통합적 지적정보를 이용한 지가정보시스템 구축

황창섭,임인섭,최석근 충북대학교 건설기술연구소 2002 建設技術論文集 Vol.21 No.2

This study focused on construction of the land price information system which can efficiently, scientifically, and accurately manage the individual announced land price. The system is adapted to the test area(Kakyung-dong, Chongju city), whose master plan is being made. As a result, it is concluded that can improve the efficiency and accuracy of land price management. Also, users can easily use it without professional knowledge since if offer convenient user environment. Furthermore, it can rapidly search character and classification of land sue-zoning, the present condition of land price and so on. And it can cause the improvement of good quality service for people by issuing accurately and rapidly documents related to a city plan.

폐결핵치료 중인 환자에서 Rifampicin에 의해 유발된 위막성 대장염 2예

김봉진,권균홍,임창섭,김자영,홍정범,옥미선,배용목,김지연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

Pseudomembranous colitis (PMC) is a disease caused by Clostridium difficile proliferation. The causative drugs are clindamycin, third-generation cephalosporins, flouroquinolone and so on. Rifampicin has been reported as a cause of PMC in the 1980s, and the frequency of PMC is increasing because rifampicin is a first line drug for anti-tuberculosis therapy. Two patients were recently admitted to our hospital due to watery diarrhea for 1 month and they were diagnosed with PMC by sigmoidoscopy. Their onset age were 74, 72 years old and latent period of symptoms were 60, 129 days, respectively. In one case, the patient displayed coexisting hypertension and diabetes. The clinical symptoms improved after discontinuing the rifampicin and then administering oral metronidazole. We report here on two cases presumed to be rifampicin-induced PMC.

체외충격파 쇄석술 시행 후 5년 뒤 발생한 요관 협착 및 농신장 1예

이현승,권균홍,조용건,김봉진,임창섭,김자영,허동,임학 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

A 40-years-old woman was admitted to this hospital with flank pain and high grade fever for 2 weeks. As a matter of her past history, extracorporeal shock wave lithotripsy (ESWL) was performed for treatment of renal stones 5 years ago. Her abdominal CT findings were hydronephrosis with pyonephrosis and renal stones. Antibiotics administered for 5 days had no effects on her symptom improvement. A right ureteral stricture was noticed by ultrasonography follow up. We inserted double J stent and continued antibiotics therapy for 10 days, and then her fever was disappeared and flank pain was improved. ESWL is one of the most important treatment of renal and ureteral stone. However, its complications should not be negligible including bleeding, pain, ureteral obstruction, infection and so on. Complications of ESWL can be divided into acute and chronic courses. When we treat pyelonephritis patient with past history of ESWL, possibility of ureteral stricture must also be considered. In this study we report a case of pyelonephritis caused by ureteral stricture, possibly as a chronic complication of ESWL performed 5 years earlier

Comparison of Various Methods of Vessel Ligation

Chang-Sup Lim,Jin-Young Jang,Mee Joo Kang,Seung Eun Lee,Sun-Whe Kim 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.4

Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma

Lim, Sun Min,Choi, Jae Woo,Hong, Min Hee,Jung, Dongmin,Lee, Chang Young,Park, Seong Yong,Shim, Hyo Sup,Sheen, Seungsoo,Kwak, Kyeong Im,Kang, Dae Ryong,Cho, Byoung Chul,Kim, Hye Ryun Elsevier 2019 Lung cancer Vol.131 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>Radon, a natural radiation, is the leading environmental cause of lung cancer in never-smokers. However, the radon exposure impact on the mutational landscape and tumor mutation burden (TMB) of lung cancer in never-smokers has not been explored. The aim of this study was to investigate the mutational landscape of lung adenocarcinoma in never-smokers who were exposed to various degrees of residential radon.</P> <P><B>Materials and methods</B></P> <P>To investigate the effect of indoor radon exposure, we estimated the cumulative exposure to indoor radon in each house of patients with lung cancer with a never-smoking history. Patients with at least 2 year-duration of residence before the diagnosis of lung adenocarcinoma were included. Patients were subgrouped based on the median radon exposure level (48 Bq/m<SUP>3</SUP>): radon-high <I>vs.</I> radon-low and targeted sequencing of tumor and matched blood were performed in all patients.</P> <P><B>Results</B></P> <P>Among 41 patients with lung adenocarcinoma, the TMB was significantly higher in the radon-high group than it was in the radon-low group (mean 4.94 <I>vs</I>. 2.6 mutations/Mb, <I>P</I> = 0.01). The recurrence rates between radon-high and radon-low group did not differ significantly. Mutational signatures of radon-high tumors showed features associated with inactivity of the base excision repair and DNA replication machineries. The analysis of tumor evolutionary trajectories also suggested a series of mutagenesis induced by radon exposure. In addition, radon-high tumors revealed a significant protein-protein interaction of genes involved in DNA damage and repair (<I>P</I> < 0.001).</P> <P><B>Conclusions</B></P> <P>Indoor radon exposure increased the TMB in never-smoker patients with lung adenocarcinoma and their mutational signature was associated with defective DNA mismatch repair.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Radon is the leading environmental cause of lung cancer in never-smokers. </LI> <LI> We investigated the mutational landscape in never-smokers who were exposed to residential radon. </LI> <LI> Indoor radon exposure increased tumor mutation burden. </LI> </UL> </P>

The Implication of Cytogenetic Alterations in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm Identified by Fluorescence <i>In Situ</i> Hybridization and Their Potential Diagnostic Utility

Chang-Sup Lim,Kyongok Im,Dong Soon Lee,Wooil Kwon,Jae Ri Kim,Youngmin Han,Sun-Whe Kim,Jin-Young Jang 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4

Background/Aims: We investigated chromosomal aberrations in patients with pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) by fluorescence in situ hybridization (FISH) to identify cytogenetic changes and molecular markers that may be useful for preoperative diagnosis. Methods: Tissue samples from 48 PDAC and 17 IPMN patients were investigated by FISH analysis using probes targeting chromosomes 7q, 17p, 18q, 20q, and 21q and the pericentromeric region of chromosome 18 (CEP18). Results: The PDAC samples harbored 17p deletion (95.8%), 18q deletion (83.3%), CEP18 deletion (81.2%), 20q gain (81.2%), 21q deletion (77.1%), and 7q gain (70.8%). The IPMN samples had 17p deletion (94.1%), CEP18 deletion (94.1%), 21q deletion (70.6%), 18q deletion (58.8%), 20q gain (58.8%), and 7q gain (58.8%). A significant difference in CEP18 gain was identified between the PDAC and IPMN groups (p=0.029). Detection of 17p or 18q deletion had the highest diagnostic accuracy (80.0%) for PDAC. Conclusions: Chromosomal alterations were frequently identified in both PDAC and IPMN with similar patterns. CEP18 gain and 17p and 18q deletions might be involved in the later stages of PDAC tumorigenesis. Chromosome 17p and 18q deletions might be excellent diagnostic markers.

Analysis of Results after Liver Resection for Metastasis from Non-Colorectal and Non-Endocrine Tumors

( Chang-sup Lim ),( Hyo-sin Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Liver metastasis from colorecal cancer and endocrine organs relatively well researched and reported. However, there have been few reports on outcome of liver metastasis from noncolorectal and non endocrinee organs. In this study, we evaluate the prgosnostic factor among the patient who underwent hepatic resection with noncolorectal nonendocrine liver metastasis. Methods: The overall study period was September 2005 - July 2015. A total of 23 patients were selected from the two different hospital database and included in the analysis Patients and tumors characteristics were reported. Overall survival and subgroup analyses based on different characteristics were performed Results: Them Mean age of the patients was 57.9 ± 11.5 years. Male was 15 (65.2%) and female 8 (34.8%) Primary malignancies distribution resulted as follows: Genitourinary 7 (30.4%) Gastrointestinal 6 (26.1%) Pancreatic cancer 3 (13.0%) Lung cance 2 (8.7%) Breast cancer 2 (8.7%) CBD cancer 1 (4.3%) Melanoma 1 (4.3%) and Nasopharyngeal cancer 1 (4.3%) The overall survival rates at 1, 3, 5 years, were 68.5%, 38.0% and 19.0% respectively .Presence of Neoajuvant treatment and recurrence after hepatic resection were significant different between Death and Survival groups (21.4% vs 77.8%, P < 0.05), (78.6% vs 22.2%, P <0.05) and Overal survival rate was high in the patients with Neoajuvant treatment (1, 3 and 5yr: 88.9%, 77.8% and 51.9% vs 53.8%, 23.1% and 0 % P < 0.05) Conclusions: Neoajuvant treatemnt could have survival benefit in the patient of noncolorectal nonendocrine liver metastasis

Long Term Treatment Results and Prognostic Factors of Hilar Cholangiocarcinoma

Chang Sup Lim,Jin-Young Jang,Seung Eun Lee,Mee Joo Kang,Sun-Whe Kim 한국간담췌외과학회 2010 한국간담췌외과학회 학술대회지 Vol.2010 No.3

크론병 환자에서 아자치오프린 용량 적정은 어떻게 할 것인가? 백혈구 정상 하한치와 내약성에 근거한 최대 용량 적정 방법

임창섭 ( Chang Sup Lim ),문원 ( Won Moon ),박선자 ( Seun Ja Park ),박무인 ( Moo In Park ),최정문 ( Jeong Moon Choi ),유재훈 ( Jae Hoon Yoo ),김종빈 ( Jong Bin Kim ),이준식 ( Jun Sik Lee ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.2

목적: 일반적으로 크론병 치료에 있어 체중에 근거한 azathioprine (AZA) 사용(2.5 mg/kg/day)이 권고되고 있지만 많은 환자들에서 골수억제 부작용이 나타나고 있다. 이 연구에서는 크론병 환자에서 관해 유지를 위한 AZA의 최대용량을 체중에 근거하지 않고 백혈구의 정상 하한치에 근거해 적정하는 방법에 대해 알아보고자 하였다. 대상 및 방법: 고신대학교 복음병원에서 크론병으로 진단받은후 2010년에서 2011년까지 고신대학교 복음병원에서 추적 관찰하던 78명의 크론병 환자들 중 내약성과 4,000/mm3 이상의 백혈구 수치를 동시에 만족시키면서 스테로이드 없이 관해를 유지하는 AZA 최대용량을 사용하는 환자들을 연구에 포함시켰다. 적정된 최대용량의 AZA 용량과 체중과의 관계에 대해 살펴보았다. 결과: 총 42명의 환자가 연구에 포함되었으며, 그 중 32명이 남자였고 평균 나이는 31세였다. 내약성과 4,000/mm3 이상의 백혈구 수치를 동시에 만족시키면서 스테로이드 없이 관해를 유지하는 AZA 최대용량은 49.1 mg/day였다. 체중당 용량은 0.87 mg/kg/day였고, 체중당 AZA 용량은 체중(γ=?0.51, p=0.01), 체질량지수(γ=?0.33, p=0.034)와 음의 상관관계가 있었다. 40세 이하 군에서의 체중당 AZA의 용량은 40세 이상 군에서보다 의미있게 많았다(p=0.039). 결론: AZA의 용량을 체중에만 근거하여 결정하는 것은 저용량 또는 고용량의 AZA 용량을 초래하여, 결과적으로 부가적인 치료를 필요로 하거나 심각한 부작용을 일으킬 수도 있다. 따라서, 백혈구의 정상 하한치와 내약성에 근거한 최대용량 적정 방법은 AZA 용량 결정에 있어 새롭고 가치있는 방법이다. Background/Aims: Although general guidelines have suggested weight-based dosing of azathioprine (AZA, 2.5 mg/kg/day) for Crohn`s disease (CD), a substantial number of patients develop bone marrow suppression. The aim of this study was to evaluate the maximum dose of AZA not based on weight but titrated according to the lower limit of leukocyte count for maintaining remission in patients with CD. Methods: Among a total of seventy-eight patients with CD, who had been followed-up at Kosin University Gospel Hospital (Busan, Korea) from 2010 to 2011, those treated with the maximum dose of AZA meeting both drug-tolerability and leukocytes count of more than 4,000/mm3 for steroid-free maintaining remission were enrolled. The titrated maximum AZA dose and its relationship with weight were evaluated. Results: A total of 42 patients (male, 32 patients; mean age, 31 years) were enrolled. The maximum dose of AZA was 49.1 mg/day. The dose per weight was 0.87 mg/kg/day and negatively correlated with body weight (γ=?0.51, p=0.01) and BMI (γ=?0.33, p=0.034). AZA dose per weight in the below 40 years old group was significantly higher than that in the above 40 years old group (p=0.039). Conclusions: Dose decision of AZA based only on weight could put the patients to inappropriately low or high dose resulting in need of additional therapy or serious side effect, respectively. Therefore, the maximum dose-titration based on the lower limit of leukocyte count and tolerability is a novel and a valuable strategy in deciding the dose of thiopurines. (Korean J Gastroenterol 2013; 62:111-116)

Establishment of the Physicochemical and Radiological Database of Raw Materials and By-Products in Domestic Distribution

Chung-Sup Lim,Jong-Myoung Lim,Ji-Young Park,Kun Ho Chung,Chang-Jong Kim,Byung-Uck Chang,Young-Yong Ji 한국방사성폐기물학회 2016 방사성폐기물학회지 Vol.14 No.4

국내 유통중인 다양한 형태의 원료물질 또는 공정부산물들에 대한 물리적, 화학적 및 방사선적 특성을 평가하기 위해 약 220 여 개, 총 16 종의 표본 시료를 선정하였다. 해당 시료들에 대하여 LaBr3 섬광검출기를 이용한 에너지 스펙트럼 측정과 에너지 분산형 X-선 형광 분광기를 이용한 U, Th, K와 물질의 주요 성분 분석을 수행하였다. 그리고 HPGe 검출기를 이용하여234Th, 234mPa 및 214Bi 등의 우라늄 붕괴계열 핵종들과 228Ac, 212Pb 및 208Tl 등의 토륨 붕괴계열 핵종들 그리고 40K 등의 방사능농도를 분석함으로써 원료물질 및 공정부산물의 특성에 관한 기초자료를 수집하였다. 추가적으로 ROI구간별 계수율과 원소성분함량, 방사능농도와 같은 특성변수들 간의 상관관계를 분석함으로써 스크리닝 장비를 이용한 방사능 농도 분포 유추가능성을 평가하였다. 본 연구에서 구축된 특성 데이터베이스는 천연방사성핵종 분석을 위한 절차 및 방법을 수립하는데 유용한 정보를 제공하고, 천연방사성핵종 분석에 대한 정확성 및 재현성을 향상시킬 수 있을 것으로 판단된다. To evaluate the physicochemical and radiological properties of raw materials and by-products in domestic distribution, about 220 samples with 16 species were prepared. We measured the energy spectrum and the chemical content, such as U, Th, and K, using a LaBr3 scintillation detector and ED-XRF. In addition, HPGe detector was used to analyze the radioactivity of 234Th, 234mPa, and 214Bi in uranium decay series and 228Ac, 212Pb, and 208Tl in thorium decay series, and 40K. The correlation between characteristic variables, such as the count rate in several ROIs, chemical content, and radioactivity, was assessed to infer the radioactivity of natural radionuclides through a rapid screening method. Based on the results, a characteristic database for raw material and by-product in domestic distribution was established and it will provide useful information in the analysis procedure and improve the accuracy and reproducibility in the analysis of natural radionuclides.