단상 멀티레벨 능동전력필터를 위한 고조파 검지 기법 비교

김윤호(Yoon-Ho Kim),김수홍(Soo-Hong Kim),김성민(Sung-Min Kim),서강문(Kang-Moon Seo) 전력전자학회 2005 전력전자학술대회 논문집 Vol.- No.-

In this paper, harmonic detecting methods for the active power application are investigated. They are RDFT, Kalman Filter, Adaptive predictive filter, Instantaneous reactive power detecting method, Improved adaptive filter detecting method. The 5 harmonic detecting methods are simulated and their characteristics for the active filter application are compared using simulation results.

The Results of Curative Radiotherapy for Carcinoma of Uterine Cervix

Ryu, Ryeong,Chang, Gee Young,Namkong, Sung Eun,Bahk, Yong Whee,Shinn, Kyung Sub,Kim, Seung Jo,Suh, Tae Suk,Yoon, Sei Chul,Kang, Ki Mun CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2

One-hundred five patients with invasive carcinoma of the uterine cervix treated with curative radiotherapy from March 1983 through October 1989 at the Department of Therapeutic Radiology, Kang-Nam St. Mary's Hospital. Among them, 78 patients received radiotherapy alone and 42 patients treated with neoadjuvant chemotherapy followed by radiotherapy and 15 patients were lost to follow up. All patients had follow up from 2 to 106 months (median; 62 months). Age of the patients ranged from 32 to 79 years at presentation (median; 59 years). The overall 5-year survival rates was 50.8%, and the 5-year survival rates by stage ⅠB, ⅡA, ⅡB, ⅢA, ⅢB, ⅣA was 47.7%, 70.2%, 64.1%, 40.0%, 23.1%, 14.3%, respectively. The 5-year survival rates was noted 51.2% of radiotherapy alone and 50.4% of neoadjuvant chemotherapy followed by radiotherapy. The overall failure rate was 18.3% (22/120) including 11.7% (14/120) locoregional failure, 5.8% (7/120) distant metastasis and 0.8% (1/120) locoregional failure with distant metastasis. Treatment failure rates by the stages were 15% (3/20) in stage ⅠB, 10.5% (2/19) in stage ⅡA, 10.2% (5/49) in stage ⅡB, 20% (1/5) for stage ⅢA, 61.5% (8/13) in stage ⅢB, and 28.6% (4/14) in stage ⅣA. The overall complication rate was 34.2% (41/120), including wet desquamation 7.5% (9/120), diarrhea 6.7% (8/120), radiation proctitis 5.8% (7/120) in decreasing order. A multivariate analysis of factors influencing the survival showed patient age (P=0.0291), FIGO stage (P=0.0001), Karnofsky performance status (P=0.0043), initial hemoglobin level (P=0.0001), and intracavitary radiation (P=0.0004), but, no significancy in histology (P=0.29) and teatment method (P=0.87).

The Results of Curative Radiotherapy for Carcinoma of Uterine cervix

강기문,유미령,장지영,서태석,윤세철,박용휘,신경섭,남궁성은,김승조,Kang Ki Mun,Ryu Mi Ryeong,Chang Gee Young,Suh Tae Suk,Yoon Sei Chul,Bahk Yong Whee,Shinn Kyung Sub,Namkoong Sung Eun,Kim Seung Jo The Korean Society for Radiation Oncology 1993 대한방사선종양학회지 Vol.11 No.1

This is a retrospective analysis of 135 patients with invasive carcinoma of the uterine cervix treated with curative radiotherapy from March 1983 through October 1989 at the Department of Therapeutic Radiology, Kang-Nam 51. Mary's Hospital. Among them, 78 patients received radiotherapy alone and 42 patients treated with neoadjuvant chemotherapy followed by radiotherapy and 15 patients were lost to follow up. All patients had follow up from 2 to 106 months (median; 62 months). Age of the patients ranged from 32 to 79 years at presentation (median; 59 years). According to FIGO classification, there were 20 ($16.7{\%}$) in stage IB, 19 ($15.8{\%}$) in stage IIA,49 ($40.8{\%}$) in stage IIB, 5 ($4.2{\%}$) in stage IIIA, 13 ($10.8{\%}$,) in stage IIIB,14 ($11.7{\%}$) in stage IVA. The pathological classification showed 96 ($80.0{\%}$) squamous cell carcinomas, 5 ($4.2{\%}$) adenocarcinomas and 19 ($15.8{\%}$) proven by cytology. The overall 5-year survival rates was $50.8{\%}$, and the 5-year survival rates by stage IB, IIA, IIB, IIIA, IIIB, IVA was $47.7{\%},\;70.2{\%},\;64.1{\%},\;40.0{\%},\;23.1{\%},\;14.3{\%}$, respectively. The 5-year survival rates was noted $51.2{\%}$ of radiotherapy alone and $50.4{\%}$of neoadjuvant chemotherapy followed by radiotherapy. The overall failure rate was $18.3{\%}$(22/120) including $11.7{\%}$ (14/120) locoregional failure, $5.8{\%}$ (7/120) distant metastasis and $0.8{\%}$(1/120) locoregional failure with distant metastasis. Treatment failure rates by the stages were $15{\%}$ (3/20) in stage IB. $10.5{\%}$ (2/19) in stage IIA, $10.2{\%}$, (5/49) in stage IIB, $20{\%}$ (1/5) in stage IIIA, $61.5{\%}$(8/13) in stage IIB, and $28.6{\%}$ (4/14) in stage IVA. The overall complication rate was $34.2{\%}$(41/120) including wet desquamation $7.5{\%}$, (9/120), diarrhea $6.7{\%}(8/120), radiation proctitis $5.8{\%}$(7/120) in decreasing order. A multivariate analysis of factors influencing the survival showed patient age (p < 0.0291), FIGO stage (p<0.0001), Karnofsky performance status (p<0.0043), initial hemoglobin level (p<0.0001), and intracavitary radiation (p<0.0004), but, no significancy in histology (p<0.29) and treatment method (p < 0.87).

Docetaxel-loaded RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated liposomes: Drug release, cytotoxicity, and antitumor efficacy

Yoon, Ho Yub,Kwak, Seong Shin,Jang, Moon Ho,Kang, Min Hyung,Sung, Si Woo,Kim, Chang Hyun,Kim, Sung Rae,Yeom, Dong Woo,Kang, Myung Joo,Choi, Young Wook Elsevier 2017 International journal of pharmaceutics Vol.523 No.1

<P><B>Abstract</B></P> <P>We previously synthesized the RIPL peptide (IPLVVPLRRRRRRRRC) to facilitate selective delivery into hepsin-expressing cancer cells and showed that RIPL peptide-conjugated liposomes (RIPL-L) enhanced the intracellular delivery of fluorescent probes <I>in vitro</I>. In this study, docetaxel-loaded RIPL-L (DTX-RIPL-L) were prepared and evaluated for <I>in vitro</I> drug release, cytotoxicity, and <I>in vivo</I> antitumor efficacy. DTX was successfully encapsulated by pre-loading, with an average encapsulation efficiency and drug loading capacity of 32.4% and 21.39±2.05 (μg/mg), respectively. A DTX release study using dialysis showed a biphasic release pattern, i.e., rapid release for 6h, followed by sustained release up to 72h. The first-order equation provided the best fit for drug release (r<SUP>2</SUP> =0.9349). <I>In vitro</I> cytotoxicity was dose-dependent, resulting in IC<SUB>50</SUB> values of 36.10 (SK-OV-3) and 48.62ng/mL (MCF-7) for hepsin-positive, and 61.12 (DU145) and 53.04ng/mL (PC-3) for hepsin-negative cell lines. Live/dead cell imaging was carried out to visualize the proportion of viable and nonviable SK-OV-3 cells. Compared to DTX solution, DTX-RIPL-L significantly inhibited tumor growth and prolonged survival time in BALB/c nude mice with SK-OV-3 cell tumors. We suggest that DTX-RIPL-L is a good candidate for efficient drug targeting to hepsin-expressing cancer cells.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Dynamic spillover effects among crude oil, precious metal, and agricultural commodity futures markets

Kang, Sang Hoon,McIver, Ron,Yoon, Seong-Min Elsevier 2017 ENERGY ECONOMICS Vol.62 No.-

<P><B>Abstract</B></P> <P>This paper examines spillover effects among six commodity futures markets – gold, silver, West Texas Intermediate crude oil, corn, wheat, and rice – by employing the multivariate DECO-GARCH model and the spillover index. Specifically, we investigate the dynamics of return and volatility spillover indices to reveal the intensity and direction of transmission during the recent global financial and European sovereign debt crises. Our empirical results are as follows. First, we estimate a positive equicorrelation between commodity futures market returns and find that it increased sharply during the crises. This effect can persist during periods of economic and financial turmoil, diminishing the benefits of international portfolio diversification for investors. Second, we identify bidirectional return and volatility spillovers across commodity futures markets, and find more pronounced trends in their levels in the post-crisis period. This indicates the strong impact of spillovers during crisis periods. Third, both gold and silver are information transmitters to other commodity futures markets, while the remaining four commodity futures investigated were receivers of spillovers during recent periods of financial stress. Finally, we analyse the optimal portfolio weights and time-varying hedge ratios between metal and other commodities futures markets. Overall, our findings provide new insights into channels of information transmission, which may improve investment decisions and inform portfolio investors' trading strategies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We investigate return and volatility spillover effects among six commodity futures. </LI> <LI> We examine the intensity and direction of information transmission. </LI> <LI> We employ both the multivariate DECO-GARCH model and spillover index. </LI> <LI> Spillover effects are particularly intensified during recent financial crises. </LI> <LI> We evaluate and compare optimal portfolio weights and time-varying hedge ratios. </LI> </UL> </P>

Gerstmann Syndrome as a Disconnection Syndrome: A Single Case Diffusion Tensor Imaging Study

Yoon Soo Hoon,Lee Jae Ik,Kang Mun Jeong,Lee Hae In,Pyun Sung-Bom 대한뇌신경재활학회 2023 뇌신경재활 Vol.16 No.1

Gerstmann syndrome (GS) is a rare syndrome that occurs when there is a lesion of the dominant inferior parietal lobule (IPL), causing agraphia, acalculia, finger agnosia, and right-left disorientation. A 49-year-old right-handed male was diagnosed as GS after left parieto-occipital lobe hemorrhage. The patient showed mild anomic aphasia with agraphia in the language test and the neuropsychological test revealed acalculia, impaired right- left discrimination, and finger agnosia. In diffusion tensor tractography, the tracts of left superior longitudinal fasciculus (SLF), middle longitudinal fasciculus, U-fibers and posterior corpus callosum (CC) were disrupted around the left IPL. In addition, fractional anisotropy (FA) values were markedly decreased in left SLF, and posterior CC when compared to twelve healthy control subjects. Our clinical and neuroimaging findings support that GS is a disconnection syndrome caused by lesion in the white matter pathway surrounding IPL. In future, more studies of the correlation between the white matter disconnection and the development of GS including high quality imaging technique are needed

Noncancer-Related Health Events and Mortality in Head and Neck Cancer Patients After Definitive Radiotherapy : A Prospective Study

Kang, Ho-Seob,Roh, Jong-Lyel,Lee, Sang-wook,Kim, Sung-Bae,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon Williams & Wilkins Co 2016 Medicine Vol.95 No.19

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The survival of patients with head and neck squamous cell carcinoma (HNSCC) can be affected not only by progression of the original cancer or occurrence of a second cancer but also by noncancer health event (NCHE). In this study, we evaluated the prognostic significance of early NCHEs in HNSCC patients after definitive radiotherapy (RT) or chemoradiotherapy (CRT).</P><P>The prospective study cohort comprised 190 HNSCC patients who underwent definitive RT (n = 75) or CRT (n = 115). An early NCHE was defined as an event requiring hospital readmission of the patient within 12 months after treatment. Univariate and multivariate analyses were performed to identify clinicopathologic factors associated with early NCHEs, and competing and all-cause mortalities.</P><P>Thirty-three patients suffered an NCHE (17.3%) and 8 succumbed to a competing cause of mortality (4.2%). Twenty-two (11.6%) patients had an early NCHE: respiratory (22.8%), cerebrovascular (13.7%), gastrointestinal (13.7%), and others (50.0%). In multivariate analysis, hypoalbuminemia (<I>P</I> = 0.022, hazard ratio [HR] = 3.66, 95% confidence interval [CI] = 1.21–11.1), chemotherapy (<I>P</I> = 0.047, HR = 3.02, 95% CI = 1.01–8.98), and tumor recurrence (<I>P</I> = 0.024, HR = 2.66, 95% CI = 1.14–6.22) were independent predictors of an early NCHE. Patients with early NCHEs were at high risk of competing mortality (<I>P</I> < 0.001, HR = 22.6, 95% CI = 4.21–121.00) and all-cause mortality (<I>P</I> = 0.002, HR = 4.44, 95% CI = 1.76–11.2).</P><P>Early NCHEs are a major contributor to competing and all-cause mortality in HNSCC patients receiving RT or CRT. The risk factors identified could be used to predict early NCHEs.</P></▼2>

Performance of a Novel CT-Derived Fractional Flow Reserve Measurement to Detect Hemodynamically Significant Coronary Stenosis

Kang Si-Hyuck,Kim Soo-Hyun,Kim Sun-Hwa,Chun Eun Ju,Chung Woo-Young,Yoon Chang-Hwan,Park Sang-Don,Nam Chang-Wook,Kwon Ki-Hwan,Doh Joon-Hyung,Byun Young-Sup,Bae Jang-Whan,Youn Tae-Jin,Chae In-Ho 대한의학회 2023 Journal of Korean medical science Vol.38 No.32

Background: Fractional flow reserve (FFR) based on computed tomography (CT) has been shown to better identify ischemia-causing coronary stenosis. However, this current technology requires high computational power, which inhibits its widespread implementation in clinical practice. This prospective, multicenter study aimed at validating the diagnostic performance of a novel simple CT based fractional flow reserve (CT-FFR) calculation method in patients with coronary artery disease. Methods: Patients who underwent coronary CT angiography (CCTA) within 90 days and invasive coronary angiography (ICA) were prospectively enrolled. A hemodynamically significant lesion was defined as an FFR ≤ 0.80, and the area under the receiver operating characteristic curve (AUC) was the primary measure. After the planned analysis for the initial algorithm A, we performed another set of exploratory analyses for an improved algorithm B. Results: Of 184 patients who agreed to participate in the study, 151 were finally analyzed. Hemodynamically significant lesions were observed in 79 patients (52.3%). The AUC was 0.71 (95% confidence interval [CI], 0.63–0.80) for CCTA, 0.65 (95% CI, 0.56–0.74) for CT-FFR algorithm A (P = 0.866), and 0.78 (95% CI, 0.70–0.86) for algorithm B (P = 0.112). Diagnostic accuracy was 0.63 (0.55–0.71) for CCTA alone, 0.66 (0.58–0.74) for algorithm A, and 0.76 (0.68–0.82) for algorithm B. Conclusion: This study suggests the feasibility of automated CT-FFR, which can be performed on-site within several hours. However, the diagnostic performance of the current algorithm does not meet the a priori criteria for superiority. Future research is required to improve the accuracy.

Financial crises and dynamic spillovers among Chinese stock and commodity futures markets

Kang, Sang Hoon,Yoon, Seong-Min Elsevier 2019 PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIO Vol.531 No.-

<P><B>Abstract</B></P> <P>This study examines the dynamics of return and volatility spillover across Chinese stock and four commodity futures, namely, CSI 300 index, aluminium, copper, fuel oil, and natural rubber, by employing both the multivariate DECO-GARCH model and the spillover index model. In particular, we investigate the dynamics of return and volatility spillover indices that reveal the intensity and direction of transmission during the recent financial crises, that is, the 2008–2009 global financial crisis and the 2010–2012 European debt crisis. From our empirical results, we find a positive equicorrelation level which sharply bursts during the recent financial crises. This effect can be particularly persistent during periods of turmoil, which diminishes the benefits of international portfolio diversification for investors. We also find the bi-directional return and volatility spillover indexes across Chinese stock and commodity future markets. These trends are more pronounced in the aftermath of the recent financial crises, indicating the strength of spillovers during periods of turmoil. Finally, we show evidence asserting that stock nexus commodity futures portfolio offers better but different diversification benefits and hedging effectiveness for the Chinese stock market. Overall, our findings shed new light for understanding the channels of information transmission, which can be useful in determining superior investment decisions and creating trading strategies for portfolio investors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Return and volatility spillovers among stock and commodity futures markets are examined. </LI> <LI> Four Shanghai commodity futures; aluminium, copper, fuel oil, and natural rubber. </LI> <LI> Multivariate DECO-GARCH model and directional spillover index are used. </LI> <LI> Positive equicorrelation is found, which sharply bursts during the financial crises. </LI> <LI> The bi-directional return and volatility spillover indexes are found. </LI> </UL> </P>

Validation of the Korean Version of the 15-Item Community Assessment of Psychic Experiences in a College Population

Sung-Wan Kim,Jae-Kyeong Kim,Ji Hun Han,Min Jhon,Ju-Wan Kim,Ju-Yeon Lee,Jae-Min Kim,Hyun Ju Na,Young-Shin Kang,Young-Chul Chung,Jin-Sang Yoon 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.4

Objective To investigate the reliability and validity of the Korean version of the Community Assessment of Psychic Experiences-15 item positive scale (CAPE-15) in college students. Methods This study had two stages: initial screening with self-report questionnaires including the CAPE-15, and semi-structured interviews to investigate the instrument’s diagnostic validity. The initial screening involved 1,749 college students. The modified Korean version of Prodromal Questionnaire-16 item (mKPQ-16) was also administered. The criteria for ultra-high risk (UHR) of psychosis in the Comprehensive Assessment of At-Risk Mental States (CAARMS) were the gold standard for diagnosis. Results Twelve of the interviewed subjects met the CAARMS criteria for UHR of psychosis. The area under the receiver operating characteristic curve was highest (0.936) for the CAPE-15 distress score (p<0.001). The use of 6 as the cutoff for the CAPE-15 distress score resulted in the best balance of sensitivity (91.7%) and specificity (85.2%), with a favorable positive predictive value of 32.4%. The coefficients of correlation between the CAPE-15 and mKPQ-16 were significant. Conclusion The Korean version of the CAPE-15 is a good instrument for screening for psychosis risk in collegiate settings. The validation of this scale could contribute to the early identification of psychosis in the Korean community.