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Kim Sun Young,Kwak Kyu-Won,Park Ji Yeong,Park Eun-Sung,Nam Chun-Ja,An Kyu Sup,Kim Hyun-Jin,Yoon Hyung Joo,Kim Yong-Soon,Park Kwanho,Kim Eunsun,Ryu Hyeon Yeol,Kim Sun-Don 한국독성학회 2023 Toxicological Research Vol.39 No.2
The migratory locust, Locusta migratoria (Orthoptera: Acrididae), is a well-known edible insect which may serve as new source of human food and animal feed. However, potential toxicity and food safety of L. migratoria had not been investigated extensively until now. Therefore, in this study, we aimed to investigate toxicity of freeze-dried powder of L. migratoria (fdLM) and identify allergic components in ELISA and PCR techniques. In this subchronic study, fdLM was administered once daily by oral gavage at the doses of 750, 1500, and 3000 mg/kg/day. No toxicological changes were observed in both sexes of rats for 13 weeks in accordance with the OECD guidelines and GLP conditions. In addition, fdLM did not induced increases of serum immunoglobulin E and 21 homologous proteins were not detected under our present conditions. In conclusion, the NOAEL (no-observed-adverse-effect level) was 3000 mg/kg/day and no target organ was identified in both sexes. In conclusion, we found that fdLM is safe with no adverse effects and offers the potential of its use as an edible ingredient or other biological uses.
Ideal Blood Pressure in Patients With Atrial Fibrillation
Kim, Daehoon,Yang, Pil-Sung,Kim, Tae-Hoon,Jang, Eunsun,Shin, Hyejung,Kim, Ha Yan,Yu, Hee Tae,Uhm, Jae-Sun,Kim, Jong-Youn,Pak, Hui-Nam,Lee, Moon-Hyoung,Joung, Boyoung,Lip, Gregory Y.H. Elsevier 2018 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - Vol.72 No.11
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>The 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline for High Blood Pressure in Adults redefined hypertension as systolic blood pressure (BP) ≥130 mm Hg or diastolic BP ≥80 mm Hg. The optimal BP for patients with atrial fibrillation (AF) is uncertain.</P> <P><B>Objectives</B></P> <P>The goal of this study was to investigate the impacts of the 2017 ACC/AHA guideline and to determine the ideal BP threshold for the management of high BP in patients with AF.</P> <P><B>Methods</B></P> <P>This study analyzed data for 298,374 Korean adults with oral anticoagulant–naive, nonvalvular AF obtained from the National Health Insurance Service database from 2005 to 2015.</P> <P><B>Results</B></P> <P>According to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure guideline, 62.2% of the individuals in our sample had hypertension. After applying the 2017 ACC/AHA guideline, 79.4% had hypertension, including 17.2% with newly redefined hypertension (130 to 139/80 to 89 mm Hg). Those with newly redefined hypertension had greater risks of major cardiovascular events (hazard ratio: 1.07; 95% confidence interval: 1.04 to 1.10; p < 0.001), ischemic stroke, intracranial hemorrhage, and heart failure admission, compared with nonhypertensive patients (<130/80 mm Hg). Among patients with AF undergoing hypertension treatment, patients with BP ≥130/80 mm Hg or <120/80 mm Hg were at significantly higher risks of major cardiovascular events than patients with BP of 120 to 129/<80 mm Hg.</P> <P><B>Conclusions</B></P> <P>Patients with AF and newly redefined hypertension according to the 2017 ACC/AHA guideline were at higher risk of major cardiovascular events, suggesting that the new BP threshold is beneficial for timely diagnosis and intervention. BP of 120 to 129/<80 mm Hg was the optimal BP treatment target for patients with AF undergoing hypertension treatment.</P> <P><B>Central Illustration</B></P> <P>[DISPLAY OMISSION]</P>
Jung Minyoung,Kang Urim,Kim Sukyung,Yoo Hye Won,Kim Hye-Young,Kim Minji,Lee Ji Young,Kim KyooSang,Lee Eunsun,Kang Byoung-Chul,Park Boram,Ahn Kangmo,Kim Jihyun 대한의학회 2023 Journal of Korean medical science Vol.38 No.27
Background: Food allergy (FA) can have a profound effect on quality of life (QoL), stress, and anxiety in the family. We aimed to validate the Korean version of the Food Allergy Quality of Life-Parental Burden (FAQL-PB) and identify factors related to the parental psychosocial burden of caring for children with FAs. Methods: Parents of children aged between 6 months and 17 years with immunoglobulin E (IgE)-mediated FAs from the Pediatric Allergy Department of five university hospitals in Korea were enrolled in the study. Parents were asked to complete the FAQL-PB, Food Allergy Independent Measure-Parent Form (FAIM-PF), Child Health Questionnaire-Parents Form 28 (CHQ-PF28), Beck’s Anxiety Inventory, Connor-Davidson Resilience Scale, and Patient Health Questionnaire-9 for depression. Statistical analyses included internal consistency, test-retest reliability, concurrent validity, discriminative validity, and logistic regression analyses. Results: A total of 190 parents were enrolled. Social activity limitation was the item with the highest FAQL-PB scores. The Cronbach’s α for each item was higher than 0.8. The test-retest reliability was good (intra-class correlation coefficient, 0.716; 95% confidence interval [CI], 0.100–0.935). An increase in the FAQL-PB was significantly associated with an increase in the FAIM-PF (β = 0.765, P < 0.001) (concurrent validity). There was a positive correlation between parental burden, anxiety, and depression, while resilience was inversely correlated with parental burden (all P < 0.001). The total FAQL-PB score in parents of children who had experienced anaphylaxis was significantly higher than that in parents of children who did not experience it (P = 0.008). When adjusting for age, sex, and underlying diseases, anaphylaxis (β = 9.32; 95% CI, 2.97 to 15.68), cow’s milk (CM) allergy (β = 8.24; 95% CI, 2.04 to 14.44), soybean allergy (β = 13.91; 95% CI, 1.62 to 26.20), higher anxiety (β = 1.05; 95% CI, 0.07 to 1.41), higher depression (β = 2.15; 95% CI, 1.61 to 2.69), and lower resilience (β = −0.42; 95% CI, −0.61 to −0.2) were significantly associated with greater parental burden in children with IgE-mediated FAs. Conclusion: FAQL-PB is a reliable and valid tool for use in Korea. Anaphylaxis, CM or soybean allergies, more anxiety and depression symptoms, and lower resilience are associated with poorer QoL in parents of children with FAs.
새로운 식품원료인 아메리카왕거저리 유충 탈지분말의 In Vivo 독성시험
김선영(Sun Young Kim),곽규원(Kyu-Won Kwak),강건(Gun Kang),오윤식(Yun-Shik Oh),윤형주(Hyung Joo Yoon),김용순(Yong-Soon Kim),박관호(Kwanho Park),김은선(Eunsun Kim),김선돈(Sun-Don Kim) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.5
딱정벌레목 거저리과 곤충으로 국내외에서 식용 또는 동물사료용으로 이용되고 있는 슈퍼 밀웜(super mealworm) 탈지분말에 대한 설치류 및 비설치류를 이용한 경구독성시험에서 시험물질 frpfdZAL에 의한 독성학적 변화를 관찰하지 못했다. 특히, Hartley계 기니피그를 이용한 피부감작성 시험에서 피부를 통한 생체 내 흡수에 따른 면역기계의 이상을 확인하지 못했다. 따라서 아메리카왕거저리 유충 탈지분말은 동물을 이용한 비임상시험에서 독성학적 변화가 없는 안전한 시험물질로 판단되며 본 연구 결과는 다른 식품원료 등에 적용 및 응용 가능한 자료로 활용될 수 있을 것으로 판단된다. Zophobas atratus (Coleoptera: Tenebrionidae), the giant mealworm beetle, has been recognized as an edible insect with a high protein content for new human food source and animal feed. On the other hand, the potential toxicity and food safety of Z. atratus is not well understood. Therefore, this study evaluated the toxicity of freeze-dried skimmed powder of Z. atratus larvae (frpfdZAL), known as the super mealworm, using different model approaches, including acute oral toxicity studies in SD rats and Beagle dogs and skin sensitization in Hartley guinea pigs (Buehler’s method) in accordance with the OECD guidelines and the principles of Good Laboratory Practice. No toxicological changes were observed in the clinical signs, body weights, and gross findings in acute single-dose administration in SD rats and Beagle dogs. In addition, skin sensitization rate was 0%, and its sensitization potential was classified as grade I (very weak) using Buehler’s method. In conclusion, frpfdZAL is safe with no adverse effects and can be applied as an edible ingredient for animal feed or used for other biological purposes.
김선영 ( Sun Young Kim ),곽규원 ( Kyu-won Kwak ),김은선 ( Eunsun Kim ),박관호 ( Kwanho Park ),김낭희 ( Nang Hee Kim ),송명하 ( Myung-ha Song ),김용순 ( Yong-soon Kim ),윤형주 ( Hyung Joo Yoon ) 한국환경농학회 2020 한국환경농학회지 Vol.39 No.3
BACKGROUND: It has been reported that the nutritional composition of Locusta migratoria (Orthoptera: Acrididae) changes nutrients depending on the host plants. In this study, to confirm whether Locusta migratoria is an edible insect, the nutrients and harmful substances such as heavy metals and pathogens were analyzed and compared according to corn (LC) or wheat (LW) as host plants. METHODS AND RESULTS: All experimental methods mainly referred to AOAC (2004). The content of crude protein per dry weight was 77.3% in (LW), 1.1 times higher than 69.8% in LC. Crude fat was 6.5% in LW, 2.2 times less than LC 14.3%. Alpha-linolenic acid, which has the highest content among unsaturated fatty acids, was 1.2 times higher in LC (39.9%) than LW (32.5%). As a result of analysis of harmful substances by LC and LW, lead and cadmium among heavy metals were at levels suitable for heavy metal standards of edible insects, and arsenic was not detected in both groups. E. coli and Salmonella spp. were not detected in both groups. CONCLUSION: When comparing the overall nutrients composition of LW and LC, it was confirmed nutrients are different depending on the host plants, and the safety was proved.