제약업종 부산물 및 화장품 제조업 폐수처리오니의 고추 비해에 미치는 영향

임동규,이상범,권순익,이승환,소규호,성기석,고문환 한국환경농학회 2004 한국환경농학회지 Vol.23 No.4

본 연구는 퇴비의 원료로 지정된 제약업종 부산물(공정오니) 및 화장품 제조업 폐수처리오니를 시용한 후 고추를 재배하면서 시용한 오니에 의한 작물의 비료의 피해를 밝히기 위해 포장에서 작물의 생육과 수량(적과, 청과), 시기별로 토양 및 식물체 중 중금속 함량 등을 조사하였다. 토양 중 유기물 및 질소성분은 시험재료의 성분함량이 높은 처리구에서 생육 초기(6월 11일)에 높았다. 토양의 중금속 성분에서 전함량의 경우 As성분은 생육 중기(7월 8일)에 함량이 급격히 높아졌다가 감소하였으며 Zn·Cu·Pb·Cd성분은 수확기에 갑자기 함량이 증가하였고, 1 N-HCI 가용함량에서 Zn·Cu·Pb·As성분은 생육 중기에 증가하였다가 감소하는 경향이었다. 고추의 생육(초장, 간경)은 초기에는 오니구(제약오니3구 제외)가 화학비료구보다 전반적으로 불량하였는데 이는 유기물 함량이 높은 미 부숙된 오니의 영향인 것으로 생각되며, 생육 후기에는 회복이 되어서 화장품 오니구를 제외하고는 서로 비슷하였다. 고추 식물체(잎, 줄기)의 질소함량에서 생육 초기 및 중기에 제약오니1과 돈분구가 높은 것은 이들 시험재료의 유기물 및 질소성분의 특성과 함량에 기인된 것으로 보이며, 식물체 중 중금속 함량에서 잎은 Zn·Pb·Ni성분이, 줄기는 Zn·Pb성분이 수확기에 급격히 높아졌으므로 이들 성분에 대해서 주의할 필요가 있다고 생각된다. 고추의 총 적과 수량은 가축분뇨 > 제약오니3 > 제약오니1 > 화학비료 > 제약오니2구 순으로 낮아졌으며, 화장품오니구는 타 처리구보다 상당히 감수하였다. 수확기 고차 청과 및 적과의 중금속 함량은 Zn과 Cu성분이 타 성분들보다 높았고, 처리별로는 청과에서 Zn 및 Ni성분은 제약오니1구가, Pb성분은 제약오니3구가 타 처리구들보다 조금 높아서 유기성 오니를 퇴비원료로 사용할 경우 오니 중의 Zn·Cu·Pb·Ni성분의 특성과 함량이 상당히 중요할 것으로 판단된다. 따라서 퇴비원료로 지정된 오니 중에서 화장품오니와 제약오니2에서 생육 후기부터 수확기에 걸쳐 질소성분의 부족 현상에 의한 생육부진과 낙엽, 어떤 원인인지 알 수 없지만 비해에 의한 수량감소 등의 원인을 앞으로 연구를 통해서 밝힐 필요가 있다고 생각된다. 본 시험의 결과는 퇴비원료로 지정하거나, 지정된 퇴비원료의 사용을 신청할 때 허가할 퇴비원료가 작물에 대해 적합한지 알아보는 방법의 일환으로 활용될 수 있을 것이다. Three sludge types from pharmaceutical byproducts and one sludge type from cosmetic waste-water sludge as raw materials of compost were used in a field based concrete pot (4 m², 2m × 2m) for investigating damage of red pepper cultivation. These sludges and pig manure (1 Mg/10a, dry basis) were incorporated into the upper of clay loam soil prior to transplanting with red pepper. Changes in concentration and properties of heavy metal for both of soil and plant were investigated 4 times during of red pepper growth. Plant height and stem diameter of red pepper in sludge treatments except to Pharmaceutical sludge 3 were poor than those of NPK treatment. This result were regarded as an effect of incompleted decomposition sludge which has a lot of organic matter concentration. Amount of total As was increased rapidly Jul. 8. in soil, total Zn·Cu·Pb·Cd were in harvest time, and 1 N-HCl extractable Zn·Cu·Pb·As were rised at middle stage and then decreased. Amounts of nitrogen in plant (leaf and stem) were high in Phamaceutical Sludge 1 and Pig Manure treatment in early and middle stage because of organic matter and nitrogen concentrations and characteristics. Amounts of Zn, Pb, and Ni in leaf and amount of Zn and Pb in stem were increased in harvest time so that we need to have a concern in detail. Total yield of red pepper was Pig Manure > Phamaceutical Sludge 3 > Phamaceutical Sludge 1 > NPK > Phamaceutical Sludge 2 and Cosmetic Sludge treatment was decreased considerably to compare to others. Amounts of Zn and Cu in green and red pepper in harvest time were higher than the other heavy metals. Finally these results can use to utilize that finding damage on crop for authorization and suitability estimation of raw material of compost.

운동선수와 일반학생의 최대운동후 회복기 혈액성분(적혈구, 백혈구, 혈소판)의 변화에 관한 연구

임병규,고동운 圓光大學校附設 生活體育硏究所 2001 生活體育硏究 Vol.12 No.-

The human blood amounts to about a third of his weight. The cellular components of blood are red blood cell, white blood cell and thrombocyte. Blood plasma is a yellow liquid including 9∼10% various solid components, such as protein(albumin, globulin, etc), inorganic substances(Na, K, Ca, Cl, Mg, etc), fibrinogen. Blood can be put in an abnormal condition under physical stress, such as environment, nutrition status and overwork. So, it is important to analyze blood components for the Prevention and treatment of diseases. The propose of this study is to know the change of red blood cell, white blood cell, thrombocyte after maximal tread mill exercise. The subjects were ten soccer players and ten non-players in kun-san che-il high school in chun-buk province. Two way ANOVA was performed for data analysis at the .05 level of significant. The result through the statistical analysis of this data were summarized as follows 1. The level of red blood cell was found significant difference(P<.001) at each group and each time, but not significant difference reaction of group×time. 2. The level of white blood cell was found significant difference(P<.001) at each group and each time, but not significant difference reaction of group×time. 3. The level of thrombocyte was found significant difference(P<.001) at each group, each time and reaction of group×time(P.05).

백서 구치의 실험적 치아이동시 견인측 치근막에서 혈관성장인자의 발현에 관한 연구

임용규,신춘식,이동렬 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.1

치주인대에 일회성의 적절한 인장력을 가하였을 때 견인측 치근막에서 나타나는 혈관성장인자(VEGF)와 그 수용체(VEGFR)의 발현의 변화를 보기 위해 본 연구를 시행하였다. 8-10주된 Sprague-Dawley계 웅성 백서(rat)에서 상악 좌측 제1대구치에 closed coil을 이용하여 근심방향으로의 교정력을 가하였으며 1시간, 12시간, 1일, 3일, 1주, 2주 군으로 분리하여 각 군 당 5마리씩의 실험동물을 배정하였다. 우측 제1대구치는 치경부에 ligature wire만 결찰하고 동일 실험시간이 지난 후 대조군으로 이용하였다. 견인력이 가해진 치근막에서 VEGF와 VEGFR및 이들의 mRNA의 발현 양상의 변화를 H&E 염색 및 면역조직화학적 염색과 in situ hybridization법으로 관찰하여 다음과 같은 결과를 얻었다. 1.치주인대에 인장력을 가하면 치주인대의 신장으로 인한 혈관의 압박에 의해 울혈과 부분적인 출혈상이 초기에 나타났으나 3일 이내에 대조군과 같은 정도로 회복되었으며 신생골의 형성은 3일 이후 나타나서 2주간 지속되었다. 2.치주인대에 인장력을 가하면 치주인대 세포와 조골세포, 백악아세포에서의 VEGF와 VEGF mRNA의 발현증가가 나타나며 이는 치주인대 혈관의 증가로 이어졌다. 3.인장력을 가하고 3일 이후에는 VEGF와 VEGF mRNA의 발현은 주로 치조골 인접면의 치주인대세포와 조골세포에서만 관찰되었으며 2주후에는 VEGF와 VEGF mRNA, 치주인대혈관 모두 대조군과 유사한 정도로 감소하였다. 4.VEGF수용체인 Flt-1과 Flk-1은 거의 동일한 발현 양상을 보였으며 주로 혈관 내피세포와 조골세포에서 관찰되었으나 치주인대에 인장력을 가하면 초기에 혈관내피세포에서 그 발현이 증가하였다. 조골세포에서의 발현증가는 내피세포에 비교해서 다소 늦게 나타났으나 발현의 증가는 더 뚜렷하였다. 결론적으로 교정력을 가했을 때 견인측 치주인대의 치주인대세포와 조골세포, 백악아세포에서 VEGF와 VEGF mRNA의 발현이 증가하며 이에 이어 혈관의 증가가 나타나고 신생골의 형성은 혈관의 증가 후에 나타나는 것을 관찰할 수 있었다. 백악아세포에서 발현이 증가된 VEGF mRNA는 치조골측으로 편재해 있던 혈관이 견인의 방향으로 치아를 향해 성장하도록 유도하는 것으로 사료되었다. VEGFR 및 VEGFR mRNA는 내피세포 뿐 아니라 조골세포와 골세포, 치주인대세포에서도 발현이 증가하여 VEGF가 paracrine한 방식 뿐 아니라 autocrine한 방식으로도 작용함을 알 수 있었다. This study was performed to analyse the expression of VEGF and it's receptor(VEGFR) in the tension side of the periodontal ligament following orthodontic tooth movement. Upper first molars of Sprague-Dawley rats were moved medially using closed coil spring for 1, 2, 24 hours and 3, 7, 14 days. H&E staining, immunohistochemical staining and in situ hybridization methods were used to analyse the change of the expression of VEGF and VEGFR. The results from trus study were as follows : 1.Following tensional force, periodontal ligament showed elongation of fibers, compression and congestion of vessels and regional hemorrhage. These tissue changes were recovered within 3 days of force application. New bone formation was seen after 3 days of force application and continued for the remaining experimental periods. 2.Following tensional force, VEGF and VEGF mRNA expression was increased in the periodontal ligament cells, osteoblasts and cementoblasts. This change was followed by increased vasculature in the periodontal ligament. 3.After 3 days of tensional force, VEGF and VEGF mRNA expression was confined mainly to the osteopaths and the periodontal ligament cells adjacent to the alveolar bone. After 2 weeks of force application, VEGF and VEGF mRNA expression was reduced to the level of control sample. 4.VEGFRs(Flt-1, Flk-1) showed similar expression pattern and it's expression was mainly seen in the endothelial cells and osteoblasts. Following tensional force VEGFR expression was increased in the endothelial cells and osteoblasts. In conclusion, in the tension side of the periodontal ligament, ligament cells, osteoblast and cementoblast showed increased expression of VEGF & VEGF mRNA. It preceded the increase of vasculature and new bone formation. The increased expression of VEGF mRNA in cementoblast may induce periodontal vessels, which distribute mainly the bone side half of periodontal ligament, group in the direction of tensional force. Increased expression of VEGFR & VEGFR mRNA not only in endothelial cell but in osteoblast, osteocyte and periodontal cells showed VEGF acts not only in paracrine manner but in autocrine one.

벼에 대한 돈분뇨 혐기성 소화액비의 시용기준 연구

임동규,박우균,권순익,남재작,박백균,김승환 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

가축분뇨물 혐기소화하여 메탄가스를 생산하고 난 다음 혐기성 소화액비를 비료자원으로 활용하기 위하여 농가포장에서 액비의 시용기준을 구명하였다. 벼 생육상황은 분얼기 및 출수기에 액비 70%+화학비료 30% 및 액비 100%구의 경수만 타 처리구보다 약간 많았다. 시기별 식물체 중 절진소함량은 표준시비구가 생육초기에 기비 및 분얼비의 영향으로 타 처리구보다 높았다. 벼 수량은 액비 70%+화학비료 30% 및 액비 100%구가 표주시비구보다 약간 증수되었으나, 액비 50%+화학비료 50%구는 표준시비구보다 약간 낮았다. 수확기 질소흡수량, 시비질소 효율 및 시비질소 이용율은 수량이 많았던 액비 70%+화학비료 30% 및 액비 100%구에서 높았다. 시기별 토양 중 NH_4-N함량 및 NO_3-N함량 변화는 표준시비구 및 액비 50%+화학비료 50%구가 생육초기에만 타 처리구보다 약간 높았다. 시기별 관개수 중 NH_4-N함량 변화는 분얼비의 영향으로 급격히 증가하였다가 급격히 감소하였는데 증가한 시기에는 표준시비구 > 액비 50%+화학비료 50%구가 타처리구보다 높았으나, NO_3-N함량은 처리 간 차이가 없었다. 시기별 침투수 중 NH_4-N함량 및 NO_3-N함량 변화는 무비구가 생육초기에 타 처리구보다 약간 높았는데, 이것은 벼 생육불량에 의한 양분흡수가 적어지면서 상대적으로 지중으로 침투가 많았기 때문인 것으로 생각다. 따라서 혐기성 소화액비의 적정 시용기준은 표준시비량의 질소성분 70%을 액비로서 전량기비로 사용하고, 나머지 30% 질소성분을 화학비료로 분얼비 10% · 수비 20% 시용하는 것이 효과적이었다. This study was conducted to evaluate the effect of the proper application level of anaerobic digestion waste water on rice. The waste water was from methane fermentation of pig manure to use as a liquid manure. The mixture treatment of 70% liquid manure and 30% chemical fertilizer (LM 70%+CF 30%) and 100% liquid manure (LM 100%) treatment were higher number of tiller than other treatments at the both tittering and heading stages of rice. The yields of LM 70%+CF 30% and LM 100% treatments were a little higher than that of NPK treatment, but the mixture treatment of 50% liquid manure and 50% chemical fertilizer (LM 50%+CF 50%) was a little lower yield than NPK treatment. The periodic changes of the NH_4-N and NO_3-N contents of the NPK and the LM 50%+CF 50% treatments in paddy soil were a little higher than those of other treatments at the early stage of rice. The NHL_4-N contents of NPK and the LM 50%+CF 50% treatments in irrigation water quality were higher than those of other treatments, however there was no difference in NO_3-N content among the treatments. The NH_4-N and NO_3-N contents of non fertilizer treatment in infiltration water quality were leached a little higher than those of other treatments. It may be due to poor growth of rice following to reduce the nutrient uptake by rice and to increase relatively the nutrient leaching to the ground water. The proper application level of anaerobic digestion waste water as a liquid manure could be suggested to apply LM 70%+CF 30%. All treatments were the same amount of nitrogen content for the standard application amount on rice.

치아의 맹출장애

임용규,이동렬 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.1

치아의 맹출장애에 관한 연구들은 많은 경우 치아의 유착이나 물리적인 장애에 의한 영구치의 맹출지연, 매복 등을 다루어 왔다. 그러나 치아의 맹출장애는 단순히 국소적이며 물리적인 현상일 수도 있지만 전신적 발육이상의 발현일 가능성도 높음을 간과해서는 안 된다. 이는 중요한 전신질환의 일부 현상으로 나타나는 경우가 많으며 맹출기전 자체에 이상이 있는 경우도 있다. 특히 영구치의 맹출장애는 치열 및 악골의 발육에 영향을 미치고 치주조직의 손상을 야기하며 기능장애 및 심미적인 문제를 가져올 수 있다. 그러므로 정상적인 치아의 맹출은 악안면의 성장과 발육, 기능에 중요하다고 할 수 있다. 따라서 교정임상의로서 우리는 치아의 맹출에 이상이 있는 환자를 조기에 진단, 발견하여 그 원인을 밝히고 이에 따라 적절히 대처할 수 있는 능력을 가져야 할 것이다. 본 연구에서는 치아의 맹출장애를 일으키는 원인요소 및 이에 따른 치료방법의 차이에 대해 알아보고 그 중 골형성 부전증 및 primary failure of eruption환자를 예로 들었다. The purpose of this study was to present the causes and their mechanisms of eruption failure of teeth and to investigate the treatment modalities. There are so many reports about eruption failure, but most of them are dealing with local mechanical interferences. But, we have patients suffered from eruption failure of another causes. Many developmental failures show eruption problems of teeth, although in some cases, the primary failure of eruption (failure of the eruption mechanism itself) can be the primary cause. We have to know about the causes, differences, and the treatment modalities for those abnormalities.

벼에 대한 돈분뇨 혐기성 소화액비의 사용적량 구명

임동규,박우균,권순익,남재작,이상범 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

가축분뇨를 혐기성소화하여 메탄가스를 생산하고 난 다음 혐기성 소화액비를 비료자원으로 활용하기 위하여 농가포장에서 액비의 시용적량을 구명하였다. 벼 생육상황은 액비 100%+화학비료구가 전 시기를 통해 가장 양호하였으며, 그 다음으로 표준시비구가 분얼기에만 양호하였으나 그 이후에는 표준시비구·액비 100%구 및 액비 150%구 간에는 서로 차이가 없었다. 시기별 식물체중 전질소함량은 분얼기 및 출수기에는 추비의 영향으로 표준시비구가, 유수형성기에는 액비 100%+화학비료구가 높았다. 벼 수량은 액비 100% 및 150%구들이 표준시비구와 비슷하거나 약간 증수되었으며, 액비 100%+화학비료구는 고중의 증가 및 도복으로 인하여 표준 시비구보다 수량이 오히려 약간 낮았다. 수확기 질소흡수량은 표준시비구가 가장 높았고 ,시비질소 효율은 액비 100%구에서, 시비질소 이용율은 액비 100%+화학비료구에서 높았다. 시기별 토양중 NH₄-N 및 NO₃-N함량 변화는 액비 100%+화학 비료구가 타 처리구보다 높았다. 시기별 관개수 중 NH₄-N 및 NO₃-N함량 변화는 분얼비의 영향으로 급격히 증가하였다가 급격히 감소하였는데, 증가한 시기에는 표준시비구 및 액비 100%+화학비료구가 가장 높았다. 시기별 침투수 중 NH₄-N함량 변화는 액비 150%구들에서 많이 용탈되었구 NO₃-N 함량은 액비에 화학비료를 추비한 구들에서 많이 용탈되었다. 혐기성 소화액비는 액비 중의 질소성분을 분석하여서 표준시비량의 질소성분에 맞추어 시용하여야 한다. This study was carried out to evaluate the proper application amount of anaerobic digestion waste water and the environmental influence on rice. The waste water collected after methane fermentation process of pig manure was used as a liquid manure. Liquid manure 100%+chemical fertilizer 30%(LM 100%+CF 30%) treatment was the most favorable at all growth stages of rice. The LM 100%+CF 30% treatment was applied to 100% amount of liquid manure which was correspond to the same amount of nitrogen for the standard application amount on rice, with adding 30% amount of chemical fertilizer(urea) at tillering stage. The yields of rice in the treatments of 100%(LM 100%) and 150% amount(LM 150%) of liquid manure were similar or a little higher than NPK treatment, but LM 100%+CF 30% treatment was less than the NPK treatment due to the increase of straw weight and plant lodging. In periodic changes of the NH_4-N and NO_3-N contents, the LM 70%+CF 30% treatment in paddy soil was the highest in all treatments. The NPK and the LM 100% treatments in irrigation water quality were higher than other treatments. In infiltration water quality, M44-N content was leached out much in the LM 150% treatment and NO_3-N content was in the LM 100%+CF 30% treatment. The proper application amount of anaerobic digestion waste water as a liquid manure must be to analyse the nitrogen content of the waste water and to apply the same amount of nitrogen for the standard application amount on rice.

성장기 Ⅲ급 부정교합의 고정식 교정 치료 후의 안정성

임용규,이주나,김정일,이동렬 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.4

본 연구에서는 성장기 골격성 Ⅲ급 부정 교합 환자의 치료 전 측모 두부방사선 계측사진에서 얻을 수 있는 골격성, 치성 분석을 통하여 안정군과 재발군을 구별하여 주는 요소를 찾아 보아 Ⅲ급 부정 교합의 치료시 안정성을 고려한 치료 선택에 도움을 주고자 하였다. 고정식 교정 장치를 통한 전치부 반대 교합 혹은 절단 교합의 골격성 Ⅲ급 부정교합 치료 후 최소 1년 동안 안정된 결과를 보인 안정군 33명과 관찰 기간 동안 절단 교합 이하의 수평 피개를 보인 재발군 22명을 연구 대상으로 하여 비교하였으며, t-test를 시행하여 다음과 같은 결론을 얻었다. 1. 전후방적 골격 형태보다는 수직적 형태, 특히 AB-maxillo-mandibular triangle내의 수직적 형태가 Ⅲ급 부정 교합 치료의 예후에 주요한 결정 인자로 나타났다. 수직 각도 계측 항목에 의한 안정군과 재발군간의 비교에서 유의성 있는 차이를 보인 항목은 AB-MP, ODI로 나타났다(P<0.01). 수직 비율 계측 항목에서도 MP-P/AL, PP-P/AL항목이 유의성 있는 차이를 보였다(P<0.05). 2. 재발의 경향은 교합 평면 특히, 하악 교합 평면이 전하방으로 급경사를 이룰수록 증가했다. 교합 평면 경사도와 관련된 계측 항목에 의한 안정군과 재발군간의 비교에서 OP(L)-PP, OP-PP, AB-PP(L), Wits appraisal 항목이 유의성 있는 차이를 보였다(P<0.05). 본 연구는 전후방 부조화가 아닌 골격성, 치성 수직 부조화가 재발을 예측하는 적절한 기준이 됨을 시사하였다. The purpose of this study was to investigate the predictors of relapse in orthodontic treatment of skeletal Class Ⅲ malocclusion in growing patients. A total of 55 patients were studied and all subjects were divided into two groups according to their stability in the post-treatment stage. Of the sample, 33 patients were included in the stable group and the remaining 22 were assigned to the relapse group. Cephalometric data of the pre-treatment stage was taken and compared between the stable and relapse group. The following results were obtained through t-test: 1. This study presented statistical evidence to show that the major skeletal determinant of prognosis in Class Ⅲ orthodontic treatment was not anteroposterior discrepancy but vertical discrepancy, especially within the AB-maxillo-mandibular triangle. Vertical angular measurements that showed statistically significant differences were AB-NIP and ODI(P<0.01) and the vertical ratio measurements were NIP-P/AL and PP-P/AL(P<0.05). 2. Relapse tendency increased with the steep occlusal plane, especially the steep lower occlusal plane. As to occlusal plane, there were statistically significant differences in OP(L)-PP, OP-PP, AB-OP(L) and Wits appraisal(P<0.05). This study claimed that anteroposterior discrepancy was not necessarily the proper criteria to predict relapse. Vertical discrepancy had a significant effect on post-treatment stability.

광중합형 레진으로 아말감 면에 브라켓 접착 시 전단결합 강도

임용규,조지영,이동렬 대한치과교정학회 발행 2005 대한치과교정학회지 Vol.35 No.6

본 연구는 아말감 면에 광중합형 레진으로 교정용 브라켓을 접착시킬 경우, 광원의 차이(할로겐 광중합기와 light-emitting diode (LED) 광중합기)와 샌드블라스팅 표면처리 여부에 따른 접착제의 전단결합강도를 비교하고자 시행되었다. 발거된 소구치 30개를 대조군으로 이용하였으며, 법랑질 표면을 산부식한 후 통상적인 방법으로 브라켓을 접착하였다. 60개의 다른 소구치에 아말감 충전을 하여 실험군으로 이용하였다. 두 군에서 할로겐 광중합기와 LED 광중합기를 이용하여 브라켓을 접착시키고 브라켓이 탈락될 때까지 힘을 가해 전단결합강도를 측정하였다. 실험 결과, 실험군의 전단결합강도는 약 3-5.5 MPa로 대조군(19MPa)보다 낮았다. 실험군에서 샌드블라스팅 표면처리를 한 경우, 할로겐 광중합기를 사용한 군이 LED 광중합기를 사용한 군보다 높은 전단결합강도를 보였으나 (p<0.05), 샌드블라스팅 표면처리를 하지 않은 경우에는 광원에 따라 전단결합강도에 차이를 보이지 않았다. (p>0.05). 할로겐 광중합 군과 LED 광중합 군 모두에서 샌드블라스팅 여부에 따른 전단결합강도에 통계적으로 유의한 차이가 없었다 (p>0.05). 아말감 면에 광중합형 레진을 이용하여 브라켓을 접착할 경우, 할로겐 광중합기와 LED 광중합기로 얻을 수 있는 접착제의 결합강도는 임상적으로 사용하기에는 낮게 나타나, 이의 증진 방법을 도모하기 위해 앞으로 더 많은 연구가 필요하리라 사료된다. This study was performed to compare the shear bond strength of orthodontic adhesive to amalgam according to different light sources (halogen-based light and light emitting diode (LED)) and amalgam surface treatments. Ninety extracted human premolars were randomly divided into 6 groups (4 experimental and 2 control groups) of 15 by light sources and surface treatments. Orthodontic brackets were bonded and shear bond strength was measured with an Instron universal testing machine. The findings were as follows: The bond strength of adhesive to amalgam surface was 3-5.5 MPa which was lower than that of acid-etched enamel (19 MPa) control. In the sandblasted amalgam surface, the shear bond strength of the halogen light group was higher than that of the LED group (p<0.05) but, in the non-treated amalgam surface, there was no significant difference in the shear bond strength according to the light sources (p>0.05). Within the same light source. sandblasting had no significant effect on the shear bond strength of the adhesive bonded to amalgam surface (p>0.05). there was no significant difference in shear bond strength according to the light sources in acid-etched enamel control groups. This results suggerst that there can be a limit in using light curing adhesives when brackets are bonded to an amalgam surface. Additional clinical studies are necessary before routine use of halogen light and LED light curing units can be recommended in bonding brackets to an amalgam surface.

Metoclopramide가 휜쥐의 血壓에 미치는 影響

임동윤,최동준,김규형,최철희,박재윤,문재규,김문석,황두환 中央醫學社 1988 中央醫學 Vol.53 No.9

Influences of metocopramide (MCP), which is a seletive dopaminergic antagonist, on blood pressure of the rat and its mechanism of action were investigated in the present study. MCP administered into a femoral vein of the rat caused markedly a dose-related fall in blood pressure followed by secondary transient pressor response. The depressor action evoked by MCP was not blocked by pretreatment of atropine or chlorisondamine, while the pressor action was inhibited significantly. Prazosin treatment reduced markedly both of depressor and pressor induced by MCP. MCP-evoked pressor action was not affected by clonidine, but the depressor response was attenuated significantly. Debrisoquin treatment made the inhibited response to MCP-induced pressor response, while did not affect the depressor action. Both of pressor and depressor responses evoked by MCP were not influenced by cyproheptadine. The hypertensive activity induced by nor epinephrine was weakened markedly by the infusion of MCP (1.50 mg/kg/30min.), but the pressor action evoked by dopamine not affected. These experimental data suggest that MCP produces biphasic responses (depressor and pressor) in blood pressure of the rat, and that the hypotensive activity is due to adrenergic alpha-receptors blockade, and that pressor activity is exerted through stimulation of cholinergic nicotinic receptors in autonmic ganglia.

연 작업자들의 업종별 보건관리에 의한 건강수준의 변화

임정규,안규동,이병국 순천향대학교 산업의학연구소 1996 순천향산업의학 Vol.2 No.1

In order to evaluate the effect of industry type specific occupational health service on the health status of lead workers, total 39,203 record of 5 year accumulated data of workers from 1989 to 1993 in lead using industries which made special contract of group occupational health service with Soonchunhyang university, institute of industrial medicine were studied. Blood zinc protoporphyrin (ZPP) and 15 lead related symptoms were selected as a health indices and air concentration of lead (PbA) was selected as a environmental index of lead industries. Blood ZPP and symptoms survey were carried out twice a year for lead workers and once a year for non-lead office workers. Environmental measurements of lead in air were done twice a year in every lead using industries. Lead industries were divided into 4 group of lead industries arbitrarily such as storage battery industries for group I, secondary smelting, litharge making and related operation for group II, telecommunication for group III and primary smelting and crystal glass making for group IV. Data for group III only available for 3.5 years from 1990 to first half of 1993. Blood ZPP was measured with hematoflurometer (Aviv model 206). Fifteen questionnaire of lead related symptoms were provided to all workers and filled by themselves and confirmed by interview doctor at the site. The results obtained were as follows: 1. While the geometric means of lead in air of group I, II, IV in 1989 were 0.333, 0.353 and 0.113 ㎎/㎥, those in 1993 were decreased to 0.081, 0.162 and 0.037 ㎎/㎥ respectively. On the other hand the geometric means of lead in air of group III were always below 0.020 ㎎/㎥ throughout the study period. 2. While the geometric mean of lead in air in medium/large storage battery industries was 0.313 ㎎/㎥ in 1989, it was decreased to below 0.05 ㎎/㎥ since 1992, that in small storage battery industries was 0.395 ㎎/㎥ and it was still 0.101 ㎎/㎥ in 1993. This data suggested that the effect of group occupational health service were more effective in medium/large storage battery industries. 3. The overall percent of distribution of lead in air of below 0.05, 0.05-0.15 and over 0.15 ㎎/㎥ in group I for 5 years were 87.54%, 9.29% and 3.16% respectively. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96% 14.47%, 5.57% respectively. 4. The mean blood ZPP of male lead workers decreased from 52.61±68.67 ㎍/100ml in 1989 to 33.31±34.62 ㎍/100ml and those of female lead workers decreased from 84.01±79.06 ㎍/100ml in 1989 to 58.35±47.30 ㎍/100ml. While the mean blood ZPP of male lead workers for group I, II and IV in 1989 was 39.65±40.41, 132.9±121.1 and 32.9±55.51 ㎍/100ml, those in 1993 were 29.75±28.38, 77.35±64.48 and 31.41±21.35 respectively. The mean blood ZPP for group III were ranged from 13.11±8.53 to 26.43±8.83 ㎍/100ml for 3 and half years period. 5. The mean blood ZPP of male lead workers in medium/large and small storage battery industries in 1989 were 32.16, 82.53 ㎍/100ml in 1989 and those in 1993 were decreased to 25.69 and 76.22 ㎍/100ml respectively. Those of female lead workers in both industries in 1989 were 53.36, 126.3 ㎍/100ml and 43.68, 90.17 ㎍/100ml respectively. 6. The overall percent of distribution of blood ZPP of below 50, 50-99, 100-149 and over 150 for 5 years were 72.83% (male: 76.63%, female: 44.59%), 16.97% (male:15.23, femlae: 29.93%), 5.23% (male: 4.18%, female: 13.04%) and 4.96% (male: 3.96%, female: 12.44%) respectively. Among 4 groups, the percent of workers whose blood ZPP over 50 ㎍/100ml was highest in group II. 7. The mean of overall symptoms of male and female lead workers in 1989 were 5.2 and 4.9 and decreased to 4.6 and 4.3 in 1993 respectively. The mean of overall symptoms of male and female lead workers in medium/large storage battery industries in 1989 were 5.7, 5.9 and decreased to 4.8, 5.2 in 1993. Those in small storage battery industries in 1989 werer 4.8, 5.2 and 3.8, 3.2 respectively. 8. The most frequent symptom among 15 lead related symptom questionnaires for 5 year duration was 'generally fatigue' (male: 63%, female: 53%) and the least frequent symptom was 'acute abdominal pain around umbilicus' (male: 12%, femlae: 9%). Among male lead workers of 4 groups the prevalence of lead related symptoms was highest in group 4 and followed by group 3, 1 and 2 in descending order. Among female lead workers it was highest in group 3 and followed by group 1, 2, and 4 in descending order. 9. The prevalence of lead related symptoms were high in group whose blood ZPP below 100㎍/100ml than those with blood ZPP over 100 ㎍/100ml. The prevalence of lead related symptoms of male lead exposed workers were higher or same with male non-lead exposed workers in every symptoms except questionnaire 11. But for female workers the prevalence of lead related symptoms of lead exposed workers were lower than non-exposed lead workers except questionnaire 1, 4, 5, 6, 7, 8, 12, 15. 10. There was very similar pattern of symptom prevalence over the 5 years in lead exposed and non-exposed workers for both sex. 11. The prevalence of lead related symptoms was higher in young age group than old age group and there was no big difference of prevalence according to the work duration. With above results, group occupational health service for lead workers improved working condition of lead industries under special contract with Soonchunhyang university, institute of industrial medicine in term of decrease of lead in air, particularly more effective in medium/large storage battery industries. It also brought out the the decrease of lead burden of most lead workers in terms of blood ZPP of lead workers which is a good index of lead intoxication. But symptom servery did not give any clue of dose-response relationship between lead exposure and lead related symptoms with current symptom questionnaire. It is recommended to revise the way of questioning lead related symptoms from lead workers. On the other hand, for group II and III, those were 77.19%, 15.21%, 7.6% and 92.78%, 3.72%, 3.5% respectively. The overall percent of distribution of lead in air of above three category in medium/large and small storage battery industries were 90.42%, 7.32%,2.25% and 79.96%, 14.47%, 5.57% respectively.