Fourier Transform Infrared Spectroscopy Studies on Thermal Decomposition of Tetrakis-dimethyl-amido Zirconium for Chemical Vapor Deposition of ZrN

( Ihl Woo Kim ),( Sung Jae Kim ),( Do Heyoung Kim ),( Hee Gweon Woo ),( Man Yong Park ),( Shi Woo Rhee ) 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.6

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

CHARACTERIZATION OF HYDRODESULFURIZATION CATALYST PREPARED BY IMPREGNATING COBALT NITRATE SOLUTION ONTO THE SULFIDED MoO3/Al2O3 CATALYST

Woo, Seong Ihl,Kim, Seo Il,Kim, Choong Hyon 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.5

CoMo/Al₂O₃ catalysts were prepared by impregnating Cobalt nitrate solution into oxidic or sulfided Mo/Al₂O₃. The properties of CoMo/Al₂O₃ catalysts were characterized by XRD, TPS, oxygen chemisorption and ESR. Catalytic activity of CoMo/Al₂O₃catalyst was evaluated by thiophene HDS as a probe reaction. When CoMo/Al₂O₃ catalyst was prepared by impregnating Cobalt nitrate solution into sulfided Mo/Al₂O₃, the interaction between Mo and alumina became weaker and the formation of synergic phase was facilitated. These structural changes may explain higher HDS activity of CoMo/Al₂O₃ catalyst prepared by impregnating Cobalt nitrate solution into sulfided Mo/Al₂O₃.

Characterization of Hydrodesulfurization Catalyst Prepared by Impregnating Cobalt Nitrate Solution onto the Sulfided MoO3/Al2O3 Catalyst

Woo, Seong Ihl,Kim, Seo Il,Kim, Choong Hyon 한국화학공학회 1996 NICE Vol.14 No.1

CoMo/Alo catalysts were prepared by impregnating Cobalt nitrate solution into oxidicur sulfided Mo/Al3. the properties of CoMo/AI3, catalssts were cbaracteried by XKD. TPS, oxygen chemisrptim and ESR. Catalytic activity of CoMo/AIU, catalyst was evaluated be thiophene (II)S as a prohe reaction. When CuMo/Al, catalyst was prepared by impregnating Cobalt nitrate solution into sulfided Mo/AIO. the nteraction between Mo and alumina became weaker and the formation of synergic phase was facilitated. These structural changes may explain higher HDS activity of CoMo/AIO catalyst prepared by impreKnating Cobalt nitrate solution into sulfided 110/41.

Circular Permutation of the DNA Genome of Temperate Bacteriophage ΦFC1 from Enterococcus faecalis KBL703

(Young Woo Kim),(Se Hwan Jang),(Bum Shik Hong),(Wang Jin Lim),(Chan Wha Kim),(Ha Chin Sung),(Hyo Ihl Chang) 한국미생물생명공학회 1999 Journal of microbiology and biotechnology Vol.9 No.4

N/A N/A

EPROM 과 EEPROM 소자의 제작 및 특성

김성일(Sung-ihl Kim),이규홍(Kyu-hong Lee),김보우(Bo-woo Kim),이진효(Jin-hyo Lee) 대한전자공학회 1985 대한전자공학회 학술대회 Vol.1985 No.6

엔지오텐신 전화효소의 유전자 다형성과 고혈압성 뇌내출혈의 관계에 대한 연구

김동환,김철진,김순기,조재우,이정청,김형일,고규영 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.4

Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways

Jeong Hwan Kim,Woo Bong Choi,Jong Hwan Lee,Sung Jong Jeon,Yung Hyun Choi,Byung Woo Kim,Hyo Ihl Chang,Soo Wan Nam 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.11

소아 난치성 측두엽 간질의 수술 예후

김선희(Sun Hui Kim),김준성(Joon Sung Kim),김찬종(Chan Jong Kim),우영종(Young Jong Woo),이민철(Min Cheol Lee),김형일(Hyoung Ihl Kim) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.1

목적 : 최근 난치성 측두엽 간질에 대한 수술적 치료가 성인에서 뿐만 아니라 소아에서도 활발히 이용되고 있으나 소아 난치성 측두엽 간질 환자에서 수술 예후를 예측할 수 있는 인자에 대한 보고는 많지 않다. 이에 저자들은 난치성 측두엽 간질로 수술을 시행받은 환아들을 대상으로 임상 양상, 병리 소견, 뇌 자기공명영상, 뇌파 소견과 수술 예후와의 연관성을 알아보고자 본 연구를 시행하였다. 방법 : 1994년 11월부터 2000년 7월까지 측두엽 절제술을 시행받은 소아 난치성 측두엽 간질 환자 환아 중 1년 이상 추적 관찰이 가능하였던 12명을 대상으로 발작간기 뇌파, 지속적 비디오-뇌파 감시를 통한 발작기 뇌파, 침습적 뇌파, 뇌 자기공명영상 및 병리 소견과 수술 후 발작 예후를 비교 검토하였다. 결과 : 수술 후 발작 예후는 Engel의 분류상 class I이 5례(41.7%), class II 1례(8.3%), class III 5례(41.7%), class IV 1례(8.3%)로 예후가 좋았던 군(class I, II)은 6례(50%)였다. 발작간기와 발작기 뇌파가 편측 측두엽에 일치되어 나오거나 비디오-뇌파 검사와 침습적인 뇌파 검사에 의해 간질 병소가 국소화되어 간질 병소를 수술로 제거한 경우에는 예후가 좋았으며 병리 검사상 해마 경화증이나 신경교증을 보였다. 그러나 양측 측두엽에서 간질 발작파를 보이거나 측두엽과 외측두엽에 간질 병소가 있었으나 수술로 제거되지 않은 경우는 좋지 않은 예후를 보였으며 병리 검사상 대부분 피질 이형성증을 보였다. MRI에서 이상 소견을 보였던 경우 수술 후 발작 예후는 Engel의 분류에 따라 class I, II가 50%였으며, MRI 검사에 이상 소견을 보이지 않았던 경우 병리 검사상 해마 경화증 소견을 보였고 75%에서 좋은 예후(class I)를 보였다. 두피 뇌파로는 발작 병소를 국소화하기 힘들었고, 비디오-뇌파 검사로 발작 병소의 편측화가 불가능한 경우에 정확한 간질 병소를 파악하기 위하여 시행한 침습적인 뇌파 검사 결과에 따라 수술 예후가 결정되었다. 결론 : 병리 소견이 해마 경화증이나 신경교증의 경우는 수술후 좋은 발작 예후를 보인 반면에 피질 이형성증은 좋지 않은 예후를 보였다. 소아 난치성 측두엽 간질의 수술적 평가에 침습적인 뇌파 검사가 반드시 고려되어야 한다. Purpose : Epilepsy surgery has become increasingly available in children with medically intractable epilepsy including temporal lobe epilepsy(TLE). TLE in children, however, has many different clinical and electrophysiologic characteristics which make presurgical evaluation difficult. The aim of this study is to evaluate the electroencephalographic(EEG) features which might be one of the predictors of postsurgical seizure outcomes in TLE. Methods : Standard EEG, video-EEG, subdural or depth EEG were investigated in 12 children who underwent anterior temporal lobectomy, and their seizure semiology, MRI, and pathologic findings were also reviewed. Postsurgical seizure outcomes were divided into favorable(class I, II) and unfavorable(class III, IV) groups by using the Engel's classification. Results : Half of the patients showed favorable outcomes, whose pathologic findings revealed hippocampal sclerosis or gliosis. Such pathologic findings were not demonstrated in MRI. Interictal epileptiform discharges were concordant with the location of the ictal onset in only 2 cases of the favorable outcomes. For the other 4 cases in the favorable group, focal ictal onset patterns were clearly evident in video-EEG monitorings or invasive EEG studies. Six cases in the unfavorable group showed unlocalized or multifocal interictal or ictal discharges -extratemporal, bitemporal or generalized epileptic activities- even in the invasive EEG studies. Five of them revealed cortical dysplasia in the pathology. Conclusion : The postsurgical seizure outcomes of hippocampal sclerosis or gliosis were more favorable than those of cortical dysplasia. Invasive EEG recordings should be considered for the localization of epileptic foci in the presurgical evaluation of children with intractable TLE.

재발된 혹은 불응성 비호지킨 림프종에서 고용량 항암요법과 표준 구출요법의 비교

홍영선,민창기,김정아,김희제,엄현석,조석구,이종욱,진종률,한치화,최일봉,박재후,민우성,김춘추,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

Background: Patients with intermediate- or high-grade non-Hodgkin's lymphoma (NHL) who have a relapse or refractoriness after initial standard chemotherapy generally have a poor prognosis. Conventional salvage treatment can induce lengthy remission. It is, however, not generally agreed that long-term survival has been expected in patients receiving salvage chemotherapy. The combination of high dose therapy and autologous stem cell transplantation has been considered promising in refractory or relapsed patients with NHL. Methods: The response rate and survival (disease-free and overall survival) of 15 patients with relapsed or refractory NHL who only received salvage chemotherapy was compared with those of 14 patients who has been assigned to receive high dose therapy and autologous stem cell transplantation. Results: the overall rate of response to salvage chemotherapy was 13% but that of high dose therapy with stem cell support was 58%. Disease free survival (DFS) in the salvage chemotherapy group was very low; only 2 patients survived in remission without a relapse of disease in long duration. On the contrary the rate of DFS in the transplantation group was 48% at 3 years. At 3 years, the rate of overall survival (OS) was 17% in the group receiving salvage chemotherapy and 31% in the transplantation group. Conclusion: As compared with salvage chemotherapy, treatment with high dose therapy and autologous stem cell transplantation increases disease-free and overall survival in relapsed or refractory patients with non-Hodgkin's lymphoma.