Comparison of Clinical Stage and Pathologic Stage in Patients with Nonsmall Cell Lung Cancer

( Hye Ran Gwon ),( Sang Hoon Lee ),( Seong Yong Park ),( Seung Hyun Yong ),( A La Woo ),( Song Yee Kim ),( Eun Yeong Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Clinical staging of non-small cell lung cancer (NSCLC) is based on radiologic and bronchoscopic finding and mediastinoscopy in the past. Currently, several new techniques including positron emission tomography (PET), endobronchial untrasoundtrnasbronchial needle aspiration (EBUS-TBNA) are available. There is no comparative analysis of clinical stage and pathologic stage after new techniques has been introduced for clinical staging work up. Methods We did a retrospective analysis of 820 patients with NSCLC those who have done curative surgery in Severance hospital from January 2019 to December 2020. The eighth edition of the American Joint Commission of Cancer (AJCC) TNM staging system for NSCLC was used in this study. Results Among 820 patients, most common clinical stage was stage I (671, 81.8%) and most common cancer was adenocarcinoma (680, 83%). For clinical staging work up, EBUS was performed in 265 (32.3%) and PET-CT was performed in 820 (100%) patients. There were 563 (68.7%) patients whose clinical TNM stage and pathologic TNM stage are concurred. When comparing T stage, 637 (77.7%) patients showed matched clinical and pathologic staging. Clinical N stage and pathologic N stage are same in 701 (85.5%) patients. Conclusions The agreement between the clinical stage and the pathologic stage is improved after new diagnostic Methods such as PET, EBUS-TBNA has been introduced for a clinical staging work up.

The Efficacy of Pirfenidone in Combined Pulmonary Fibrosis and Emphysema (CPFE)

( Hye Ran Gwon ),( Song Yee Kim ),( Sung Hwan Jeong ),( Jong Sun Park ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0

Background and Aims CPFE is a syndrome characterized by upper lobe emphysema and lower lobe fibrosis. It is demonstrated that pirfenidone has survival benefit in IPF. However, the efficacy of pirfenidone in CPFE is still not well known. Methods This multicenter retrospective cohort study investigated 1,364 patients with IPF those who have enrolled Korea IPF Cohort (KICO) in 30 hospitals in South Korea. We analyzed demographics, pulmonary function (PFT), and survival of them. Results Among 1,364 patients with IPF, 479 patients were CPFE (35.1%; mean age 71 years; men 94.8%). CPFE group showed significantly higher proportion of smokers (93.5% vs. 64.7%, P < 0.0001), heart disease (17.5% vs. 13.4%, P = 0.043), chronic obstructive pulmonary disease (COPD) (17.1% vs. 4.9%, P < 0.001) and lung cancer (16.7% vs 6.9%, P < 0.001) than non-CPFE group. At diagnosis, CPFE has significantly higher mean forced vital capacity (FVC) % predicted (80.2% vs 75%, P < 0.001), lower mean diffuse capacity of carbon monoxide (DLCO) % predicted (61.6% vs. 66%, P < 0.001) and lower FEV1/FVC ratio (79.5% vs. 86.9%, P < 0.001) than non-CPFE. There was no significant difference in survival rate between CPFE and non-CPFE group (P = 0.233). Among patients who did not treated with pirfenidone, the 5-year survival rate of CPFE is significantly lower than non- CPFE group (52.1% vs. 55.8%, P = 0.013). Among patients treated with pirfenidone, CPFE showed no significant difference in survival rate than non-CPFE (P = 0.519). Among CPFE group, those who treated with pirfenidone showed significantly higher 5- year survival rate than those who did not treated with pirfenidone (61.5% vs. 52.1%, P = 0.018) Conclusions Pirfenidone has survival benefit in CPFE patients.

지리산 노각나무(Stewartia koreana)림의 식생구조

권혜진 ( Hye Jin Kwon ),권재환 ( Jae Hwan Gwon ),정혜란 ( Hye Ran Jeong ),이지혜 ( Ji Hye Lee ),송호경 ( Ho Kyung Song ) 한국환경생태학회 2011 한국환경생태학회지 Vol.25 No.5

본 연구는 지리산지역의 노각나무림을 대상으로 식물사회학적 방법으로 군락을 분류하고, 식생과 토양과의 상관관계를 밝히고자 구배분석을 실시하였다. 노각나무림은 노각나무-졸참나무군락, 노각나무-신갈나무군락, 노각나무전형군락으로 분류되었으며, 노각나무-졸참나무군락은 서어나무아군락과 전형아군락으로 구분되었다. 노각나무는 해발고 409m에서 최고 1,604m까지 자생하였다. 노각나무군락의 중요치 분석결과 노각나무가 75.47%로 가장 높았으며, 졸참나무 21.83%, 신갈나무 18.65%, 당단풍나무 18.19%, 철쭉 10.56%, 때죽나무 10.36% 순으로 나타났다. 본 조사지의 토양분석 결과 평균적으로 유기물함량 3.15~39.1%, 전질소함량 0.37~11.7%, 유효인산함량 0.9~45.4mg/kg, 치환성 양이온 K+ 0.09~1.48cmol+/kg, 토양 수분 19.28~55.47%, 토양 pH는 4.08~5.65인 것으로 조사되었다. DCCA ordination을 이용한 노각나무군락과 환경요인과의 상관관계 분석결과, 해발고에 의해 노각나무-신갈나무군락, 노각나무전형군락, 노각나무-졸참나무전형아군락, 서어나무아군락 순으로 분포하였다. This study was carried out to analyze the vegetation properties, soil characteristics, and ordination of Stewartia koreana community of Mt. Jirisan in Korea. The S. koreana community was classified into S. koreana-Quercus serrata community, S. koreana-Quercus mongolica community, and Typical community. In specific, S. koreana-Q. serrata community was classified into two subgroups such as Carpinus laxiflora subcommunity and typical subcommunity. The S. koreana community was found out to be located at an elevation of 409m to 1,604m. The Results of importance value on the S. koreana community consisted of the following in order: 75.47% of S. koreana, the highest, 21.83% of Q. serrata, 18.65% of Q. mongolica, 18.19% of Acer pseudosieboldianum, 10.56% of Rhododendron schlippenbachii, 10.36% of Styrax japonicus. In the targeted study sites, soil organic matter, total nitrogen, available phosphate, exchangeable potassium, soil moisture and soil pH were 3.15~39.1%, 0.37~11.7%, 0.9~45.4mg/kg, 0.09~1.48cmol+/kg, 19.28~55.47% and 4.08~5.65, respectively. The results of the correlation between communities and soil conditions of S. koreana community by DCCA ordination method are as follows: S. koreana-Q. serrata community was found in the highest elevation and followed in order S. koreana typical community, S. koreana-Q. serrata typical subcommunity, and C. laxiflora subcommunity.

유기물 처리에 따른 벼 재배 논 토양에서의 온실가스 배출 평가

박혜란(Hye-Ran Park),권효숙(Hyo-Suk Gwon),이선일(Sun-Il Lee),이형석(Hyoung-Seok Lee),이종문(Jong-Mun Lee),최은정(Eun-Jung Choi) 한국토양비료학회 2022 한국토양비료학회 학술발표회 초록집 Vol.2022 No.10

중국에서 사체 신장이식을 받은 환자들의 임상적 특징

차란희 ( Ran Hui Cha ),김선문 ( Sun Moon Kim ),김효상 ( Hyo Sang Kim ),장혜련 ( Hye Ryoun Jang ),이태우 ( Tae Woo Lee ),오국환 ( Kook Hwan Oh ),안규리 ( Cu Rie Ahn ),한진석 ( Jin Suk Han ),김성권 ( Suhng Gwon Kim ),김연수 ( Yon Su 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.1

목적: 신장이식은 말기 신부전의 중요한 신대체 요법이나 공여 신장의 부족으로 이식 대기 환자는 급격히 늘어나고 있다. 이에, 중국을 포함한 해외에서의 신장이식이 최근 급증하고 있으나 우리나라에서 이들의 치료 경과 및 성적에 대한 보고는 제한적이다. 연구자들은 중국에서 사체 신장이식을 받은 환자들의 임상상을 살펴보고, 이들의 단기 성적을 국내에서 사체 신장이식을 받은 환자들과 비교해 보고자 하였다. 방법: 2002년 1월부터 2006년 1월까지 중국에서 사체 신장이식을 받고 서울대학교병원에서 유지 면역억제 치료를 받고 있는 44명의 환자들과 2000년 2월부터 2006년 1월까지 서울대학교병원에서 사체 신장이식을 받은 33명의 환자들을 대상으로 후향적 연구를 진행하였다. 결과: 양 군 간에 인구학적인 차이는 없었고, 원인 신장 질환과 기존의 신대체 요법, 이식 전 혈청 크레아티닌 값도 차이가 없었다. 기존의 신대체 요법 기간은 국내이식군에서 길었으며 (중국이식군 vs. 국내이식군; 24.6 months vs. 89.9 months; p<0.05), 이식 후 관찰 기간도 국내이식군에서 길었다 (중국이식군 vs. 국내이식군; 13.9 months vs. 31.9 months; p<0.05). 이식 후 6개월 째와 1년 째 사구체 여과율은 양 군 간에 차이가 없었으나 마지막 사구체 여과율은 중국이식군에서 낮았다 (중국이식군 vs. 국내이식군; 54.97 mL/min. vs. 62.46 mL/min.; p<0.05). 이식 후 감염증과 거부 반응의 빈도는 중국이식군에서 많았다 (p<0.05). 국내이식군에서는 사망자가 없었으나 중국이식군에서는 3명이 있었고, 신기능의 소실은 국내이식군에서 1명, 중국이식군에서 4명이 있었다. 결론: 중국이식군에서 국내이식군에 비해 신기능의 저하와 합병증 발생의 증가 등이 관찰되었으며, 이를 해결하기 위해서는 이식 적응증 및 이식 전 평가, 초기 면역억제를 포함한 중국에서의 치료, 공여자 정보의 제공 등에 대해 해외 이식 기관과의 의견 교환이 있어야 할 것이다. Purpose: Number of patients expecting for kidney transplantation and transplantations in foreign countries are rapidly increasing. However, there was a lack of information about clinical progresses and outcomes of kidney recipients, underwent cadaveric kidney transplantation in China. Methods: We included 44 patients (China group), received cadaveric kidney transplantation in China and have been managed at our institute from Jan 2002 to Jan 2006 and 33 patients (domestic group), received cadaveric kidney transplantation at our institute from Feb 2000 to Jan 2006. We performed retrospective study based on medical records. Results: Duration of pre-transplantation renal replacement therapy and of post-transplantation follow up was longer in domestic group (China group vs. domestic group; 89.9 months vs. 24.6 months, 31.9 months vs. 13.9 months) (p<0.05, p<0.05). Final GFR of China group was lower than domestic group (China group vs. domestic group; 54.97±18.92 mL/min vs. 64.26±18.23 mL/min) (p<0.05). Infection and rejection rates of China group were higher than domestic group (Incidences/ Pantients *Yr./1000; China group vs. domestic group; infection; 2.05 vs. 0.76, rejection; 1.34 vs. 0.51) (p<0.05). There was no difference of patient and graft survival between two groups. Conclusion: Korean recipients of Chinese cadaveric kidneys showed lower final GFR and higher rates of infection and rejection. We should be aware of the possible rejections and complications of kidney recipients undergoing cadaveric kidney transplantation in China. Mutual exchange of information about current status of patients, transplantation indications, donor status and treatment protocols is needed between foreign transplantation centers and our medical centers.

환경과 인간 그리고 예술을 논하다

권혜란,Gwon, Hye-Ran 한국주택협회 2006 주택과 사람들 Vol.196 No.-

헤이리 아트 밸리는 이제껏 볼 수 없었던 새로운 문화, 예술의 공간이자 일반인들에게는 삶의 휴식처로 급부상하고 있는 곳이다. 편안하면서도 환경 친화적인 마을을 만들고자 뜻 있는 예술인들이 모여 만든 이곳은 마치 건출물과 그림, 공연을 한꺼번에 볼 수 있는 커다란 갤러리 같다.

신생아 HHH 증후군

권순학,윤혜란,Gwon, Sun-Hak,Yun, Hye-Ran 대한유전성대사질환학회 2004 대한유전성대사질환학회지 Vol.4 No.1

Acute Renal Failure Following Off-pump Coronary Artery Bypass Surgery (OPCAB): Incidence, Risk Factors, and Outcomes

( Sun Moon Kim ),( Hye Ryoun Jang ),( Ran Hui Cha ),( Yon Su Kim ),( Curie Ahn ),( Jin Suk Han ),( Suhng Gwon Kim ),( Jung Sang Lee ),( Ki Bong Kim ),( Kwon Wook Joo ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.4

Purpose : Off-pump coronary artery bypass (OPCAB) is known to be associated with a lower risk acute renal failure (ARF) than on-pump method. However, little data is available on ARF in OPCAB. The aim of the present study was to identify the incidence, risk factors, and mortality of ARF OPCAB. Methods : Perioperative variables in medical records of 573 patients who had undergone OPCAB from Jan 2000 to June 2004 were evaluated. ARF was defined as a 50% increase in preoperative serum creatinine (over 1.4 mg/dL) within 72 hours after operation, or as the need for postoperative dialysis. Results : The incidence of ARF and ARF requiring dialysis were 9.8% and 2.6%, respectively. The independent risk factors for ARF after OPCAB were the perioperative use of an intra-aortic balloon pump (OR, 4.425; 95% CI, 2.342-8.403), high preoperative serum creatinine (OR 2.099; 95% CI, 1.422-3.098), diabetes (OR, 1.961; 95% CI, 1.078-3.571), and old age (OR, 1.479; 95% CI, 1.034-2.116). The in-hospital mortality rate was 53.3% for patients requiring dialysis, 19.6% for all ARF patients and 0.8% for patients without ARF (p<0.001). The 3-year cumulative mortality rate was 38.4 in all ARF patients and 5.2% in patients without ARF (p<0.001). Conclusion : ARF was not an uncommon complication in adults who underwent OPCAB. Perioperative hemodynamic instability, preoperative renal dysfunction, diabetes, and age could independently predict the development of ARF after OPCAB and the severity of ARF was related to higher in-hospital and long-term mortality rates.

고추장 이야기 - 순창고추장은 언제부터 유명했는가? -

정경란,장대자,양혜정,권대영,Jeong, Gyeong-Ran,Jang, Dae-Ja,Yang, Hye-Jeong,Gwon, Dae-Yeong 한국식품연구원 2009 한맛한얼 Vol.2 No.3

전통.대륙.나라 - 고추는 과연 임진왜란 때 일본으로부터 들어 왔는가?

정경란,장대자,양혜정,권대영,Jeong, Gyeong-Ran,Jang, Dae-Ja,Yang, Hye-Jeong,Gwon, Dae-Yeong 한국식품연구원 2008 한맛한얼 Vol.1 No.3

오래전부터 한국 고추의 전래에 대해 많은 관심을 갖고 있었으나 임진왜란 때 일본을 통해 서양의 고추가 담배와 함께 우리나라에 전래되었다는 설이 통설로 굳어지는 상황에 대해서는 소수의 몇 명만이 아닌 일반적인 다수의 사람들도 보다 정확한 사실을 알아야 한다는 매우 안타까운 생각이 들었다. 왜냐하면 우리가 알고 있는 일본에서의 유래설에 대해 꼭 옳다고는 할 수 없는 여러 반증이 곳곳에서 발견되고 있기 때문이다. 따라서 우리는 우리나라 한국의 고추가 일본에서 들어왔다고 주장하는 근거에 대해 분석하고 또한 이에 대한 반증을 제시함으로써 고추의 일본 전래설에 대해 강한 의문을 제기하고자 한다. 그리고 이번 기회를 통해 그동안 고추에 대해 임진왜란 때 일본을 통한 남방 전래설과 그 이전에 고추가 만주, 요동 등 북방으로 전래되어 이미 재배해오고 있었고 김치, 고추장 제조에 사용되었다는 북방 전래설에 대한 문제제기를 함과 동시에 고추 전래설에 대하여 적어도 균형감각을 갖도록 하고자 이 글을 쓰기로 한다.