patients undergoing RFA for HBVrelated HCC were included in this study. Mean age of study population was 56.8±8.7 years and 177 (70%) were males. Two hundred and forty-six had Child-Pugh class A and 9 had class B. One hundred and thirty-two had no previous history of HCC treatment, 29 received resection, 3 for RFA, 27 for percutaneous ethanol injection, and 64 for transarterial chemoembolization. The type of recurrence was as follows; local recurrence (33): remote recurrence (112): both local and remote recurrence (13). In multivariate analysis, AFP >50% decline (HR 0.507; 95% CI 0.348-0.738; p<0.001), previous history of TACE (HR 2.149; 95% CI 1.439-3.210; p<0.001), and male gender (HR 1.715; 95% CI 1.090-2.699; p=0.020) were independent predictors of remote recurrence. Conclusions: Biologic response such as initial serum AFP decline significantly predicted intrahepatic remote recurrence after RFA for locoregional HCC. Moreover, HCC patients with initial AFP decline ≤50% after RFA should be considered for further treatment modalities.
( Jee Hye Kwon ),( Won Kim ),( Dong Hee Kim ),( Yong Jin Jung ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Initial alpha-fetoprotein (AFP) response might affect clinical outcomes after systemic chemotherapy for advanced HCC. In this study, we aimed to find the correlation between initial AFP response and intrahepatic recurrence of hepatitis B-related HCC after RFA. Methods: A total of 615 consecutive patients underwent RFA for HBV-related HCC at Seoul National University Hospital from January 2005 to June 2010. We retrospectively collected and reviewed clinical data from electronic medical records. Patients with no available AFP data at baseline or initial serum AFP <20 ng/mL were excluded from analysis. AFP response was defined as >50% decline from baseline 1 month after RFA. Results: A total of 255 patients undergoing RFA for HBVrelated HCC were included in this study. Mean age of study population was 56.8±8.7 years and 177 (70%) were males. Two hundred and forty-six had Child-Pugh class A and 9 had class B. One hundred and thirty-two had no previous history of HCC treatment, 29 received resection, 3 for RFA, 27 for percutaneous ethanol injection, and 64 for transarterial chemoembolization. The type of recurrence was as follows; local recurrence (33): remote recurrence (112): both local and remote recurrence (13). In multivariate analysis, AFP >50% decline (HR 0.507; 95% CI 0.348-0.738; p<0.001), previous history of TACE (HR 2.149; 95% CI 1.439-3.210; p<0.001), and male gender (HR 1.715; 95% CI 1.090-2.699; p=0.020) were independent predictors of remote recurrence. Conclusions: Biologic response such as initial serum AFP decline significantly predicted intrahepatic remote recurrence after RFA for locoregional HCC. Moreover, HCC patients with initial AFP decline ≤50% after RFA should be considered for further treatment modalities.
( Jee Hye Kwon ),( Seong Joon Koh ),( Joo Sung Kim ),( Jong Pil Im ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although the frequency of kidney transplantation (TPL) is rising, there are no consensus for its colonoscopic surveillance due to the lack of epidemiological data about incidence of colorectal polyp and neoplasm after TPL. The aim of this study was to investigate whether incidence of colorectal neoplasm increases in kidney transplant recipients compared to general population. Methods: A total of 677 patients who underwent kidney TPL in Seoul National University Hospital from 1996 to 2008 and age- and gender-matched 900 healthy controls who received screening colonoscopy between 2010 and 2011 were analyzed. We retrospectively reviewed electronic medical records about patient`s demographic, clinical characteristics, use of immunosuppressive agents, colonoscopy fi ndings, and histology of colon polyp. Cox regression analysis was performed to evaluate risk factors affecting development of advanced neoplasm in TPL patients. Results: Of patients who underwent TPL, Two hundred forty eight patients were identi- fi ed as receiving post-transplant colonoscopy. Overall adenomatous polyp was founded in to 23.4 % of TPL patients compared to 21.8 % of healthy controls (P=0.589). There was a signifi cant difference in incidence of advanced neoplasm between two groups (P=0.003). Incidence of advanced neoplasm was higher in transplant patient aged 50 and over (P=0.009). Advanced neoplasm according to the lesion location did not signifi cantly differ in transplant patients (P=0.557). In multivariate analysis, age was only associated with an increased risk of developing advanced neoplasm in TPL patients (adjusted odds ratio [aOR], 1.068; 95% confi dence interval [CI], 1.007 to 1.134; P=0.029).Conclusions: Incidence of overall colorectal adenoma was similar between two groups. However, development of advanced adenoma and colon cancer was significantly higher in kidney TPL patients. Authors suggest that kidney TPL patients aged 50 and over should be performed colonoscopy surveillance more strictly following currently recommended interval for general population.
Kwon, Jee Hye,Im, Jong Pil,Ye, Byong Duk,Cheon, Jae Hee,Jang, Hyun Joo,Lee, Kang Moon,Kim, You Sun,Kim, Sang Wook,Kim, Young Ho,Song, Geun Am,Han, Dong Soo,Kim, Won Ho,Kim, Joo Sung Editorial Office of Gut and Liver 2016 Gut and Liver Vol.10 No.4
<P><B>Background/Aims</B></P><P>C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn’s disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course.</P><P><B>Methods</B></P><P>We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients’ demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed.</P><P><B>Results</B></P><P>A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027). There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP.</P><P><B>Conclusions</B></P><P>The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP.</P>
( Jee Hye Kwon ),( Changhyun Lee ),( Ji Min Choi ),( Yoo Min Han ),( Young Hoon Choi ),( June Young Lee ),( Hyuk Yoon ),( Jaeyoung Chun ),( Kyu Joo Park ),( Jong Pil Im ),( Sang Gyun Kim ),( Joo Sung 대한장연구학회 2013 Intestinal Research Vol.11 No.4
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology, associated with extraintestinal manifestations, including the rarely reported immune thrombocytopenic purpura. Here, we present a case of immune thrombocytopenic purpura associated with preexisting ulcerative colitis. The patient was diagnosed with ulcerative colitis 13 years ago. Two years after diagnosis, he presented with hematochezia and active ulcerative colitis. Despite steroid use, the platelet count gradually decreased to 21,000/mm3. Hematochezia and the platelet count recovered after the administration of cyclosporine, and ulcerative colitis was in near complete remission for 11 years. However, the patient was re-admitted for hematochezia and thrombocytopenia persisting over a month. Medical management including increased doses of steroids in combination with cyclosporin failed to control hematochezia and thrombocytopenia. Immune thrombocytopenic purpura was suspected on the basis of normocellular marrow with a normal number of megakaryocytes. To treat uncontrolled colitis and steroid-refractory thrombocytopenia, total proctocolectomy with ileal pouch-anal anastomosis and splenectomy were performed. The patient was followed up for 10 months after surgery and was found to be in good health with a normal platelet count. Therefore, colectomy alone or in combination with splenectomy should be considered in cases of life-threatening ulcerative colitis complicated with steroid-refractory immune thrombocytopenic purpura. (Intest Res 2013;11:310-316)
권광일(Kwang Il Kwon),박소현(So Hyun Park),이준형(Jun Hyung Lee),김지영(Jee Young Kim),유광수(Kwang Soo Yoo),이지선(Jee Sun Lee),김서영(Seo Young Kim),성현이(Hyun I Sung),남혜선(Hye Seon Nam),김종욱(Jong Wook Kim),이혜영(Hye Young Le 대한지역사회영양학회 2007 대한지역사회영양학회지 Vol.12 No.2
This study investigated the prevalence of nutrition labeling and claims on processed and packaged foods. The final database consists of 1,287 foods, which were collected in two supermarkets in the Seoul area from September to November, 2006. An estimated 78% of KFDA-regulated processed, and packaged foods have nutrition labels. Nutrient content claims on food labels were identified in 21% of the foods which have nutrition labels. The prevalence of nutrition labels in this study is much higher than in previous studies due to the current expansion of the mandatory labeling regulation. However, false labeling and misleading contents claims were also identified. The food label is an important tool for enhancing the public`s understanding of healthy choices of processed foods. Therefore, to maximize the benefits of the nutrition labeling regulation, industries, government agencies and health professionals should work together to help consumers make healthy dietary choices and improve their health. (Korean J Community Nutrition 12(2) : 206~213, 2007)
Modification of Starch Composition Using Downregulation of GBSS1 gene in Japonica Rice
Hye-Jung Lee,Moo-Geun Jee,Dal-A Yu,Me-Sun Kim,Franz Nogoy,Mingmao Sun,Sailila E. Abdula,Kwon-Kyoo Kang,Illsup Nou,Yong-Gu Cho 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
There is a great consideration on rice eating quality aside from improving its tolerance to various stresses. High yielding and pest and disease tolerant rice is highly desirable but it is more commercially important if it also has a high eating quality. There are various factors contributing to the good eating quality of rice. This study focuses on modifying the expression of GBSS1 genes which are responsible for amylopectin and amylose synthesis in rice by using RNAi and antisense techniques. We have developed 40 transgenic plants with RNAi-GBSS1 gene and 60 transgenic lines with antisense-GBSS1 gene. The transgenic plants show diverse amylose contents in rice seed. We selected candidate lines according to PCR, RNA expression and amylose contents. A semi-quantitative RT-PCR was carried out to measure the expression level of GBSS1 gene at several time points after the flowering of transgenic plants. The expression level of GBSS1 gene in rice grains decreases over time and the mRNA expression among the transgenic plants were lower compare to its wild type. In the SEM analysis, the starch granule of wild type Gopumbyeo has very large structures accompanied with small ones around the area. However, the starch structures in transgenic plants were smaller and more uniform in size and shape throughout the viewing area