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Dynamics of microbiome composition from placenta to fetus and neonate
( Da Young Kang ),( Moon Yeon Hwang ),( Sun Woo Choi ),( So Young Kim ),( Ji Eun Jung ),( Jae Hong Ryoo ),( Woo Yeon Hwang ),( Young Joo Lee ),( Byung Su Kwon ),( Young Sun Kim ),( Min Hyung Jung ) 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-
Angulin-1/lipolysis-stimulated Lipoprotein Receptor in Asthma
( Da Yeon Hwang ),( Min-hyeok An ),( Pureun-haneul Lee ),( Jung-hyun Kim ),( Yunha Nam ),( Shinhee Park ),( Ae-rin Baek ),( June Hyuck Lee ),( Do Jin Kim ),( Sung Woo Park ),( An Soo Jang ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0
갈만 추출물의 미백 기능 및 안전성에 대한 임상적 유용성 평가
황연실(Yeon Sil Hwang),김대성(Dae Sung Kim),조다정(Da Jung Jo),김다은(Da Eun Kim),장보윤(Bo Yoon Chang),류자현(Ja Hyun Ryu),김혜수(Hye Soo Kim),조형권(Hyoung Kwon Cho),김성연(Sung Yeon Kim) 대한약학회 2017 약학회지 Vol.61 No.4
Melanin is major factor that determines skin color as well as one of the defense systems that prevent the UV-induced damage. White and clean skin is very important part of the satisfaction of appearance and life quality. The purpose of this clinical study was to investigate the anti-melanogenesis activity for whitening product containing aerial part of Puer-aria lobata extract (APPL) can be utilized based on the increase in demands for cosmetics, particularly natural products. A total of 23 subjects who visited Dermapro Skin Research Center were included in this study. Volunteers were irradiated at a test site with UVA+B to induce pigmentation then applied 3% APPL at the test site for 8 weeks. Changes in visual eval-uation on pigmentation, average melanin content were observed, and subjective skin lightness and color improvements were analyzed. In all parameters measured in this clinical study, APPL treated group showed significant improvement com-pared with the control group. After 4 weeks, subjects with 3% APPL treatment started to improve melanin content and visual evaluation on pigmentation and skin lightness. Skin colors have improved from 8 weeks of treatment with 3% APPL. The safety of product containing 3% APPL was also confirmed. Indexes of subjective irritation(itching, prickling, tickling, burning, stinging, stiffness, tightening etc.) and objective irritation(erythema, edema, scale, papule etc.) proved that there was no adverse reaction on skin upon treatment of products. Considering all the results obtained, 3% APPL product can be used as a safe and effective skin-whitening agent.
Prognostic Implications of CT Feature Analysis in Patients with COVID-19: a Nationwide Cohort Study
Yeon Joo Jeong,Bo Da Nam,Jin Young Yoo,Kun-Il Kim,Hee Kang,Jung Hwa Hwang,Yun-Hyeon Kim,Kyung Soo Lee 대한의학회 2021 Journal of Korean medical science Vol.36 No.8
Background: Few studies have classified chest computed tomography (CT) findings of coronavirus disease 2019 (COVID-19) and analyzed their correlations with prognosis. The present study aimed to evaluate retrospectively the clinical and chest CT findings of COVID-19 and to analyze CT findings and determine their relationships with clinical severity. Methods: Chest CT and clinical features of 271 COVID-19 patients were assessed. The presence of CT findings and distribution of parenchymal abnormalities were evaluated, and CT patterns were classified as bronchopneumonia, organizing pneumonia (OP), or diffuse alveolar damage (DAD). Total extents were assessed using a visual scoring system and artificial intelligence software. Patients were allocated to two groups based on clinical outcomes, that is, to a severe group (requiring O2 therapy or mechanical ventilation, n = 55) or a mild group (not requiring O2 therapy or mechanical ventilation, n = 216). Clinical and CT features of these two groups were compared and univariate and multivariate logistic regression analyses were performed to identify independent prognostic factors. Results: Age, lymphocyte count, levels of C-reactive protein, and procalcitonin were significantly different in the two groups. Forty-five of the 271 patients had normal chest CT findings. The most common CT findings among the remaining 226 patients were ground-glass opacity (98%), followed by consolidation (53%). CT findings were classified as OP (93%), DAD (4%), or bronchopneumonia (3%) and all nine patients with DAD pattern were included in the severe group. Uivariate and multivariate analyses showed an elevated procalcitonin (odds ratio [OR], 2.521; 95% confidence interval [CI], 1.001–6.303, P = 0.048), and higher visual CT scores (OR, 1.137; 95% CI, 1.042–1.236; P = 0.003) or higher total extent by AI measurement (OR, 1.048; 95% CI, 1.020–1.076; P < 0.001) were significantly associated with a severe clinical course. Conclusion: CT findings of COVID-19 pneumonia can be classified into OP, DAD, or bronchopneumonia patterns and all patients with DAD pattern were included in severe group. Elevated inflammatory markers and higher CT scores were found to be significant predictors of poor prognosis in patients with COVID-19 pneumonia.
Applications of Hydrochemical Models for the Assessment of Groundwater
( Jong Yeon Hwang ),( Sunhwa Park ),( Moon-su Kim ),( Hun-je Jo ),( Gyeong-mi Lee ),( In Kyu Shin ),( Sang Ho Jeon ),( Da Hee Song ),( Deok-hyun Kim ),( Tae-seung Kim ),( Hyen Mi Chung ),( Hyun-koo Ki 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.3
In this study, we focused on the evaluation and comparison of the physico-chemical characteristics and distribution of cations and anions in groundwater sampled from 2015 (485 samples) to 2016 (145 samples) in rural provinces of Korea. The major objectives of this study were as follows: 1) quality assessment of groundwater for special usage, such as agricultural or industrial applications; 2) the determination of groundwater types; and 3) the tracing of ion sources in groundwater. The assessment of the groundwater qualities from 2015 (n=480 samples) to 2016 (n=145 samples)) for agricultural usages were conducted using SAR (Sodium Adsorption Ratio), Na(%), RSC (Residual Sodium Carbonate), PI (Permeability Index), SSP (Soluble Sodium Percent), MH (Magnesium Hazard), KR (Kelly’s Ratio) and PS (Potential soil Salinity). Furthermore, the results of samples in 2015 were classified as SAR [Excellent (100%)], Sodium [(Excellent (34%), Good (55%), Permissible (9%), Doubtful (1.6%), Unsuitable (0.4%)], RSC [(Good (95.7%), Medium (3.5%), Bad (0.8%)], PI [(Excellent (40.6%), Good (59%), Unsuitable (0.4%)], SSP [(Excellent (26.3%), Good (59.8%), Fair (13.1%), Poor (0.8%)], MH [(Acceptable (94.4%), Non-Acceptable (5.6%)], and Kelly’s Ratio [(Permissible (93%), Non-Permissible (7%)], PS [(Excellent to Good (98%), Good to Injurious (1.2%), and Injurious to Unsatisfactory (0.2%)]. In addition, the groundwater sampled in 2016 was classified as SAR [Excellent (100%)], Sodium [Excellent (2.1%), Good (51.1%), Permissible (39.3%), Doubtful (6.2%), Unsuitable (0.7%)], RSC [Good (100%)], PI [Excellent (100%)], SSP [Excellent (0.7%), Good (37.2%), Fair (61.4%), Poor (0.7%)], MH [Acceptable (96.6%), Non- Acceptable (3.4%)], KR [Permissible (69.7%), (Non-Permissible (30.3%)], and PS [Excellent to Good (100%)]. Evaluations based on the Wilcox diagram were classified as “excellent to good” or “good to permissible” and the water quality evaluated using the U.S. Salinity Laboratory’s Diagram was classified as C1S1 (Excellent/ Excellent) and C2S1 (Good/Excellent) for all samples from 2015 to 2016. Moreover, in the application of two factors of the Langelier Saturation Index (LSI) and Corrosive ratio (CR), we obtained similar results for defining the suitability of groundwater for industrial purposes.