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중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향
최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.
Moon, Hyeong Cheol,Won, So Yoon,Kim, Eung Gook,Kim, Hyong Kyu,Cho, Chul Bum,Park, Young Seok Elsevier/North-Holland 2018 Neuroscience letters Vol.662 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson’s disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP). The aim of the present study was to determine if optogenetic modulation of the EP could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model.</P> <P><B>Methods</B></P> <P>We injected an adeno-associated virus type-2 expressing α-synuclein (AAV2-α-syn) into the substantia nigra pars compacta (SNc) of the right hemisphere and confirmed parkinsonian behavior using an amphetamine-induced rotation test. Then we injected activated or inhibited neurons, using the channelrhodopsin2 (ChR2)/halorhodopsin (NpHR) system in the EP of the hemiparkinson rat model and examined downstream effects <I>in vivo</I>. We assessed alterations in parkinsonian behaviors using the stepping and cylinder tests before, during, and after optogenetic stimulation.</P> <P><B>Results</B></P> <P>Importantly, optogenetic inhibition of the EP improved parkinsonian motor behaviors. When we monitored thalamic neuronal activity following optogenetic neuromodulation <I>in vivo</I>, and we observed alterations in thalamic discharge The thalamic neuronal activity is increased for optogenetic inhibition stimulation, whereas decreased for optogenetic activation stimulation.</P> <P><B>Conclusions</B></P> <P>Taken together, our data demonstrate that optical neuromodulation of the EP can successfully control contralateral forelimb movement and thalamic discharge in an AAV2-α-synuclein-induced hemiparkinson rat model.</P> <P><B>Highlights</B></P> <P> <UL> <LI> To test whether optogenetic modulation of the entopeduncular nucleus(EP) could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model. </LI> <LI> The globus pallidus internus (GPi) in primates is homologous to the entopeduncular nucleus (EP) in rats. </LI> <LI> The author compared parkinson behavior and recorded <I>in vivo</I> neuronal activity between pre- and post-stimulation in hemiparkinson rat model. </LI> <LI> Optical neuromodulation of the EP can be used to successfully control contralateral forelimb movement and thalamic discharge to alleviate symptoms in an AAV2-α-syn-induced hemiparkinson rat model. </LI> </UL> </P>
Avoiding a Collision in Gamma Knife Radiosurgery : A Modified Mask Fixation Method
Hyeong Cheol Moon,Doheui Lee,Byung Jun Min,Young Gyu Kim,도윤식 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.4
Objective : The latest version of the Leksell Gamma Knife IconTM allows for mask- and frame-based fixation. Although mask fixation provides fractionated treatment and immobilization using a noninvasive method, it is not free from collision. The authors investigated the collision problem with a modified mask fixation method. Methods : This study presents a case of two meningiomas in the frontal area, where a collision occurs in the occipital area. A modified mask fixation method was introduced to avoid the collision : first, the edges of the head cushion were cut off and polystyrene beads with a diameter of approximately 5 cm were removed. Next, the head cushion was sealed using a stapler. Finally, the head cushion was flattened in the adapter. We compared the shot coordinates, 3-dimensional (3D) error, clearance distance, and vertical depth of the head cushion between the initial and modified mask fixations. Results : When comparing the initial and modified mask fixations, the difference in the shot coordinates was +10.5 mm along the y-axis, the difference in the 3D error was approximately 18 mm, and the difference in clearance was -10.2 mm. The head cushion was approximately 8 mm deeper in the modified mask fixation. Conclusion : Based on these findings, we recommend a modified mask fixation method for gamma knife radiosurgery using ICON with a collision.
( Hyeong Cheol Moon ),( Hyeon-man Baek ),( Young Seok Park ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.2
Obstructive hydrocephalus caused by tectal glioma, which relived by neuroendoscopy, have been de-scribed using 3.0 Tesla magnetic resonance imaging (3T MRI) so far, we present the results obtained from 3T and 7T MRI in this patient. A 21-year-old woman presented at our hospital with gait disturbance, hormonal insufficiency, and urinary incontinence that began prior to 6 years of age. 3.0T MRI revealed a non-enhancing tectal mass along with obstructive hydrocephalus. The mass measured approximately 1.1×1.0×1.2 cm. An endoscopic third ventriculostomy was performed to relieve the hydrocephalus. We compared hydrocephalus and cerebrospinal fluid (CSF) flow findings from 3T and 7T MRI, both preoper-ative and postoperative at 1, 6 months. Intraventricular CSF voiding on T2-weighted images obtained with 7T MRI showed greater fluid inversion than those obtained with 3T MRI. This study shows that 7T brain MRI can provide detailed information on hydrocephalus caused by tectal glioma. Further studies are needed to develop refined 7T MRI protocols for better images of hydrocephalus.
7.0 Tesla MRI tractography in patients with trigeminal neuralgia
Moon, Hyeong Cheol,You, Soon-Tae,Baek, Hyeon Man,Jeon, Young Jai,Park, Chan-A,Cheong, Jei Jun,Lee, Youn Joo,Park, Young Seok Elsevier 2018 Magnetic resonance imaging Vol.54 No.-
<P><B>Abstract</B></P> <P>7.0 Tesla (T) high-resolution diffusion tensor imaging (DTI) can supply information on changing microstructures in cranial nerves. We investigated DTI parameters and the feasibility of DTI criteria for diagnosing trigeminal neuralgia (TN). In this study, 14 patients (28 hemispheres) of mean age 49.0 years (range, 31–64) with TN underwent DTI using 7.0 TMRI. We compared fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) of affected-side and unaffected-side trigeminal nerves using DTI. We examined associations between DTI parameters and clinical characteristics for patients with TN. In patients with TN, affected sides showed significantly decreased FA and significantly increased MD, and RD compared with unaffected sides of trigeminal nerves. Nuclei were not significantly different among patients with TN. Barrow Neurological Institute (BNI) pain scores did not correlate with affected sides. 7.0 T DTI was useful for detecting neurovascular compression in patients with TN. The increased signal-to-noise ratio provided by 7 T MRI should be advantageous for increasing spatial resolution to detect microstructure changes to trigeminal nerves in patients with TN.</P>
Moon, Hyeong Cheol,Park, Chan-A,Jeon, Yeong-Jae,You, Soon Tae,Baek, Hyun Man,Lee, Youn Joo,Cho, Chul Beom,Cheong, Chae Joon,Park, Young Seok Elsevier 2018 Magnetic resonance imaging Vol.51 No.-
<P><B>Abstract</B></P> <P>The cingulate cortex (CC) is a brain region that plays a key role in pain processing, but CC abnormalities are not unclear in patients with trigeminal neuralgia (TN). The purpose of this study was to determine the central causal mechanisms of TN and the surrounding brain structure in healthy controls and patients with TN using 7 Tesla (T) magnetic resonance imaging (MRI). Whole-brain parcellation in gray matter volume and thickness was assessed in 15 patients with TN and 16 healthy controls matched for sex, age, and regional variability using T1-weighted imaging. Regions of interest (ROIs) were measured in rostral anterior CC (rACC), caudal anterior CC (cACC) and posterior CC (PCC). We also investigated associations between gray matter volume or thickness and clinical symptoms, such as pain duration, Barrow Neurologic Institute (BNI) scores, offender vessel, and medications, in patients with TN. The cACC and PCC exhibited gray matter atrophy and reduced thickness between the TN and control groups. However, the rACC did not. Cortical volumes were negatively correlated with pain duration in transverse and inferior temporal areas, and thickness was also negatively correlated with pain duration in superior frontal and parietal areas. The cACC and PCC gray matter atrophy occurred in the patients with TN, and pain duration was associated with frontal, parietal, and temporal cortical regions. These results suggest that the cACC, PCC but not the rACC are associated with central pain mechanisms in TN.</P>
Park, Hyeong-Cheol,Kim, Man-Lyang,Kang, Yun-Hwan,Jeon, Joo-Mi,Yoo, Jae-Hyuk,Kim, Min-Chul,Park, Chan-Young,Jeong, Jae-Cheol,Moon, Byeong-Cheol,Lee, Ju-Huck,Yoon, Hae-Won,Lee, Sung-Ho,Chung, Woo-Sik,Li Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
The Ca^(2+)-binding protein calmodulin mediates cellular Ca^(2+) signals in response to a wide array of stimuli in higher eukaryotes. Plants express numerous CaM isoforms. Transcription of one soybean (Glycine max) CaM isoform, SCaM-4, is dramatically induced within 30 min of pathogen or NaCl stresses. To characterize the cis-acting element(s) of this gene, we isolated an approximately 2-kb promoter sequence of the gene. Deletion analysis of the promoter revealed that a 130-bp region located between nucleotide positions -858 and -728 is required for the stressors to induce expression of SCaM-4. A hexameric DNA sequence within this region, GAAAAA (GT-1 cis-element), was identified as a core cis-acting element for the induction of the SCaM-4 gene. The GT-1 cis-element interacts with an Arabidopsis GT-1-like transcription factor, AtGT-3b, in vitro and in a yeast selection system. Transcription of AtGT-3b is also rapidly induced within 30 min after pathogen and NaCl treatment. These results suggest that an interaction between? GT-1 cis-element and a GT-1-like transcription factor plays a role in pathogen- and salt-induced SCaM-4 gene expression in both soybean and Arabidopsis.