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Lee Jung Su,Lee Jeong Hoon,Kim Jinyoung,Na Hee Kyong,Ahn Ji Yong,Jung Kee Wook,Kim Do Hoon,Choi Kee Don,Song Ho June,Lee Gin Hyug,Jung Hwoon-Yong 대한의학회 2021 Journal of Korean medical science Vol.36 No.14
Background: Endoscopic surveillance after total gastrectomy (TG) for gastric cancer is routinely performed to detect tumor recurrence and postoperative adverse events. However, the reports on the clinical benefits of endoscopic surveillance are ambiguous. We investigated the clinical benefit of endoscopic surveillance after TG for gastric cancer. Methods: We analyzed 848 patients who underwent TG with R0 resection for gastric cancer between 2011 and 2012 (380 early gastric cancer and 468 advanced gastric cancer) and underwent regular postoperative surveillance with endoscopy and abdominopelvic computed tomography (CT) with contrast. Results: Median follow-up periods were 58 months for both endoscopy (range, 3–96) and abdominopelvic CT (range, 1–96). Tumor recurrence occurred in 167 patients (19.7%), of whom seven (4.2%) were locoregional recurrences in the peri-anastomotic area (n = 5) or regional gastric lymph nodes (n = 2). Whereas the peri-anastomotic recurrences were detected by both endoscopy and abdominopelvic CT, regional lymph node recurrences were only detected by abdominopelvic CT. Out of the 23 events of postoperative adverse events, the majority (87%) were detected by radiologic examinations; three events of benign strictures in the anastomotic site were detected only by endoscopy. Conclusion: Endoscopic surveillance did not have a significant role in detecting locoregional tumor recurrence and postoperative adverse events after TG with R0 resection for gastric cancer. Routine endoscopic surveillance after TG may be considered optional and performed according to the capacities of each clinical setting.
Efficacy of a Three-Dimensional-Printed Training Simulator for Endoscopic Biopsy in the Stomach
Sunpyo Lee,Ji Yong Ahn,Minkyu Han,Gin Hyug Lee,나희경,Kee Wook Jung,Jeong Hoon Lee,Do Hoon Kim,Kee Don Choi,Ho June Song,Hwoon-Yong Jung 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2
Background/Aims: We used three-dimensional (3D) printing technology to create a new biopsy simulator for the stomach and investigated its efficacy and realism in endoscopic biopsy training. Methods: A novel stomach biopsy simulator, with 10 biopsy sites, was produced using a 3D printer. We enrolled 26 participants, including 10 residents, six first-year fellows, five second-year fellows, and five faculty members. We recorded and reviewed five training sessions and evaluated the simulator with questionnaires using a 7-point Likert scale. Results: The mean completion time (seconds) was 244.8±11.5 for the residents, 107.9±33.4 for the first-year fellows, 106.8±20.1 for the second-year fellows, and 103.8±19.2 for the faculty members. The completion time became shorter with repetition and was significantly lower for residents by the fifth trial (first trial, 347.0±159.5; fifth trial, 169.6±57.7; p=0.007). The faculty members strongly agreed that the simulator realistically reflected endoscopic handling and was reasonable for endoscopic training (scores of 6.2±0.8 and 6.4±0.9, respectively). Importantly, experienced endoscopists reported that the difficulty levels of the 10 biopsy sites in the simulator were a realistic match for the actual stomach. Conclusions: This endoscopic biopsy simulator created using a 3D printer is a realistic and useful method to improve the biopsy skills of trainee endoscopists.
한국인 크론병 환자에서 NOD2 유전자 돌연변이의 빈도분석
이진혁 ( Gin Hyug Lee ),김찬규 ( Chan Gyoo Kim ),김주성 ( Joo Sung Kim ),정현채 ( Hyun Chae Jung ),송인성 ( In Sung Song ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.3
Background/Aims: Several studies from Western populations have recently shown that three mutations in NOD2 gene (C2104T, G2722C, and 3020insC) are associated with susceptibility to Crohn`s disease (CD). However, three mutations were shown not to be associ
( Jin Seo Lee ),( Ji Yong Ahn ),( Jeong Hoon Lee ),( Do Hoon Kim ),( Kee Don Choi ),( Ho June Song ),( Yong Hee Kim ),( Gin Hyug Lee ),( Hwoon Yong Jung ),( Jin Sook Ryu ),( Sung Bae Kim ),( Jong Hoon 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: To evaluate clinical features and treatment outcome of patients with synchronous second primary cancers (SPC) detected at the initial staging of squamous esophageal cancer (EC). Methods: We identifi ed a total of 317 consecutive patients diagnosed with squamous EC. Relevant clinical and cancer-specifi c information were reviewed retrospectively. Results: EC patients with synchronous SPC were identified in 21 patients (6.6%). There were signifi cant differences in median age (70 vs. 63 years; p=0.01) and body mass index (20.4 vs. 22.8 kg/m²; p=0.01) between EC patients with and without SPC. Head and neck, lung and gastric cancers accounted for 18.2%, 22.7% and 18.2% of SPC, respectively. Positron emission tomography-computed tomography (PET-CT) detected 4 cases (18.2%) of SPC that were missed on CT. Management plans were altered in 13 of 21 patients (61.9%) with detected SPC. Curative esophagectomy was attempted in 28.6% of EC patients with SPC (vs. 59.1% of patients without SPC; p=0.006). EC patients with SPC demonstrated signifi cantly lower 5-year survival than patients without SPC (10.6% vs. 36.7%; p=0.008). Conclusions: Synchronous second primary cancers (SPC) were found in 6.6% of squamous EC patients and gastric cancer was one of the most common SPC. EC patients with SPC were older with a signifi cantly lower body mass index than patients without SPC. PET-CT contributed substantially to the detection of synchronous SPC. EC patients with SPC demonstrated dismal survival because of the diffi culties of stage-appropriate treatment.
Ji Wan Lee,Charles J. Cho,Do Hoon Kim,Ji Yong Ahn,Jeong Hoon Lee,Kee Don Choi,Ho June Song,Sook Ryun Park,Hyun Joo Lee,Hyun Joo Lee,Gin Hyug Lee,Hwoon-Yong Jung,Sung-Bae Kim,Jong Hoon Kim,Seung-Il Par 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.5
Background/Aims: To report the long-term survival and tumor recurrence outcomes in patients with superficial esophageal cancer(SEC) after complete non-curative endoscopic resection (ER). Methods: We retrieved ER data for 24 patients with non-curatively resected SEC. Non-curative resection was defined as the presence ofsubmucosal and/or lymphovascular invasion on ER pathology. Relevant clinical and tumor-specific parameters were reviewed. Results: The mean age of the 24 study patients was 66.3±8.3 years. Ten patients were closely followed up without treatment, while14 received additional treatment. During a mean follow-up of 59.0±33.2 months, the 3- and 5-year survival rates of all cases were90.7% and 77.6%, respectively. The 5-year overall survival rates were 72.9% in the close observation group and 82.1% in the additionaltreatment group (p=0.958). The 5-year cumulative incidences of all cases of recurrence (25.0% vs. 43.3%, p=0.388), primary ECrecurrence (10.0% vs. 16.4%, p=0.558), and metachronous EC recurrence (16.7% vs. 26.7%, p=0.667) were similar between the twogroups. Conclusions: Patients with non-curatively resected SEC showed good long-term survival outcomes. Given the similar oncologicoutcomes, close observation may be an option with appropriate caution taken for patients who are medically unfit to receive additionaltherapy
Dong Seok Lee,Gin Hyug Lee,Sang Gyun Kim,Kook Lae Lee,Ji Won Kim,Ji Bong Jeong,Yong Jin Jung,Hyoun Woo Kang 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5
Background/Aims: We developed a new endoscopic submucosal dissection (ESD) simulator and evaluated its efficacy and realism foruse training endoscopists. Methods: An ESD simulator was constructed using polyvinyl alcohol hydrogel sheets and compared to a previous ESD simulator. BetweenMarch 1, 2020, and December 30, 2021, eight expert endoscopists from three different centers analyzed the procedure-relatedfactors of the simulator. Five trainees performed gastric ESD exercises under the guidance of these experts. Results: Although the two ESD simulators provided overall favorable outcomes in terms of ESD-related factors, the new simulator hadseveral benefits, including better marking of the target lesion’s limits (p<0.001) and overall handling (p<0.001). Trainees tested the usefulnessof the new ESD simulator. The complete resection rate improved after 3 ESD training sessions (9 procedures), and the perforationrate decreased after 4 sessions (12 procedures). Conclusions: We have developed a new ESD simulator that can help beginners achieve a high level of technical experience before performingreal-time ESD procedures in patients.
십이지장 궤양 발생과 Helicobacter pylori 균주의 cagA, vacA 및 iceA 유전자형과의 상관관계
이경아 ( Kyung A Lee ),명승재 ( Seung Jae Myung ),홍성수 ( Seong Soo Hong ),김진호 ( Jin Ho Kim ),조윤경 ( Yoon Kyung Cho ),정훈용 ( Hwoon Yong Jung ),이진혁 ( Gin Hyug Lee ),이윤정 ( Yun Jung Lee ),변정식 ( Jeong Sik Byeon ),양 대한내과학회 2005 대한내과학회지 Vol.69 No.3
Background: The aims of this study were to evaluate whether genotypes of Helicobacter pylori are different between the gastric antrum and duodenal bulb in order to assess the roles of duodenal H. pylori strains in development of duodenal ulcer. Methods: Forty-eight H. pylori infected patients (duodenal ulcer 28, chronic gastritis 20) were included for the study. Biopsy specimens were taken separately from the antrum and duodenal bulb for the histologic examination and H. pylori culture. cagA, vacA, and iceA genotypes of H. pylori were examined by polymerase chain reaction and H. pylori DNA subtypes by random amplified polymorphic DNA (RAPD) fingerprinting. Results: H. pylori genotypes were not significantly different between antrum and duodenal bulb of the duodenal ulcer and chronic gastritis. RAPD fingerprinting showed different H. pylori strains between the gastric antrum and duodenal bulb in 2 patients with duodenal ulcer. Most prevalent genotype was cagA+ vacA s1/m1 iceA1 in duodenal ulcer (15/16). Conclusion: The host factor or other genotypes may play the major roles in duodenal ulcerogenesis compared with H. pylori genotype itself. (Korean J Med 69:264-273, 2005)
23 오심 및 구토의 발생으로 Azathioprine투여를 중단했던 크론병 환자에서 6-Mercaptopurine의 사용
이현주 ( Hyun Ju Lee ),양석균 ( Suk Kyun Yang ),명승재 ( Seung Jae Myung ),이장교 ( Chang Gyo Lee ),김태훈 ( Tae Hun Kim ),이진혁 ( Gin Hyug Lee ),정훈용 ( Hwoon Yong Jung ),홍원선 ( Weon Seon Hong ),김진호 ( Jin Ho Kim ),민영일 ( 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-
( Ji Yong Ahn ),( Jin Seo Lee ),( Gin Hyug Lee ),( Ji Wan Lee ),( Hee Kyong Na ),( Kee Wook Jung ),( Jeong Hoon Lee ),( Do Hoon Kim ),( Kee Don Choi ),( Ho June Song ),( Hwoon-yong Jung ),( Jin-ho Kim 대한간학회 2016 Gut and Liver Vol.10 No.5
Background/Aims: We developed a new endoscopic biopsy training simulator and determined its efficacy for improving the endoscopic biopsy skills of beginners. Methods: This biopsy simulator, which presents seven biopsy sites, was constructed using readily available materials. We enrolled 40 participants: 14 residents, 11 first-year clinical fellows, 10 second-year clinical fellows, and five staff members. We recorded the simulation completion time for all participants, and then simulator performance was assessed via a questionnaire using the 7-point Likert scale. Results: The mean times for completing the five trials were 417.7±138.8, 145.2±31.5, 112.7±21.9, and 90.5±20.0 seconds for the residents, first-year clinical fellows, second-year clinical fellows, and staff members, respectively. Endoscopists with less experience reported that they found this simulator more useful for improving their biopsy technique (6.8±0.4 in the resident group and 5.7±1.0 in the first-year clinical fellow group). The realism score of the simulator for endoscopic handling was 6.4±0.5 in the staff group. Conclusions: This new, easy-to-manufacture endoscopic biopsy simulator is useful for biopsy training for beginner endoscopists and shows good efficacy and realism. (Gut Liver 2016;10:764-772)
이진혁 대한소화기학회 2004 대한소화기학회지 Vol.43 No.6
이 연구는 Helicobacter pylori CagA (cytotoxinassociatedgene A)의 다양성과 임상 양상 사이의 관계를 보기 위해 시행되었다. 총 115개의 Helicobacter pylori (H.pylori) 균주에서 cagA 유전자의 염기서열을 분석하였으며 SHP-2에 대한 CagA의 결합력을 in vitro로 측정하였다.CagA의 아형은 염기서열의 분석을 통해 동아시아형과 서구형으로 분류하였다. 동아시아형 CagA 양성 H. pylori에 감염된 위염 환자의 경우, CagA가 음성이거나 서구형 CagA 양성인 경우에 비해 환자의 위에서 관찰된 만성 염증의 등급, 위염의 활성도, 그리고 위축의 등급이 더 높았다. 위암 환자에서 분리된 H. pylori는 모두 동아시아형 CagA양성이었다. SHP-2에 대한 결합력은 서구형 CagA에 비해 동아시아형 CagA가 더 강하였다. 이 소견들은 동아시아형 CagA 양성 H. pylori의 감염이 위축성 위염 및 위암과 연관되어 있고, 동아시아형 CagA 양성 균주에 의해 초래된 지속적인 활동성 염증이 주된 발병 기전일 수 있음을 시사한다.