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Kyeong Seop Kim,Tae Ha Kim,Mi Ae Kim,Jae Won Kim,Han Kyu Lim,Jung Sick Lee,Young Chang Sohn 한국발생생물학회 2017 한국발생생물학회 학술발표대회 Vol.2017 No.8
Gonadotropin-releasing hormone (GnRH) is a key neuropeptide regulating reproduction in humans and other vertebrates. Here, we evaluated the reproductive control system mediated by GnRH in the Pacific abalone Haliotis discus hannai. We cloned a prepro-GnRH cDNA (Hdh-GnRH) from the pleural-pedal ganglion (PPG) in H. discus hannai, and analyzed its spatiotemporal gene expression pattern. The open reading frame of Hdh-GnRH encodes a protein of 101 amino acids, consisting of a signal peptide, a GnRH dodecapeptide, a cleavage site, and a GnRH-associated peptide. This structure and sequence are highly similar to GnRH-like peptides reported for mollusks and other invertebrates. Quantitative polymerase chain reaction demonstrated that Hdh-GnRH mRNA was more strongly expressed in the ganglions (PPG and cerebral ganglion [CG]) than in other tissues (gonads, gills, intestine, hemocytes, muscle, and mantle) in both sexes. In females, the expression levels of Hdh-GnRH mRNA in the PPG and branchial ganglion (BG) were significantly higher at the ripe and partial spent stages than at the early and late active stages. In males, Hdh-GnRH mRNA levels in the BG showed a significant increase in the partial spent stage. Unexpectedly, Hdh-GnRH levels in the CG were not significantly different among the examined stages in both sexes. These results suggest that Hdh-GnRH mRNA expression profiles in the BG and possibly the PPG are tightly correlated with abalone reproductive activities.
Use of inhaler devices in elderly patients with respiratory disease
( Ha Youn Lee ),( Jin Hwa Song ),( Yeonkyung Park ),( Ha-kyeong Won ),( Keun Bum Chung ),( Young Mee Ahn ),( Byoung Jun Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: We aimed to investigate inhaler device handling in elderly patients with respiratory disease. Also, we compared the differences between inhaler devices with respect to misuse and error correction. Methods: Participants were eligible if they were aged ≥65 years, using inhaler for at least 3 months, and received inhaler training previously. Patients were assessed for inhaler technique using standardized checklists at first and 90 day follow-up visit after face-to-face retraining. We compared five different types of inhalers. The primary outcome was the differences of adequate use ratio between inhaler devices. Secondary outcomes included comparison of error correction after training, patient satisfaction on each device and most common step of misuse. Results: A total of 256 patients (mean age 76.43±6.13, male 93.4%) were included and the handling of 320 devices (MDI, 75; DPI, 199; Respimat®, 46) was assessed in the study. All have been trained in the past, but only 24.7% of them use it correctly. Appropriate use were respectively 38.7%, 50.0%, 61.4%, 60.8% and 43.2% of inhalation assessment tests with Evohaler® (n=75), Respimat® (n=46), Turbuhaler® (n=44), Ellipta® (n=74), and Breezhaler/Handihaler(n=81) (p=0.026). After retraining, appropriate usage ratio increased and there was no significant difference between inhaler device types (Evohaler® (63.9%), Respimat® (86.1%), Turbuhaler® (74.3%), Ellipta® (64.6%), and Breezhaler/Handihaler (65.3%), respectively; p=0.129). Conclusion: New inhalers were developed, but the accuracy of inhaler use was still low. This study results suggest that repeat training is more important than inhaler type.
Ha, Jeong Su,Jin, Dong Eun,Park, Seon Kyeong,Park, Chang Hyeon,Seung, Tae Wan,Bae, Dong-Won,Kim, Dae-Ok,Heo, Ho Jin Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>The antiamnesic effects of ethyl acetate fraction from <I>Actinidia arguta</I> (EFAA) on trimethyltin- (TMT-) induced memory impairment were investigated to find the possibility of functional food substances. EFAA showed a potent AChE inhibitory effect (IC<SUB>50</SUB> = 53 <I>μ</I>g/mL) and efficient neuroprotection against H<SUB>2</SUB>O<SUB>2</SUB>-induced oxidative stress. The administration of EFAA significantly decreased TMT-induced cognitive deficit in Y-maze, passive avoidance, and Morris water maze (MWM) tests. After the behavioral tests, the antioxidant activities were confirmed using mice brain tissues. EFAA not only showed the inhibition of AChE activity and the decline of malondialdehyde (MDA) level as a sign of lipid peroxidation but also presented the increase of the superoxide dismutase (SOD) level and the decrease of the oxidized glutathione (GSSG)/total glutathione (GSH + GSSG) ratio. Finally, the phenolics in EFAA were identified using liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry, and four main phenolics, such as quinic acid, chlorogenic acid, caffeoyl hexose, and quercetin-3-glucoside, were identified. These results suggest that EFAA containing physiological phenolics might enhance drug-induced amnesia through AChE inhibition and neuroprotection.</P>
S-665 Non-irritating concentration of skin test with commonly prescribed antibiotics in Kore an
( Ha-kyeong Won ),( Min-suk Yang ),( Woo-jung Song ),( Sea-hoon Kim ),( Heung-woo Park ),( Yoon-seok Chang ),( Kyung-up Min ),( Sang-heon Cho ) 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1
Backgrounds: Although the data on validity of skin test with drugs expect for penicillin is still scarce, positive skin reaction at non-irritating concentrations with relevant history is generally accepted for diagnosis of drug allergy. In this study, we investigated the maximal non-irritant drug concentrations for intradermal skin test with commonly prescribed antibiotics in Korean adults. Methods: Sixty one healthy volunteers were recruited. Seventeen parenteral antibiotics including beta-lactams and fluoroquinolones were evaluated. The maximal concentration of antibiotics was investigated by two steps as following; A) Intradermal skin test were repeatedly performed from full strength concentration of each drug and, if the result was positive, then serially diluted concentration till the result was negative in the first volunteer; B) establishing the nonirritating concentration identified in step A in 19 more subjects. All subjects were allowed to participate in multiple testing using different drugs. The established maximal nonirritating concentration for each type of antibiotics from this study were compared with a ‘known nonirritating concentration’ of each drug from the previous studies. Results: The mean age of the subjects is 35.0 and there were more females (77%) than males. The maximal nonirritating concentrations for ampicillin/sulbactam, aztreonam, ciprofloxacin, clindamycin, nafcillin and penicillin G from this study were comparable with the known nonirritating concentration of each agent. The maximal nonirritating concentrations of cephalosporins except for ceftriaxone were different from those from previous studies. In addition, the discrepancy between previous known concentrations and the values from this study was 10-fold and more for azithromycin, levofloxacin, meropenem, piperacillin/tazobactam, SMT/TMP, and vancomycin. The difference in nonirritating concentration among volunteers were greater than 100 fold for cefotetan, azithromycin, and vancomycin. Conclusions: To improve the reliability of skin test, study with the numerous subjects would be necessary to standardize non-irritating drug concentration for skin test.
Ha-Kyeong Won,Ji-Hyang Lee,Jin An,손경희,Min-Gyu Kang,Sung-Yoon Kang,Alyn H. Morice,조상헌,송우정 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.6
Purpose: Chronic cough is a prevalent condition in the community and may pose considerable impairment to quality of life (QoL). However, its disease burden remains largely undefined in the general population. The present study investigated the relationship between chronic cough and health-related QoL in a Korean nationwide population database, with an emphasis on clinical conditions which may confound the impact of cough. Methods: This study analyzed cross-sectional datasets of adults (aged ≥ 40 years) in the Korean National Health and Nutrition Examination Survey 2010–2016. Health-related QoL was assessed using the 3-level EuroQoL 5-dimension component (EQ-5D-3L) index score. The presence of chronic cough and other conditions were defined using structured questionnaires. Results: The prevalence of chronic cough was 3.48% ± 0.17% among adults aged ≥ 40 years. The overall EQ-5D-3L index score was significantly lower in subjects with than without chronic cough (0.79 ± 0.01 vs. 0.86 ± 0.00, P < 0.001). In subgroup analyses by age and sex, chronic cough had a notably large impact on QoL in women aged ≥ 65 years (vs. those without chronic cough: 0.55 ± 0.04 vs. 0.70 ± 0.01, P < 0.001), although the mean difference in the scores exceeded the minimally important difference score of 0.05 in all subgroups. In multivariate analyses, chronic cough was significantly associated with QoL, independent of confounders including depression, arthritis, asthma, and chronic obstructive pulmonary disease. In dimension analyses, chronic cough was more associated with anxiety/depression, pain/discomfort, and usual activities than with self-care or mobility in the EQ-5D. Conclusions: The present study demonstrated significant associations between chronic cough and health-related QoL in a nationwide large general adult population aged ≥ 40 years, which were independent of clinical confounders. The impact of chronic cough was greater in women aged ≥ 65 years. These findings indicate a considerable burden of chronic cough in the general population and warrant further investigations to assess the disease burden of chronic cough in a global scale.
( Kyeong Ok Kim ),( Kyu Chan Huh ),( Sung Pil Hong ),( Won Hee Kim ),( Hyuk Yoon ),( Sang Wook Kim ),( Yeon Soo Kim ),( Jong Ha Park ),( Jun Lee ),( Bum Jae Lee ),( Young Sook Park ) 대한간학회 2018 Gut and Liver Vol.12 No.5
Background/Aims: The aims of the present study were to determine the frequency of interval colorectal cancers (CRCs) after surveillance colonoscopy and to compare the clinicopathologic features and survival outcomes with those of noninterval CRCs. Methods: From January 2003 to December 2013, 66,016 follow-up colonoscopies for 38,412 patients performed within recommended time were reviewed retrospectively based on data from 11 tertiary hospitals in South Korea. To compare clinicopathologic features and survival rates for interval CRC, 106 patients with non-interval CRC matched in age and gender were included. Results: Among the 66,016 colonoscopies performed within the surveillance period, 63 cases (63/66,016) of interval CRC were detected, and 53 were finally included in the analysis. The mean age was 69.9±8.8 years, and the male to female ratio was 1.94:1. Although the occurrence rate of cancer in the right side colon was higher than that of non-interval CRC, interval CRCs were predominantly left sided. Other clinicopathologic features and overall survival were not significantly different between the two groups. Missed lesion was suspected to be the most common cause (29 cases, 54.7%). Conclusions: The frequency of interval CRC among patients who had undergone a surveillance colonoscopy was 0.095%. While sharing some similar clinical features and survival outcomes, interval CRCs in Korea developed more often in males and on the left side in contrast to results from Western studies. (Gut Liver 2018;12:537-543)